{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:59:29Z","timestamp":1770821969683,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7772,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1038\/modpathol.3880423","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T13:04:46Z","timestamp":1081947886000},"page":"985-994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Clinicopathologic and DNA Cytometric Analysis of Carcinoid Tumors of the Thymus"],"prefix":"10.1016","volume":"14","author":[{"given":"Koichi","family":"Goto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yokose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Asamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriki","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Shimosato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3880423_bib1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/1097-0142(197204)29:4<1061::AID-CNCR2820290456>3.0.CO;2-3","article-title":"Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid tumor. Clinicopathologic study of 8 cases","volume":"29","author":"Rosai","year":"1972","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/1097-0142(197204)29:4<1075::AID-CNCR2820290457>3.0.CO;2-O","article-title":"Mediastinal endocrine neoplasm in patients with multiple endocrine adenomatosis. A previously unrecognized association","volume":"29","author":"Rosai","year":"1972","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/1097-0142(19930101)71:1<106::AID-CNCR2820710117>3.0.CO;2-U","article-title":"Adrenocorticotropic hormone\u2013producing thymic carcinoid in a teenager","volume":"71","author":"Gartner","year":"1993","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00000478-198204000-00001","article-title":"Primary mediastinal carcinoid tumors","volume":"6","author":"Wick","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880423_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0003-4975(90)90070-M","article-title":"Bronchial and thymic carcinoids and the ectopic ACTH syndrome","volume":"50","author":"Odell","year":"1990","journal-title":"Ann Thorac Surg"},{"key":"10.1038\/modpathol.3880423_bib6","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/1097-0142(197602)37:2<958::AID-CNCR2820370253>3.0.CO;2-9","article-title":"Carcinoid tumors of the thymus","volume":"37","author":"Salyer","year":"1976","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0003-4975(90)90085-K","article-title":"Management of the ectopic ACTH syndrome due to thoracic carcinoids","volume":"50","author":"Pass","year":"1990","journal-title":"Ann Thorac Surg"},{"key":"10.1038\/modpathol.3880423_bib8","first-page":"875","article-title":"A case of thymic carcinoid with multiple endocrine neoplasm (MEN)-type I [Japanese]","volume":"52","author":"Kondo","year":"1999","journal-title":"Kyobu Geka"},{"key":"10.1038\/modpathol.3880423_bib9","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1002\/1097-0142(197906)43:6<2497::AID-CNCR2820430648>3.0.CO;2-J","article-title":"Mediastinal carcinoid with an incomplete Sipple's syndrome","volume":"43","author":"Marchevsky","year":"1979","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0002-9610(87)90305-9","article-title":"Carcinoids associated with multiple endocrine neoplasia syndromes","volume":"154","author":"Duh","year":"1987","journal-title":"Am J Surg"},{"key":"10.1038\/modpathol.3880423_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00000658-199807000-00015","article-title":"Thymic carcinoids in multiple endocrine neoplasia type 1","volume":"228","author":"Teh","year":"1998","journal-title":"Ann Surg"},{"key":"10.1038\/modpathol.3880423_bib12","first-page":"430","article-title":"Thymic carcinoid in association with MEN syndromes","volume":"58","author":"Zeiger","year":"1992","journal-title":"Am Surg"},{"key":"10.1038\/modpathol.3880423_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0022-5223(96)70409-9","article-title":"Thymic neuroendocrine carcinoma (carcinoid): a clinicopathologic study of fourteen cases","volume":"111","author":"de Montpreville","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1038\/modpathol.3880423_bib14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00000478-199106000-00003","article-title":"Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases","volume":"15","author":"Travis","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880423_bib15","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-60157-6","author":"Rosai","year":"1999","journal-title":"Histological typing of tumours of the thymus. World Health Organization international histological classification of tumours"},{"key":"10.1038\/modpathol.3880423_bib16","first-page":"158","article-title":"Tumor of the mediastinum. Atlas of tumor pathology","author":"Shimosato","year":"1997","journal-title":"Atlas of tumor pathology"},{"key":"10.1038\/modpathol.3880423_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2559.1994.tb00539.x","article-title":"Atypical carcinoid tumour of the thymus: a study of eight cases","volume":"24","author":"Valli","year":"1994","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3880423_bib18","first-page":"246","article-title":"Carcinoid tumor of the thymus: a clinicopathologic report of seven cases with a review of the literature","volume":"55","author":"Wick","year":"1980","journal-title":"Mayo Clin Proc"},{"key":"10.1038\/modpathol.3880423_bib19","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/1097-0142(19871115)60:10<2465::AID-CNCR2820601020>3.0.CO;2-0","article-title":"Carcinoid tumors of the thymus. An immunohistochemical study","volume":"60","author":"Herbst","year":"1987","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0003-4975(90)90087-M","article-title":"Carcinoid tumors of the thymus","volume":"50","author":"Economopoulos","year":"1990","journal-title":"Ann Thorac Surg"},{"key":"10.1038\/modpathol.3880423_bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0046-8177(94)90205-4","article-title":"Carcinoid tumor of the thymus with divergent sarcomatoid differentiation: report of a case with histogenetic consideration","volume":"25","author":"Kuo","year":"1994","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3880423_bib22","first-page":"587","article-title":"Spindle-cell neuroendocrine carcinomas of the thymus (spindle-cell thymic carcinoid): a clinicopathologic and immunohistochemical study of seven cases","volume":"12","author":"Moran","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3880423_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/1097-0142(19840201)53:3<475::AID-CNCR2820530318>3.0.CO;2-W","article-title":"Thymic carcinoid. A histologic, immunohistochemical, and ultrastructural study of 12 cases","volume":"53","author":"Wick","year":"1984","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib24","first-page":"946","article-title":"Pigmented thymic carcinoids: a clinicopathological and immunohistochemical study of two cases","volume":"12","author":"Klemm","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3880423_bib25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2559.1977.tb01673.x","article-title":"Pigmented carcinoid tumour of the thymus","volume":"1","author":"Ho","year":"1977","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3880423_bib26","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/00000478-199511000-00008","article-title":"Thymic carcinoid with prominent mucinous stroma. Report of a distinctive morphologic variant of thymic neuroendocrine neoplasm","volume":"19","author":"Suster","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880423_bib27","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/00000478-199808000-00003","article-title":"Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid","volume":"22","author":"Travis","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880423_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/cyto.990060106","article-title":"Flow cytometric determination of DNA ploidy level in nuclei isolated from paraffin-embedded tissue","volume":"6","author":"Schutte","year":"1985","journal-title":"Cytometry"},{"key":"10.1038\/modpathol.3880423_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/cyto.990030503","article-title":"A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis","volume":"3","author":"Vindelov","year":"1983","journal-title":"Cytometry"},{"key":"10.1038\/modpathol.3880423_bib30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1046\/j.1440-1827.1999.00937.x","article-title":"Assessment of DNA content in formalin-fixed, paraffin-embedded tissue of lung cancer by laser scanning cytometer","volume":"49","author":"Kamiya","year":"1999","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.3880423_bib31","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/ajcp\/102.4.432","article-title":"Evaluation of a new slide-based laser scanning cytometer for DNA analysis of tumors. Comparison with flow cytometry and image analysis","volume":"102","author":"Martin-Reay","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3880423_bib32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/(SICI)1097-0320(19960201)23:2<106::AID-CYTO3>3.0.CO;2-I","article-title":"DNA ploidy analysis by laser scanning cytometry (LSC) in colorectal cancers and comparison with flow cytometry","volume":"23","author":"Sasaki","year":"1996","journal-title":"Cytometry"},{"key":"10.1038\/modpathol.3880423_bib33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1440-1827.1994.tb02600.x","article-title":"Thymic carcinoma: proposal for pathological TNM and staging","volume":"44","author":"Tsuchiya","year":"1994","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.3880423_bib34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1309\/3PDN-PMT5-EQTM-H0CD","article-title":"Neuroendocrine carcinomas (carcinoid tumor) of the thymus. A clinicopathologic analysis of 80 cases","volume":"114","author":"Moran","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3880423_bib35","first-page":"107","article-title":"Therapeutic strategy for malignant thymic epithelial tumors. Questionnaire survey on thymic epithelial tumors in Japan [Japanese]","volume":"14","author":"Kondo","year":"2000","journal-title":"J Jpn Assoc Chest Surg"},{"key":"10.1038\/modpathol.3880423_bib36","first-page":"5","article-title":"The endodermal origin of digestive and respiratory tract APUD cells. Histopathologic evidence and a review of the literature","volume":"96","author":"Sidhu","year":"1979","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880423_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/thx.49.4.357","article-title":"Carcinoid tumours of the thymus","volume":"49","author":"Wang","year":"1994","journal-title":"Thorax"},{"key":"10.1038\/modpathol.3880423_bib38","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/00000478-199810000-00012","article-title":"Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors","volume":"22","author":"Lantuejoul","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880423_bib39","first-page":"1146","article-title":"A bronchial carcinoid tumor in a patient with a high level of serum carcinoembryonic antigen [Japanese]","volume":"33","author":"Arai","year":"1995","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"10.1038\/modpathol.3880423_bib40","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/1097-0142(19860915)58:6<1316::AID-CNCR2820580622>3.0.CO;2-D","article-title":"Carcinoembryonic antigen in primary carcinoid tumors of the lung","volume":"58","author":"Bishopric","year":"1986","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib41","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/ajcp\/95.6.828","article-title":"Typical and atypical bronchopulmonary carcinoids. A clinicopathologic and flow cytometric study","volume":"95","author":"el-Naggar","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3880423_bib42","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/1097-0142(19910715)68:2<374::AID-CNCR2820680227>3.0.CO;2-2","article-title":"Flow cytometric DNA content analysis in neuroendocrine carcinoma of the lung. Correlation with survival and histologic subtype","volume":"68","author":"Jackson-York","year":"1991","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880423_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/thx.43.3.195","article-title":"DNA ploidy in bronchopulmonary carcinoid tumours","volume":"43","author":"Jones","year":"1988","journal-title":"Thorax"},{"key":"10.1038\/modpathol.3880423_bib44","first-page":"119","article-title":"Bronchopulmonary carcinoids and regional lymph node metastases. A quantitative pathologic investigation","volume":"132","author":"Thunnissen","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880423_bib45","first-page":"502","article-title":"Typical and atypical carcinoid tumors of lung: a clinicopathologic and DNA analysis of 20 tumors","volume":"3","author":"Yousem","year":"1990","journal-title":"Mod Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3880423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880423","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222036821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222036821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:12:43Z","timestamp":1760231563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222036821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S0893395222036821"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3880423","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathologic and DNA Cytometric Analysis of Carcinoid Tumors of the Thymus","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3880423","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2001 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}