{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:08:46Z","timestamp":1770836926154,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6615,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1038\/modpathol.3800220","type":"journal-article","created":{"date-parts":[[2004,7,16]],"date-time":"2004-07-16T06:18:35Z","timestamp":1089958715000},"page":"1464-1474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior"],"prefix":"10.1016","volume":"17","author":[{"given":"Kristina","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Landberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800220_bib1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/01.MP.0000032536.48264.D1","article-title":"Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin","volume":"15","author":"Hodges","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3800220_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3835(01)00757-1","article-title":"Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16INK4a tumor suppressor","volume":"176","author":"Mortier","year":"2002","journal-title":"Cancer Lett"},{"key":"10.1038\/modpathol.3800220_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0959-437X(99)80004-5","article-title":"The INK4A\/ARF locus and its two gene products","volume":"9","author":"Sharpless","year":"1999","journal-title":"Curr Opin Genet Dev"},{"key":"10.1038\/modpathol.3800220_bib4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/excr.2000.5149","article-title":"p16(MTS-1\/CDKN2\/INK4a) in cancer progression","volume":"264","author":"Rocco","year":"2001","journal-title":"Exp Cell Res"},{"key":"10.1038\/modpathol.3800220_bib5","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1038\/sj.onc.1202915","article-title":"p16 UV mutations in human skin epithelial tumors","volume":"18","author":"Soufir","year":"1999","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.3800220_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/bbrc.1997.6217","article-title":"Mutations of the INK4a locus in squamous cell carcinomas of human skin","volume":"232","author":"Kubo","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/modpathol.3800220_bib7","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1046\/j.1365-2133.2003.05230.x","article-title":"Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin","volume":"148","author":"Saridaki","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1038\/modpathol.3800220_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1038\/modpathol.3800220_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/366704a0","article-title":"A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D\/CDK4","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature"},{"key":"10.1038\/modpathol.3800220_bib10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/35096061","article-title":"The INK4a\/ARF network in tumour suppression","volume":"2","author":"Sherr","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/modpathol.3800220_bib11","first-page":"2516","article-title":"Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4a upon immortalization","volume":"59","author":"Munro","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800220_bib12","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1083\/jcb.150.6.1467","article-title":"A novel function for the tumor suppressor p16INK4a: induction of anoikis via upregulation of the \u03b15\u03b21 fibronectin receptor","volume":"150","author":"Plath","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1038\/modpathol.3800220_bib13","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/sj.onc.1201382","article-title":"Adenovirus-mediated p16\/CDKN2 gene transfer suppresses glioma invasion in vitro","volume":"25","author":"Chintala","year":"1997","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.3800220_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.onc.1204999","article-title":"Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences","volume":"21","author":"Adachi","year":"2002","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.3800220_bib15","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/emboj\/18.8.2106","article-title":"The p16INK4a tumour suppressor protein inhibits alpha vbeta 3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alpha vbeta 3 to focal contacts","volume":"18","author":"Fahraeus","year":"1999","journal-title":"EMBO J"},{"key":"10.1038\/modpathol.3800220_bib16","first-page":"3783","article-title":"Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas","volume":"59","author":"Harada","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800220_bib17","first-page":"1737","article-title":"Invade or proliferate? Two contrasting events in malignant behavior governed by p16(INK4a) and an intact Rb pathway illustrated by a model system of basal cell carcinoma","volume":"63","author":"Svensson","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800220_bib18","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0002-9440(10)64833-X","article-title":"Human colorectal cancers with an intact p16\/cyclin D1\/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters","volume":"157","author":"Palmqvist","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3800220_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0002-9440(10)63677-2","article-title":"Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture","volume":"163","author":"Natarajan","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3800220_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00129039-200003000-00011","article-title":"Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2\/MTS1 gene","volume":"8","author":"Geradts","year":"2000","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/modpathol.3800220_bib21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/(SICI)1097-0215(19971104)73:3<356::AID-IJC9>3.0.CO;2-Z","article-title":"Prevailing papillomavirus types in non-melanoma carcinomas of the skin in renal allograft recipients","volume":"73","author":"de Villiers","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.3800220_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1096-9071(200007)61:3<289::AID-JMV2>3.0.CO;2-Z","article-title":"Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals","volume":"61","author":"Harwood","year":"2000","journal-title":"J Med Virol"},{"key":"10.1038\/modpathol.3800220_bib23","first-page":"F115","article-title":"The p16INK4a\/CDKN2A tumor suppressor and its relatives","volume":"1378","author":"Ruas","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/modpathol.3800220_bib24","doi-asserted-by":"crossref","first-page":"47171","DOI":"10.1074\/jbc.M104334200","article-title":"Down-regulation of integrin \u03b1(v)\u03b2(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes","volume":"276","author":"Adachi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.3800220_bib25","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1242\/jcs.111.9.1185","article-title":"Up-regulation of p27Kip1, p21WAF1\/Cip1 and p16INK4a is associated with, but not sufficient for, induction of squamous differentiation","volume":"111","author":"Harvat","year":"1998","journal-title":"J Cell Sci"},{"key":"10.1038\/modpathol.3800220_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0303-7207(03)00202-8","article-title":"TGF\u03b21 induces multiple independent signals to regulate human trophoblastic differentiation: mechanistic insights","volume":"206","author":"Rama","year":"2003","journal-title":"Mol Cell Endocrinol"},{"key":"10.1038\/modpathol.3800220_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-472X(03)00040-7","article-title":"p16INK4a induces differentiation and apoptosis in erythroid lineage cells","volume":"31","author":"Minami","year":"2003","journal-title":"Exp Hematol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800220","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222042211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222042211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:17:37Z","timestamp":1760231857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222042211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0893395222042211"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800220","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}