{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:48:13Z","timestamp":1785682093497,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6464,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1038\/modpathol.3800348","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T07:12:22Z","timestamp":1102057942000},"page":"603-614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia"],"prefix":"10.1016","volume":"18","author":[{"given":"Attilio","family":"Orazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P","family":"O'Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail H","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Czader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800348_bib1","first-page":"472","article-title":"Malignant myelosclerosis","volume":"ii","author":"Lewis","year":"1963","journal-title":"Br Med J"},{"key":"10.1038\/modpathol.3800348_bib2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.7326\/0003-4819-74-2-232","article-title":"Acute myelofibrosis: an accelerated variant of agnogenic myeloid metaplasia","volume":"74","author":"Bergsman","year":"1971","journal-title":"Ann Intern Med"},{"key":"10.1038\/modpathol.3800348_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/ajcp\/62.1.52","article-title":"Acute megakaryocytic myelofibrosis. Case report of an unusual myeloproliferative syndrome","volume":"62","author":"Estevez","year":"1974","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/ajcp\/67.4.334","article-title":"Acute myelofibrosis: a report of three cases","volume":"67","author":"Fabich","year":"1977","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/1097-0142(197901)43:1<279::AID-CNCR2820430141>3.0.CO;2-L","article-title":"Acute (malignant) myelosclerosis","volume":"43","author":"Bearman","year":"1979","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3800348_bib6","series-title":"World Health Organization Classification of Tumors, Tumors of Haematopoietic and Lymphoid Tissues","first-page":"103","article-title":"Acute myeloid leukemia not otherwise categorized\u2014acute panmyelosis with myelofibrosis","author":"Brunning","year":"2001"},{"key":"10.1038\/modpathol.3800348_bib7","first-page":"79","article-title":"Acute myelofibrosis in children: report on two cases","volume":"27","author":"Maj","year":"1996","journal-title":"Acta Haematol Polonica"},{"key":"10.1038\/modpathol.3800348_bib8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/ajcp\/73.1.128","article-title":"Acute myelofibrosis terminating as acute myeloblastic leukemia","volume":"73","author":"Weisenburger","year":"1980","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1096-8652(199601)51:1<85::AID-AJH14>3.0.CO;2-A","article-title":"Acute myelofibrosis terminating in acute lymphoblastic leukemia: case report and review of the literature","volume":"51","author":"Dunphy","year":"1996","journal-title":"Am J Hematol"},{"key":"10.1038\/modpathol.3800348_bib10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1182\/blood.V58.2.206.206","article-title":"Megakaryoblastic leukemia presenting as acute myelofibrosis\u2014a study of four cases with the platelet\u2013peroxidase reaction","volume":"58","author":"Bain","year":"1981","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800348_bib11","series-title":"World Health Organization Classification of Tumors, Tumors of Haematopoietic and Lymphoid Tissues","first-page":"99","article-title":"Acute myeloid leukemia not otherwise categorized\u2014acute megakaryoblastic leukemia","author":"Brunning","year":"2001"},{"key":"10.1038\/modpathol.3800348_bib12","doi-asserted-by":"crossref","first-page":"460","DOI":"10.7326\/0003-4819-103-3-460","article-title":"Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7)","volume":"103","author":"Bennett","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1038\/modpathol.3800348_bib13","first-page":"43","article-title":"Expression of platelet proteins during the in vitroin vivo differentiation of megakaryocytes and morphological aspects of their maturation","volume":"23","author":"Breton-Gorius","year":"1986","journal-title":"Semin Hematol"},{"key":"10.1038\/modpathol.3800348_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2559.1990.tb00665.x","article-title":"Megakaryocytes in myelodysplasia: an immunohistochemical study on bone marrow trephines","volume":"17","author":"Fox","year":"1990","journal-title":"Histopathol"},{"key":"10.1038\/modpathol.3800348_bib15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/jcp.44.4.300","article-title":"Dysmegakaryopoiesis in myelodysplastic syndromes (MDS): an immunomorphometric study of bone marrow trephine biopsy specimens","volume":"44","author":"Thiele","year":"1991","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2141.1979.tb03740.x","article-title":"The reticulin content of bone marrow in acute leukaemia in adults","volume":"43","author":"Manoharan","year":"1979","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3800348_bib17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/ajmg.1320570403","article-title":"Cytogenetics and molecular analysis of a ring (21) in a patient with partial trisomy 21 and megakaryocytic leukemia","volume":"57","author":"Palmer","year":"1995","journal-title":"Am J Med Genet"},{"key":"10.1038\/modpathol.3800348_bib18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/ajcp\/88.5.578","article-title":"Acute myelofibrosis. Immunohistochemical study of four cases and comparison with acute megakaryocytic leukemia","volume":"88","author":"Hruban","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib19","first-page":"409","article-title":"Acute myelofibrosis\u2014a leukemia of pluripotent stem cell","volume":"20","author":"Amberger","year":"1990","journal-title":"Ann Clin Lab Sci"},{"key":"10.1038\/modpathol.3800348_bib20","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ajcp\/67.6.512","article-title":"Malignant myelosclerosis: myeloproliferative disorder or leukemia","volume":"67","author":"Bird","year":"1977","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2141.1979.tb03693.x","article-title":"Megakaryoblastic leukaemia (acute myelofibrosis): a report of three cases","volume":"42","author":"den Ottolander","year":"1979","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3800348_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2141.1981.tb07191.x","article-title":"Acute myelodysplasia with myelofibrosis; a report of eight cases","volume":"49","author":"Sultan","year":"1981","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3800348_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0145-2126(92)90100-L","article-title":"Myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML) with myelofibrosis","volume":"16","author":"Imbert","year":"1992","journal-title":"Leukemia Res"},{"key":"10.1038\/modpathol.3800348_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0165-4608(96)00037-4","article-title":"A case of acute myelofibrosis with complex karyotypic changes: a type of myelodysplastic syndrome","volume":"90","author":"Allen","year":"1996","journal-title":"Cancer Gene Cytogene"},{"key":"10.1038\/modpathol.3800348_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2141.1991.tb04411.x","article-title":"Myelodysplastic syndrome with increased marrow fibrosis: a distinct clinicopathological entity","volume":"78","author":"Lambertenghi-Deliliers","year":"1991","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3800348_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0609.1992.tb01587.x","article-title":"Myelofibrosis in primary myelodysplastic syndromes: a retrospective study of 352 patients","volume":"48","author":"Maschek","year":"1992","journal-title":"Eur J Haematol"},{"key":"10.1038\/modpathol.3800348_bib27","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1001\/archinte.1969.00300120080013","article-title":"Abnormal (Marker) chromosomes in two patients with acute myelofibrosis","volume":"123","author":"Mitus","year":"1969","journal-title":"Arch Intern Med"},{"key":"10.1038\/modpathol.3800348_bib28","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1182\/blood.V36.6.729.729","article-title":"Chromosomal evidence for the secondary role of fibroblastic proliferation in acute myelofibrosis","volume":"36","author":"Van Slyck","year":"1970","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800348_bib29","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/1097-0142(197611)38:5<1873::AID-CNCR2820380502>3.0.CO;2-I","article-title":"Chromosome studies in \u2018preleukemia' III. Myelofibrosis","volume":"38","author":"Nowell","year":"1976","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3800348_bib30","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1182\/blood.V60.4.841.841","article-title":"Karyotypic polymorphism in acute myelofibrosis","volume":"60","author":"Shah","year":"1982","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800348_bib31","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood.V74.5.1781.1781","article-title":"Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients","volume":"74","author":"Cuneo","year":"1989","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800348_bib32","first-page":"1026","article-title":"Identification of CD34+cells in normal and pathological bone marrow biopsies by QBEND10 monoclonal antibody","volume":"12","author":"Soligo","year":"1991","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.3800348_bib33","first-page":"838","article-title":"Therapy-related myelodysplastic syndromes: FAB classification, bone marrow histology, and immunohistology in the prognostic assessment","volume":"7","author":"Orazi","year":"1993","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.3800348_bib34","first-page":"521","article-title":"Frequent p53 overexpression in therapy related myelodysplastic syndromes and acute myeloid leukemias: an immunohistochemical study of bone marrow biopsies","volume":"6","author":"Orazi","year":"1993","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3800348_bib35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ajcp\/101.4.426","article-title":"CD34 immunostaining of bone marrow biopsy specimens is a reliable way to classify the phases of chronic myeloid leukemia","volume":"101","author":"Orazi","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2141.1987.tb06140.x","article-title":"Detection of cells of megakaryocyte lineage in haematological malignancies by immuno-alkaline phosphatase labelling cell smears with a panel of monoclonal antibodies","volume":"65","author":"Erber","year":"1987","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3800348_bib37","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/ajcp\/107.4.410","article-title":"Useful panel of antibodies for the classification of acute leukemia by immunohistochemical methods in bone marrow trephine biopsy specimens","volume":"107","author":"Chuang","year":"1997","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF02899200","article-title":"The use of the anti-factor VIII method on trephine biopsies of the bone marrow for the identification of immature and atypical megakaryocytes in myeloproliferative diseases and allied disorders. A morphometric study","volume":"54","author":"Thiele","year":"1987","journal-title":"Virchows Arch B Cell Pathol"},{"key":"10.1038\/modpathol.3800348_bib39","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/jcp.44.4.300","article-title":"Dysmegakaryopoiesis in myelodysplastic syndromes (MDS): an immunomorphometric study of bone marrow trephine biopsy specimens","volume":"44","author":"Thiele","year":"1991","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib40","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0002-9440(10)65356-4","article-title":"Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions","volume":"154","author":"Facchetti","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3800348_bib41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s102420200059","article-title":"LAT (linker for activation of T cells): a useful marker for megakaryocyte evaluation on bone marrow biopsies","volume":"94","author":"Ungari","year":"2002","journal-title":"Patologica"},{"key":"10.1038\/modpathol.3800348_bib42","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcp\/83.1.114","article-title":"An acute myeloproliferative disorder characterized by myelofibrosis and blast cells that express phenotypic properties associated with multiple hematopoietic lineages","volume":"83","author":"Schreeder","year":"1985","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3800348_bib43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/1097-0142(19800801)46:3<615::AID-CNCR2820460331>3.0.CO;2-X","article-title":"Acute myelofibrosis terminating in an acute lymphoblastic leukemia","volume":"46","author":"Amjad","year":"1980","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3800348_bib44","doi-asserted-by":"crossref","first-page":"545","DOI":"10.7326\/0003-4819-94-4-545_3","article-title":"Acute myelofibrosis evolving into acute myeloblastic leukemia","volume":"94","author":"Puckett","year":"1981","journal-title":"Ann Inter Med"},{"key":"10.1038\/modpathol.3800348_bib45","series-title":"World Health Organization Classification of Tumors, Tumors of Haematopoietic and Lymphoid Tissues","first-page":"88","article-title":"Acute myeloid leukemia with multilineage dysplasia","author":"Brunning","year":"2001"},{"key":"10.1038\/modpathol.3800348_bib46","series-title":"World Health Organization Classification of Tumors, Tumors of Haematopoietic and Lymphoid Tissues","first-page":"35","article-title":"Chronic idiopathic myelofibrosis","author":"Thiele","year":"2001"},{"key":"10.1038\/modpathol.3800348_bib47","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/10428190310001625692","article-title":"Acute panmyelosis with myelofibrosis","volume":"45","author":"Thiele","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.3800348_bib48","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0145-2126(01)00055-8","article-title":"Myelodysplasia with fibrosis: a distinct entity?","volume":"25","author":"Steensma","year":"2001","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.3800348_bib49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2141.1989.tb06309.x","article-title":"Myelofibrosis in primary myelodysplastic syndromes: a clinico-morphological study of 10 cases","volume":"71","author":"Pagliuca","year":"1989","journal-title":"Br J Haematol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800348","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222046324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222046324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:21:51Z","timestamp":1760232111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222046324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0893395222046324"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800348","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}