{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:37:23Z","timestamp":1792039043219,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3207,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1038\/modpathol.2013.131","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T07:40:16Z","timestamp":1385106016000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Stromal signatures in endometrioid endometrial carcinomas"],"prefix":"10.1016","volume":"27","author":[{"given":"I\u00f1igo","family":"Espinosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Catasus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"D\u2032Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mozos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Pedrola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"B\u00e9rtolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Franco","family":"Zannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"van de Rijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Matias-Guiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2013.131_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1038\/modpathol.2013.131_bib2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/35094059","article-title":"Putting tumours in context","volume":"1","author":"Bissell","year":"2001","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2013.131_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/excr.2000.5133","article-title":"Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation","volume":"264","author":"Elenbaas","year":"2001","journal-title":"Exp Cell Res"},{"key":"10.1038\/modpathol.2013.131_bib4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrc1477","article-title":"Friends or foes - bipolar effects of the tumour stroma in cancer","volume":"4","author":"Mueller","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2013.131_bib5","first-page":"5002","article-title":"Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium","volume":"59","author":"Olumi","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2013.131_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1011369026168","article-title":"Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence","volume":"6","author":"Tlsty","year":"2001","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10.1038\/modpathol.2013.131_bib7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1038\/modpathol.2013.131_bib8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.humpath.2004.02.007","article-title":"Prognostic parameters of endometrial carcinoma","volume":"35","author":"Prat","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.131_bib9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1158\/1078-0432.CCR-08-1283","article-title":"The macrophage colony-stimulating factor 1 response signature in breast carcinoma","volume":"15","author":"Beck","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2013.131_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/labinvest.2008.31","article-title":"The fibromatosis signature defines a robust stromal response in breast carcinoma","volume":"88","author":"Beck","year":"2008","journal-title":"Lab Invest"},{"key":"10.1038\/modpathol.2013.131_bib11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10549-009-0654-0","article-title":"Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ","volume":"123","author":"Sharma","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1038\/modpathol.2013.131_bib12","doi-asserted-by":"crossref","first-page":"10669","DOI":"10.1158\/0008-5472.CAN-05-2620","article-title":"High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma","volume":"65","author":"Oda","year":"2005","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2013.131_bib13","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.humpath.2006.05.007","article-title":"PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations","volume":"37","author":"Velasco","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.131_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/modpathol.3800992","article-title":"PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters","volume":"21","author":"Catasus","year":"2008","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2013.131_bib15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/path.1666","article-title":"Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma","volume":"204","author":"Pallares","year":"2004","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2013.131_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc780","article-title":"NF-kappaB in cancer: from innocent bystander to major culprit","volume":"2","author":"Karin","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2013.131_bib17","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri1703","article-title":"NF-kappaB: linking inflammation and immunity to cancer development and progression","volume":"5","author":"Karin","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/modpathol.2013.131_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9440(10)63279-8","article-title":"The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status","volume":"165","author":"West","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2013.131_bib19","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1126\/science.1096502","article-title":"High frequency of mutations of the PIK3CA gene in human cancers","volume":"304","author":"Samuels","year":"2004","journal-title":"Science"},{"key":"10.1038\/modpathol.2013.131_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.leukres.2006.04.011","article-title":"Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene","volume":"31","author":"Muller","year":"2007","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.2013.131_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.gde.2004.12.003","article-title":"Tumor-stroma interactions","volume":"15","author":"Bhowmick","year":"2005","journal-title":"Curr Opin Genet Dev"},{"key":"10.1038\/modpathol.2013.131_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.11335","article-title":"Role of the stromal microenvironment in carcinogenesis of the prostate","volume":"107","author":"Cunha","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.2013.131_bib23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature06188","article-title":"Mesenchymal stem cells within tumour stroma promote breast cancer metastasis","volume":"449","author":"Karnoub","year":"2007","journal-title":"Nature"},{"key":"10.1038\/modpathol.2013.131_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.pathol.1.110304.100224","article-title":"Tumor stroma and regulation of cancer development","volume":"1","author":"Tlsty","year":"2006","journal-title":"Annu Rev Pathol"},{"key":"10.1038\/modpathol.2013.131_bib25","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1371\/journal.pbio.0030187","article-title":"Determination of stromal signatures in breast carcinoma","volume":"3","author":"West","year":"2005","journal-title":"PLoS Biol"},{"key":"10.1038\/modpathol.2013.131_bib26","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1158\/1078-0432.CCR-10-0540","article-title":"A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas","volume":"17","author":"Rudd","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2013.131_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/gyno.1994.1158","article-title":"Traditional and nontraditional histopathologic predictors of recurrence in uterine endometrioid adenocarcinoma","volume":"54","author":"Lee","year":"1994","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.2013.131_bib28","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/00000478-198810000-00003","article-title":"Diffusely infiltrating adenocarcinoma of the endometrium. A subtype with poor prognosis","volume":"12","author":"Mittal","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.131_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00000478-199901000-00007","article-title":"Diffusely infiltrative endometrial adenocarcinoma: an adenoma malignum pattern of myoinvasion","volume":"23","author":"Longacre","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.131_bib30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/path.2738","article-title":"Variations in stromal signatures in breast and colorectal cancer metastases","volume":"222","author":"Webster","year":"2010","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2013.131_bib31","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1097\/PAS.0b013e3181f32168","article-title":"Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role","volume":"34","author":"Espinosa","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.131_bib32","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.2741\/2327","article-title":"Targeting the tumor microenvironment","volume":"12","author":"Kenny","year":"2007","journal-title":"Front Biosci"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2013131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2013131","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222018555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222018555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2013131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:54:21Z","timestamp":1760230461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222018555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0893395222018555"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2013.131","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stromal signatures in endometrioid endometrial carcinomas","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2013.131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}