{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:15:42Z","timestamp":1791292542479,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6219,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1038\/modpathol.3800632","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T05:33:53Z","timestamp":1149831233000},"page":"1192-1202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pathway-specific apoptotic gene expression profiling in chronic lymphocytic leukemia and follicular lymphoma"],"prefix":"10.1016","volume":"19","author":[{"given":"David","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Satkunam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moayad","family":"Al Kaptan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Reiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800632_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1182\/asheducation-2004.1.163","article-title":"Chronic lymphocytic leukemia","volume":"1","author":"Byrd","year":"2004","journal-title":"Hematology"},{"key":"10.1038\/modpathol.3800632_bib2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","article-title":"Chronic lymphocytic leukemia","volume":"352","author":"Chiorazzi","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.3800632_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3816\/CLM.2005.n.022","article-title":"Prognosis of follicular lymphomas","volume":"6","author":"Solal-Celigny","year":"2005","journal-title":"Clin Lymphoma"},{"key":"10.1038\/modpathol.3800632_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.blre.2004.09.001","article-title":"Follicular lymphoma: time for a re-think?","volume":"19","author":"Gandhi","year":"2005","journal-title":"Blood Rev"},{"key":"10.1038\/modpathol.3800632_bib5","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.1200\/JCO.2005.07.019","article-title":"Treatment strategies in follicular lymphomas: current status and future perspectives","volume":"23","author":"Hiddemann","year":"2005","journal-title":"J Clin Oncol"},{"issue":"Supplement ii","key":"10.1038\/modpathol.3800632_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/annonc\/mdi731","article-title":"Biology and treatment of chronic lymphocytic leukemia","volume":"16","author":"Kokhaei","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1038\/modpathol.3800632_bib7","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.3874430","article-title":"Involvement of the bcl-2 gene in human follicular lymphoma","volume":"228","author":"Tsujimoto","year":"1985","journal-title":"Science"},{"key":"10.1038\/modpathol.3800632_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(89)90174-8","article-title":"bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation","volume":"57","author":"McDonnell","year":"1989","journal-title":"Cell"},{"key":"10.1038\/modpathol.3800632_bib9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1182\/blood.V99.1.282","article-title":"Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays","volume":"99","author":"Husson","year":"2002","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800632_bib10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2567.2005.02117.x","article-title":"Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia","volume":"114","author":"Packham","year":"2005","journal-title":"Immunology"},{"key":"10.1038\/modpathol.3800632_bib11","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.194.11.1625","article-title":"Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells","volume":"194","author":"Klein","year":"2001","journal-title":"J Exp Med"},{"key":"10.1038\/modpathol.3800632_bib12","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1084\/jem.194.11.1639","article-title":"Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia","volume":"194","author":"Rosenwald","year":"2001","journal-title":"J Exp Med"},{"key":"10.1038\/modpathol.3800632_bib13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/sj.leu.2403293","article-title":"Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma","volume":"18","author":"Schmechel","year":"2004","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.3800632_bib14","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/10428190500158789","article-title":"TNF family molecules in the serum of patients with B-cell chronic lymphocytic leukemia (B-CLL)","volume":"46","author":"Jablonska","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.3800632_bib15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/modpathol.3800409","article-title":"Immunohistochemical detection of cdc2 is useful in predicting survival in patients with mantle cell lymphoma","volume":"18","author":"Hui","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3800632_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.leukres.2003.10.013","article-title":"Differential expression of survivin in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemia","volume":"28","author":"Nakagawa","year":"2004","journal-title":"Leuk Res"},{"key":"10.1038\/modpathol.3800632_bib17","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/blood.V97.9.2777","article-title":"Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia","volume":"97","author":"Granziero","year":"2001","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800632_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1200\/JCO.1995.13.1.140","article-title":"Patterns of survival in patients with recurrent follicular lymphoma: a 20-year study from a single center","volume":"13","author":"Johnson","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.3800632_bib19","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1200\/JCO.1995.13.4.983","article-title":"Cladribine in the treatment of relapsed or refractory chronic lymphocytic leukemia","volume":"13","author":"Tallman","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1038\/modpathol.3800632_bib20","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1046\/j.0007-1048.2002.03362.x","article-title":"High-dose chlorambucil for the treatment of chronic lymphocytic leukaemia and low-grade non-Hodgkin's lymphoma","volume":"116","author":"Summerfield","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3800632_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/02841860151116303","article-title":"A systematic overview of chemotherapy effects in B-cell chronic lymphocytic leukaemia","volume":"40","author":"Kimby","year":"2001","journal-title":"Acta Oncol"},{"key":"10.1038\/modpathol.3800632_bib22","first-page":"454","article-title":"Chlorambucil drug resistance in chronic lymphocytic leukemia: the emerging role of DNA repair","volume":"7","author":"Panasci","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1038\/modpathol.3800632_bib23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/path.1768","article-title":"Expression of the NF-kappaB targets BCL2 and BIRC5\/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively","volume":"206","author":"Tracey","year":"2005","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.3800632_bib24","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1182\/blood.V91.9.3379","article-title":"Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitroIn vivo chemoresponses","volume":"91","author":"Kitada","year":"1998","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800632_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ajh.10453","article-title":"Mcl-1 and Bcl-2\/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia","volume":"75","author":"Saxena","year":"2004","journal-title":"Am J Hematol"},{"key":"10.1038\/modpathol.3800632_bib26","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1080\/10428190410001723317","article-title":"Role of myeloid cell factor-1 (Mcl-1) in chronic lymphocytic leukemia","volume":"45","author":"Johnston","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.3800632_bib27","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1182\/blood.V92.9.3226","article-title":"Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage","volume":"92","author":"Zhou","year":"1998","journal-title":"Blood"},{"key":"10.1038\/modpathol.3800632_bib28","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/S0002-9440(10)61178-9","article-title":"Overexpression of Mcl-1 in anaplastic large cell lymphoma cell lines and tumors","volume":"160","author":"Rassidakis","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3800632_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/path.1254","article-title":"Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression","volume":"199","author":"Khoury","year":"2003","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.3800632_bib30","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ajh.10139","article-title":"Bcl-2 family of proteins in indolent B-cell non-Hodgkin's lymphoma: study of 116 cases","volume":"70","author":"Agarwal","year":"2002","journal-title":"Am J Hematol"},{"key":"10.1038\/modpathol.3800632_bib31","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1093\/bioinformatics\/bth381","article-title":"Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies","volume":"20","author":"Wang","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1038\/modpathol.3800632_bib32","doi-asserted-by":"crossref","first-page":"46950","DOI":"10.1074\/jbc.M209050200","article-title":"CD27 and CD40 inhibit p53-independent mitochondrial pathways in apoptosis of B cells induced by B cell receptor ligation","volume":"277","author":"Hase","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/modpathol.3800632_bib33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1242\/jcs.01640","article-title":"Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors","volume":"118","author":"Depuydt","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1038\/modpathol.3800632_bib34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1365-2141.2005.05690.x","article-title":"Expression of C-IAP1, C-IAP2 and SURVIVIN discriminates different types of lymphoid malignancies","volume":"130","author":"Graaf","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3800632_bib35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/10611860108998769","article-title":"Treatment-induced expression of anti-apoptotic proteins in WSU-CLL, a human chronic lymphocytic leukemia cell line","volume":"9","author":"Wall","year":"2001","journal-title":"J Drug Target"},{"key":"10.1038\/modpathol.3800632_bib36","first-page":"1327","article-title":"Survivin apoptosis: an interloper between cell death and cell proliferation in cancer","volume":"79","author":"Altieri","year":"1999","journal-title":"Lab Invest"},{"key":"10.1038\/modpathol.3800632_bib37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1532\/IJH97.04031","article-title":"Clinical relevance of survivin as a biomarker in neoplasms, especially in adult T-cell leukemias and acute leukemias","volume":"80","author":"Sugahara","year":"2004","journal-title":"Int J Hematol"},{"key":"10.1038\/modpathol.3800632_bib38","first-page":"11","article-title":"Molecular biology of chronic lymphocytic leukemia","volume":"25","author":"Reed","year":"1998","journal-title":"Semin Oncol"},{"key":"10.1038\/modpathol.3800632_bib39","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.4161\/cc.3.9.1093","article-title":"An IAP in action: the multiple roles of survivin in differentiation, immunity and malignancy","volume":"3","author":"Zangemeister-Wittke","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1038\/modpathol.3800632_bib40","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1007\/s00018-002-8518-3","article-title":"Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer","volume":"59","author":"Zaffaroni","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"10.1038\/modpathol.3800632_bib41","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1038\/sj.onc.1208490","article-title":"Survivin mediates resistance to antiandrogen therapy in prostate cancer","volume":"24","author":"Zhang","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/modpathol.3800632_bib42","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1089\/106652702760277372","article-title":"Identifying and quantifying sources of variation in microarray data using high-density cDNA membrane arrays","volume":"9","author":"Coombes","year":"2002","journal-title":"J Comput Biol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800632.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800632","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522203335X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522203335X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800632.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:09:55Z","timestamp":1760231395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089339522203335X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006]]}},"alternative-id":["S089339522203335X"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800632","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathway-specific apoptotic gene expression profiling in chronic lymphocytic leukemia and follicular lymphoma","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}