{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:25:34Z","timestamp":1790281534832,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":1836,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/modpathol.2017.108","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T07:40:41Z","timestamp":1504856441000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma"],"prefix":"10.1016","volume":"31","author":[{"given":"Marina","family":"Vivero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian R","family":"Chirieac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.2017.108_bib1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/oem.51.12.804","article-title":"Malignant mesothelioma: attributable risk of asbestos exposure","volume":"51","author":"Spirtas","year":"1994","journal-title":"Occup Environ Med"},{"key":"10.1038\/modpathol.2017.108_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/oem.52.11.775","article-title":"Differences in occupational mortality from pleural cancer, peritoneal cancer, and asbestosis","volume":"52","author":"Coggon","year":"1995","journal-title":"Occup Environ Med"},{"key":"10.1038\/modpathol.2017.108_bib3","unstructured":"Galateau-Salle F, Churg A, Roggli V et al. Diffuse malignant mesothelioma: epithelioid mesothelioma. In: Travis WD, Brambilla E, Burke AP et al. (eds). WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. IARC: Lyon, France, 2015, pp 156\u2013154."},{"key":"10.1038\/modpathol.2017.108_bib4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s004200100240","article-title":"Malignant mesothelioma\u2014German mesothelioma register 1987-1999","volume":"74","author":"Neumann","year":"2001","journal-title":"Int Arch Occup Environ Health"},{"key":"10.1038\/modpathol.2017.108_bib5","unstructured":"Centers for Disease Control. Work-Related Lung Disease Surveillance System: Mesothelioma. Available at: http:\/\/www.n.cdc.gov\/eworld\/Grouping\/Malignant_mesothelioma\/100 (accessed 20 February 2017)."},{"key":"10.1038\/modpathol.2017.108_bib6","unstructured":"National Cancer Institute. Surveillance, Epidemiology, and End Results Program: Incidence\u2014age distribution of incidence cases by site, 1975\u20132012. Available at: http:\/\/seer.cancer.gov\/csr\/1975_2012\/results_single\/sect_01_table.11_2pgs.pdf (accessed 25 February 2017, accessed 20 February 2017)."},{"key":"10.1038\/modpathol.2017.108_bib7","doi-asserted-by":"crossref","first-page":"16766","DOI":"10.18632\/oncotarget.4414","article-title":"Distinctive clinical characteristics of malignant mesothelioma in young patients","volume":"6","author":"Thomas","year":"2015","journal-title":"Oncotarget"},{"key":"10.1038\/modpathol.2017.108_bib8","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2471\/BLT.11.086678","article-title":"Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008","volume":"89","author":"Delgermaa","year":"2011","journal-title":"Bull World Health Organ"},{"key":"10.1038\/modpathol.2017.108_bib9","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/1097-0142(19900315)65:6<1449::AID-CNCR2820650633>3.0.CO;2-0","article-title":"Malignant mesothelioma in young adults","volume":"65","author":"Kane","year":"1990","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2017.108_bib10","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/1097-0142(19880815)62:4<838::AID-CNCR2820620433>3.0.CO;2-9","article-title":"Mesothelioma of childhood","volume":"62","author":"Fraire","year":"1988","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2017.108_bib11","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/CEJ.0b013e3282f0c0a2","article-title":"US mesothelioma patterns 1973-2002: indicators of change and insights into background rates","volume":"17","author":"Teta","year":"2008","journal-title":"Eur J Cancer Prev"},{"key":"10.1038\/modpathol.2017.108_bib12","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1365-2559.2008.03029.x","article-title":"Primary peritoneal mesotheliomas in children: a clinicopathological and immunohistochemical study of eight cases","volume":"52","author":"Moran","year":"2008","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.2017.108_bib13","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/1097-0142(197211)30:5<1216::AID-CNCR2820300511>3.0.CO;2-5","article-title":"Malignant mesothelioma in childhood: report of 13 cases","volume":"30","author":"Grundy","year":"1972","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2017.108_bib14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/mpo.2950090409","article-title":"Malignant mesothelioma in children: report of seven cases and review of the literature","volume":"9","author":"Brenner","year":"1981","journal-title":"Med Pediatr Oncol"},{"key":"10.1038\/modpathol.2017.108_bib15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/modpathol.2011.146","article-title":"A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma","volume":"25","author":"Kadota","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2017.108_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/cncy.20036","article-title":"Cytogenetics and fluorescence in situ hybridization as adjuncts to cytology in the diagnosis of malignant mesothelioma","volume":"117","author":"Factor","year":"2009","journal-title":"Cancer Cytopathol"},{"key":"10.1038\/modpathol.2017.108_bib17","doi-asserted-by":"crossref","first-page":"e87062","DOI":"10.1172\/jci.insight.87062","article-title":"Institutional implementation of clinical tumor profiling on an unselected cancer population","volume":"1","author":"Sholl","year":"2016","journal-title":"JCI Insight"},{"key":"10.1038\/modpathol.2017.108_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1038\/modpathol.2017.108_bib19","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/gim.2015.156","article-title":"VisCap: inference and visualization of germ-line copy-number variants from targeted clinical sequencing data","volume":"18","author":"Pugh","year":"2016","journal-title":"Genet Med"},{"key":"10.1038\/modpathol.2017.108_bib20","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1093\/nar\/gku1211","article-title":"BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers","volume":"43","author":"Abo","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/modpathol.2017.108_bib21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1378\/chest.06-1690","article-title":"Age and sex differences in malignant mesothelioma after residential exposure to blue asbestos (Crocidolite)","volume":"131","author":"Reid","year":"2007","journal-title":"Chest"},{"key":"10.1038\/modpathol.2017.108_bib22","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/thx.38.10.744","article-title":"Evidence for longer survival of patients with pleural mesothelioma without asbestos exposure","volume":"38","author":"Law","year":"1983","journal-title":"Thorax"},{"key":"10.1038\/modpathol.2017.108_bib23","first-page":"298","article-title":"Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy","volume":"40","author":"Sugarbaker","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1038\/modpathol.2017.108_bib24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0140-6736(00)04013-7","article-title":"Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey","volume":"357","author":"Roushdy-Hammady","year":"2001","journal-title":"Lancet"},{"key":"10.1038\/modpathol.2017.108_bib25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/carcin\/bgu227","article-title":"Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival","volume":"36","author":"Baumann","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1038\/modpathol.2017.108_bib26","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1200\/JCO.2013.49.9616","article-title":"Clinicopathologic characteristics of malignant mesotheliomas arising in patients with a history of radiation for hodgkin and non-hodgkin lymphoma","volume":"31","author":"Chirieac","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2017.108_bib27","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/cncr.22526","article-title":"Therapeutic radiation for lymphoma risk of malignant mesothelioma","volume":"109","author":"Teta","year":"2007","journal-title":"Cancer"},{"key":"10.1038\/modpathol.2017.108_bib28","first-page":"2108","article-title":"Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas","volume":"9","author":"Illei","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.2017.108_bib29","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/modpathol.2008.45","article-title":"Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas","volume":"21","author":"Chiosea","year":"2008","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.2017.108_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/(SICI)1097-4652(199908)180:2<150::AID-JCP2>3.0.CO;2-H","article-title":"Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma","volume":"180","author":"Murthy","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1038\/modpathol.2017.108_bib31","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.855","article-title":"The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma","volume":"43","author":"Bott","year":"2011","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.2017.108_bib32","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1349-7006.2012.02223.x","article-title":"Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma","volume":"103","author":"Yoshikawa","year":"2012","journal-title":"Cancer Sci"},{"key":"10.1038\/modpathol.2017.108_bib33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00428-008-0689-3","article-title":"Prognostic significance of p16\/[CDKN2A] loss in pleural malignant mesotheliomas","volume":"453","author":"Dacic","year":"2008","journal-title":"Virchows Arch"},{"key":"10.1038\/modpathol.2017.108_bib34","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1158\/0008-5472.CAN-05-3907","article-title":"Global gene expression profiling of pleural mesotheliomas: overexpression of Aurora kinases and P16\/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction","volume":"66","author":"L\u00f3pez-R\u00edos","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.2017.108_bib35","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1097\/JTO.0b013e31829e7ef9","article-title":"Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 mutations","volume":"8","author":"Zauderer","year":"2013","journal-title":"J Thorac Oncol"},{"key":"10.1038\/modpathol.2017.108_bib36","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/ng.912","article-title":"Germline BAP1 mutations predispose to malignant mesothelioma","volume":"43","author":"Testa","year":"2011","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.2017.108_bib37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/15384047.2016.1145850","article-title":"Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration","volume":"17","author":"Borczuk","year":"2016","journal-title":"Cancer Biol Ther"},{"key":"10.1038\/modpathol.2017.108_bib38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1200\/JCO.1988.6.1.147","article-title":"Malignant mesothelioma: prognostic variables in a registry of 180 patients, the Dana-Farber Cancer Institute and Brigham and Women's Hospital experience over two decades, 1965-1985","volume":"6","author":"Antman","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.2017.108_bib39","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ijc.2910410409","article-title":"Survival patterns for malignant mesothelioma","volume":"41","author":"Spirtas","year":"1988","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.2017.108_bib40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-5223(99)70469-1","article-title":"Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients","volume":"117","author":"Sugarbaker","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1038\/modpathol.2017.108_bib41","first-page":"3671","article-title":"Mesothelioma: treatment and survival of a patient population and review of the literature","volume":"25","author":"Stathopoulos","year":"2005","journal-title":"Anticancer Res"},{"key":"10.1038\/modpathol.2017.108_bib42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0003-4878(01)00047-3","article-title":"Case-referent survey of young adults with mesothelioma: II. Occupational analyses","volume":"45","author":"McDonald","year":"2001","journal-title":"Ann Occup Hyg"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/modpathol2017108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2017108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222017276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222017276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/modpathol.2017.108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/modpathol2017108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:52:57Z","timestamp":1760230377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222017276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0893395222017276"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.2017.108","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2017.108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}