{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:13:48Z","timestamp":1791972828970,"version":"4.3.4"},"reference-count":80,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3238,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1038\/modpathol.2013.80","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T07:40:40Z","timestamp":1378453240000},"page":"472-491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":309,"title":["Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium"],"prefix":"10.1016","volume":"27","author":[{"given":"Dolores","family":"L\u00f3pez-Terrada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T","family":"de D\u00e1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Czauderna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiso","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Katzenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Leuschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Malogolowkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecka","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarangarajan","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Fabr\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton J","family":"Finegold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2013.80_bib1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/jhep.2003.50375","article-title":"Epidemiology of primary hepatic malignancies in U.S. children","volume":"38","author":"Darbari","year":"2003","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2013.80_bib2","series-title":"Pathology of Pediatric Gastrointestinal and Liver Disease","article-title":"Hepatic tumors in childhood","author":"Finegold","year":"2004"},{"key":"10.1038\/modpathol.2013.80_bib3","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/1097-0142(20011215)92:12<3130::AID-CNCR10115>3.0.CO;2-#","article-title":"Small cell undifferentiated histology in hepatoblastoma may be unfavorable","volume":"92","author":"Haas","year":"2001","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.80_bib4","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/1097-0142(19890901)64:5<1082::AID-CNCR2820640520>3.0.CO;2-G","article-title":"Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma","volume":"64","author":"Haas","year":"1989","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.80_bib5","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1200\/JCO.2000.18.14.2665","article-title":"Randomized comparison of cisplatin\/vincristine\/fluorouracil and cisplatin\/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group","volume":"18","author":"Ortega","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.80_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0046-8177(83)80005-7","article-title":"Primary hepatic tumors of childhood","volume":"14","author":"Weinberg","year":"1983","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.80_bib7","series-title":"Hepatic Tumors in Children","author":"Stocker","year":"2001"},{"key":"10.1038\/modpathol.2013.80_bib8","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1002\/1097-0142(19860601)57:11<2168::AID-CNCR2820571115>3.0.CO;2-M","article-title":"Teratoid hepatoblastoma. The nosologic dilemma of solid embryonic neoplasms of childhood","volume":"57","author":"Manivel","year":"1986","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.80_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/1097-0142(1967)20:3<396::AID-CNCR2820200308>3.0.CO;2-O","article-title":"Hepatoblastoma and hepatocarcinoma in infancy and childhood. Report of 47 cases","volume":"20","author":"Ishak","year":"1967","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.80_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/1097-0142(197003)25:3<551::AID-CNCR2820250309>3.0.CO;2-5","article-title":"Histologic classification of liver-cell carcinoma in infancy and childhood and its clinical evaluation. A study of 70 cases collected in Japan","volume":"25","author":"Kasai","year":"1970","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.80_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1055\/s-2008-1066170","article-title":"Liver tumors in neonates and very young infants: diagnostic pitfalls and therapeutic problems","volume":"5","author":"von Schweinitz","year":"1995","journal-title":"Eur J Pediatr Surg"},{"key":"10.1038\/modpathol.2013.80_bib12","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1200\/JCO.2010.29.3837","article-title":"Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group","volume":"29","author":"Malogolowkin","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.80_bib13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cld.2011.03.011","article-title":"Liver neoplasia in children","volume":"15","author":"Hadzic","year":"2011","journal-title":"Clin Liver Dis"},{"key":"10.1038\/modpathol.2013.80_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/PAS.0b013e3181ce5f1e","article-title":"Effects of neoadjuvant chemotherapy on hepatoblastoma: a morphologic and immunohistochemical study","volume":"34","author":"Wang","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.80_bib15","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/mpo.10177","article-title":"Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin","volume":"39","author":"Prokurat","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1038\/modpathol.2013.80_bib16","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1365-2559.2003.01615.x","article-title":"Stages of normal and aberrant intrahepatic bile duct development in a mixed hepatoblastoma","volume":"42","author":"Libbrecht","year":"2003","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2013.80_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/mpo.10173","article-title":"Hepatoblastoma with cholangioblastic features (\u2018cholangioblastic hepatoblastoma') and other liver tumors with bimodal differentiation in young patients","volume":"39","author":"Zimmermann","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1038\/modpathol.2013.80_bib18","series-title":"Pediatric Liver Tumors","first-page":"83","article-title":"Pathology of pediatric liver tumors","author":"Zimmermann","year":"2011"},{"key":"10.1038\/modpathol.2013.80_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/01.pas.0000147398.03015.9e","article-title":"Nested stromal epithelial tumor of the liver: six cases of a distinctive pediatric neoplasm with frequent calcifications and association with cushing syndrome","volume":"29","author":"Heerema-McKenney","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.80_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000478-200501000-00001","article-title":"Desmoplastic nested spindle cell tumor of liver: report of four cases of a proposed new entity","volume":"29","author":"Hill","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.80_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00000478-198210000-00002","article-title":"Hepatoblastoma. Attempt at characterization of histologic subtypes","volume":"6","author":"Gonzalez-Crussi","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2013.80_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.humpath.2007.06.006","article-title":"Expression of glypican 3 in hepatoblastoma: an immunohistochemical study of 65 cases","volume":"39","author":"Zynger","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.80_bib23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejca.2007.11.022","article-title":"Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience","volume":"44","author":"De Ioris","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1038\/modpathol.2013.80_bib24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/pbc.21834","article-title":"Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors","volume":"52","author":"Trobaugh-Lotrario","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/modpathol.2013.80_bib25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1200\/JCO.1993.11.1.96","article-title":"vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study","volume":"11","author":"Douglass","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.80_bib26","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/1097-0142(19930201)71:3<859::AID-CNCR2820710333>3.0.CO;2-T","article-title":"Treatment of pulmonary metastases of initial stage I hepatoblastoma in childhood. Report from the Childrens Cancer Group","volume":"71","author":"Feusner","year":"1993","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.80_bib27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cncr.10632","article-title":"Pretreatment prognostic factors and treatment results in children with hepatoblastoma: a report from the German Cooperative Pediatric Liver Tumor Study HB 94","volume":"95","author":"Fuchs","year":"2002","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2013.80_bib28","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.ejca.2011.12.011","article-title":"Prognostic stratification for children with hepatoblastoma: The SIOPEL experience","volume":"48","author":"Maibach","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1038\/modpathol.2013.80_bib29","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/pbc.22088","article-title":"Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children's Oncology Group","volume":"53","author":"Meyers","year":"2009","journal-title":"Pediatr Blood Cancer"},{"issue":"5","key":"10.1038\/modpathol.2013.80_bib30","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/labinvest.2010.66","article-title":"Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets","volume":"90","author":"Gadd","year":"2010","journal-title":"Laboratory Investigation"},{"key":"10.1038\/modpathol.2013.80_bib31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/pbc.21893","article-title":"SMARCB1\/INI1 alterations and hepatoblastoma: another extrarenal rhabdoid tumor revealed?","volume":"52","author":"Russo","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/modpathol.2013.80_bib32","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2350\/06-08-0155.1","article-title":"Malignant rhabdoid tumor mimicking hepatoblastoma: a case report and literature review","volume":"10","author":"Wagner","year":"2007","journal-title":"Pediatr Dev Pathol"},{"key":"10.1038\/modpathol.2013.80_bib33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/pbc.22857","article-title":"Rhabdoid tumors of the liver: rare, aggressive, and poorly responsive to standard cytotoxic chemotherapy","volume":"57","author":"Trobaugh-Lotrario","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/modpathol.2013.80_bib34","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.ejca.2005.02.035","article-title":"The emerging family of hepatoblastoma tumours: from ontogenesis to oncogenesis","volume":"41","author":"Zimmermann","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1038\/modpathol.2013.80_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/15513819209023293","article-title":"Hepatoblastoma: the prognostic significance of histologic type","volume":"12","author":"Conran","year":"1992","journal-title":"Pediatr Pathol"},{"key":"10.1038\/modpathol.2013.80_bib36","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1001\/archinte.160.21.3227","article-title":"Risk factors for the rising rates of primary liver cancer in the United States","volume":"160","author":"El-Serag","year":"2000","journal-title":"Arch Int Med"},{"key":"10.1038\/modpathol.2013.80_bib37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-0031-1272835","article-title":"Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors","volume":"31","author":"Ward","year":"2011","journal-title":"Semin Liver Dis"},{"key":"10.1038\/modpathol.2013.80_bib38","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/pbc.22893","article-title":"Critical review of controversial issues in the management of advanced pediatric liver tumors","volume":"56","author":"Gupta","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/modpathol.2013.80_bib39","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1200\/JCO.2009.22.4857","article-title":"Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study","volume":"28","author":"Zsiros","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.80_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/mpo.10178","article-title":"Adult type vs childhood hepatocellular carcinoma\u2014are they the same or different lesions? Biology, natural history, prognosis, and treatment","volume":"39","author":"Czauderna","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1038\/modpathol.2013.80_bib41","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2013.80_bib42","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1200\/JCO.2002.07.400","article-title":"Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study","volume":"20","author":"Katzenstein","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.80_bib43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/modpathol.2008.178","article-title":"Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization","volume":"22","author":"Kakar","year":"2009","journal-title":"Modern pathol"},{"key":"10.1038\/modpathol.2013.80_bib44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/pbc.24038","article-title":"Tumor necrosis predicts survival following neo-adjuvant chemotherapy for hepatoblastoma","volume":"59","author":"Venkatramani","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1038\/modpathol.2013.80_bib45","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1111\/j.1399-3046.2008.01123.x","article-title":"The role of liver transplantation for hepatic adenomatosis in the pediatric population: case report and review of the literature","volume":"14","author":"Wellen","year":"2010","journal-title":"Pediatr Transpl"},{"key":"10.1038\/modpathol.2013.80_bib46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.21068","article-title":"Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC","volume":"43","author":"Zucman-Rossi","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2013.80_bib47","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jhep.2006.12.007","article-title":"Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update","volume":"46","author":"Bioulac-Sage","year":"2007","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.2013.80_bib48","series-title":"Liver Disease in Children","article-title":"Tumors of the liver","author":"Lopez-Terrada","year":"2012"},{"key":"10.1038\/modpathol.2013.80_bib49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpedsurg.2006.09.041","article-title":"Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry","volume":"42","author":"Christison-Lagay","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1038\/modpathol.2013.80_bib50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.humpath.2003.09.017","article-title":"GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation","volume":"35","author":"Mo","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.80_bib51","first-page":"459","article-title":"Infantile hemangioendothelioma with a highly elevated serum alpha-fetoprotein level","volume":"45","author":"Han","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"10.1038\/modpathol.2013.80_bib52","unstructured":"Available from:www.childrenshospital.org\/cfapps\/liverhem\/index.cfm."},{"key":"10.1038\/modpathol.2013.80_bib53","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/MPG.0b013e318230146c","article-title":"Widening spectrum of liver angiosarcoma in children","volume":"53","author":"Ackermann","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1038\/modpathol.2013.80_bib54","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3109\/08880018.2011.584609","article-title":"Not all hemangiomas are benign\u2014epithelioid hemangioendothelioma: an aggressive vascular lesion in children","volume":"28","author":"Eckardt","year":"2011","journal-title":"Pediatr hematol oncol"},{"key":"10.1038\/modpathol.2013.80_bib55","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.humpath.2011.06.016","article-title":"Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver","volume":"43","author":"Levy","year":"2012","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.80_bib56","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s100249900060","article-title":"Third report of t(19q)(13.4) in mesenchymal hamartoma of liver with comments on link to embryonal sarcoma","volume":"1","author":"Bove","year":"1998","journal-title":"Pediatr Dev Pathol"},{"key":"10.1038\/modpathol.2013.80_bib57","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.prp.2009.01.003","article-title":"Pediatric extra-renal rhabdoid tumors with unusual morphology: a diagnostic pitfall for small biopsies","volume":"205","author":"Alaggio","year":"2009","journal-title":"Pathol res prac"},{"key":"10.1038\/modpathol.2013.80_bib58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0165-4608(97)00432-9","article-title":"Cytogenetic analysis of hepatoblastoma: hypothesis of cytogenetic evolution in such tumors and results of a multicentric study","volume":"104","author":"Sainati","year":"1998","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2013.80_bib59","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1098-2264(199708)19:4<291::AID-GCC13>3.0.CO;2-J","article-title":"The first recurring chromosome translocation in hepatoblastoma: der(4)t(1;4)(q12;q34)","volume":"19","author":"Schneider","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2013.80_bib60","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/gcc.20227","article-title":"Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21","volume":"44","author":"Tomlinson","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.2013.80_bib61","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/gut.39.6.867","article-title":"Hepatoblastoma and APC gene mutation in familial adenomatous polyposis","volume":"39","author":"Giardiello","year":"1996","journal-title":"Gut"},{"key":"10.1038\/modpathol.2013.80_bib62","first-page":"269","article-title":"Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene","volume":"59","author":"Koch","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2013.80_bib63","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1038\/sj.onc.1205591","article-title":"Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas","volume":"21","author":"Taniguchi","year":"2002","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2013.80_bib64","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/hep.22649","article-title":"Blocking the hedgehog pathway inhibits hepatoblastoma growth","volume":"49","author":"Eichenmuller","year":"2009","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2013.80_bib65","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1038\/sj.bjc.6604754","article-title":"Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma","volume":"99","author":"Honda","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1038\/modpathol.2013.80_bib66","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.humpath.2008.07.022","article-title":"Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors","volume":"40","author":"Lopez-Terrada","year":"2009","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.80_bib67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s100380300008","article-title":"Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK\/STAT inhibitor, in human hepatoblastomas","volume":"48","author":"Nagai","year":"2003","journal-title":"J Hum Genet"},{"key":"10.1038\/modpathol.2013.80_bib68","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1055\/s-2008-1071139","article-title":"The occurrence of liver growth factor in hepatoblastoma","volume":"8","author":"von Schweinitz","year":"1998","journal-title":"Eur J Pediatr Surg"},{"key":"10.1038\/modpathol.2013.80_bib69","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.ejca.2011.12.032","article-title":"Rapamycin blocks hepatoblastoma growth in vitroin vivo implicating new treatment options in high-risk patients","volume":"48","author":"Wagner","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1038\/modpathol.2013.80_bib70","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.humpath.2008.10.022","article-title":"Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways","volume":"40","author":"Adesina","year":"2009","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2013.80_bib71","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccr.2008.11.002","article-title":"Hepatic stem-like phenotype and interplay of Wnt\/beta-catenin and Myc signaling in aggressive childhood liver cancer","volume":"14","author":"Cairo","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1038\/modpathol.2013.80_bib72","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/hep.21328","article-title":"Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas","volume":"44","author":"Luo","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2013.80_bib73","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0165-4608(03)00065-7","article-title":"Transcriptional profiling in hepatoblastomas using high-density oligonucleotide DNA array","volume":"145","author":"Nagata","year":"2003","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.2013.80_bib74","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1038\/sj.onc.1207782","article-title":"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas","volume":"23","author":"Yamada","year":"2004","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2013.80_bib75","doi-asserted-by":"crossref","first-page":"20471","DOI":"10.1073\/pnas.1009009107","article-title":"Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer","volume":"107","author":"Cairo","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2013.80_bib76","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1200\/JCO.2005.02.6013","article-title":"Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma","volume":"24","author":"Malogolowkin","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.80_bib77","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa0810613","article-title":"Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma","volume":"361","author":"Perilongo","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2013.80_bib78","doi-asserted-by":"crossref","first-page":"520","DOI":"10.5858\/2007-131-520-PFTEOS","article-title":"Protocol for the examination of specimens from pediatric patients with hepatoblastoma","volume":"131","author":"Finegold","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.2013.80_bib79","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1200\/JCO.2005.07.145","article-title":"Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study","volume":"23","author":"Aronson","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2013.80_bib80","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/138920107780487456","article-title":"Drug resistance in hepatoblastoma","volume":"8","author":"Warmann","year":"2007","journal-title":"Curr Pharm Biotechnol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol201380.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol201380","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222018385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222018385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol201380.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:54:01Z","timestamp":1760230441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222018385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0893395222018385"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2013.80","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2013.80","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}