{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:08:52Z","timestamp":1787987332526,"version":"build-2784847793"},"reference-count":63,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2993,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/modpathol.2014.48","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T08:14:34Z","timestamp":1397808874000},"page":"1540-1548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular characteristics of urothelial neoplasms in children and young adults: a subset of tumors from young patients harbors chromosomal abnormalities but not FGFR3 or TP53 gene mutations"],"prefix":"10.1016","volume":"27","author":[{"given":"Sean R","family":"Williamson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Montironi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Eble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lopez-Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeboye O","family":"Osunkoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael O","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2014.48_bib1","series-title":"Bladder Pathology","author":"Cheng","year":"2012"},{"key":"10.1038\/modpathol.2014.48_bib2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.urolonc.2010.08.003","article-title":"Unique clinicopathologic and molecular characteristics of urinary bladder tumors in children and young adults","volume":"31","author":"Williamson","year":"2013","journal-title":"Urol Oncol"},{"key":"10.1038\/modpathol.2014.48_bib3","first-page":"11","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"10.1038\/modpathol.2014.48_bib4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0022-5347(17)62407-8","article-title":"Primary epithelial tumors of the bladder in the first two decades of life","volume":"101","author":"Javadpour","year":"1969","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-5347(17)50950-7","article-title":"Transitional cell carcinoma of the bladder in children and adolescents","volume":"130","author":"Benson","year":"1983","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib6","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/01.ju.0000176801.16827.82","article-title":"Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the World Health Organization 2004 Bladder Consensus Classification","volume":"174","author":"Fine","year":"2005","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0090-4295(79)90453-9","article-title":"Transitional cell carcinoma of bladder in patients under thirty years of age","volume":"13","author":"McCarthy","year":"1979","journal-title":"Urology"},{"key":"10.1038\/modpathol.2014.48_bib8","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0022-5347(17)42640-1","article-title":"Primary epithelial tumors of the bladder in children","volume":"139","author":"Paduano","year":"1988","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib9","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.5858\/arpa.2012-0322-OA","article-title":"Urothelial tumors of the urinary bladder in young patients: a clinicopathologic study of 59 cases","volume":"137","author":"Stanton","year":"2013","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.2014.48_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/path.2075","article-title":"Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger","volume":"211","author":"Wild","year":"2007","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2014.48_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.juro.2010.03.131","article-title":"Low frequency of epigenetic events in urothelial tumors in young patients","volume":"184","author":"Owen","year":"2010","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib12","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/00005392-199805000-00022","article-title":"The molecular characteristics of bladder cancer in young patients","volume":"159","author":"Linn","year":"1998","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib13","series-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs","author":"Eble","year":"2004"},{"key":"10.1038\/modpathol.2014.48_bib14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1442-2042.2006.01724.x","article-title":"Comparative genomic hybridization (CGH) of augmentation cystoplasties","volume":"14","author":"Appanna","year":"2007","journal-title":"Int J Urol"},{"key":"10.1038\/modpathol.2014.48_bib15","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1097\/01.ju.0000140194.87974.56","article-title":"Transitional cell carcinoma of the bladder following augmentation cystoplasty for the neuropathic bladder","volume":"172","author":"Soergel","year":"2004","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2559.2009.03363.x","article-title":"Urothelial carcinoma following augmentation cystoplasty: an aggressive variant with distinct clinicopathological characteristics and molecular genetic alterations","volume":"55","author":"Sung","year":"2009","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2014.48_bib17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/PAS.0b013e31820f709e","article-title":"Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features","volume":"35","author":"Williamson","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2014.48_bib18","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1309\/DFJUHY3WPC9GUU2W","article-title":"Chromosomal alterations detected by fluorescence in situ hybridization in urothelial carcinoma and rarer histologic variants of bladder cancer","volume":"130","author":"Kipp","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2014.48_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/PAP.0b013e3181832320","article-title":"Bladder cancer detection using FISH (UroVysion assay)","volume":"15","author":"Halling","year":"2008","journal-title":"Adv Anat Pathol"},{"key":"10.1038\/modpathol.2014.48_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/jcp.2007.049684","article-title":"Value of multicolour fluorescence in situ hybridisation (UroVysion) in the differential diagnosis of flat urothelial lesions","volume":"61","author":"Schwarz","year":"2008","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2014.48_bib21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/modpathol.2009.28","article-title":"FGFR3 and TP53 mutation analysis in inverted urothelial papilloma: incidence and etiological considerations","volume":"22","author":"Lott","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2014.48_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/modpathol.2008.176","article-title":"TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder","volume":"22","author":"Armstrong","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2014.48_bib23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.humpath.2010.07.007","article-title":"Bladder cancer: translating molecular genetic insights into clinical practice","volume":"42","author":"Cheng","year":"2011","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2014.48_bib24","first-page":"1265","article-title":"The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate","volume":"61","author":"van Rhijn","year":"2001","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib25","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/1097-0142(20011115)92:10<2555::AID-CNCR1607>3.0.CO;2-M","article-title":"The incidence of thanatophoric dysplasia mutations in FGFR3 gene is higher in low-grade or superficial bladder carcinomas","volume":"92","author":"Kimura","year":"2001","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2014.48_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1593\/neo.07178","article-title":"Fibroblast growth factor receptor 3 mutations in bladder tumors correlate with low frequency of chromosome alterations","volume":"10","author":"Junker","year":"2008","journal-title":"Neoplasia"},{"key":"10.1038\/modpathol.2014.48_bib27","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.eururo.2007.12.026","article-title":"Prediction of progression of non-muscle-invasive bladder cancer by WHO 1973 and 2004 grading and by FGFR3 mutation status: a prospective study","volume":"54","author":"Burger","year":"2008","journal-title":"Eur Urol"},{"key":"10.1038\/modpathol.2014.48_bib28","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0002-9440(10)64665-2","article-title":"Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors","volume":"158","author":"Billerey","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2014.48_bib29","first-page":"8108","article-title":"FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder","volume":"63","author":"Bakkar","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib30","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/path.2892","article-title":"Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma","volume":"224","author":"Al-Ahmadie","year":"2011","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2014.48_bib31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/path.2202","article-title":"Molecular genetic evidence supporting the neoplastic nature of stromal cells in \u2018fibrosis' after chemotherapy for testicular germ cell tumours","volume":"213","author":"Cheng","year":"2007","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2014.48_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/cncr.20343","article-title":"Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder","volume":"101","author":"Cheng","year":"2004","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2014.48_bib33","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1038\/sj.onc.1208705","article-title":"FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma","volume":"24","author":"Jebar","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2014.48_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/path.2207","article-title":"FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer","volume":"213","author":"Tomlinson","year":"2007","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2014.48_bib35","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1200\/JCO.2002.20.4.1105","article-title":"Determination of the molecular relationship between multiple tumors within one patient is of clinical importance","volume":"20","author":"van der Sijp","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2014.48_bib36","first-page":"837","article-title":"Comparison of P53 protein overexpression with P53 mutation in bladder cancer: clinical and biologic aspects","volume":"73","author":"Vet","year":"1995","journal-title":"Lab Invest"},{"key":"10.1038\/modpathol.2014.48_bib37","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0022-5347(17)42721-2","article-title":"Long-term followup of patients less than 30 years old with transitional cell carcinoma of bladder","volume":"139","author":"Madgar","year":"1988","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib38","first-page":"32","article-title":"Urothelial tumors of the bladder","volume":"12","author":"Androulakakis","year":"1992","journal-title":"Child Nephrol Urol"},{"key":"10.1038\/modpathol.2014.48_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0022-5347(05)64832-X","article-title":"Transitional cell carcinoma of the bladder in young adults: presentation, natural history and outcome","volume":"168","author":"Yossepowitch","year":"2002","journal-title":"J Urol"},{"key":"10.1038\/modpathol.2014.48_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/PAP.0b013e3182863f80","article-title":"Clinical applications of recent molecular advances in urologic malignancies: no longer chasing a \u2018mirage'?","volume":"20","author":"Netto","year":"2013","journal-title":"Adv Anat Pathol"},{"key":"10.1038\/modpathol.2014.48_bib41","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00345-003-0382-8","article-title":"The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review","volume":"21","author":"Zeegers","year":"2004","journal-title":"World J Urol"},{"key":"10.1038\/modpathol.2014.48_bib42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1098-2388(199709\/10)13:5<291::AID-SSU2>3.0.CO;2-8","article-title":"Epidemiology and etiology of bladder cancer","volume":"13","author":"Johansson","year":"1997","journal-title":"Semin Surg Oncol"},{"key":"10.1038\/modpathol.2014.48_bib43","first-page":"784","article-title":"Two molecular pathways to transitional cell carcinoma of the bladder","volume":"54","author":"Spruck","year":"1994","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib44","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2217\/fon.09.50","article-title":"Molecular determinants of tumor recurrence in the urinary bladder","volume":"5","author":"Cheng","year":"2009","journal-title":"Future Oncol"},{"key":"10.1038\/modpathol.2014.48_bib45","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/ijc.24619","article-title":"Consistent genomic alterations in carcinoma in situ of the urinary bladder confirm the presence of two major pathways in bladder cancer development","volume":"125","author":"Zieger","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.2014.48_bib46","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1158\/1078-0432.CCR-05-0122","article-title":"FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: independent distribution and lack of association with prognosis","volume":"11","author":"Hernandez","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib47","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/sj.onc.1209249","article-title":"Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q","volume":"25","author":"Lindgren","year":"2006","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2014.48_bib48","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1158\/1078-0432.CCR-05-1130","article-title":"Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors","volume":"11","author":"Zieger","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib49","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1200\/JCO.2012.46.5740","article-title":"Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer","volume":"31","author":"Iyer","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2014.48_bib50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.4176","article-title":"TSC1 involvement in bladder cancer: diverse effects and therapeutic implications","volume":"230","author":"Guo","year":"2013","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2014.48_bib51","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1158\/1078-0432.CCR-09-0898","article-title":"Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer","volume":"15","author":"Platt","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib52","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1158\/0008-5472.CAN-12-4198","article-title":"Constitutive beta-catenin activation induces male-specific tumorigenesis in the bladder urothelium","volume":"73","author":"Lin","year":"2013","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib53","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1525-1578(10)60625-3","article-title":"The development of a multitarget, multicolor fluorescence in situ hybridization assay for the detection of urothelial carcinoma in urine","volume":"2","author":"Sokolova","year":"2000","journal-title":"J Mol Diagn"},{"key":"10.1038\/modpathol.2014.48_bib54","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/onc.2010.399","article-title":"beta-Catenin activation synergizes with PTEN loss to cause bladder cancer formation","volume":"30","author":"Ahmad","year":"2011","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2014.48_bib55","first-page":"1083","article-title":"Initiation of bladder cancer may involve deletion of a tumour-suppressor gene on chromosome 9","volume":"8","author":"Cairns","year":"1993","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2014.48_bib56","first-page":"5093","article-title":"Evidence for two bladder cancer suppressor loci on human chromosome 9","volume":"53","author":"Ruppert","year":"1993","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2014.48_bib57","first-page":"41","article-title":"Numerical aberrations of chromosome 17 and the 9p21 locus are independent predictors of tumor recurrence in non-invasive transitional cell carcinoma of the urinary bladder","volume":"23","author":"Kruger","year":"2003","journal-title":"Int J Oncol"},{"key":"10.1038\/modpathol.2014.48_bib58","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jss.2007.01.012","article-title":"Loss of P16 expression and chromosome 9p21 LOH in predicting outcome of patients affected by superficial bladder cancer","volume":"143","author":"Bartoletti","year":"2007","journal-title":"J Surg Res"},{"key":"10.1038\/modpathol.2014.48_bib59","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1093\/jnci\/87.20.1524","article-title":"Deletion of the p16 and p15 genes in human bladder tumors","volume":"87","author":"Orlow","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/modpathol.2014.48_bib60","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0002-9440(10)65105-X","article-title":"Deletions of the INK4A gene in superficial bladder tumors. Association with recurrence","volume":"155","author":"Orlow","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2014.48_bib61","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1309\/K5P2-4Y8B-7L5A-FAA9","article-title":"Multiprobe FISH for enhanced detection of bladder cancer in voided urine specimens and bladder washings","volume":"116","author":"Bubendorf","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2014.48_bib62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.urology.2005.08.064","article-title":"Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers","volume":"66","author":"Lokeshwar","year":"2005","journal-title":"Urology"},{"key":"10.1038\/modpathol.2014.48_bib63","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/00000478-198912000-00008","article-title":"Aggressive bladder carcinoma in an adolescent. Report of a case with immunohistochemical, cytogenetic, and flow cytometric characterization","volume":"13","author":"Scott","year":"1989","journal-title":"Am J Surg Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol201448.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol201448","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522203544X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522203544X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol201448.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:12:36Z","timestamp":1760231556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089339522203544X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S089339522203544X"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2014.48","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characteristics of urothelial neoplasms in children and young adults: a subset of tumors from young patients harbors chromosomal abnormalities but not FGFR3 or TP53 gene mutations","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2014.48","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2014.134","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}