{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:49:16Z","timestamp":1773809356005,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2781,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1038\/modpathol.2015.2","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T07:35:34Z","timestamp":1423812934000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Overdiagnosis of high-grade dysplasia in Barrett's esophagus: a multicenter, international study"],"prefix":"10.1016","volume":"28","author":[{"given":"Nikhil A","family":"Sangle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari L","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J","family":"Emond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Depot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bergein F","family":"Overholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary P","family":"Bronner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2015.2_bib1","first-page":"881","article-title":"The lower esophagus lined by columnar epithelium","volume":"41","author":"Barrett","year":"1957","journal-title":"Surgery"},{"key":"10.1038\/modpathol.2015.2_bib2","doi-asserted-by":"crossref","unstructured":"Wang KK, Sampliner RE . Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus. Am J Gastroenterol 2008103:788\u2013797.","DOI":"10.1111\/j.1572-0241.2008.01835.x"},{"key":"10.1038\/modpathol.2015.2_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.gie.2005.06.047","article-title":"Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trial","volume":"62","author":"Overholt","year":"2005","journal-title":"Gastrointest Endosc"},{"key":"10.1038\/modpathol.2015.2_bib4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.gie.2006.12.037","article-title":"Five-year efficacy and safety of photodynamic therapy with Photofrin in Barrett's high-grade dysplasia","volume":"66","author":"Overholt","year":"2007","journal-title":"Gastrointest Endosc"},{"key":"10.1038\/modpathol.2015.2_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1053\/hupa.2001.23510","article-title":"Reproducibility of the diagnosis of dysplasia in Barrett esophagus: a reaffirmation","volume":"32","author":"Montgomery","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2015.2_bib6","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/0046-8177(94)90057-4","article-title":"Barrett's esophagus, dysplasia, and adenocarcinoma","volume":"25","author":"Haggitt","year":"1994","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2015.2_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/PAS.0b013e3182354e43","article-title":"Prediction of adenocarcinoma in esophagectomy specimens based upon analysis of preresection biopsies of barrett esophagus with at least high-grade dysplasia: a comparison of 2 systems","volume":"36","author":"Patil","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.2_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1309\/AJCP78CKIOJWOVFN","article-title":"A histologically defined subset of high-grade dysplasia in Barrett mucosa is predictive of associated carcinoma","volume":"132","author":"Zhu","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2015.2_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"key":"10.1038\/modpathol.2015.2_bib10","unstructured":"Cohen JA . A coefficient of agreement for nominal scales. Educ Psychol Assess 1960;2037\u20132046."},{"key":"10.1038\/modpathol.2015.2_bib11","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/j.1572-0241.2008.02020.x","article-title":"Poor interobserver agreement in the distinction of high-grade dysplasia and adenocarcinoma in pretreatment Barrett's esophagus biopsies","volume":"103","author":"Downs-Kelly","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/modpathol.2015.2_bib12","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1136\/jcp.2005.035337","article-title":"Diagnosis and grading of dysplasia in Barrett's oesophagus","volume":"59","author":"Odze","year":"2006","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.2015.2_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/PAS.0b013e3181ffdd14","article-title":"Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus","volume":"35","author":"Coco","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.2_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00000478-200604000-00001","article-title":"Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort","volume":"30","author":"Lomo","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.2_bib15","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/PAS.0b013e31816b6459","article-title":"DNA ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions","volume":"32","author":"Zhang","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.2_bib16","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/PAS.0b013e318198a1d4","article-title":"Nonadenomatous dysplasia in Barrett esophagus: a clinical, pathologic, and DNA content flow cytometric study","volume":"33","author":"Rucker-Schmidt","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2015.2_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/modpathol.2009.147","article-title":"Grading of gastric foveolar-type dysplasia in Barrett's esophagus","volume":"23","author":"Mahajan","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2015.2_bib18","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/modpathol.2010.59","article-title":"Foveolar type dysplasia in Barrett esophagus","volume":"23","author":"Brown","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2015.2_bib19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0046-8177(88)80344-7","article-title":"Observer variation in the diagnosis of dysplasia in Barrett's esophagus","volume":"19","author":"Reid","year":"1988","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.2015.2_bib20","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1365-2559.2010.03571.x","article-title":"A study of indefinite for dysplasia in Barrett's oesophagus: reproducibility of diagnosis, clinical outcomes and predicting progression with AMACR (alpha-methylacyl-CoA-racemase)","volume":"56","author":"Sonwalkar","year":"2010","journal-title":"Histopathology"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol20152.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol20152","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222014119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222014119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol20152.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:48:50Z","timestamp":1760230130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222014119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0893395222014119"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2015.2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725355077.793507328","asserted-by":"object"}]},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overdiagnosis of high-grade dysplasia in Barrett's esophagus: a multicenter, international study","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2015.2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}