{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:38:42Z","timestamp":1780097922751,"version":"3.54.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6219,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1038\/modpathol.3800548","type":"journal-article","created":{"date-parts":[[2006,3,22]],"date-time":"2006-03-22T10:28:28Z","timestamp":1143023308000},"page":"524-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Aberrant expression of CHFR in malignant peripheral nerve sheath tumors"],"prefix":"10.1016","volume":"19","author":[{"given":"Chikashi","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonari","family":"Takahira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiyu","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadafumi","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihide","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masazumi","family":"Tsuneyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800548_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1097-0215(19991008)83:2<171::AID-IJC5>3.0.CO;2-S","article-title":"Computer-assisted cytogenetic analysis of 51 malignant peripheral-nerve-sheath tumors: sporadic vs neurofibromatosis-type-1-associated malignant schwannomas","volume":"83","author":"Plaat","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.3800548_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-9896(200001)190:1<31::AID-PATH505>3.0.CO;2-#","article-title":"Cytogenetic characterization of peripheral nerve sheath tumours: a report of the CHAMP study group","volume":"190","author":"Mertens","year":"2000","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.3800548_bib3","unstructured":"Kobayashi C, Oda Y, Takahira T, et al. Chromosomal aberration and microsatellite instability of malignant peripheral nerve sheath tumors: a study of 10 tumors from 9 patients. Cancer Genet Cytogenet, in press."},{"key":"10.1038\/modpathol.3800548_bib4","first-page":"4132","article-title":"p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors","volume":"9","author":"Perrone","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.3800548_bib5","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/labinvest.3780293","article-title":"Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors","volume":"81","author":"Birindelli","year":"2001","journal-title":"Lab Invest"},{"key":"10.1038\/modpathol.3800548_bib6","first-page":"1129","article-title":"Targeted inactivation of p53 in human cells does not result in aneuploidy","volume":"62","author":"Bunz","year":"2002","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800548_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0092-8674(00)81870-X","article-title":"When checkpoints fail","volume":"88","author":"Paulovich","year":"1997","journal-title":"Cell"},{"key":"10.1038\/modpathol.3800548_bib8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/32688","article-title":"Mutations of mitotic checkpoint genes in human cancers","volume":"392","author":"Cahill","year":"1998","journal-title":"Nature"},{"key":"10.1038\/modpathol.3800548_bib9","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1073\/pnas.0401142101","article-title":"Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint","volume":"101","author":"Kops","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.3800548_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3835(00)00675-3","article-title":"Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers","volume":"162","author":"Haruki","year":"2001","journal-title":"Cancer Lett"},{"key":"10.1038\/modpathol.3800548_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0169-5002(00)00223-3","article-title":"Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers","volume":"32","author":"Gemma","year":"2001","journal-title":"Lung Cancer"},{"key":"10.1038\/modpathol.3800548_bib12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/35019108","article-title":"Chfr defines a mitotic stress checkpoint that delays entry into metaphase","volume":"406","author":"Scolnick","year":"2000","journal-title":"Nature"},{"key":"10.1038\/modpathol.3800548_bib13","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/carcin\/23.10.1695","article-title":"Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer","volume":"23","author":"Shibata","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1038\/modpathol.3800548_bib14","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1038\/sj.onc.1207078","article-title":"Chfr inactivation is not associated to chromosomal instability in colon cancers","volume":"22","author":"Bertholon","year":"2003","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.3800548_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/carcin\/24.1.47","article-title":"Frequent hypermethylation of the 5\u2032 CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer","volume":"24","author":"Corn","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1038\/modpathol.3800548_bib16","first-page":"8606","article-title":"Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer","volume":"63","author":"Satoh","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800548_bib17","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1073\/pnas.1337066100","article-title":"Epigenetic inactivation of CHFR in human tumors","volume":"100","author":"Toyota","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.3800548_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ijc.2910330108","article-title":"Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system","volume":"33","author":"Trojani","year":"1984","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.3800548_bib19","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1200\/JCO.1997.15.1.350","article-title":"Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma","volume":"15","author":"Guillou","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.3800548_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000012081","article-title":"Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma","volume":"58","author":"Hasegawa","year":"2000","journal-title":"Oncology"},{"key":"10.1038\/modpathol.3800548_bib21","unstructured":"National Institute of Health. Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol 1998;45:575\u2013578."},{"key":"10.1038\/modpathol.3800548_bib22","series-title":"AJCC Cancer Staging Manual","author":"Fleming","year":"1997"},{"key":"10.1038\/modpathol.3800548_bib23","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/1097-0142(20010515)91:10<1914::AID-CNCR1214>3.0.CO;2-3","article-title":"Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group","volume":"91","author":"Coindre","year":"2001","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3800548_bib24","first-page":"705","article-title":"Nonrhabdomyosarcomatous soft tissue sarcomas of childhood: formulation of a simplified system for grading","volume":"8","author":"Parham","year":"1995","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3800548_bib25","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/00000478-200310000-00006","article-title":"Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle\/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions","volume":"27","author":"Zhou","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800548_bib26","author":"Weiss","year":"2001","journal-title":"Enzinger and Weiss's Soft Tissue Tumors"},{"key":"10.1038\/modpathol.3800548_bib27","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nsmb837","article-title":"PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein","volume":"11","author":"Daniels","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"10.1038\/modpathol.3800548_bib28","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0002-9440(10)64464-1","article-title":"Differential expression of the epithelial\u2013mesenchymal transition regulators snail, SIP1, and twist in gastric cancer","volume":"161","author":"Rosivatz","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3800548_bib29","first-page":"1797","article-title":"Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity","volume":"62","author":"Chaturvedi","year":"2002","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3800548_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ng1538","article-title":"Chfr is required for tumor suppression and Aurora A regulation","volume":"37","author":"Yu","year":"2005","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.3800548_bib31","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1093\/emboj\/17.11.3052","article-title":"A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers","volume":"17","author":"Bischoff","year":"1998","journal-title":"EMBO J"},{"key":"10.1038\/modpathol.3800548_bib32","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1054\/bjoc.2000.1684","article-title":"Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation","volume":"84","author":"Sakakura","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1038\/modpathol.3800548_bib33","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/ijc.1200","article-title":"Association of centrosomal kinase STK15\/BTAK mRNA expression with chromosomal instability in human breast cancers","volume":"92","author":"Miyoshi","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1038\/modpathol.3800548_bib34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/emboj\/21.4.483","article-title":"Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53\u2212\/\u2212 cells","volume":"21","author":"Meraldi","year":"2002","journal-title":"EMBO J"},{"key":"10.1038\/modpathol.3800548_bib35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0360-3016(98)00223-5","article-title":"Malignant peripheral nerve sheath tumor: analysis of treatment outcome","volume":"42","author":"Wong","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1038\/modpathol.3800548_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/106689690100900203","article-title":"Immunoreactivity of p53, mdm2, and p21WAF1 in dedifferentiated liposarcoma: special emphasis on the distinct immunophenotype of the well-differentiated component","volume":"9","author":"Adachi","year":"2001","journal-title":"Int J Surg Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800548","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222033816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222033816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800548.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:10:11Z","timestamp":1760231411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222033816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006]]}},"alternative-id":["S0893395222033816"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800548","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant expression of CHFR in malignant peripheral nerve sheath tumors","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800548","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}