{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:36:15Z","timestamp":1792193775873,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6525,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1038\/modpathol.3800293","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T12:03:58Z","timestamp":1097237038000},"page":"439-445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Distribution of Y-chromosome-bearing cells in gonadoblastoma and dysgenetic testis in 45,X\/46,XY infants"],"prefix":"10.1016","volume":"18","author":[{"given":"Roc\u00edo","family":"Pe\u00f1a-Alonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karem","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Icela","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayelli","family":"N\u00e1jera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Era\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M","family":"Dorantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Kofman-Alfaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Queipo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800293_bib1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/1097-0142(197006)25:6<1340::AID-CNCR2820250612>3.0.CO;2-N","article-title":"Gonadoblastoma. A review of 74 cases","volume":"25","author":"Scully","year":"1970","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3800293_bib2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0090-4295(94)90251-8","article-title":"Gonadal tumors in disorders of sexual differentiation","volume":"43","author":"Gourlay","year":"1994","journal-title":"Urology"},{"key":"10.1038\/modpathol.3800293_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1600-0463.2003.1110104.x","article-title":"Early manifestations of testicular dysgenesis in children: pathological phenotypes, karyotype correlations and precursor stages of tumors development","volume":"111","author":"Chemes","year":"2003","journal-title":"APMIS"},{"key":"10.1038\/modpathol.3800293_bib4","first-page":"3199","article-title":"Occurrence of gonadoblastoma in females with Turner syndrome and Y chromosome material: a population study","volume":"85","author":"Gravholt","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/modpathol.3800293_bib5","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/humrep\/14.3.664","article-title":"Androgen receptor gene mutations in 46,XY females with germ cell tumors","volume":"14","author":"Chen","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1038\/modpathol.3800293_bib6","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1002\/1097-0142(19901215)66:12<2668::AID-CNCR2820661234>3.0.CO;2-5","article-title":"True hermaphrodite with bilateral ovotestes, bilateral gonadoblastomas and dysgerminomas, 46,XX\/46,XY karyotype, and successful pregnancy","volume":"66","author":"Talerman","year":"1990","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3800293_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1055\/s-2008-1043759","article-title":"Screening of patients with Turner syndrome for \u2018hidden\u2019 Y-mosaicism","volume":"211","author":"Vlasak","year":"1999","journal-title":"Klin Padiat"},{"key":"10.1038\/modpathol.3800293_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/j.1939-4640.2003.tb02672.x","article-title":"Neoplastic potential of germ cells in relation to disturbances of gonadal organogenesis and changes in karyotype","volume":"24","author":"Slowikowska-Hilczer","year":"2003","journal-title":"J Androl"},{"key":"10.1038\/modpathol.3800293_bib9","series-title":"Pathology of the Female Reproductive Tract","first-page":"641","article-title":"Germ cell tumors of the ovaries","author":"Russell","year":"2002"},{"key":"10.1038\/modpathol.3800293_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF03348838","article-title":"Bilateral gonadoblastoma in a 9-month-old infant with 46,XY gonadal dysgenesis","volume":"16","author":"Dumic","year":"1993","journal-title":"J Endocrinol Invest"},{"key":"10.1038\/modpathol.3800293_bib11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0022-3476(03)00132-X","article-title":"Seminoma and a gonadoblastoma in an infant with mixed gonadal dysgenesis","volume":"143","author":"Haddad","year":"2003","journal-title":"J Pediatr"},{"key":"10.1038\/modpathol.3800293_bib12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/15513819609168683","article-title":"Testicular sex cord stromal tumors in children: Clinicopathologic study of sixteen children with review of the literature","volume":"16","author":"Goswith","year":"1996","journal-title":"Pediatr Pathol Lab Med"},{"key":"10.1038\/modpathol.3800293_bib13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.1440-1754.1999.00319.x","article-title":"Risk of gonadoblastoma in female patients with Y chromosome abnormalities and dysgenetic gonads","volume":"35","author":"Gibbons","year":"1999","journal-title":"J Pediatr Child Health"},{"key":"10.1038\/modpathol.3800293_bib14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/gyno.1995.1195","article-title":"Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46,XX karyotype","volume":"58","author":"Obata","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.3800293_bib15","first-page":"299","article-title":"Gonocytoma III (gonadoblastoma) in a 12-year-old girl with mixed gonadal dysgenesis","volume":"27","author":"Krawczynski","year":"1976","journal-title":"Endokrynol Pol"},{"key":"10.1038\/modpathol.3800293_bib16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/jpsu.2003.50025","article-title":"Surgical management and genotype\/phenotype correlations in WT1 gene-related diseases Drash, Frasier syndromes","volume":"38","author":"Auber","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1038\/modpathol.3800293_bib17","first-page":"30","article-title":"Mixed gonadal dysgenesis and precocious puberty","volume":"58","author":"Iliev","year":"2002","journal-title":"Horm Res"},{"key":"10.1038\/modpathol.3800293_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/(SICI)1096-8628(19980305)76:2<120::AID-AJMG3>3.0.CO;2-X","article-title":"Frequency of Y chromosomal material in Mexican patients with Ullrich-Turner syndrome","volume":"5","author":"Lopez","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1038\/modpathol.3800293_bib19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1101\/SQB.1986.051.01.018","article-title":"Cytogenetic analysis by in situ hybridization with flourescently labeled nucleic acid probes","volume":"1","author":"Pinkel","year":"1986","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1038\/modpathol.3800293_bib20","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1073\/pnas.83.9.2934","article-title":"Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization","volume":"83","author":"Pinkel","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.3800293_bib21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1046\/j.1442-2042.1999.06331.x","article-title":"Case of gonadoblastoma in a 9-year-old boy without physical abnormalities","volume":"6","author":"Hatano","year":"1999","journal-title":"Int J Urol"},{"key":"10.1038\/modpathol.3800293_bib22","series-title":"Atlas of Tumor Pathology","first-page":"307","article-title":"Tumors of the ovary, mal developed gonads, fallopian tubes and Broad Ligament","author":"Scully","year":"1996"},{"key":"10.1038\/modpathol.3800293_bib23","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/0022-3468(95)90468-9","article-title":"3-Year-old phenotypic female with campomelic dysplasia and bilateral gonadoblastoma","volume":"30","author":"Hong","year":"1995","journal-title":"J Pediatr Surg"},{"key":"10.1038\/modpathol.3800293_bib24","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1515\/JPEM.2002.15.7.1047","article-title":"Molecular analysis of Frasier syndrome: mutation in the WT1 gene in a girl with gonadal dysgenesis and nephronophthisis","volume":"15","author":"Perez de Nanclares","year":"2002","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1038\/modpathol.3800293_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00431-001-0867-7","article-title":"A girl with bilateral ovarian tumors: Frasier syndrome","volume":"16","author":"Shimoyama","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1038\/modpathol.3800293_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0046-8177(87)80199-5","article-title":"Complete and incomplete Drash syndrome: a clinicopathologic study of six cases of a dysontogenetic-neoplastic complex","volume":"18","author":"Manivel","year":"1987","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3800293_bib27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00000478-199403000-00013","article-title":"Testicular juvenile granulosa cell tumor in an infant with X\/XY mosaicism clinically diagnosed as true hermaphroditism","volume":"18","author":"Tanaka","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800293_bib28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/00000478-198510000-00005","article-title":"Juvenile granulosa cell tumor. Another neoplasm associated with abnormal chromosomes and ambiguous genitalia","volume":"9","author":"Young","year":"1985","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800293_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00000478-198608000-00008","article-title":"Congenital testicular juvenile granulosa cell tumor in a neonate with X\/XY mosaicism","volume":"10","author":"Raju","year":"1986","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800293_bib30","first-page":"3061","article-title":"Recommendations for the diagnosis and management of Turner syndrome","volume":"86","author":"Saenger","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/modpathol.3800293_bib31","first-page":"455","article-title":"Malignant potential of the dysgenetic gonad. II","volume":"44","author":"Schellhas","year":"1974","journal-title":"Obstet Gynecol"},{"key":"10.1038\/modpathol.3800293_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0165-4608(87)90180-4","article-title":"Abnormal sexual differentiation and neoplasia","volume":"25","author":"Verp","year":"1987","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/modpathol.3800293_bib33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s00439-002-0772-9","article-title":"Molecular analysis in true hermaphroditism: demonstration of low-level hidden mosaicism for Y-derived sequences in 46,XX cases","volume":"111","author":"Queipo","year":"2002","journal-title":"Hum Genet"},{"key":"10.1038\/modpathol.3800293_bib34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/ajcp\/108.2.197","article-title":"Gonadoblastomas in 45,X\/46,XY mosaicism: analysis of Y chromosome distribution by fluorescence in situ hybridization","volume":"108","author":"Iezzoni","year":"1997","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800293_bib35","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000074345","article-title":"Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer","volume":"101","author":"Lau","year":"2003","journal-title":"Cytogenet Genome Res"},{"key":"10.1038\/modpathol.3800293_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1242\/dev.101.Supplement.151","article-title":"Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads","volume":"101","author":"Page","year":"1987","journal-title":"Development"},{"key":"10.1038\/modpathol.3800293_bib37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/gcc.2870140309","article-title":"Molecular mapping of the putative gonadoblastoma locus on the Y chromosome","volume":"14","author":"Salo","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/modpathol.3800293_bib38","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nature01722","article-title":"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes","volume":"423","author":"Skaletsky","year":"2003","journal-title":"Nature"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800293","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222041734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222041734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:16:37Z","timestamp":1760231797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222041734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0893395222041734"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800293","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution of Y-chromosome-bearing cells in gonadoblastoma and dysgenetic testis in 45,X\/46,XY infants","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800293","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}