{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:54:36Z","timestamp":1791471276936,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5458,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1038\/modpathol.3801002","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T12:38:42Z","timestamp":1197635922000},"page":"192-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":259,"title":["Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms"],"prefix":"10.1016","volume":"21","author":[{"given":"Daisuke","family":"Nonaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Chiriboga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Ghossein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3801002_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1440-1827.2006.01959.x","article-title":"Immunohistochemical analysis of thyroid-specific transcription factors in thyroid tumors","volume":"56","author":"Zhang","year":"2006","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.3801002_bib2","series-title":"Pathology & Genetics, Tumours of Endocrine Organs","first-page":"49","article-title":"Tumours of the thyroid and parathyroid","author":"DeLellis","year":"2004"},{"key":"10.1038\/modpathol.3801002_bib3","series-title":"Rosai and Ackerman's Surgical Pathology","first-page":"515","article-title":"Thyroid gland","author":"Rosai","year":"2004"},{"key":"10.1038\/modpathol.3801002_bib4","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nm0798-844","article-title":"Tissue microarrays for high-throughput molecular profiling of tumor specimens","volume":"4","author":"Kononen","year":"1998","journal-title":"Nat Med"},{"key":"10.1038\/modpathol.3801002_bib5","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0002-9440(10)64075-8","article-title":"Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors","volume":"158","author":"Hoos","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3801002_bib6","first-page":"106","article-title":"Cancer statistics, 2006","volume":"56","author":"Jemal","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"10.1038\/modpathol.3801002_bib7","series-title":"Endocrine Tumors","first-page":"278","article-title":"Thyroid carcinoma: papillary and follicular","author":"Mazzaferri","year":"1993"},{"key":"10.1038\/modpathol.3801002_bib8","series-title":"Tumors of the Lower Respiratory Tract","first-page":"107","article-title":"Carcinoma of the lung; clinical, radiographic aspects, spread, staging, management, and prognosis","author":"Colby","year":"1995"},{"key":"10.1038\/modpathol.3801002_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/thy.1998.8.149","article-title":"Clinical and pathological characteristics of secondary thyroid cancer","volume":"8","author":"Lin","year":"1998","journal-title":"Thyroid"},{"key":"10.1038\/modpathol.3801002_bib10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/1097-0142(196205\/06)15:3<557::AID-CNCR2820150315>3.0.CO;2-H","article-title":"Metastatic neoplasms in the thyroid gland. Pathological and clinical findings","volume":"15","author":"Shimaoka","year":"1962","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3801002_bib11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<574::AID-CNCR21>3.0.CO;2-#","article-title":"Metastasis to the thyroid gland. A report of 43 cases","volume":"79","author":"Nakhjavani","year":"1997","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3801002_bib12","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/1097-0142(19840215)53:4<982::AID-CNCR2820530427>3.0.CO;2-E","article-title":"Pulmonary metastases in differentiated thyroid carcinoma. Study of 58 cases with implications for the primary tumor treatment","volume":"53","author":"Massin","year":"1984","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3801002_bib13","series-title":"Morphogenesis of Peripheral Type Adenocarcinoma of the Lung","first-page":"65","author":"Shimosato","year":"1982"},{"key":"10.1038\/modpathol.3801002_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00428-001-0552-2","article-title":"Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases","volume":"440","author":"Zamecnik","year":"2002","journal-title":"Virchows Arch"},{"key":"10.1038\/modpathol.3801002_bib15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/modpathol.3880098","article-title":"Thyroid transcription factor-1 in normal, hyperplastic, and neoplastic follicular thyroid cells examined by immunohistochemistry and nonradioactive in situ hybridization","volume":"13","author":"Katoh","year":"2000","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3801002_bib16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00000478-200206000-00010","article-title":"TTF-1 expression in pulmonary adenocarcinomas","volume":"26","author":"Yatabe","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3801002_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00129039-200009000-00004","article-title":"Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms","volume":"8","author":"Bejarano","year":"2000","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/modpathol.3801002_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ajcp\/83.2.135","article-title":"Anaplastic thyroid carcinoma. A study of 70 cases","volume":"83","author":"Carcangiu","year":"1985","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3801002_bib19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/ajcp\/87.4.434","article-title":"Anaplastic thyroid tumors. Immunohistology","volume":"87","author":"LiVolsi","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3801002_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00000478-200303000-00004","article-title":"Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases","volume":"27","author":"Rossi","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3801002_bib21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1053\/hupa.2000.16667","article-title":"Variable expression of keratins and nearly uniform lack of thyroid transcription factor 1 in thyroid anaplastic carcinoma","volume":"31","author":"Miettinen","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3801002_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/PAP.0b013e31802f0495","article-title":"New transcription factors in diagnostic hematopathology","volume":"14","author":"Ponzoni","year":"2007","journal-title":"Adv Anat Pathol"},{"key":"10.1038\/modpathol.3801002_bib23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1210\/jc.2004-1358","article-title":"PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations","volume":"90","author":"Trueba","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/modpathol.3801002_bib24","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/thy.2004.14.1037","article-title":"Cytoplasmic localization of the paired box gene, Pax-8, is found in pediatric thyroid cancer and may be associated with a greater risk of recurrence","volume":"14","author":"Scouten","year":"2004","journal-title":"Thyroid"},{"key":"10.1038\/modpathol.3801002_bib25","doi-asserted-by":"crossref","first-page":"13144","DOI":"10.1073\/pnas.240336397","article-title":"Pax8 has a key role in thyroid cell differentiation","volume":"97","author":"Pasca","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.3801002_bib26","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1002\/j.1460-2075.1990.tb07574.x","article-title":"Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity","volume":"9","author":"Guazzi","year":"1990","journal-title":"EMBO J"},{"key":"10.1038\/modpathol.3801002_bib27","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/jmg.2004.024158","article-title":"Genetics of congenital hypothyroidism","volume":"42","author":"Park","year":"2005","journal-title":"J Med Genet"},{"key":"10.1038\/modpathol.3801002_bib28","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1089\/105072503322511328","article-title":"Production and application of polyclonal antibody to human thyroid transcription factor 2 reveals thyroid transcription factor 2 protein expression in adult thyroid and hair follicles and prepubertal testis","volume":"13","author":"Sequeira","year":"2003","journal-title":"Thyroid"},{"key":"10.1038\/modpathol.3801002_bib29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/1294","article-title":"Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia","volume":"19","author":"Clifton-Bligh","year":"1998","journal-title":"Nat Genet"},{"key":"10.1038\/modpathol.3801002_bib30","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1093\/hmg\/11.17.2051","article-title":"A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate","volume":"11","author":"Castanet","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1038\/modpathol.3801002_bib31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1242\/dev.116.3.611","article-title":"PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms\u2019 tumors","volume":"116","author":"Poleev","year":"1992","journal-title":"Development"},{"key":"10.1038\/modpathol.3801002_bib32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1210\/en.2006-1054","article-title":"Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy","volume":"148","author":"Mittag","year":"2007","journal-title":"Endocrinology"},{"key":"10.1038\/modpathol.3801002_bib33","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1210\/er.2003-0028","article-title":"Thyroid development and its disorders: genetics and molecular mechanisms","volume":"25","author":"De Felice","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1038\/modpathol.3801002_bib34","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/0303-7207(91)90018-N","article-title":"Human thyrotropin receptor gene: expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation","volume":"82","author":"Brabant","year":"1991","journal-title":"Mol Cell Endocrinol"},{"key":"10.1038\/modpathol.3801002_bib35","first-page":"3228","article-title":"Expression of the Na+\/I\u2212 symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes","volume":"84","author":"Lazar","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/modpathol.3801002_bib36","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/dvdy.20655","article-title":"Origin of the ultimobranchial body cyst: T\/ebp\/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid","volume":"235","author":"Kusakabe","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1038\/modpathol.3801002_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ygcen.2007.02.017","article-title":"Functional analysis of Nkx2.1 and Pax9 for calcitonin gene transcription","volume":"152","author":"Suzuki","year":"2007","journal-title":"Gen Comp Endocrinol"},{"key":"10.1038\/modpathol.3801002_bib38","first-page":"311","article-title":"Expression of Pax-8, p53 and bcl-2 in human benign and malignant thyroid diseases","volume":"20","author":"Puglisi","year":"2000","journal-title":"Anticancer Res"},{"key":"10.1038\/modpathol.3801002_bib39","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/105072501753271662","article-title":"Thyroid transcription factor-2 gene expression in benign and malignant thyroid lesions","volume":"11","author":"Sequeira","year":"2001","journal-title":"Thyroid"},{"key":"10.1038\/modpathol.3801002_bib40","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0046-8177(00)80255-5","article-title":"Expression of thyroid transcription factor-1 (TTF-1) in human C cells and medullary thyroid carcinomas","volume":"31","author":"Katoh","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3801002_bib41","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1681\/ASN.2006070739","article-title":"Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney","volume":"18","author":"Narlis","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/modpathol.3801002_bib42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ygyno.2006.08.052","article-title":"Emerging roles for PAX8 in ovarian cancer and endosalpingeal development","volume":"104","author":"Bowen","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1038\/modpathol.3801002_bib43","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1245\/ASO.2006.05.042","article-title":"Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches","volume":"13","author":"Are","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"10.1038\/modpathol.3801002_bib44","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1097\/01.JTO.0000269736.28833.b5","article-title":"Optimizing chemotherapy for patients with advanced non-small cell lung cancer","volume":"2","author":"Scagliotti","year":"2007","journal-title":"J Thorac Oncol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3801002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3801002","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222034767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222034767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3801002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:11:22Z","timestamp":1760231482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222034767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0893395222034767"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3801002","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3801002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}