{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:09:25Z","timestamp":1761293365280,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2507,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1038\/modpathol.2015.152","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T14:13:34Z","timestamp":1452867214000},"page":"293-301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern"],"prefix":"10.1016","volume":"29","author":[{"given":"Tetsuo","family":"Tsukahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Ebata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Igami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junpei","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2015.152_bib1","series-title":"WHO Classification of Tumours of the Digestive System","first-page":"217","article-title":"Intrahepatic cholangiocarcinoma","author":"Nakanuma","year":"2010"},{"key":"10.1038\/modpathol.2015.152_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.surg.2013.08.011","article-title":"Prognostic delineation of papillary cholangiocarcinoma based on the invasive proportion: a single-institution study with 184 patients","volume":"155","author":"Onoe","year":"2014","journal-title":"Surgery"},{"key":"10.1038\/modpathol.2015.152_bib3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/modpathol.2011.71","article-title":"Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct","volume":"24","author":"Zen","year":"2011","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2015.152_bib4","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.21387","article-title":"Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas","volume":"44","author":"Zen","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2015.152_bib5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jhep.2005.09.025","volume":"44","author":"Zen","year":"2006","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.2015.152_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/PAS.0b013e3182103f36","article-title":"Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion","volume":"35","author":"Ohtsuka","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.152_bib7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1053\/jhep.2001.28199","article-title":"Intraductal papillary neoplasia of the liver associated with hepatolithiasis","volume":"34","author":"Chen","year":"2001","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2015.152_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/bjs.4366","article-title":"An intraductal papillary component is associated with prolonged survival after hepatic resection for intrahepatic cholangiocarcinoma","volume":"91","author":"Tajima","year":"2004","journal-title":"Br J Surg"},{"key":"10.1038\/modpathol.2015.152_bib9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s00534-002-0842-3","article-title":"Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma","volume":"10","author":"Morimoto","year":"2003","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1038\/modpathol.2015.152_bib10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s00534-002-0732-8","article-title":"Intrahepatic cholangiocarcinoma: macroscopic type and stage classification","volume":"10","author":"Yamasaki","year":"2003","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1038\/modpathol.2015.152_bib11","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1007\/s00268-008-9726-2","article-title":"Perineural invasion is a prognostic factor in intrahepatic cholangiocarcinoma","volume":"32","author":"Shirai","year":"2008","journal-title":"World J Surg"},{"key":"10.1038\/modpathol.2015.152_bib12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/(SICI)1096-9098(199811)69:3<162::AID-JSO8>3.0.CO;2-L","article-title":"Does gross appearance indicate prognosis in intrahepatic cholangiocarcinoma?","volume":"69","author":"Yamamoto","year":"1998","journal-title":"J Surg Oncol"},{"key":"10.1038\/modpathol.2015.152_bib13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00000658-199803000-00013","article-title":"The pattern of infiltration at the proximal border of hilar bile duct carcinoma: a histologic analysis of 62 resected cases","volume":"227","author":"Sakamoto","year":"1998","journal-title":"Ann Surg"},{"key":"10.1038\/modpathol.2015.152_bib14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1365-2168.2000.01343.x","article-title":"Radical resection of hilar bile duct carcinoma and predictors of survival","volume":"87","author":"Todoroki","year":"2000","journal-title":"Br J Surg"},{"key":"10.1038\/modpathol.2015.152_bib15","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/BF01659134","article-title":"Clinicopathologic factors influencing survival of patients with bile duct carcinoma: multivariate statistical analysis","volume":"17","author":"Bhuiya","year":"1993","journal-title":"World J Surg"},{"key":"10.1038\/modpathol.2015.152_bib16","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/1097-0142(20000801)89:3<508::AID-CNCR5>3.0.CO;2-D","article-title":"Noninvasive and minimally invasive papillary carcinomas of the extrahepatic bile ducts","volume":"89","author":"Albores-Saavedra","year":"2000","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2015.152_bib17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/hep.20837","article-title":"Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions","volume":"42","author":"Yeh","year":"2005","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.2015.152_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4254\/wjh.v2.i12.419","article-title":"Pathological classification of intrahepatic cholangiocarcinoma based on a new concept","volume":"2","author":"Nakanuma","year":"2010","journal-title":"World J Hepatol"},{"key":"10.1038\/modpathol.2015.152_bib19","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1440-1827.2010.02572.x","article-title":"A potential case of intraductal tubulopapillary neoplasms of the bile duct","volume":"60","author":"Park","year":"2010","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.2015.152_bib20","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1097\/PAS.0b013e3182684d4f","article-title":"Intraductal tubular neoplasms of the bile ducts","volume":"36","author":"Katabi","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.152_bib21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1440-1827.2010.02550.x","article-title":"Intraductal tubular neoplasm of the common bile duct","volume":"60","author":"Sato","year":"2010","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.2015.152_bib22","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.humpath.2011.03.013","article-title":"Intraductal tubulopapillary neoplasm of the bile duct: potential origin from peribiliary cysts","volume":"43","author":"Zen","year":"2012","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2015.152_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/01.pas.0000213384.25042.86","article-title":"Measurement of the invasion depth of extrahepatic bile duct carcinoma: An alternative method overcoming the current T classification problems of the AJCC staging system","volume":"31","author":"Hong","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.152_bib24","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/SLA.0b013e318190a647","article-title":"Clinicopathologic study of cholangiocarcinoma with superficial spread","volume":"249","author":"Igami","year":"2009","journal-title":"Ann Surg"},{"key":"10.1038\/modpathol.2015.152_bib25","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/cncr.20906","article-title":"Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma","volume":"103","author":"Wakai","year":"2005","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2015.152_bib26","series-title":"TNM Classification of Malignant Tumours","article-title":"International Union Against Cancer","author":"Sobin","year":"2010"},{"key":"10.1038\/modpathol.2015.152_bib27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/modpathol.3800788","article-title":"Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria","volume":"20","author":"Zen","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2015.152_bib28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1440-1827.2005.01816.x","article-title":"Proposal of histological criteria for intraepithelial atypical\/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement","volume":"55","author":"Zen","year":"2005","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.2015.152_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000335164","article-title":"Pathobiological implications of MUC16\/CA125 expression in intrahepatic cholangiocarcinoma-mass forming type","volume":"79","author":"Higashi","year":"2012","journal-title":"Pathobiology"},{"key":"10.1038\/modpathol.2015.152_bib30","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/PAS.0b013e3181a162e5","article-title":"Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms","volume":"33","author":"Yamaguchi","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.152_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0248-4900(01)01125-X","article-title":"The Raf\/MEK\/ERK pathway: new concepts of activation","volume":"93","author":"Peyssonnaux","year":"2001","journal-title":"Biol Cell"},{"key":"10.1038\/modpathol.2015.152_bib32","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/bjc.1996.459","article-title":"Ki-ras point mutations and proliferation activity in biliary tract carcinomas","volume":"74","author":"Ohashi","year":"1996","journal-title":"Br J Cancer"},{"key":"10.1038\/modpathol.2015.152_bib33","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/gut.52.5.706","article-title":"Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma","volume":"52","author":"Tannapfel","year":"2003","journal-title":"Gut"},{"key":"10.1038\/modpathol.2015.152_bib34","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1053\/j.gastro.2011.12.005","article-title":"Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors","volume":"142","author":"Andersen","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.2015.152_bib35","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/cncr.27955","article-title":"KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas","volume":"119","author":"Hsu","year":"2013","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2015.152_bib36","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.humpath.2012.11.006","article-title":"Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions","volume":"44","author":"Voss","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2015.152_bib37","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/modpathol.3800204","article-title":"The V599E BRAF mutation is uncommon in biliary tract cancers","volume":"17","author":"Goldenberg","year":"2004","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2015.152_bib38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1477-2574.2012.00504.x","article-title":"GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct","volume":"14","author":"Matthaei","year":"2012","journal-title":"HPB (Oxford)"},{"key":"10.1038\/modpathol.2015.152_bib39","doi-asserted-by":"crossref","first-page":"e81706","DOI":"10.1371\/journal.pone.0081706","article-title":"GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct","volume":"8","author":"Sasaki","year":"2013","journal-title":"PLoS One"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2015152.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2015152","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2015152.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:47:44Z","timestamp":1760230064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222012984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0893395222012984"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2015.152","relation":{},"ISSN":["0893-3952"],"issn-type":[{"type":"print","value":"0893-3952"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2015.152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}