{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:00:15Z","timestamp":1790434815102,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5703,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1038\/modpathol.3800788","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T05:07:57Z","timestamp":1176440877000},"page":"701-709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":258,"title":["Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria"],"prefix":"10.1016","volume":"20","author":[{"given":"Yoh","family":"Zen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Volkan","family":"Adsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystof","family":"Bardadin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano","family":"Colombari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Ferrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Mo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prodromos","family":"Hytiroglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Kl\u00f6ppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y","family":"Lauwers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Notohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoko","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Quaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Sessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arief","family":"Suriawinata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Atomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3800788_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-131-4-199908170-00003","article-title":"Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer","volume":"131","author":"Brentnall","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1038\/modpathol.3800788_bib2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S1542-3565(04)00244-7","article-title":"Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach","volume":"2","author":"Canto","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1038\/modpathol.3800788_bib3","first-page":"1785","article-title":"Cold-knife conization versus photodynamic therapy with topical 5-aminolevulinic acid (5-ALA) in cervical intraepithelial neoplasia (CIN) II with associated human papillomavirus infection: a comparison of preliminary results","volume":"23","author":"Bodner","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1038\/modpathol.3800788_bib4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00000478-199508000-00002","article-title":"Interobserver reproducibility in the diagnosis of prostatic intraepithelial neoplasia","volume":"19","author":"Epstein","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800788_bib5","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/00000478-200211000-00001","article-title":"p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia","volume":"26","author":"Klaes","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800788_bib6","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/00000478-199909000-00014","article-title":"A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens","volume":"23","author":"Bergeron","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800788_bib7","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.mpa.0000186245.35716.18","article-title":"Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreement","volume":"31","author":"Longnecker","year":"2005","journal-title":"Pancreas"},{"key":"10.1038\/modpathol.3800788_bib8","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/01.pas.0000163360.40357.f1","article-title":"A proposal for a new and more practical grading scheme for pancreatic ductal adenocarcinoma","volume":"29","author":"Adsay","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800788_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00534-002-0729-3","article-title":"Anatomic and molecular pathology of intrahepatic cholangiocarcinoma","volume":"10","author":"Nakanuma","year":"2003","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1038\/modpathol.3800788_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0168-8278(00)00034-9","article-title":"Biliary dysplasia as a marker of cholangiocarcinoma in primary sclerosing cholangitis","volume":"34","author":"Fleming","year":"2001","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.3800788_bib11","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jhep.2005.09.025","volume":"44","author":"Zen","year":"2006","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.3800788_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-2004-828897","article-title":"Invasive colloid carcinoma arising from intraductal papillary neoplasm in a 50-year-old woman with primary sclerosing cholangitis","volume":"24","author":"Bu-Ghanim","year":"2004","journal-title":"Semin Liver Dis"},{"key":"10.1038\/modpathol.3800788_bib13","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0046-8177(03)00337-X","article-title":"Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract","volume":"34","author":"Abraham","year":"2003","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3800788_bib14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1055\/s-2007-1001418","article-title":"Biliary papillomatosis: clinical, cholangiographic and cholangioscopic findings","volume":"30","author":"Kim","year":"1998","journal-title":"Endoscopy"},{"key":"10.1038\/modpathol.3800788_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1053\/jhep.2001.28199","article-title":"Intraductal papillary neoplasia of the liver associated with hepatolithiasis","volume":"34","author":"Chen","year":"2001","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800788_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jhep.2005.11.035","article-title":"Is the intraductal papillary mucinous neoplasia of the biliary tract a counterpart of pancreatic papillary mucinous neoplasm?","volume":"44","author":"Kloppel","year":"2006","journal-title":"J Hepatol"},{"key":"10.1038\/modpathol.3800788_bib17","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.21387","article-title":"Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas","volume":"44","author":"Zen","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800788_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1440-1827.2005.01816.x","article-title":"Proposal of histological criteria for intraepithelial atypical\/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement","volume":"55","author":"Zen","year":"2005","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.3800788_bib19","series-title":"World Health Organization Classification of Tumours Pathology and Genetics of Tumours of the Digestive System","first-page":"173","article-title":"Intrahepatic cholangiocarcinoma","author":"Nakanuma","year":"2000"},{"key":"10.1038\/modpathol.3800788_bib20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/01.pas.0000126675.59108.80","article-title":"An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms","volume":"28","author":"Hruban","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800788_bib21","first-page":"527","article-title":"Pathology of prostatic intraepithelial neoplasia and adenocarcinoma of the prostate: prognostic influences of stage, tumor volume, grade, and margins of resection","volume":"21","author":"Epstein","year":"1994","journal-title":"Semin Oncol"},{"key":"10.1038\/modpathol.3800788_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1038\/modpathol.3800788_bib23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1053\/hupa.2002.127444","article-title":"Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4\/Dpc4 in intrahepatic cholangiocarcinoma","volume":"33","author":"Kang","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3800788_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1365-2796.2001.00775.x","article-title":"Biliary dysplasia, cell proliferation and nuclear DNA-fragmentation in primary sclerosing cholangitis with and without cholangiocarcinoma","volume":"249","author":"Bergquist","year":"2001","journal-title":"J Intern Med"},{"key":"10.1038\/modpathol.3800788_bib25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0748-7983(97)92436-7","article-title":"Ras p21 protein immunoreactivity and its relationship to p53 expression and prognosis in gallbladder and extrahepatic biliary carcinoma","volume":"23","author":"Lee","year":"1997","journal-title":"Eur J Surg Oncol"},{"key":"10.1038\/modpathol.3800788_bib26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/00000478-200105000-00003","article-title":"Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions","volume":"25","author":"Hruban","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800788_bib27","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/01.MP.0000028647.98725.8B","article-title":"The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis","volume":"15","author":"Adsay","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3800788_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/hep.20837","article-title":"Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions","volume":"42","author":"Yeh","year":"2005","journal-title":"Hepatology"},{"key":"10.1038\/modpathol.3800788_bib29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00000478-200403000-00005","article-title":"Pathologic features of mucin-producing bile duct tumors: two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms","volume":"28","author":"Shibahara","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3800788_bib30","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/modpathol.3800643","article-title":"Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct","volume":"19","author":"Zen","year":"2006","journal-title":"Mod Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3800788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800788","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222049547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222049547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3800788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:21:58Z","timestamp":1760232118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222049547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0893395222049547"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3800788","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3800788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}