{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:01:08Z","timestamp":1770822068244,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":8014,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1038\/modpathol.3880269","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T13:06:55Z","timestamp":1081948015000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Megakaryopoiesis and Myelofibrosis in Chronic Myeloid Leukemia after Allogeneic Bone Marrow Transplantation: An Immunohistochemical Study of 127 Patients"],"prefix":"10.1016","volume":"14","author":[{"given":"Juergen","family":"Thiele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Michael","family":"Kvasnicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich Wilhelm","family":"Beelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Flucke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Spoer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Paperno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz-Dietrich","family":"Leder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich Wilhelm","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3880269_bib1","first-page":"405","article-title":"Bone marrow transplantation for chronic myelogenous leukemia","volume":"22","author":"Appelbaum","year":"1995","journal-title":"Semin Oncol"},{"key":"10.1038\/modpathol.3880269_bib2","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1182\/blood.V85.10.2981.bloodjournal85102981","article-title":"Prolonged administration of interferon-\u03b1 in patients with chronic-phase Philadelphia chromosome-positive chronic myelogenous leukemia before allogeneic bone marrow transplantation may adversely affect transplant outcome","volume":"36","author":"Beelen","year":"1995","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0950-3536(97)80010-8","article-title":"Allografting for chronic myeloid leukaemia","volume":"10","author":"Clift","year":"1997","journal-title":"Baillieres Clin Haematol"},{"key":"10.1038\/modpathol.3880269_bib4","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/sj.bmt.1701031","article-title":"Bone marrow transplantation for chronic myeloid leukemia (CML) from unrelated and sibling donors: single center experience","volume":"20","author":"Lamparelli","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"10.1038\/modpathol.3880269_bib5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.bmt.1700933","article-title":"Long-term results after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase: a report from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation","volume":"20","author":"Van Rhee","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"10.1038\/modpathol.3880269_bib6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1046\/j.1365-2141.1998.00790.x","article-title":"Unrelated donor marrow transplantation for chronic myelogenous leukaemia","volume":"102","author":"Dini","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3880269_bib7","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1056\/NEJM199804023381405","article-title":"Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia","volume":"338","author":"Hansen","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1038\/modpathol.3880269_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0344-0338(84)80124-7","article-title":"Chronic myeloproliferative disorders (CMPD)","volume":"179","author":"Burkhardt","year":"1984","journal-title":"Pathol Res Pract"},{"key":"10.1038\/modpathol.3880269_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0344-0338(11)81008-3","article-title":"Chronic myeloproliferative disorders in bone marrow biopsies","volume":"186","author":"Georgii","year":"1990","journal-title":"Pathol Res Pract"},{"key":"10.1038\/modpathol.3880269_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01600283","article-title":"Megakaryocytopoiesis in haematological disorders: diagnostic features of bone marrow biopsies. An overview","volume":"418","author":"Thiele","year":"1991","journal-title":"Virchows Archiv A Pathol Anat"},{"key":"10.1038\/modpathol.3880269_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/BF01600251","article-title":"The impact of megakaryocyte proliferation for the evolution of myelofibrosis. Histological follow-up study in 186 patients with chronic myeloid leukemia","volume":"420","author":"Buhr","year":"1992","journal-title":"Virchows Arch A Pathol Anat"},{"key":"10.1038\/modpathol.3880269_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0609.1993.tb00073.x","article-title":"Potential of bone marrow biopsy in chronic myeloproliferative disorders (MPD)","volume":"50","author":"Bartl","year":"1993","journal-title":"Eur J Haematol"},{"key":"10.1038\/modpathol.3880269_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2141.1994.tb04969.x","article-title":"Pathogenesis of idiopathic myelofibrosis: present status and future directions","volume":"88","author":"Reilly","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3880269_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/10428199509059613","article-title":"Platelet derived growth factor expression, myelofibrosis and chronic myelogenous leukemia","volume":"18","author":"Kimura","year":"1995","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.3880269_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/10428199509054751","article-title":"TGF-\u03b2 and megakaryocytes in the pathogenesis of myelofibrosis in myeloproliferative disorders","volume":"20","author":"Martyr\u00e9","year":"1995","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.3880269_bib16","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1182\/blood.V75.7.1540.1540","article-title":"The production of transforming growth factor-\u03b2 in acute megakaryoblastic leukemia and its possible implication in myelofibrosis","volume":"75","author":"Terui","year":"1990","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2141.1993.tb04631.x","article-title":"Characterization of an acute micromegakaryocytic leukemia: evidence for the pathogenesis of myelofibrosis","volume":"83","author":"Reilly","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3880269_bib18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2559.1988.tb02037.x","article-title":"The immunohistological detection of platelet, megakaryocytes and thrombi in routinely processed specimens","volume":"13","author":"Gatter","year":"1988","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3880269_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-0609.1990.tb00349.x","article-title":"An immunomorphometric study on megakaryocyte precursor cells in bone marrow tissue from patients with chronic myeloid leukemia (CML)","volume":"44","author":"Thiele","year":"1990","journal-title":"Eur J Haematol"},{"key":"10.1038\/modpathol.3880269_bib20","first-page":"509","article-title":"Bone marrow transplantation for chronic myeloid leukemia: long-term results","volume":"12","author":"Gratwohl","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"10.1038\/modpathol.3880269_bib21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/jcp.43.5.365","article-title":"Early reconstitution of haematopoiesis after allogeneic bone marrow transplantation: a prospective histopathological study of bone marrow biopsy specimens","volume":"43","author":"Van den Berg","year":"1990","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.3880269_bib22","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0344-0338(96)80052-5","article-title":"Histopathology of bone marrow after allogeneic bone marrow transplantation for chronic myeloid leukaemia","volume":"192","author":"Rousselet","year":"1996","journal-title":"Pathol Res Pract"},{"key":"10.1038\/modpathol.3880269_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0968-6053(05)80062-6","article-title":"Bone marrow trephine biopsy changes following chemotherapy and\/or bone marrow transplantation","volume":"4","author":"Hurwitz","year":"1997","journal-title":"Curr Diagn Pathol"},{"key":"10.1038\/modpathol.3880269_bib24","first-page":"1241","article-title":"Bone marrow histopathology in chronic myelogenous leukemia (CML)\u2014evaluation of distinctive features with clinical impact","volume":"14","author":"Thiele","year":"1999","journal-title":"Histol Histopathol"},{"key":"10.1038\/modpathol.3880269_bib25","first-page":"310","article-title":"Detection and quantification of transforming growth factor \u03b2 (TGF-\u03b2) and platelet-derived growth factor (PDGF) release by normal human megakaryocytes","volume":"9","author":"Wickenhauser","year":"1995","journal-title":"Leukemia"},{"key":"10.1038\/modpathol.3880269_bib26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1182\/blood.V85.3.685.bloodjournal853685","article-title":"Secretion of cytokines (IL-1a, IL-3, and IL6 and GM-CSF) by normal human bone marrow megakaryocytes","volume":"85","author":"Wickenhauser","year":"1995","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-0609.1995.tb00229.x","article-title":"Influence of cytokines (IL-1a. IL-11, GM-CSF) on megakaryocyte-fibroblasts interactions in normal human bone marrow","volume":"55","author":"Schmitz","year":"1995","journal-title":"Eur J Haematol"},{"key":"10.1038\/modpathol.3880269_bib28","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1182\/blood.V79.7.1647.1647","article-title":"Determinants of engraftment after allogeneic marrow transplantation","volume":"79","author":"Martin","year":"1992","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib29","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1182\/blood.V76.9.1872.1872","article-title":"Induction of donor-type chimerism in murine recipients of bone marrow allografts by different radiation regimens currently used in treatment of leukemia patients","volume":"76","author":"Salomon","year":"1990","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/10428199809050913","article-title":"Changes in functional capacity of marrow stromal cells after autologous bone marrow transplantation","volume":"29","author":"Domenech","year":"1998","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/modpathol.3880269_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.1985.tb04064.x","article-title":"Increased growth and collagen synthesis of bone marrow fibroblasts from patients with chronic myelocytic leukaemia","volume":"61","author":"Yonekura","year":"1985","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3880269_bib32","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood.V51.6.1039.1039","article-title":"Cytogenetics of fibroblastic colonies in Ph1-positive chronic myelogenous leukemia","volume":"51","author":"Greenberg","year":"1978","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib33","first-page":"25","article-title":"Lack of cluster region rearrangement in marrow fibroblasts of patients with Philadelphia chromosome-positive chronic myelogenous leukemia","volume":"2","author":"O'Brien","year":"1988","journal-title":"Hematol Pathol"},{"key":"10.1038\/modpathol.3880269_bib34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2141.1980.tb01200.x","article-title":"Origin of human bone marrow fibroblasts","volume":"44","author":"Golde","year":"1980","journal-title":"Br J Haematol"},{"key":"10.1038\/modpathol.3880269_bib35","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1182\/blood.V60.5.1122.1122","article-title":"The significance of megakaryocyte size","volume":"60","author":"Levine","year":"1982","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib36","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1182\/blood.V67.5.1286.1286","article-title":"Separation of human megakaryocytes by state of differentiation on continuous gradients of Percoll: size and ploidy analysis of cells identified by monoclonal antibody to glycoprotein IIb\/IIIa","volume":"67","author":"Ishibashi","year":"1986","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib37","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1182\/blood.V74.2.594.594","article-title":"Flow cytometric analysis of megakaryocytes from patients with abnormal platelet counts","volume":"74","author":"Tomer","year":"1989","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib38","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1699-0463.1990.tb05005.x","article-title":"DNA content and nuclear size of megakaryocytes in thrombocythaemia","volume":"98","author":"Ridell","year":"1990","journal-title":"APMIS"},{"key":"10.1038\/modpathol.3880269_bib39","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1600-0609.1990.tb00383.x","article-title":"Megakaryocyte ploidy in thrombocytosis: improved microdensitometric measurement with a new image analysis system","volume":"44","author":"Woods","year":"1990","journal-title":"Eur J Haematol"},{"key":"10.1038\/modpathol.3880269_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1365-2559.1997.2480853.x","article-title":"Fluorescence in-situ hybridization (FISH) reveals that in chronic myelogenous leukaemia (CML) following interferon-\u03b1 therapy, normalization of megakaryocyte size is associated with the loss of bcr\/abl translocation","volume":"31","author":"Thiele","year":"1997","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3880269_bib42","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1182\/blood.V67.6.1693.1693","article-title":"Adverse effect of severe marrow fibrosis on hematologic recovery after chemoradiotherapy and allogeneic bone marrow transplantation","volume":"67","author":"Rajantie","year":"1986","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib43","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1182\/blood.V86.12.4667.bloodjournal86124667","article-title":"Relevance of marrow fibrosis in bone marrow transplantation: a retrospective analysis of engraftment","volume":"86","author":"Soll","year":"1995","journal-title":"Blood"},{"key":"10.1038\/modpathol.3880269_bib41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb03880.x","article-title":"Reversal of severe bone marrow fibrosis and osteosclerosis following allogeneic bone marrow transplantation for chronic granulolytic leukaemia","volume":"52","author":"McGlave","year":"1982","journal-title":"Br J Haematol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3880269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880269","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522203856X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522203856X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:14:15Z","timestamp":1760231655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089339522203856X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S089339522203856X"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3880269","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Megakaryopoiesis and Myelofibrosis in Chronic Myeloid Leukemia after Allogeneic Bone Marrow Transplantation: An Immunohistochemical Study of 127 Patients","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3880269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2001 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}