{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:02:57Z","timestamp":1775746977631,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5795,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1038\/modpathol.3800748","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T20:51:04Z","timestamp":1170535864000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Colonic neuropathological aspects in patients with intractable constipation due to obstructed defecation"],"prefix":"10.1016","volume":"20","author":[{"given":"Gabrio","family":"Bassotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Nascimbeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado R","family":"Asteria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Fisogni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Nesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Legrenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Mariano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Tonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Salerni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800748_bib1","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1056\/NEJMra020995","article-title":"Chronic constipation","volume":"349","author":"Lembo","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.3800748_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1463-1318.2003.00497.x","article-title":"Obstructed defecation","volume":"5","author":"D'Hoore","year":"2003","journal-title":"Colorectal Dis"},{"key":"10.1038\/modpathol.3800748_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2982.2004.00526.x","article-title":"Investigation of the utility of colorectal function tests and Rome II criteria in dyssynergic defecation (anismus)","volume":"16","author":"Rao","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1038\/modpathol.3800748_bib4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1053\/j.gastro.2005.03.021","article-title":"Phenotypic variation in functional disorders of defecation","volume":"128","author":"Bharucha","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.3800748_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF01318172","article-title":"Anismus in chronic constipation","volume":"30","author":"Preston","year":"1985","journal-title":"Dig Dis Sci"},{"key":"10.1038\/modpathol.3800748_bib6","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/j.1572-0241.1998.00326.x","article-title":"Obstructed defecation: a failure of rectoanal coordination","volume":"93","author":"Rao","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/modpathol.3800748_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/bmj.328.7436.393","article-title":"Biofeedback for pelvic floor dysfunction in constipation","volume":"328","author":"Bassotti","year":"2004","journal-title":"BMJ"},{"key":"10.1038\/modpathol.3800748_bib8","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/BF02236736","article-title":"Rectal akinesia as a new cause of impaired defecation","volume":"43","author":"Faucheron","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"10.1038\/modpathol.3800748_bib9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/BF02235485","article-title":"Rectal compliance in females with obstructed defecation","volume":"44","author":"Gosselink","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"10.1038\/modpathol.3800748_bib10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-2982.2003.00392.x","article-title":"Rectal sensorimotor characteristics in female patients with idiopathic constipation with or without paradoxical sphincter contraction","volume":"15","author":"Sloots","year":"2003","journal-title":"Neurogastroenterol Motil"},{"key":"10.1038\/modpathol.3800748_bib11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1463-1318.2004.00632.x","article-title":"Anorectal physiology in relation to clinical subgroups of patients with severe constipation","volume":"6","author":"Karlbom","year":"2004","journal-title":"Colorectal Dis"},{"key":"10.1038\/modpathol.3800748_bib12","first-page":"859","article-title":"Bowel content shift during normal defaecation","volume":"58","author":"Halls","year":"1986","journal-title":"Proc R Soc Med"},{"key":"10.1038\/modpathol.3800748_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00341204","article-title":"Scintigraphic assessment of colonic function during defaecation","volume":"10","author":"Lubowski","year":"1995","journal-title":"Int J Colorectal Dis"},{"key":"10.1038\/modpathol.3800748_bib14","first-page":"G660","article-title":"Manometric investigation of high-amplitude propagated contractile activity of the human colon","volume":"255","author":"Bassotti","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1038\/modpathol.3800748_bib15","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.1572-0241.1999.01203.x","article-title":"Colonic motility in man: features in normal subjects and in patients with chronic idiopathic constipation","volume":"94","author":"Bassotti","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/modpathol.3800748_bib16","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/j.1572-0241.2000.01839.x","article-title":"Spatial and temporal organization of pressare patterns throughout the unprepared colon during spontaneous defecation","volume":"95","author":"Bampton","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/modpathol.3800748_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/j.gastro.2004.03.066","article-title":"Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation","volume":"127","author":"Dinning","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.3800748_bib18","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s10350-005-0087-8","article-title":"Impaired proximal colonic motor response to rectal mechanical and chemical stimulation in obstructed defecation","volume":"48","author":"Dinning","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"10.1038\/modpathol.3800748_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gut.45.2008.ii43","article-title":"Functional bowel disorders and functional abdominal pain","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"10.1038\/modpathol.3800748_bib20","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1007\/s10350-004-6717-8","article-title":"Biofeedback treatment of constipation: a critical review","volume":"46","author":"Heymen","year":"2003","journal-title":"Dis Colon Rectum"},{"key":"10.1038\/modpathol.3800748_bib21","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1053\/j.gastro.2005.11.064","article-title":"Functional anorectal disorders","volume":"130","author":"Bharucha","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.3800748_bib22","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/gut.51.4.496","article-title":"Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation","volume":"51","author":"Lyford","year":"2002","journal-title":"Gut"},{"key":"10.1038\/modpathol.3800748_bib23","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/jcp.2005.026112","article-title":"Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease","volume":"58","author":"Bassotti","year":"2005","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.3800748_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.2005.073197","article-title":"The role of glial cells and apoptosis of enteric neurons in the neuropathology of intractable slow transit constipation","volume":"55","author":"Bassotti","year":"2006","journal-title":"Gut"},{"key":"10.1038\/modpathol.3800748_bib25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2559.2006.02481.x","article-title":"Is pseudomelanosis coli a marker of colonic neuropathy in severely constipated patients?","volume":"49","author":"Villanacci","year":"2006","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3800748_bib26","doi-asserted-by":"crossref","unstructured":"Bassotti G, Villanacci V, Fisogni S, et al. Apoptotic phenomena are not a major cause of enteric neuronal loss in constipated patients with dementia. Neuropathology 2006 (in press).","DOI":"10.1111\/j.1440-1789.2006.00740.x"},{"key":"10.1038\/modpathol.3800748_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(90)90297-R","article-title":"Identification of a ligand for the c-kit proto-oncogene","volume":"63","author":"Williams","year":"1990","journal-title":"Cell"},{"key":"10.1038\/modpathol.3800748_bib28","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0022-3468(98)90152-X","article-title":"Distribution of c-Kit immunopositive cells in normal human colon and in Hirschsprung's disease","volume":"33","author":"Horisawa","year":"1998","journal-title":"J Pediatr Surg"},{"key":"10.1038\/modpathol.3800748_bib29","first-page":"59","article-title":"CD34+ cells in human intestine are fibroblasts adjacent to, but distinct from interstitial cells of Cajal","volume":"79","author":"Vanderwinden","year":"1999","journal-title":"Lab Invest"},{"key":"10.1038\/modpathol.3800748_bib30","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1038\/modpathol.3800748_bib31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.5858\/1999-123-1264-EOBIEN","article-title":"Expression of bcl-2 in enteric neurons in normal human bowel and in Hirschsprung disease","volume":"123","author":"Wester","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.3800748_bib32","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/01.pas.0000166365.83706.e6","article-title":"Immunohistochemical studies of pediatric intestinal pseudo-obstruction: bcl2, a valuable biomarker to detect immature enteric ganglion cells","volume":"29","author":"Park","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800748_bib33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/002215540104900311","article-title":"Identification of apoptotic cells by formamide-induced DNA denaturation in condensed chromatin","volume":"49","author":"Frankfurt","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/modpathol.3800748_bib34","unstructured":"Bassotti G, Villanacci V, Fisogni S, et al. Comparison of three methods to assess enteric neuronal apoptosis in patients with slow transit constipation. Apoptosis (in press)."},{"key":"10.1038\/modpathol.3800748_bib35","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1023\/A:1026695025990","article-title":"Apoptosis inhibiting factor Bcl-XL might be the crucial member of the Bcl-2 gene family in colorectal cancer","volume":"43","author":"Maurer","year":"1988","journal-title":"Dig Dis Sci"},{"key":"10.1038\/modpathol.3800748_bib36","first-page":"G1309","article-title":"Regional and transmural density of interstitial cells of Cajal in human colon and rectum","volume":"38","author":"Hagger","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1038\/modpathol.3800748_bib37","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1053\/gast.1996.v111.pm8690216","article-title":"A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract","volume":"111","author":"Sanders","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.3800748_bib38","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1743-3150.2004.00485.x","article-title":"Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles","volume":"16","author":"Ward","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1038\/modpathol.3800748_bib39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00384-003-0577-x","article-title":"Decreased interstitial cells of Cajal in the sigmoid colon of patients with slow transit constipation","volume":"19","author":"Tong","year":"2004","journal-title":"Int J Colorect Dis"},{"key":"10.1038\/modpathol.3800748_bib40","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00000478-200302000-00012","article-title":"Loss of CD117 (c-kit)- and CD34-positive ICC and associated CD34-positive fibroblasts defines a subpopulation of chronic intestinal pseudo-obstruction","volume":"27","author":"Streutker","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800748_bib41","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1055\/s-2008-1066121","article-title":"Experience with neuronal intestinal dysplasia (NID) in adults","volume":"4","author":"Stoss","year":"1994","journal-title":"Eur J Pediatr Surg"},{"key":"10.1038\/modpathol.3800748_bib42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0306-4522(81)90135-4","article-title":"Ultrastructure of the nerve plexuses of the mammalian intestine: the enteric glial cells","volume":"6","author":"Gabella","year":"1981","journal-title":"Neuroscience"},{"key":"10.1038\/modpathol.3800748_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/glia.440040211","article-title":"Enteric glia","volume":"4","author":"Gershon","year":"1991","journal-title":"Glia"},{"key":"10.1038\/modpathol.3800748_bib44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2982.2005.00687.x","article-title":"Glial cells in the gut","volume":"17","author":"R\u00fbhl","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1038\/modpathol.3800748_bib45","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF01318690","article-title":"Immunohistochemical characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon in inflammatory bowel disease","volume":"31","author":"Hirata","year":"1986","journal-title":"Dig Dis Sci"},{"key":"10.1038\/modpathol.3800748_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/glia.10169","article-title":"Role of enteric glial cells in inflammatory bowel disease","volume":"41","author":"Cabarrocas","year":"2003","journal-title":"Glia"},{"key":"10.1038\/modpathol.3800748_bib47","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000046901","article-title":"L-arginine immunoreactive enteric glial cells in the enteric nervous system of rat ileum","volume":"10","author":"Nagahama","year":"2001","journal-title":"Biol Signals Recept"},{"key":"10.1038\/modpathol.3800748_bib48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(03)02147-2","article-title":"Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors","volume":"476","author":"Giaroni","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/modpathol.3800748_bib49","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/glia.10215","article-title":"Intercellular calcium waves in cultured enteric glia from neonatal guinea pig","volume":"42","author":"Zhang","year":"2003","journal-title":"Glia"},{"key":"10.1038\/modpathol.3800748_bib50","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/bies.10039","article-title":"Enteric glial cells. An upstream target for induction of necrotizing enterocolitis and Crohn's disease?","volume":"24","author":"Bush","year":"2002","journal-title":"Bioessays"},{"key":"10.1038\/modpathol.3800748_bib51","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/gut.2005.067595","article-title":"Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption","volume":"55","author":"Aube","year":"2006","journal-title":"Gut"},{"key":"10.1038\/modpathol.3800748_bib52","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/gut.2005.084426","article-title":"Glial regulation of neuronal plasticity in the gut: implications for clinicians","volume":"55","author":"R\u00fbhl","year":"2006","journal-title":"Gut"},{"key":"10.1038\/modpathol.3800748_bib53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1743-3150.2004.00476.x","article-title":"The human enteric nervous system","volume":"16","author":"Schemann","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1038\/modpathol.3800748_bib54","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0016-5085(90)90003-J","article-title":"An in vitro study of the projections of enteric vasoactive intestinal polypeptide-immunoreactive neurons in the human colon","volume":"98","author":"Domoto","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.3800748_bib55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1053\/j.gastro.2005.11.014","article-title":"Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia","volume":"130","author":"Chiarioni","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1038\/modpathol.3800748_bib56","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/qjmed\/90.8.545","article-title":"Biofeedback, relaxation training, and cognitive behaviour modification as treatments for lower functional gastrointestinal disorders","volume":"90","author":"Bassotti","year":"1997","journal-title":"Q J Med"},{"key":"10.1038\/modpathol.3800748_bib57","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/gut.42.4.517","article-title":"Biofeedback provides long-term benefit for patients with intractable, slow and normal transit constipation","volume":"42","author":"Chiotakakou-Faliakou","year":"1998","journal-title":"Gut"},{"key":"10.1038\/modpathol.3800748_bib58","series-title":"Schuster Atlas of Gastrointestinal Motility","first-page":"381","article-title":"Motility as a therapeutic modality: biofeedback treatment of gastrointestinal disorders","author":"Whitehead","year":"2002"},{"key":"10.1038\/modpathol.3800748_bib59","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/bmj.39007.760174.47","article-title":"Chronic constipation in children","volume":"333","author":"Rubin","year":"2006","journal-title":"BMJ"},{"key":"10.1038\/modpathol.3800748_bib60","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/gut.39.3.486","article-title":"What has happened to the cathartic colon?","volume":"39","author":"Muller-Lissner","year":"1996","journal-title":"Gut"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800748.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800748","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222016453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222016453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800748.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:51:27Z","timestamp":1760230287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222016453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0893395222016453"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800748","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colonic neuropathological aspects in patients with intractable constipation due to obstructed defecation","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}