{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:07:14Z","timestamp":1790140034685,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3207,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1038\/modpathol.2013.166","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T07:44:29Z","timestamp":1379663069000},"page":"621-630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker"],"prefix":"10.1016","volume":"27","author":[{"given":"Luisa F","family":"Escobar-Hoyos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie-Ann","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonius","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily I","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R","family":"Shroyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2013.166_bib1","first-page":"10","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"10.1038\/modpathol.2013.166_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/jnci\/djq562","article-title":"Human papillomavirus testing in the prevention of cervical cancer","volume":"103","author":"Schiffman","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/modpathol.2013.166_bib3","first-page":"S3","article-title":"Natural history of HPV infections","volume":"58","author":"Wright","year":"2009","journal-title":"J Fam Pract"},{"key":"10.1038\/modpathol.2013.166_bib4","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/PAI.0b013e3182167c66","article-title":"Dual stain immunohistochemical localization of p16INK4A and ki-67: a synergistic approach to identify clinically significant cervical mucosal lesions","volume":"19","author":"Samarawardana","year":"2011","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/modpathol.2013.166_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/jclinpath-2011-200362","article-title":"P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas","volume":"65","author":"Huang","year":"2012","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2013.166_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000096018","article-title":"P16-immunostaining pattern as a predictive marker of lymph node metastasis and recurrence in early uterine cervical cancer","volume":"73","author":"Yamazaki","year":"2006","journal-title":"Pathobiology"},{"key":"10.1038\/modpathol.2013.166_bib7","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2559.2006.02510.x","article-title":"Loss of p16 INK4 expression in invasive squamous cell carcinoma of the uterine cervix is an adverse prognostic marker","volume":"49","author":"Masoudi","year":"2006","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2013.166_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0090-8258(03)00010-6","article-title":"Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis","volume":"89","author":"van de Putte","year":"2003","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.2013.166_bib9","first-page":"573","article-title":"Arguments for a magnetic resonance imaging-assisted FIGO staging system for cervical cancer","volume":"15","author":"Narayan","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"10.1038\/modpathol.2013.166_bib10","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1001\/jama.298.19.2289","article-title":"Association of posttherapy positron emission tomography with tumor response and survival in cervical carcinoma","volume":"298","author":"Schwarz","year":"2007","journal-title":"JAMA"},{"key":"10.1038\/modpathol.2013.166_bib11","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1200\/JCO.2004.07.197","article-title":"Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01","volume":"22","author":"Eifel","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.166_bib12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ygyno.2012.08.036","article-title":"FOXM1 promotes tumor cell invasion and correlates with poor prognosis in early-stage cervical cancer","volume":"127","author":"He","year":"2012","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.2013.166_bib13","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/annonc\/mdr290","article-title":"Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer","volume":"23","author":"Li","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1038\/modpathol.2013.166_bib14","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1200\/JCO.2007.11.2995","article-title":"Role of human papillomavirus genotype in prognosis of early-stage cervical cancer undergoing primary surgery","volume":"25","author":"Lai","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.166_bib15","first-page":"4693","article-title":"Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer","volume":"60","author":"Birner","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2013.166_bib16","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM","volume":"17","author":"Edge","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1038\/modpathol.2013.166_bib17","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/pr060682a","article-title":"Optimization of mass spectrometry-compatible surfactants for shotgun proteomics","volume":"6","author":"Chen","year":"2007","journal-title":"J Proteome Res"},{"key":"10.1038\/modpathol.2013.166_bib18","doi-asserted-by":"crossref","first-page":"D71","DOI":"10.1093\/nar\/gkr981","article-title":"Reorganizing the protein space at the Universal Protein Resource (UniProt)","volume":"40","author":"UniProtConsortium","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/modpathol.2013.166_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","article-title":"Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry","volume":"4","author":"Elias","year":"2007","journal-title":"Nat Methods"},{"key":"10.1038\/modpathol.2013.166_bib20","doi-asserted-by":"crossref","unstructured":"Lundgren DH, Martinez H, Wright ME et al. Protein identification using Sorcerer 2 and SEQUEST. Curr Protoc Bioinformatics 2009, Chapter 13: Unit 13.3.","DOI":"10.1002\/0471250953.bi1303s28"},{"key":"10.1038\/modpathol.2013.166_bib21","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/ac00104a020","article-title":"Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database","volume":"67","author":"Eng","year":"1995","journal-title":"Anal Chem"},{"key":"10.1038\/modpathol.2013.166_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.2013.166_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"Youden","year":"1950","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.166_bib24","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1021\/ac0498563","article-title":"A model for random sampling and estimation of relative protein abundance in shotgun proteomics","volume":"76","author":"Liu","year":"2004","journal-title":"Anal Chem"},{"key":"10.1038\/modpathol.2013.166_bib25","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/cncr.22171","article-title":"Validation of a novel immunocytochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression in cervical cytology","volume":"108","author":"Shroyer","year":"2006","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.166_bib26","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.5858\/2008-132-1648-PCIAHH","article-title":"ProEx C immunocytochemistry and high-risk human papillomavirus DNA testing in papanicolaou tests with atypical squamous cell (ASC-US) cytology: correlation study with histologic biopsy","volume":"132","author":"Siddiqui","year":"2008","journal-title":"Arch Pathol Lab Med"},{"issue":"Suppl 5","key":"10.1038\/modpathol.2013.166_bib27","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","article-title":"The biology and life-cycle of human papillomaviruses","volume":"30","author":"Doorbar","year":"2012","journal-title":"Vaccine"},{"key":"10.1038\/modpathol.2013.166_bib28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.5858\/2008-132-795-TUOPID","article-title":"The utility of p16(Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix","volume":"132","author":"Redman","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.2013.166_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/PGP.0b013e31817e9ac5","article-title":"p16 INK4a immunostaining identifies occult CIN lesions in HPV-positive women","volume":"28","author":"Ordi","year":"2009","journal-title":"Int J Gynecol Pathol"},{"key":"10.1038\/modpathol.2013.166_bib30","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/00000478-200211000-00001","article-title":"p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia","volume":"26","author":"Klaes","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.166_bib31","first-page":"601","article-title":"Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia","volume":"140","author":"Smedts","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2013.166_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/jcp.52.1.41","article-title":"Differential expression of keratins 10, 17, and 19 in normal cervical epithelium, cervical intraepithelial neoplasia, and cervical carcinoma","volume":"52","author":"Maddox","year":"1999","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2013.166_bib33","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.humpath.2004.01.021","article-title":"Keratins 8, 10, 13, and 17 are useful markers in the diagnosis of human cervix carcinomas","volume":"35","author":"Carrilho","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.166_bib34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ygyno.2007.11.042","article-title":"Coordinate expression of cytokeratin 8 and cytokeratin 17 immunohistochemical staining in cervical intraepithelial neoplasia and cervical squamous cell carcinoma: an immunohistochemical analysis and review of the literature","volume":"108","author":"Ikeda","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.2013.166_bib35","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2559.2007.02652.x","article-title":"CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III)","volume":"50","author":"Regauer","year":"2007","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2013.166_bib36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00418-008-0435-6","article-title":"The human keratins: biology and pathology","volume":"129","author":"Moll","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"10.1038\/modpathol.2013.166_bib37","doi-asserted-by":"crossref","unstructured":"Ide M, Kato T, Ogata K et al. Keratin 17 expression correlates with tumor progression and poor prognosis in gastric adenocarcinoma. Ann Surg Oncol 2012.","DOI":"10.1245\/s10434-012-2437-9"},{"key":"10.1038\/modpathol.2013.166_bib38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s004280050226","article-title":"Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas","volume":"433","author":"Malzahn","year":"1998","journal-title":"Virchows Arch"},{"key":"10.1038\/modpathol.2013.166_bib39","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/S0002-9440(10)64476-8","article-title":"Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome","volume":"161","author":"van de Rijn","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2013.166_bib40","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/PAS.0b013e3181e02f45","article-title":"Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers","volume":"34","author":"Thike","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.166_bib41","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/0895-4356(95)00510-2","article-title":"Importance of events per independent variable in proportional hazards analysis. I. Background, goals, and general strategy","volume":"48","author":"Concato","year":"1995","journal-title":"J Clin Epidemiol"},{"key":"10.1038\/modpathol.2013.166_bib42","first-page":"1129","article-title":"Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteri","volume":"22","author":"Feng","year":"2009","journal-title":"Oncol Rep"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2013166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2013166","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222018543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222018543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2013166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:54:16Z","timestamp":1760230456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222018543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0893395222018543"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2013.166","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2013.166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}