{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:16:00Z","timestamp":1790702160926,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2170,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1038\/modpathol.2016.160","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T07:43:23Z","timestamp":1477035803000},"page":"297-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis"],"prefix":"10.1016","volume":"30","author":[{"given":"Ayse","family":"Ayhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Chin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Bahadirli-Talbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Lien","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie-Ming","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2016.160_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajpath.2015.11.011","article-title":"The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded","volume":"186","author":"Kurman","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.2016.160_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1158\/1078-0432.CCR-07-1614","article-title":"Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress","volume":"14","author":"Yamaguchi","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2016.160_bib3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4161\/cbt.28411","article-title":"The emerging roles of ARID1A in tumor suppression","volume":"15","author":"Wu","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"10.1038\/modpathol.2016.160_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/PAS.0b013e3181788546","article-title":"A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary","volume":"33","author":"Kobel","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2016.160_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/PAT.0000000000000223","article-title":"Comparative analysis of Napsin A, alpha-methylacyl-coenzyme A racemase (AMACR, P504S), and hepatocyte nuclear factor 1 beta as diagnostic markers of ovarian clear cell carcinoma: an immunohistochemical study of 279 ovarian tumours","volume":"47","author":"Fadare","year":"2015","journal-title":"Pathology"},{"key":"10.1038\/modpathol.2016.160_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1309\/AJCP8WO2EOIAHSOF","article-title":"The lung-restricted marker napsin A is highly expressed in clear cell carcinomas of the ovary","volume":"142","author":"Kandalaft","year":"2014","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.2016.160_bib7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1186\/1471-2407-13-524","article-title":"Napsin A as a marker of clear cell ovarian carcinoma","volume":"13","author":"Skirnisdottir","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1038\/modpathol.2016.160_bib8","doi-asserted-by":"crossref","first-page":"dju 146","DOI":"10.1093\/jnci\/dju146","article-title":"Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis","volume":"106","author":"Guan","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/modpathol.2016.160_bib9","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1038\/ncomms7118","article-title":"Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling","volume":"6","author":"Chandler","year":"2015","journal-title":"Nat Commun"},{"key":"10.1038\/modpathol.2016.160_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.1196333","article-title":"Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma","volume":"330","author":"Jones","year":"2010","journal-title":"Science"},{"key":"10.1038\/modpathol.2016.160_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nm0203-152","article-title":"Cyclin E is a more powerful predictor of breast cancer outcome than proliferation","volume":"9","author":"Keyomarsi","year":"2003","journal-title":"Nat Med"},{"key":"10.1038\/modpathol.2016.160_bib12","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1002\/cncr.24987","article-title":"Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer","volume":"116","author":"Nakayama","year":"2010","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2016.160_bib13","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/cncr.21767","article-title":"Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma","volume":"106","author":"Rosen","year":"2006","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2016.160_bib14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/jnci\/djs345","article-title":"Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses","volume":"104","author":"Kuhn","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/modpathol.2016.160_bib15","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/modpathol.2013.209","article-title":"Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma","volume":"27","author":"Kuhn","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2016.160_bib16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/path.1474","article-title":"Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma","volume":"201","author":"Cassia","year":"2003","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2016.160_bib17","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1038\/sj.onc.1207408","article-title":"Cyclin E deregulation alters the biologic properties of ovarian cancer cells","volume":"23","author":"Bedrosian","year":"2004","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2016.160_bib18","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1158\/0008-5472.CAN-13-2247","article-title":"Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers","volume":"74","author":"Karst","year":"2014","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2016.160_bib19","doi-asserted-by":"crossref","unstructured":"Kuhn E, Wang TL, Doberstein K et al. CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma. Mod Pathol (e-pub ahead of print 22 July 2016; 10.1038\/modpathol.2016.101).","DOI":"10.1038\/modpathol.2016.101"},{"key":"10.1038\/modpathol.2016.160_bib20","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1158\/0008-5472.CAN-11-1562","article-title":"ARID1A, a factor that promotes formation of SWI\/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers","volume":"71","author":"Guan","year":"2011","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2016.160_bib21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/path.4315","article-title":"Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy","volume":"232","author":"Wu","year":"2014","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.2016.160_bib22","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/IGC.0b013e31826b5dcc","article-title":"Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma","volume":"22","author":"Ayhan","year":"2012","journal-title":"Int J Gynecol Cancer"},{"key":"10.1038\/modpathol.2016.160_bib23","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/ijc.22609","article-title":"Amplicon profiles in ovarian serous carcinomas","volume":"120","author":"Nakayama","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.2016.160_bib24","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1158\/0008-5472.CAN-14-3370","article-title":"VR23: a quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin E-mediated centrosome amplification","volume":"75","author":"Pundir","year":"2015","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2016.160_bib25","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1158\/0008-5472.CAN-03-3908","article-title":"Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression","volume":"64","author":"Kawamura","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2016.160_bib26","first-page":"432","article-title":"Clear-cell cancer of the ovary-is it chemosensitive?","volume":"15","author":"Pather","year":"2005","journal-title":"Int J Gynecol Cancer"},{"key":"10.1038\/modpathol.2016.160_bib27","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1525-1438.2007.01158.x","article-title":"Low response rate of second-line chemotherapy for recurrent or refractory clear cell carcinoma of the ovary: a retrospective Japan Clear Cell Carcinoma Study","volume":"18","author":"Takano","year":"2008","journal-title":"Int J Gynecol Cancer"},{"key":"10.1038\/modpathol.2016.160_bib28","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1230062","article-title":"TERT promoter mutations in familial and sporadic melanoma","volume":"339","author":"Horn","year":"2013","journal-title":"Science"},{"key":"10.1038\/modpathol.2016.160_bib29","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.1229259","article-title":"Highly recurrent TERT promoter mutations in human melanoma","volume":"339","author":"Huang","year":"2013","journal-title":"Science"},{"key":"10.1038\/modpathol.2016.160_bib30","first-page":"549","article-title":"Telomerase activity is associated with cell cycle deregulation in human breast cancer","volume":"57","author":"Landberg","year":"1997","journal-title":"Cancer Res"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016160","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:47:42Z","timestamp":1760230062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222012844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0893395222012844"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2016.160","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2016.160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}