{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:20:34Z","timestamp":1791048034556,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1038\/mp.2008.100","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T08:10:32Z","timestamp":1221552632000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Population-based linkage analysis of schizophrenia and bipolar case\u2013control cohorts identifies a potential susceptibility locus on 19q13"],"prefix":"10.1038","volume":"15","author":[{"given":"C","family":"Francks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Tozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Farmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Rujescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"St Clair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Muglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,16]]},"reference":[{"key":"BFmp2008100_CR1","first-page":"68","volume":"2","author":"W Berrettini","year":"2003","unstructured":"Berrettini W . Bipolar disorder and schizophrenia: not so distant relatives? World Psychiatry 2003; 2: 68\u201372.","journal-title":"World Psychiatry"},{"key":"BFmp2008100_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrg2344","volume":"9","author":"MI McCarthy","year":"2008","unstructured":"McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JPA et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008; 9: 356\u2013369.","journal-title":"Nat Rev Genet"},{"key":"BFmp2008100_CR3","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1192\/bjp.bp.106.025585","volume":"190","author":"JM McClellan","year":"2007","unstructured":"McClellan JM, Susser E, King MC . Schizophrenia: a common disease caused by multiple rare alleles. Br J Psychiatry 2007; 190: 194\u2013199.","journal-title":"Br J Psychiatry"},{"key":"BFmp2008100_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1126\/science.1138659","volume":"316","author":"J Sebat","year":"2007","unstructured":"Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T et al. Strong association of de novo copy number mutations with autism. Science 2007; 316: 445\u2013449.","journal-title":"Science"},{"key":"BFmp2008100_CR5","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.ajhg.2007.12.009","volume":"82","author":"CR Marshall","year":"2008","unstructured":"Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J et al. Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet 2008; 82: 477\u2013488.","journal-title":"Am J Hum Genet"},{"key":"BFmp2008100_CR6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1126\/science.1155174","volume":"320","author":"T Walsh","year":"2008","unstructured":"Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 2008; 320: 539\u2013543.","journal-title":"Science"},{"key":"BFmp2008100_CR7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559\u2013575.","journal-title":"Am J Hum Genet"},{"key":"BFmp2008100_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.schres.2005.09.002","volume":"82","author":"EJCG Van den Oord","year":"2006","unstructured":"Van den Oord EJCG, Rujescu D, Robles JR, Giegling I, Birrell C, Bukszar J et al. Factor structure and external validity of the PANSS revisited. Schizophr Res 2006; 82: 213\u2013223.","journal-title":"Schizophr Res"},{"key":"BFmp2008100_CR9","volume-title":"Mini-Mental-Status-Test: German Version","author":"J Kessler","year":"1990","unstructured":"Kessler J, Folstein SE, Denzler P . Mini-Mental-Status-Test: German Version. Beltz: Weinheim, 1990."},{"key":"BFmp2008100_CR10","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D . Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38: 904\u2013909.","journal-title":"Nat Genet"},{"key":"BFmp2008100_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/(SICI)1098-2272(1997)14:3<223::AID-GEPI1>3.0.CO;2-6","volume":"14","author":"S Sawcer","year":"1997","unstructured":"Sawcer S, Jones HB, Judge D, Visser F, Compston A, Goodfellow PN et al. Empirical genomewide significance levels established by whole genome simulations. Genet Epidemiol 1997; 14: 223\u2013229.","journal-title":"Genet Epidemiol"},{"key":"BFmp2008100_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng917","volume":"31","author":"A Kong","year":"2002","unstructured":"Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B et al. A high-resolution recombination map of the human genome. Nat Genet 2002; 31: 241\u2013247.","journal-title":"Nat Genet"},{"key":"BFmp2008100_CR13","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/nature06258","volume":"449","author":"International HapMap Consortium","year":"2007","unstructured":"International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449: 851\u2013861.","journal-title":"Nature"},{"key":"BFmp2008100_CR14","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1371\/journal.pbio.0040072","volume":"4","author":"BF Voight","year":"2006","unstructured":"Voight BF, Kudaravalli S, Wen X, Pritchard JK . A map of recent positive selection in the human genome. PLoS Biol 2006; 4: e72.","journal-title":"PLoS Biol"},{"key":"BFmp2008100_CR15","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/sj.mp.4001114","volume":"7","author":"RF Badenhop","year":"2002","unstructured":"Badenhop RF, Moses MJ, Scimone A, Mitchell PB, Ewen-White KR, Rosso A et al. A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19. Mol Psychiatry 2002; 7: 851\u2013859.","journal-title":"Mol Psychiatry"},{"key":"BFmp2008100_CR16","unstructured":"OMIM\u2014Online Mendelian Inheritance in Man. OMIM 2008##http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?db=omim."},{"key":"BFmp2008100_CR17","doi-asserted-by":"publisher","first-page":"15533","DOI":"10.1073\/pnas.0507666102","volume":"102","author":"SJ Glatt","year":"2005","unstructured":"Glatt SJ, Everall IP, Kremen WS, Corbeil J, Sasik R, Khanlou N et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci 2005; 102: 15533\u201315538.","journal-title":"Proc Natl Acad Sci"},{"key":"BFmp2008100_CR18","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.2174\/1389450110607011421","volume":"7","author":"RS Jope","year":"2006","unstructured":"Jope RS, Roh MS . Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr Drug Targets 2006; 7: 1421\u20131434.","journal-title":"Curr Drug Targets"},{"key":"BFmp2008100_CR19","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.biopsych.2007.03.023","volume":"62","author":"M Adli","year":"2007","unstructured":"Adli M, Hollinde DL, Stamm T, Wiethoff K, Tsahuridu M, Kirchheiner J et al. Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T\/C single nucleotide polymorphism. Biol Psychiatry 2007; 62: 1295\u20131302.","journal-title":"Biol Psychiatry"},{"key":"BFmp2008100_CR20","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/sj.mp.4001867","volume":"11","author":"BS Pickard","year":"2006","unstructured":"Pickard BS, Malloy MP, Christoforou A, Thomson PA, Evans KL, Morris SW et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol Psychiatry 2006; 11: 847\u2013857.","journal-title":"Mol Psychiatry"},{"key":"BFmp2008100_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1086\/376549","volume":"73","author":"CM Lewis","year":"2003","unstructured":"Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 2003; 73: 34\u201348.","journal-title":"Am J Hum Genet"},{"key":"BFmp2008100_CR22","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1086\/376547","volume":"73","author":"R Segurado","year":"2003","unstructured":"Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger Jr JI et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am J Hum Genet 2003; 73: 49\u201362.","journal-title":"Am J Hum Genet"},{"key":"BFmp2008100_CR23","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/sj.mp.4001012","volume":"7","author":"JA Badner","year":"2002","unstructured":"Badner JA, Gershon ES . Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7: 405\u2013411.","journal-title":"Mol Psychiatry"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp2008100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2008100","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2008100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:37:52Z","timestamp":1648780672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp2008100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,16]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["BFmp2008100"],"URL":"https:\/\/doi.org\/10.1038\/mp.2008.100","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,16]]},"assertion":[{"value":"13 May 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}