{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:51:55Z","timestamp":1791229915021,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5703,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1038\/modpathol.3800784","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T05:07:57Z","timestamp":1176440877000},"page":"676-684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Significance of C4d staining in ABO-identical\/compatible liver transplantation"],"prefix":"10.1016","volume":"20","author":[{"given":"Hiromi","family":"Sakashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishi","family":"Ashihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Chin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Miyagawa-Hayashino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Egawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutsugu","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taira","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Uemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800784_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0889-8553(21)00343-5","article-title":"Immunological factors influencing liver graft survival","volume":"17","author":"Gordon","year":"1988","journal-title":"Gastroenterol Clin N Am"},{"key":"10.1038\/modpathol.3800784_bib2","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/hep.1840160618","article-title":"Preformed lymphocytotoxic antibodies: the effects of class, titer and specificity on liver vs heart allografts","volume":"16","author":"Furuya","year":"1992","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800784_bib3","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1097\/00007890-199511000-00024","article-title":"IgG donor-specific crossmatches are not associated with graft rejection or poor graft survival after liver transplantation. An assessment by cytotoxicity and flow cytometry","volume":"60","author":"Donaldson","year":"1995","journal-title":"Transplantation"},{"key":"10.1038\/modpathol.3800784_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/10408369509084688","article-title":"Effect of crossmatching on outcome in organ transplantation","volume":"32","author":"Wang-Rodriguez","year":"1995","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1038\/modpathol.3800784_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/hep.1840160310","article-title":"A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies","volume":"16","author":"Demetris","year":"1992","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800784_bib6","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0168-8278(96)80166-8","article-title":"Influence of anti-HLA antibodies and positive T-lymphocytotoxic crossmatch on survival and graft rejection in human liver transplantation","volume":"24","author":"Charco","year":"1996","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.3800784_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.trim.2005.03.013","article-title":"Liver recipients harbouring anti-donor preformed lymphocytotoxic antibodies exhibit a poor allograft survival at the first year after transplantation: experience of one centre","volume":"14","author":"Muro","year":"2005","journal-title":"Transplant Immunol"},{"key":"10.1038\/modpathol.3800784_bib8","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1034\/j.1600-6143.2003.00072.x","article-title":"Antibody-mediated rejection criteria\u2014an addition to the Banff 97 classification of renal allograft rejection","volume":"3","author":"Racusen","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1038\/modpathol.3800784_bib9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1600-6143.2004.00500.x","article-title":"National conference to assess antibody-mediated rejection in solid organ transplantation","volume":"4","author":"Takemoto","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1038\/modpathol.3800784_bib10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nri1702","article-title":"Antibody-mediated organ-allograft rejection","volume":"5","author":"Colvin","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/modpathol.3800784_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/01.TP.0000132324.14207.8B","article-title":"Description of B lymphocytes and plasma cells, complement, and chemokines\/receptors in acute liver allograft rejection","volume":"78","author":"Krukemeyer","year":"2004","journal-title":"Transplantation"},{"key":"10.1038\/modpathol.3800784_bib12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1399-0012.2004.00310.x","article-title":"Lobular damage caused by cellular and humoral immunity in liver allograft rejection","volume":"19","author":"Sawada","year":"2005","journal-title":"Clin Transplant"},{"key":"10.1038\/modpathol.3800784_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00428-004-1182-2","article-title":"Molecular case report: IgVH analysis in acute humoral and cellular liver allograft rejection suggests a selected accumulation of effector B cells and plasma cells","volume":"446","author":"Moeller","year":"2005","journal-title":"Virchows Arch"},{"key":"10.1038\/modpathol.3800784_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00428-005-1245-z","article-title":"Portal capillary C4d deposits and increased infiltration by macrophages indicate humorally mediated mechanisms in acute cellular liver allograft rejection","volume":"447","author":"Dankof","year":"2005","journal-title":"Virchows Arch"},{"key":"10.1038\/modpathol.3800784_bib15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1600-6143.2005.01180.x","article-title":"C4d in acute rejection after liver transplantation\u2014a valuable tool in differential diagnosis to hepatitis C recurrence","volume":"6","author":"Schmeding","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1038\/modpathol.3800784_bib16","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.transproceed.2006.03.018","article-title":"Significance of C4d deposition in the diagnosis of rejection after liver transplantation","volume":"38","author":"Bu","year":"2006","journal-title":"Transplant Proc"},{"key":"10.1038\/modpathol.3800784_bib17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1399-0012.2006.00528.x","article-title":"Characterization of CD4, CD8, CD56 positive lymphocytes and C4d deposits to distinguish acute cellular rejection from recurrent hepatitis C in post-liver transplant biopsies","volume":"20","author":"Jain","year":"2006","journal-title":"Clin Transplant"},{"key":"10.1038\/modpathol.3800784_bib18","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.transproceed.2006.06.120","article-title":"C4d: a marker for hepatic transplant rejection","volume":"38","author":"Lorho","year":"2006","journal-title":"Transplant Proc"},{"key":"10.1038\/modpathol.3800784_bib19","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.5858\/2006-130-1489-EOCSIL","article-title":"Evaluation of C4d staining in liver and small intestine allografts","volume":"130","author":"Troxell","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.3800784_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/lt.20652","article-title":"Acute humoral rejection and C4d immunostaining in ABO blood type-incompatible liver transplantation","volume":"12","author":"Haga","year":"2006","journal-title":"Liver Transplant"},{"key":"10.1038\/modpathol.3800784_bib21","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.510250328","article-title":"Banff schema for grading liver allograft rejection: an international consensus document","volume":"25","author":"International Panel","year":"1997","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800784_bib22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.510310337","article-title":"Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel","volume":"31","author":"Demetris","year":"2000","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800784_bib23","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1111\/j.1600-6143.2006.01531.x","article-title":"Liver transplantation from an identical twin without immunosuppression, with early recurrence of Hepatitis C","volume":"6","author":"Yoshizawa","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1038\/modpathol.3800784_bib24","first-page":"270","article-title":"Complement activation in human lymphoid germinal centres","volume":"66","author":"Zwirner","year":"1989","journal-title":"Immunology"},{"key":"10.1038\/modpathol.3800784_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/lt.20002","article-title":"Periportal edema and necrosis as diagnostic histological features of early humoral rejection in ABO-incompatible liver transplantation","volume":"10","author":"Haga","year":"2004","journal-title":"Liver Transplant"},{"key":"10.1038\/modpathol.3800784_bib26","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.humpath.2005.08.002","article-title":"Comparative study for the detection of peritubular capillary C4d deposition in human renal allografts using different methodologies","volume":"36","author":"Nadasdy","year":"2005","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3800784_bib27","first-page":"489","article-title":"Antibody-mediated rejection of human orthotopic liver allografts. A study of liver transplantation across ABO blood group barriers","volume":"132","author":"Demetris","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3800784_bib28","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0168-8278(00)80247-0","article-title":"Complement activation induced by ischemia-reperfusion in humans: a study in patients undergoing partial hepatectomy","volume":"32","author":"Straatsburg","year":"2000","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.3800784_bib29","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1111\/j.1600-6143.2006.01554.x","article-title":"Isolated donor specific alloantibody-mediated rejection after ABO compatible liver transplantation","volume":"6","author":"Watson","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1038\/modpathol.3800784_bib30","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/ndt\/gfl594","article-title":"C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques","volume":"22","author":"Seemayer","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/modpathol.3800784_bib31","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0140-6736(83)90845-0","article-title":"Expression of HLA-DR antigens on bile duct cells of rejected liver transplant","volume":"2","author":"Takacs","year":"1983","journal-title":"Lancet"},{"key":"10.1038\/modpathol.3800784_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/path.1711620210","article-title":"Changes in the expression of major histocompatibility complex class II antigens in liver allograft rejection","volume":"162","author":"Hubscher","year":"1990","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.3800784_bib33","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4049\/jimmunol.173.1.230","article-title":"Liver sinusoidal endothelial cells are insufficient to activate T cells","volume":"173","author":"Katz","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/modpathol.3800784_bib34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1432-2277.2004.00025.x","article-title":"Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers","volume":"18","author":"Onoe","year":"2005","journal-title":"Transpl Int"},{"key":"10.1038\/modpathol.3800784_bib35","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/lt.20415","article-title":"Intragraft expression of recipient-type ABO blood group antigens: long-term follow-up and histological features after liver transplantation","volume":"11","author":"Tanaka","year":"2005","journal-title":"Liver Transpl"},{"key":"10.1038\/modpathol.3800784_bib36","first-page":"50","article-title":"Expression of ABH blood group antigens, Ulex europaeus agglutinin I, and type IV collagen in the sinusoids of hepatocellular carcinoma","volume":"115","author":"Terada","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.3800784_bib37","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/gut.22.12.985","article-title":"Immunohistochemical analysis of HLA (A, B, C) antigens in liver disease using a monoclonal antibody","volume":"22","author":"Barbatis","year":"1981","journal-title":"Gut"},{"key":"10.1038\/modpathol.3800784_bib38","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.20434","article-title":"A novel mechanism of liver allograft rejection facilitated by antibodies to liver sinusoidal endothelial cells","volume":"40","author":"Sumitran-Holgersson","year":"2004","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800784_bib39","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/00007890-199902270-00014","article-title":"Postoperative flow cytometry crossmatch in living donor liver transplantation: clinical significance of humoral immunity in acute rejection","volume":"67","author":"Kasahara","year":"1999","journal-title":"Transplantation"},{"key":"10.1038\/modpathol.3800784_bib40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/01.TP.0000110295.88926.5C","article-title":"Impact of recipient age on outcome of ABO-incompatible living-donor liver transplantation","volume":"77","author":"Egawa","year":"2004","journal-title":"Transplantation"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800784.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800784","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222049511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222049511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800784.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:21:53Z","timestamp":1760232113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222049511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0893395222049511"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800784","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Significance of C4d staining in ABO-identical\/compatible liver transplantation","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}