{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:31:26Z","timestamp":1787002286566,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2142,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/modpathol.2016.206","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T07:51:53Z","timestamp":1481269913000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Immunohistochemistry for p53 is a useful tool to identify cases of acute myeloid leukemia with myelodysplasia-related changes that are TP53 mutated, have complex karyotype, and have poor prognosis"],"prefix":"10.1016","volume":"30","author":[{"given":"Sebastian","family":"Fernandez-Pol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S","family":"Ohgami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Arber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2016.206_bib1","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","first-page":"439","author":"Swerdlow","year":"2008"},{"key":"10.1038\/modpathol.2016.206_bib2","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1182\/blood-2008-10-182782","article-title":"Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system","volume":"113","author":"Weinberg","year":"2009","journal-title":"Blood"},{"key":"10.1038\/modpathol.2016.206_bib3","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"10.1038\/modpathol.2016.206_bib4","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrc2723","article-title":"The first 30 years of p53: growing ever more complex","volume":"9","author":"Levine","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/modpathol.2016.206_bib5","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1182\/blood-2011-08-375758","article-title":"TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome","volume":"119","author":"R\u00fccker","year":"2012","journal-title":"Blood"},{"key":"10.1038\/modpathol.2016.206_bib6","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/leu.2014.55","article-title":"Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients","volume":"28","author":"Kihara","year":"2014","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2016.206_bib7","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/modpathol.2014.160","article-title":"Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations","volume":"28","author":"Ohgami","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2016.206_bib8","doi-asserted-by":"crossref","first-page":"a001016","DOI":"10.1101\/cshperspect.a001016","article-title":"Clinical outcomes and correlates of TP53 mutations and cancer","volume":"2","author":"Robles","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1038\/modpathol.2016.206_bib9","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/leu.2008.143","article-title":"Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype","volume":"22","author":"Haferlach","year":"2008","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2016.206_bib10","first-page":"893","article-title":"Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines","volume":"5","author":"Bartek","year":"1990","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.2016.206_bib11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/02841860802047411","article-title":"A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients","volume":"47","author":"Alsner","year":"2008","journal-title":"Acta Oncol"},{"key":"10.1038\/modpathol.2016.206_bib12","first-page":"1342","article-title":"Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis","volume":"8","author":"Lepelley","year":"1994","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.2016.206_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.prp.2007.01.010","article-title":"Expression of the regulatory cell cycle proteins p21, p27, p14, p16, p53, mdm2, and cyclin E in bone marrow biopsies with acute myeloid leukemia. Correlation with patients' survival","volume":"203","author":"Zolota","year":"2007","journal-title":"Pathol Res Pract"},{"key":"10.1038\/modpathol.2016.206_bib14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/modpathol.2014.153","article-title":"Ok CY, et al. High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome","volume":"28","author":"Cleven","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2016.206_bib15","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.3324\/haematol.2014.104760","article-title":"Response to azacitidine is independent of p53 expression in higher-risk myelodysplastic syndromes and secondary acute myeloid leukemia","volume":"99","author":"M\u00fcller-Thomas","year":"2014","journal-title":"Haematologica"},{"key":"10.1038\/modpathol.2016.206_bib16","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/modpathol.2014.160","article-title":"Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations","volume":"28","author":"Ohgami","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2016.206_bib17","first-page":"1","article-title":"TP53 Mutations in Nonsmall Cell Lung Cancer","volume":"2011","author":"Mogi","year":"2011","journal-title":"Journal of Biomedicine and Biotechnology"},{"key":"10.1038\/modpathol.2016.206_bib18","first-page":"3","article-title":"Smoking, p53 Mutation, and Lung Cancer","volume":"12","author":"Gibbons","year":"2014","journal-title":"Am Assoc Cancer Res"},{"key":"10.1038\/modpathol.2016.206_bib19","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3324\/haematol.2013.098103","article-title":"p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)","volume":"99","author":"Saft","year":"2014","journal-title":"Haematologica"},{"key":"10.1038\/modpathol.2016.206_bib20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/modpathol.2014.153","article-title":"High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome","volume":"28","author":"Cleven","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2016.206_bib21","first-page":"4055","article-title":"Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis","volume":"6","author":"Mitsudomi","year":"2000","journal-title":"Clin Cancer Res"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016206","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222012613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2016206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:46:19Z","timestamp":1760229979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222012613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0893395222012613"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2016.206","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunohistochemistry for p53 is a useful tool to identify cases of acute myeloid leukemia with myelodysplasia-related changes that are TP53 mutated, have complex karyotype, and have poor prognosis","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2016.206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}