{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:24:42Z","timestamp":1791267882987,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3693,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1038\/modpathol.2012.122","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T07:45:37Z","timestamp":1344584737000},"page":"1609-1622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"title":["MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma"],"prefix":"10.1016","volume":"25","author":[{"given":"Nicolai A","family":"Schultz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanni","family":"Willenbrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Roslind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Giese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"W\u00f8jdemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia S","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2012.122_bib1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(04)15841-8","article-title":"Pancreatic cancer","volume":"363","author":"Li","year":"2004","journal-title":"Lancet"},{"key":"10.1038\/modpathol.2012.122_bib2","first-page":"10","article-title":"Cancer Statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"10.1038\/modpathol.2012.122_bib3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/bjs.4484","article-title":"Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma","volume":"91","author":"Wagner","year":"2004","journal-title":"Br J Surg"},{"key":"10.1038\/modpathol.2012.122_bib4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00534-004-0895-6","article-title":"Pathogenesis and treatment of neoplastic diseases of the papilla of Vater: Kausch-Whipple procedure with lymph node dissection in cancer of the papilla of Vater","volume":"11","author":"Beger","year":"2004","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1038\/modpathol.2012.122_bib5","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/bjs.4787","article-title":"Presentation, treatment and outcome in patients with ampullary tumours","volume":"91","author":"Bettschart","year":"2004","journal-title":"Br J Surg"},{"key":"10.1038\/modpathol.2012.122_bib6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/1097-0142(20000801)89:3<508::AID-CNCR5>3.0.CO;2-D","article-title":"Noninvasive ad minimally invasive papillary carcinomas of the extrahepatic bileducts","volume":"89","author":"Albores-Saavedra","year":"2000","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2012.122_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1349-7006.1994.tb02077.x","article-title":"Different clinopathologic findings in two histologic types of carcinoma of papilla of vater","volume":"85","author":"Kimura","year":"1994","journal-title":"Jpn J Cancer Res"},{"key":"10.1038\/modpathol.2012.122_bib8","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/00000478-200407000-00005","article-title":"Carcinoma of the ampulla of Vater: comparative histologic\/immunohistochemical classification and follow-up","volume":"28","author":"Zhou","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2012.122_bib9","first-page":"649","article-title":"Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability","volume":"451","author":"Sessa","year":"2007","journal-title":"Wirchovs Arch"},{"key":"10.1038\/modpathol.2012.122_bib10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.bjc.6603023","article-title":"MicroRNAs in cell proliferation, cell death, and tumorigenesis","volume":"94","author":"Hwang","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1038\/modpathol.2012.122_bib11","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1001\/jama.297.17.1923","article-title":"Translating MicroRNA discovery into clinical biomarkers in cancer","volume":"297","author":"Waldman","year":"2007","journal-title":"JAMA"},{"key":"10.1038\/modpathol.2012.122_bib12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00268-008-9836-x","article-title":"MicroRNAs: control and loss of control in human physiology and disease","volume":"33","author":"Li","year":"2009","journal-title":"World J Surg"},{"key":"10.1038\/modpathol.2012.122_bib13","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1158\/1535-7163.MCT-08-0586","article-title":"MicroRNAs and cancer: past, present, and potential future","volume":"7","author":"Nelson","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/modpathol.2012.122_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2009.11.010","article-title":"MicroRNA in pancreatic cancer: pathological, diagnostic and therapeutic implications","volume":"292","author":"Rachagani","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1038\/modpathol.2012.122_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/path.2806","article-title":"MiRNAs in human cancer","volume":"223","author":"Farazi","year":"2010","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2012.122_bib16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1038\/modpathol.2012.122_bib17","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"MicroRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2012.122_bib18","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A mammalian microRNA expression atlas based on small RNA library sequencing","volume":"129","author":"Landgraf","year":"2007","journal-title":"Cell"},{"key":"10.1038\/modpathol.2012.122_bib19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nbt1392","article-title":"MicroRNAs accurately identify cancer tissue origin","volume":"26","author":"Rosenfeld","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1038\/modpathol.2012.122_bib20","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.297.17.1901","article-title":"MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis","volume":"297","author":"Bloomston","year":"2007","journal-title":"JAMA"},{"key":"10.1038\/modpathol.2012.122_bib21","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1038\/sj.onc.1210228","article-title":"expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma","volume":"26","author":"Szafranska","year":"2007","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2012.122_bib22","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11605-008-0584-x","article-title":"MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival","volume":"12","author":"Dillhoff","year":"2008","journal-title":"J Gastrointest Surg"},{"key":"10.1038\/modpathol.2012.122_bib23","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s00268-008-9833-0","article-title":"Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis","volume":"33","author":"Zhang","year":"2009","journal-title":"World J Surg"},{"key":"10.1038\/modpathol.2012.122_bib24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4161\/cbt.8.4.7338","article-title":"MicroRNA miR-155 is a biomarker of early pancreatic neoplasia","volume":"8","author":"Habbe","year":"2009","journal-title":"Cancer Biol Ther"},{"key":"10.1038\/modpathol.2012.122_bib25","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1200\/JCO.2009.24.0317","article-title":"MicroRNAs in cancer: small molecules with a huge impact","volume":"27","author":"Iorio","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2012.122_bib26","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1373\/clinchem.2008.109603","article-title":"Analysis of microRNAs in pancreatic fine-needle aspirates can classify benign and malignant tissues","volume":"54","author":"Szafranska","year":"2008","journal-title":"Clin Chem"},{"key":"10.1038\/modpathol.2012.122_bib27","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/ijc.22394","article-title":"Expression profiling identifies microRNA signature in pancreatic cancer","volume":"120","author":"Lee","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.2012.122_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1472-6750-7-36","article-title":"Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells","volume":"7","author":"Li","year":"2007","journal-title":"BMC Biotechnol"},{"key":"10.1038\/modpathol.2012.122_bib29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2353\/jmoldx.2008.080077","article-title":"An array-based analysis of microRNA expression comparing matched frozen and formalin-fixed paraffin-embedded human tissue samples","volume":"10","author":"Zhang","year":"2008","journal-title":"J Mol Diagn"},{"key":"10.1038\/modpathol.2012.122_bib30","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/jcb.21209","article-title":"Stromal biology of pancreatic cancer","volume":"101","author":"Chu","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1038\/modpathol.2012.122_bib31","unstructured":"Hamilton SR, Aaltonen LA (editors). World Health Organisation Classification of Tumors. Pathology and Genetics of Tumors of the Gastrointestinal Tract. IARC Press Lyon, 2000, 219\u2013250."},{"key":"10.1038\/modpathol.2012.122_bib32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2105-10-110","article-title":"Data-driven normalization strategies for high-throughput quantitative RT-PCR","volume":"10","author":"Mar","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1038\/modpathol.2012.122_bib33","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/biostatistics\/kxm045","article-title":"Sparse inverse covariance estimation with the graphical lasso","volume":"9","author":"Friedman","year":"2008","journal-title":"Biostatistics"},{"key":"10.1038\/modpathol.2012.122_bib34","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3349\/ymj.2010.51.5.622","article-title":"MicroRNAs in human embryonic and cancer stem cells","volume":"51","author":"Navarro","year":"2010","journal-title":"Yonsei Med J"},{"key":"10.1038\/modpathol.2012.122_bib35","doi-asserted-by":"crossref","first-page":"843","DOI":"10.4161\/cc.8.6.7907","article-title":"Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression","volume":"8","author":"Peter","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1038\/modpathol.2012.122_bib36","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1","volume":"10","author":"Gregory","year":"2008","journal-title":"Nat Cell Biol"},{"key":"10.1038\/modpathol.2012.122_bib37","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1038\/modpathol.2012.122_bib38","doi-asserted-by":"crossref","first-page":"e10630","DOI":"10.1371\/journal.pone.0010630","article-title":"Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer","volume":"14","author":"Hwang","year":"2010","journal-title":"PLoS One"},{"key":"10.1038\/modpathol.2012.122_bib39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/modpathol.2011.142","article-title":"Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma","volume":"25","author":"Nagao","year":"2012","journal-title":"Modern Pathol"},{"key":"10.1038\/modpathol.2012.122_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1582-4934.2008.00556.x","article-title":"MiR-21: a small multi-faceted RNA","volume":"13","author":"Krichevsky","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1038\/modpathol.2012.122_bib41","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/carcin\/bgq160","article-title":"The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS","volume":"31","author":"Zhao","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1038\/modpathol.2012.122_bib42","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1373\/clinchem.2010.144709","article-title":"The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis","volume":"56","author":"Hanoun","year":"2010","journal-title":"Clin Chem"},{"key":"10.1038\/modpathol.2012.122_bib43","first-page":"1819","article-title":"A pancreatic cancer-specific expression profile","volume":"13","author":"Gress","year":"1996","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2012.122_bib44","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature10888","article-title":"The microcosmos of cancer","volume":"482","author":"Lujambio","year":"2012","journal-title":"Nature"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2012122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2012122","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222029490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222029490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2012122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:05:20Z","timestamp":1760231120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222029490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0893395222029490"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2012.122","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2012.122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}