{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:09:23Z","timestamp":1787893763032,"version":"build-2784847793"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7529,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1038\/modpathol.3880575","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T13:10:10Z","timestamp":1081948210000},"page":"617-624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Aberrant Nuclear Localization and Gene Mutation of \u03b2-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules"],"prefix":"10.1016","volume":"15","author":[{"given":"Yukio","family":"Nakatani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Masudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Inayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ishiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Notohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Resl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene J","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/modpathol.3880575_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00000478-198203000-00009","article-title":"Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung)","volume":"6","author":"Kradin","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880575_bib2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0046-8177(90)90145-U","article-title":"Pulmonary endodermal tumor resembling fetal lung. A clinicopathologic study of five cases with immunohistochemical and ultrastructural characterization","volume":"21","author":"Nakatani","year":"1990","journal-title":"Hum Pathol"},{"key":"10.1038\/modpathol.3880575_bib3","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/1097-0142(19910501)67:9<2368::AID-CNCR2820670926>3.0.CO;2-G","article-title":"Pulmonary blastomas","volume":"67","author":"Koss","year":"1991","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880575_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00000478-199804000-00003","article-title":"Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms","volume":"22","author":"Nakatani","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880575_bib5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00000478-199406000-00008","article-title":"Pulmonary endodermal tumor resembling fetal lung. The optically clear nucleus is rich in biotin","volume":"18","author":"Nakatani","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880575_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/00000478-198410000-00002","article-title":"Six cases of well-differentiated adenocarcinoma simulating fetal lung tubules in pseudoglandular stage. Comparison with pulmonary blastoma","volume":"8","author":"Kodama","year":"1984","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880575_bib7","first-page":"783","article-title":"Immunohistochemical and electron microscopic study of the intranuclear inclusion bodies containing biotin in the ovarian endometrioid carcinoma","volume":"24","author":"Tsujimoto","year":"1991","journal-title":"J Clin Electron Microsc"},{"key":"10.1038\/modpathol.3880575_bib8","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1002\/1097-0142(19921215)70:12<2923::AID-CNCR2820701232>3.0.CO;2-G","article-title":"Peculiar nuclear clearing composed of microfilaments in papillary carcinoma of the thyroid","volume":"70","author":"Yamashita","year":"1992","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880575_bib9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/1097-0142(19930701)72:1<300::AID-CNCR2820720153>3.0.CO;2-1","article-title":"Peculiar nuclear clearing composed of microfilaments in papillary carcinoma of the thyroid [letter]","volume":"72","author":"Tsang","year":"1993","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880575_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1440-1827.1995.tb03505.x","article-title":"Morule with biotin-containing intranuclear inclusions in thyroid carcinoma","volume":"45","author":"Okamoto","year":"1995","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.3880575_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1440-1827.1996.tb03633.x","article-title":"p53 and Ki-67 immunoreactivity and nuclear morphometry of \u201ccarcinoma-in-adenoma\u201d and adenoma of the gall-bladder","volume":"46","author":"Takei","year":"1996","journal-title":"Pathol Int"},{"key":"10.1038\/modpathol.3880575_bib12","first-page":"945","article-title":"Pancreatoblastoma. Optically clear nuclei in squamoid corpuscles are rich in biotin","volume":"11","author":"Tanaka","year":"1998","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3880575_bib13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00000478-199903000-00014","article-title":"Morules with biotin-containing optically clear nuclei in colonic tubular adenoma","volume":"23","author":"Sasaki","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/modpathol.3880575_bib14","first-page":"400","article-title":"Cribriform-morular variant of papillary carcinoma. A distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma","volume":"12","author":"Cameselle-Teijeiro","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3880575_bib15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-2559.1994.tb01374.x","article-title":"Familial adenomatous polyposis associated thyroid carcinoma. A distinct type of follicular cell neoplasm","volume":"25","author":"Harach","year":"1994","journal-title":"Histopathology"},{"key":"10.1038\/modpathol.3880575_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0002-9440(10)65259-5","article-title":"Familial adenomatous polyposis-associated thyroid cancer. A clinical, pathological, and molecular genetics study","volume":"154","author":"Soravia","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880575_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jso.2930600314","article-title":"Familial adenomatous polyposis and lung cancer","volume":"60","author":"Wong","year":"1995","journal-title":"J Surg Oncol"},{"key":"10.1038\/modpathol.3880575_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1749-6632.2000.tb06698.x","article-title":"Control of \u03b2-catenin signaling in tumor development","volume":"910","author":"Behrens","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/modpathol.3880575_bib19","first-page":"1130","article-title":"Mutational analysis of the APC\/\u03b2-catenin\/Tcf pathway in colorectal cancer","volume":"58","author":"Sparks","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3880575_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0344-0338(98)80129-5","article-title":"Nuclear overexpression of the oncoprotein b-catenin in colorectal cancer is localized predominantly at the invasion front","volume":"194","author":"Brabletz","year":"1998","journal-title":"Pathol Res Prac"},{"key":"10.1038\/modpathol.3880575_bib21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/jcp.51.12.891","article-title":"The expression of \u03b2-catenin in non-small-cell lung cancer","volume":"51","author":"Retera","year":"1998","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.3880575_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/jcp.54.5.391","article-title":"Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer","volume":"54","author":"Pirinen","year":"2001","journal-title":"J Clin Pathol"},{"key":"10.1038\/modpathol.3880575_bib23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1097>3.0.CO;2-9","article-title":"Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinomas","volume":"30","author":"Sunaga","year":"2001","journal-title":"Genes Chromosom Cancer"},{"key":"10.1038\/modpathol.3880575_bib24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1309\/T9CC-JNMD-1WGP-YPAF","article-title":"Somatic but not germline mutation of the APC gene in a case of cribriform-morular variant of papillary thyroid carcinoma","volume":"115","author":"Cameselle-Teijeiro","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/modpathol.3880575_bib25","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1083\/jcb.153.6.1161","article-title":"Tumor suppressor PTEN inhibits nuclear accumulation of \u03b2-catenin and T cell\/lymphoid enhancer factor 1-mediated transcriptional activation","volume":"153","author":"Persada","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1038\/modpathol.3880575_bib26","first-page":"6611","article-title":"Mutations of adenomatous polyposis coli and \u03b2-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydropropyl)amine in rats","volume":"60","author":"Tsujiuchi","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3880575_bib27","unstructured":"International Agency for Research on Cancer (IARC). Tobacco smoking.In: IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, Vol. 38. Lyon, France: IARC Press; 1985.p. 86\u2013392."},{"key":"10.1038\/modpathol.3880575_bib28","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0002-9440(10)64626-3","article-title":"Patterning and nuclear \u03b2-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation","volume":"157","author":"Kirchner","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880575_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1242\/dev.126.2.345","article-title":"Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo","volume":"126","author":"Logan","year":"1999","journal-title":"Development"},{"key":"10.1038\/modpathol.3880575_bib30","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10024001-0037-y","article-title":"Wnt signaling in human development. Beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage","volume":"4","author":"Eberhart","year":"2001","journal-title":"Pediatr Dev Pathol"},{"key":"10.1038\/modpathol.3880575_bib31","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1073\/pnas.95.8.4374","article-title":"Cell adhesion and the integrin-linked kinase regulate the LEF-1 and \u03b2-catenin signalling pathways","volume":"95","author":"Novak","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/modpathol.3880575_bib32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)65148-6","article-title":"\u03b2-catenin expression pattern in stage I and II ovarian carcinomas. Relationship with \u03b2-catenin gene mutations, clinicopathological features, and clinical outcome","volume":"155","author":"Gamallo","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880575_bib33","first-page":"19","article-title":"More frequent \u03b2-catenin exon 3 mutations in gallbladder adenomas than in carcinomas indicate different lineages","volume":"61","author":"Yanagisawa","year":"2001","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3880575_bib34","first-page":"3526","article-title":"\u03b2-catenin mutation in carcinoma of the uterine endometrium","volume":"58","author":"Fukuchi","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3880575_bib35","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/modpathol.3880196","article-title":"Mutational analysis of the CTNNB1 APC genes in uterine endometrioid carcinoma","volume":"13","author":"Schlosshauer","year":"2000","journal-title":"Mod Pathol"},{"key":"10.1038\/modpathol.3880575_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/path.856","article-title":"Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation","volume":"194","author":"Saegusa","year":"2001","journal-title":"J Pathol"},{"key":"10.1038\/modpathol.3880575_bib37","first-page":"346a","article-title":"Cribriform-morular variant of papillary thyroid carcinoma. A pathologic analysis of 15 cases","volume":"90","author":"Masudo","year":"2001","journal-title":"Proc Jpn Soc Pathol"},{"key":"10.1038\/modpathol.3880575_bib38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/1097-0142(20010101)91:1<42::AID-CNCR6>3.0.CO;2-7","article-title":"Frequent nuclear accumulation of \u03b2-catenin in pituitary adenoma","volume":"91","author":"Semba","year":"2001","journal-title":"Cancer"},{"key":"10.1038\/modpathol.3880575_bib39","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0002-9440(10)64047-3","article-title":"Sporadic fundic gland polyps. Common gastric polyps arising through activating mutations in the \u03b2-catenin gene","volume":"158","author":"Abraham","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880575_bib40","first-page":"3320","article-title":"Somatic mutations of the APC gene in sporadic hepatoblastomas","volume":"56","author":"Oda","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/modpathol.3880575_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3835(99)00433-4","article-title":"Somatic mutations of \u03b2-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma","volume":"152","author":"Jeng","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1038\/modpathol.3880575_bib42","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0002-9440(10)64045-X","article-title":"Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis","volume":"158","author":"Garcia-Rostan","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880575_bib43","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0002-9440(10)63008-8","article-title":"Distinctive molecular alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas. Frequent alterations in the APC\/\u03b2-catenin pathway and chromosome 11p","volume":"159","author":"Abraham","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/modpathol.3880575_bib44","first-page":"312a","article-title":"Abnormality of the Wmt signaling pathway in pancreatoblastoma and solid-pseudopapillary neoplasm","volume":"91","author":"Kato","year":"2002","journal-title":"Proc Jpn Soc Pathol"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3880575.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880575","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222048608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0893395222048608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3880575.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:22:45Z","timestamp":1760232165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0893395222048608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["S0893395222048608"],"URL":"https:\/\/doi.org\/10.1038\/modpathol.3880575","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant Nuclear Localization and Gene Mutation of \u03b2-catenin in Low-Grade Adenocarcinoma of Fetal Lung Type: Up-Regulation of the Wnt Signaling Pathway May Be a Common Denominator for the Development of Tumors that Form Morules","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.3880575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}