{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:18:21Z","timestamp":1790252301161,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2170,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1038\/modpathol.2016.185","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T09:04:55Z","timestamp":1478250295000},"page":"278-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"title":["Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas"],"prefix":"10.1016","volume":"30","author":[{"given":"Shingo","family":"Inaguma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Lasota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Felisiak-Golabek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Miettinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2016.185_bib1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1471-4906(01)01888-9","article-title":"PD-1: an inhibitory immunoreceptor involved in peripheral tolerance","volume":"22","author":"Nishimura","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1038\/modpathol.2016.185_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1074-7613(00)80089-8","article-title":"Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor","volume":"11","author":"Nishimura","year":"1999","journal-title":"Immunity"},{"key":"10.1038\/modpathol.2016.185_bib3","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/70932","article-title":"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion","volume":"5","author":"Dong","year":"1999","journal-title":"Nat Med"},{"key":"10.1038\/modpathol.2016.185_bib4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J Exp Med"},{"key":"10.1038\/modpathol.2016.185_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/85330","article-title":"PD-L2 is a second ligand for PD-1 and inhibits T cell activation","volume":"2","author":"Latchman","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1038\/modpathol.2016.185_bib6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1084\/jem.193.7.839","article-title":"B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells","volume":"193","author":"Tseng","year":"2001","journal-title":"J Exp Med"},{"key":"10.1038\/modpathol.2016.185_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.imlet.2010.09.022","article-title":"New monoclonal antibodies against B-cell antigens: possible new strategies for diagnosis of primary cutaneous B-cell lymphomas","volume":"134","author":"Fanoni","year":"2011","journal-title":"Immunol Lett"},{"key":"10.1038\/modpathol.2016.185_bib8","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1158\/0008-5472.CAN-11-0993","article-title":"IL-18 induces PD-1-dependent immunosuppression in cancer","volume":"71","author":"Terme","year":"2011","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2016.185_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1600-065X.2008.00662.x","article-title":"Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways","volume":"224","author":"Fife","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1038\/modpathol.2016.185_bib10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1158\/1078-0432.CCR-08-1608","article-title":"Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma","volume":"15","author":"Gao","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2016.185_bib11","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1158\/1078-0432.CCR-04-1469","article-title":"Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer","volume":"11","author":"Ohigashi","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2016.185_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.acthis.2006.01.003","article-title":"Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance","volume":"108","author":"Wu","year":"2006","journal-title":"Acta Histochem"},{"key":"10.1038\/modpathol.2016.185_bib13","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/PAS.0000000000000653","article-title":"Comprehensive immunohistochemical study of programmed cell death ligand 1 (PD-L1): analysis in 5536 cases revealed consistent expression in trophoblastic tumors","volume":"40","author":"Inaguma","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2016.185_bib14","doi-asserted-by":"crossref","unstructured":"Masugi Y, Nishihara R, Yang J et al, Tumour CD274 (PD-L1) expression and T cells in colorectal cancer. Gut 2016; 10.1136\/gutjnl-2016-311421.","DOI":"10.1136\/gutjnl-2016-311421"},{"key":"10.1038\/modpathol.2016.185_bib15","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/modpathol.2016.95","article-title":"PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes","volume":"29","author":"Rosenbaum","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2016.185_bib16","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.ejca.2013.02.015","article-title":"Clinical impact of programmed cell death ligand 1 expression in colorectal cancer","volume":"49","author":"Droeser","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1038\/modpathol.2016.185_bib17","doi-asserted-by":"crossref","unstructured":"Lee LH, Cavalcanti MS, Segal NH et al, Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma. Mod Pathol 2016; 10.1038\/modpathol.2016.139.","DOI":"10.1038\/modpathol.2016.139"},{"key":"10.1038\/modpathol.2016.185_bib18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrgastro.2015.73","article-title":"Serrated neoplasia-role in colorectal carcinogenesis and clinical implications","volume":"12","author":"JE","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1038\/modpathol.2016.185_bib19","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/cncr.2820360944","article-title":"The evolution of cancer of the colon and rectum","volume":"36","author":"Muto","year":"1975","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2016.185_bib20","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1053\/j.gastro.2010.08.053","article-title":"Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract","volume":"139","author":"Levin","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.2016.185_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.stem.2007.08.014","article-title":"ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome","volume":"1","author":"Ginestier","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1038\/modpathol.2016.185_bib22","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1158\/0008-5472.CAN-08-4418","article-title":"Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis","volume":"69","author":"Huang","year":"2009","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2016.185_bib23","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.3892\/or.2015.4168","article-title":"miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4","volume":"34","author":"Cheng","year":"2015","journal-title":"Oncol Rep"},{"key":"10.1038\/modpathol.2016.185_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1506597","article-title":"CDX2 as a prognostic biomarker in stage II and stage III colon cancer","volume":"374","author":"Dalerba","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2016.185_bib25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/PAI.0b013e318245c82f","article-title":"A simple method for generating multitissue blocks without special equipment","volume":"20","author":"Miettinen","year":"2012","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/modpathol.2016.185_bib26","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1097\/PAS.0000000000000229","article-title":"Detection of the BRAF V600E mutation in colon carcinoma: critical evaluation of the imunohistochemical approach","volume":"38","author":"Lasota","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.2016.185_bib27","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1038\/modpathol.2016.185_bib28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJMoa1411087","article-title":"PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma","volume":"372","author":"Ansell","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2016.185_bib29","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1056\/NEJMoa1507643","article-title":"Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer","volume":"373","author":"Borghaei","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2016.185_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa1504627","article-title":"Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer","volume":"373","author":"Brahmer","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2016.185_bib31","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1510665","article-title":"Nivolumab versus everolimus in advanced renal-cell carcinoma","volume":"373","author":"Motzer","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.2016.185_bib32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1053\/j.gastro.2011.04.008","article-title":"SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells","volume":"141","author":"Hwang","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.2016.185_bib33","doi-asserted-by":"crossref","first-page":"20852","DOI":"10.1073\/pnas.0810958105","article-title":"Oncogenic kinase NPM\/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)","volume":"105","author":"Marzec","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.2016.185_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nm1517","article-title":"Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma","volume":"13","author":"Parsa","year":"2007","journal-title":"Nat Med"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016185","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:46:43Z","timestamp":1760230003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222012820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0893395222012820"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2016.185","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2016.185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}