{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T13:41:02Z","timestamp":1786196462322,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":8167,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1038\/modpathol.3880178","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T12:59:44Z","timestamp":1081947584000},"page":"978-987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":162,"title":["Splenic Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 28 Cases"],"prefix":"10.1016","volume":"13","author":[{"given":"Thomas S","family":"Neuhauser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A","family":"Derringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester D R","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C","family":"Fanburg-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Miettinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Saaristo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L","family":"Abbondanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3880178_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00000478-198204000-00005","article-title":"Primary nonlymphoreticular malignant neoplasms of the spleen","volume":"6","author":"Wick","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880178_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/mpo.2950090403","article-title":"Primary hemangiosarcoma of the spleen: report of four cases","volume":"9","author":"Sordillo","year":"1981","journal-title":"Med Pediatr Oncol"},{"key":"10.1038\/modpathol.3880178_bib3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/00000478-199310000-00001","article-title":"Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases","volume":"17","author":"Falk","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880178_bib4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/00007611-199508000-00020","article-title":"Primary angiosarcoma of the spleen: a case report and review of the literature","volume":"88","author":"McGinley","year":"1995","journal-title":"South Med J"},{"key":"10.1038\/modpathol.3880178_bib5","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/1097-0142(19850401)55:7<1625::AID-CNCR2820550736>3.0.CO;2-W","article-title":"Primary splenic angiosarcoma. Case report and literature review","volume":"55","author":"Smith","year":"1985","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880178_bib6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotin-peroxidase techniques in comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/modpathol.3880178_bib7","first-page":"641","article-title":"Malignant vascular tumors","author":"Enzinger","year":"1994","journal-title":"Soft tissue tumors"},{"key":"10.1038\/modpathol.3880178_bib8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF01605079","article-title":"Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome","volume":"419","author":"Kindblom","year":"1991","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1038\/modpathol.3880178_bib9","first-page":"122","article-title":"Angiosarcoma of the spleen: a report of two cases and review of the literature","volume":"103","author":"Chen","year":"1979","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/modpathol.3880178_bib10","first-page":"61","article-title":"Cysts and nonlymphomatous tumors of the spleen","volume":"16","author":"Garvin","year":"1981","journal-title":"Pathol Annu"},{"key":"10.1038\/modpathol.3880178_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/15513818509026906","article-title":"Angiosarcoma of the liver and spleen in an infant","volume":"4","author":"Alt","year":"1985","journal-title":"Pediatr Pathol"},{"key":"10.1038\/modpathol.3880178_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/(SICI)1096-9098(199603)61:3<170::AID-JSO2>3.0.CO;2-8","article-title":"Prognostic factors in angiosarcoma: a multivariate analysis of 55 cases","volume":"61","author":"Naka","year":"1996","journal-title":"J Surg Oncol"},{"key":"10.1038\/modpathol.3880178_bib13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/00000478-199806000-00005","article-title":"Angiosarcoma of soft tissue: a study of 80 cases","volume":"22","author":"Meis-Kindblom","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880178_bib14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/path.1700420310","article-title":"Angioblastoma of the spleen with metastasis in the liver","volume":"42","author":"DeNavasquez","year":"1936","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.3880178_bib15","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/1097-0142(197609)38:3<1386::AID-CNCR2820380343>3.0.CO;2-1","article-title":"Hemangiosarcoma of liver and spleen treated by hepatic artery ligation, intraportal infusion chemotherapy, and splenectomy","volume":"38","author":"Nagasue","year":"1976","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880178_bib16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00003072-199005000-00010","article-title":"Functional asplenia and portal hypertension in a patient with primary splenic hemangiosarcoma","volume":"15","author":"Yucel","year":"1990","journal-title":"Clin Nucl Med"},{"key":"10.1038\/modpathol.3880178_bib17","first-page":"65","article-title":"Case report of malignant splenic tumor","volume":"10","author":"Hayasaka","year":"1992","journal-title":"Radiat Med"},{"key":"10.1038\/modpathol.3880178_bib18","first-page":"213","article-title":"Primary splenic angiosarcoma. A case report","volume":"85","author":"Wilkinson","year":"1968","journal-title":"Arch Pathol"},{"key":"10.1038\/modpathol.3880178_bib19","first-page":"510","article-title":"Primary hemangiosarcoma of the spleen with sarcomatosis","volume":"74","author":"VanDerburgh","year":"1975","journal-title":"J Am Osteopath Assoc"},{"key":"10.1038\/modpathol.3880178_bib20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00004728-199203000-00021","article-title":"MRI of primary spleen angiosarcoma with iron accumulation","volume":"16","author":"Kaneko","year":"1992","journal-title":"J Comput Assist Tomogr"},{"key":"10.1038\/modpathol.3880178_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/028418519403500512","article-title":"Primary angiosarcoma of the spleen","volume":"35","author":"Ha","year":"1994","journal-title":"Acta Radiol"},{"key":"10.1038\/modpathol.3880178_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00000478-199401000-00006","article-title":"Epithelioid angiosarcoma of the adrenal glands. A clinicopathologic study of nine cases with a discussion of the implications of finding \u201cepithelial-specific\u201d markers","volume":"18","author":"Wenig","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880178_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0955-0674(98)80137-3","article-title":"Signaling angiogenesis and lymphangiogenesis","volume":"10","author":"Korpelainen","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/modpathol.3880178_bib24","first-page":"1599","article-title":"Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3","volume":"58","author":"Jussila","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3880178_bib25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0002-9440(10)65583-6","article-title":"Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors","volume":"153","author":"Lymboussaki","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880178_bib26","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0002-9440(10)65392-8","article-title":"VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer","volume":"154","author":"Valtola","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880178_bib27","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1002\/(SICI)1097-0142(19991201)86:11<2406::AID-CNCR31>3.0.CO;2-E","article-title":"Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors","volume":"86","author":"Partanen","year":"1999","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880178_bib28","unstructured":"McHugh M, Miettinen M . KP1 (CD68), it's limited specificity for histiocytic tumors. Appl Immunohistochem 1994; 186\u2013190."},{"key":"10.1038\/modpathol.3880178_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jcp.28.2.124","article-title":"The distribution of muramidase (lysozyme) in human tissues","volume":"28","author":"Mason","year":"1975","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.3880178_bib30","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/37.4.2926127","article-title":"Tissue distribution of antileukoprotease and lysozyme in humans","volume":"37","author":"Franken","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/modpathol.3880178_bib31","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/00000478-199707000-00011","article-title":"Splenic vascular tumors: a histologic, immunophenotypic, and virologic study","volume":"21","author":"Arber","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880178_bib32","first-page":"147","article-title":"Phenotypic subpopulations of macrophages and dendritic cells in human spleen","volume":"5","author":"Buckley","year":"1991","journal-title":"Scanning Microsc"},{"key":"10.1038\/modpathol.3880178_bib33","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4049\/jimmunol.134.4.2310","article-title":"Human splenic sinusoidal lining cells express antigens associated with monocytes, macrophages, endothelial cells, and T lymphocytes","volume":"134","author":"Buckley","year":"1985","journal-title":"J Immunol"},{"key":"10.1038\/modpathol.3880178_bib34","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s002920050233","article-title":"Littoralzellangiosarkom der Milz. Morphologische, immunhistochemische Befunde und Uberlegungen zur Histogenese eines seltenen Milztumors","volume":"18","author":"Meybehm","year":"1997","journal-title":"Pathologe"},{"key":"10.1038\/modpathol.3880178_bib35","first-page":"702","article-title":"Splenic hemangiosarcoma with sinus endothelial differentiation","volume":"43","author":"Takato","year":"1993","journal-title":"Acta Pathol Jpn"},{"key":"10.1038\/modpathol.3880178_bib36","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1600-0560.1994.tb00270.x","article-title":"Cutaneous granular cell angiosarcoma","volume":"21","author":"Hitchcock","year":"1994","journal-title":"J Cutan Pathol"},{"key":"10.1038\/modpathol.3880178_bib37","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/00000478-199111000-00001","article-title":"Littoral cell angioma, a novel splenic vascular lesion demonstrating histiocytic differentiation","volume":"15","author":"Falk","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880178_bib38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1365-2559.1989.tb02201.x","article-title":"Hamartomas of the spleen: a study of 20 biopsy cases","volume":"14","author":"Falk","year":"1989","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3880178_bib39","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/0046-8177(91)90108-2","article-title":"Splenic hamartoma and capillary hemangioma are distinct entities: immunohistochemical analysis of CD8 expression by endothelial cells","volume":"22","author":"Zukerberg","year":"1991","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3880178_bib40","first-page":"505","article-title":"Human spleen contains phenotypic subsets of macrophages and dendritic cells that occupy discrete microanatomic locations","volume":"128","author":"Buckley","year":"1987","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880178_bib41","first-page":"150","article-title":"Angiosarcoma of liver in the manufacture of polyvinyl chloride","volume":"16","author":"Creech","year":"1974","journal-title":"J Occup Med"},{"key":"10.1038\/modpathol.3880178_bib42","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1749-6632.1967.tb50270.x","article-title":"Late effects of thorotrast on the liver and spleen, and their efferent lymph nodes","volume":"145","author":"Horta","year":"1967","journal-title":"Ann N Y Acad Sci"},{"key":"10.1038\/modpathol.3880178_bib43","first-page":"113","article-title":"Angiosarcoma of liver and spleen in a scrap metal merchant","volume":"40","author":"Fawcett","year":"1983","journal-title":"Br J Ind Med"},{"key":"10.1038\/modpathol.3880178_bib44","first-page":"229","article-title":"Malignancy and other injuries following Thorotrast administration: follow-up study of 147 cases in Japan","volume":"134","author":"Mori","year":"1967","journal-title":"Strahlentherapie"},{"key":"10.1038\/modpathol.3880178_bib45","first-page":"349","article-title":"Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic. Comparison with cases of unknown etiology","volume":"92","author":"Popper","year":"1978","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880178_bib46","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/1097-0142(19811001)48:7<1674::AID-CNCR2820480733>3.0.CO;2-H","article-title":"Lymphangiosarcoma","volume":"48","author":"Sordillo","year":"1981","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880178_bib47","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/jso.2930380415","article-title":"Lymphangiosarcoma in postmastectomy lymphedema (Stewart-Treves syndrome): ultrastructural and immunohistologic characteristics","volume":"38","author":"Tomita","year":"1988","journal-title":"J Surg Oncol"},{"key":"10.1038\/modpathol.3880178_bib48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0748-7983(95)90765-3","article-title":"Lymphangiosarcoma. Reports of 3 cases and review of the literature","volume":"21","author":"Gebhart","year":"1995","journal-title":"Eur J Surg Oncol"},{"key":"10.1038\/modpathol.3880178_bib49","first-page":"511","article-title":"Lymphangiosarcoma of the pubic region: a rare complication arising in congenital non-hereditary lymphedema","volume":"8","author":"Cerri","year":"1998","journal-title":"Eur J Dermatol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3880178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880178","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222039370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222039370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:15:09Z","timestamp":1760231709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222039370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0893395222039370"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3880178","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Splenic Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 28 Cases","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3880178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2000 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}