{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:29:40Z","timestamp":1790735380411,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2008,6,3]],"date-time":"2008-06-03T00:00:00Z","timestamp":1212451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,6,3]],"date-time":"2008-06-03T00:00:00Z","timestamp":1212451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1038\/mp.2008.56","type":"journal-article","created":{"date-parts":[[2008,6,3]],"date-time":"2008-06-03T08:23:27Z","timestamp":1212481407000},"page":"804-819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study"],"prefix":"10.1038","volume":"14","author":[{"given":"C","family":"Lavedan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Licamele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Lannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C D","family":"Wolfgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Polymeropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,3]]},"reference":[{"key":"BFmp200856_CR1","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC, 2000."},{"key":"BFmp200856_CR2","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/YCO.0b013e328017f69f","volume":"20","author":"B Bondy","year":"2007","unstructured":"Bondy B, Spellmann I . Pharmacogenetics of antipsychotics: useful for the clinician? Curr Opin Psychiatry 2007; 20: 126\u2013130.","journal-title":"Curr Opin Psychiatry"},{"key":"BFmp200856_CR3","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1517\/14656566.7.11.1429","volume":"7","author":"GP Reynolds","year":"2006","unstructured":"Reynolds GP, Templeman LA, Godlewska BR . Pharmacogenetics of schizophrenia. Expert Opin Pharmacother 2006; 7: 1429\u20131440.","journal-title":"Expert Opin Pharmacother"},{"key":"BFmp200856_CR4","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/NEJMoa051688","volume":"353","author":"JA Lieberman","year":"2005","unstructured":"Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005; 353: 1209\u20131223.","journal-title":"N Engl J Med"},{"key":"BFmp200856_CR5","first-page":"81","volume":"2","author":"JM Kane","year":"2003","unstructured":"Kane JM, Malhotra A . The future of pharmacotherapy for schizophrenia. World Psychiatry 2003; 2: 81\u201386.","journal-title":"World Psychiatry"},{"key":"BFmp200856_CR6","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/S0893-133X(01)00285-8","volume":"25","author":"HO Kalkman","year":"2001","unstructured":"Kalkman HO, Subramanian N, Hoyer D . Extended radioligand binding profile of iloperidone: a broad spectrum dopamine\/serotonin\/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology 2001; 25: 904\u2013914.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp200856_CR7","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0024-3205(03)00419-3","volume":"73","author":"HO Kalkman","year":"2003","unstructured":"Kalkman HO, Feuerbach D, Lotscher E, Schoeffter P . Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors. Life Sci 2003; 73: 1151\u20131159.","journal-title":"Life Sci"},{"key":"BFmp200856_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0024-3205(00)00911-5","volume":"68","author":"E Richelson","year":"2000","unstructured":"Richelson E, Souder T . Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci 2000; 68: 29\u201339.","journal-title":"Life Sci"},{"issue":"Suppl 4","key":"BFmp200856_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/PL00014190","volume":"249","author":"J Ichikawa","year":"1999","unstructured":"Ichikawa J, Meltzer HY . Relationship between dopaminergic and serotonergic neuronal activity in the frontal cortex and the action of typical and atypical antipsychotic drugs. Eur Arch Psychiatry Clin Neurosci 1999; 249 (Suppl 4): 90\u201398.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"BFmp200856_CR10","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1517\/13543784.9.12.2935","volume":"9","author":"KK Jain","year":"2000","unstructured":"Jain KK . An assessment of iloperidone for the treatment of schizophrenia. Expert Opin Investig Drugs 2000; 9: 2935\u20132943.","journal-title":"Expert Opin Investig Drugs"},{"issue":"Suppl 1","key":"BFmp200856_CR11","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1097\/JCP.0b013e318169d4ce","volume":"28","author":"AJ Cutler","year":"2008","unstructured":"Cutler AJ, Kalali AH, Weiden P, Hamilton J, Wolfgang CD . Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. J Clin Psychopharmacol 2008; 28 (Suppl 1): S20\u2013S28.","journal-title":"J Clin Psychopharmacol"},{"issue":"Suppl 1","key":"BFmp200856_CR12","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1097\/JCP.0b013e3181694f5a","volume":"28","author":"PJ Weiden","year":"2008","unstructured":"Weiden PJ, Cutler A, Polymeropoulos MH, Wolfgang CD . Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. J Clin Psychopharmacol 2008; 28 (Suppl 1): S12\u2013S19.","journal-title":"J Clin Psychopharmacol"},{"key":"BFmp200856_CR13","unstructured":"Baroldi P, Wolfgang C . A Pharmacokinetic (PK)-Pharmacodynamic (PD) Relationship Exists for Efficacy of Iloperidone, a Novel Investigational Atypical Antipsychotic Agent. American Psychiatric Association 2007 Meeting POSTER NR507\u2014available at: http:\/\/www.psych.org\/edu\/other_res\/lib_archives\/archives\/meetings\/AMN\/2007nra.pdf."},{"key":"BFmp200856_CR14","volume-title":"Linear Mixed Models for Longitudinal Data","author":"G Verbeke","year":"2000","unstructured":"Verbeke G, Molenberghs G . Linear Mixed Models for Longitudinal Data. Springer: New York, 2000."},{"key":"BFmp200856_CR15","volume-title":"Statistical Analysis with Missing Data","author":"RJA Little","year":"2003","unstructured":"Little RJA, Rubin DB . Statistical Analysis with Missing Data, 2nd edn. Wiley: New York, 2003."},{"key":"BFmp200856_CR16","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/biostatistics\/kxh001","volume":"5","author":"G Molenberghs","year":"2004","unstructured":"Molenberghs G, Thijs H, Jansen I, Beunckens C, Kenward MG, Mallinck-rodt C et al. Analyzing incomplete longitudinal clinical trial data. Biostatistics 2004; 5: 445\u2013464.","journal-title":"Biostatistics"},{"key":"BFmp200856_CR17","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1111\/j.0006-341X.2004.00234.x","volume":"60","author":"RJ Cook","year":"2004","unstructured":"Cook RJ, Zeng L, Yi Y . Marginal analysis of incomplete longitudinal binary data: a cautionary note on LOCF imputation. Biometrics 2004; 60: 820\u2013828.","journal-title":"Biometrics"},{"key":"BFmp200856_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1081\/BIP-100104194","volume":"11","author":"CH Mallinckrodt","year":"2001","unstructured":"Mallinckrodt CH, Clark WS, David SR . Accounting for dropout bias using mixed-effects models. J Biopharm Stat 2001; 11: 9\u201321.","journal-title":"J Biopharm Stat"},{"key":"BFmp200856_CR19","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","volume":"2","author":"JK Pritchard","year":"2000","unstructured":"Pritchard JK, Stephens M, Donnelly P . Inference of population structure using multilocus genotype data. Genetics 2000; 2: 945\u2013959.","journal-title":"Genetics"},{"key":"BFmp200856_CR20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y . Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc 1995; 57: 289\u2013300.","journal-title":"J R Stat Soc"},{"key":"BFmp200856_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neulet.2005.08.059","volume":"392","author":"R Kukreti","year":"2006","unstructured":"Kukreti R, Tripathi S, Bhatnagar P, Gupta S, Chauhan C, Kubendran S et al. Association of DRD2 gene variant with schizophrenia. Neurosci Lett 2006; 392: 68\u201371.","journal-title":"Neurosci Lett"},{"key":"BFmp200856_CR22","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.schres.2005.04.001","volume":"77","author":"JR Bishop","year":"2005","unstructured":"Bishop JR, Ellingrod VL, Moline J, Miller D . Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. Schizophr Res 2005; 77: 253\u2013260.","journal-title":"Schizophr Res"},{"key":"BFmp200856_CR23","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1086\/497703","volume":"77","author":"MD Fallin","year":"2005","unstructured":"Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA et al. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am J Hum Genet 2005; 77: 918\u2013936.","journal-title":"Am J Hum Genet"},{"key":"BFmp200856_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1744-9081-1-15","volume":"1","author":"HJ Lee","year":"2005","unstructured":"Lee HJ, Song JY, Kim JW, Jin S-Y, Hong MS, Park JK et al. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Behav Brain Funct 2005; 1: 15.","journal-title":"Behav Brain Funct"},{"key":"BFmp200856_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/PL00012073","volume":"6","author":"N Hamajima","year":"2001","unstructured":"Hamajima N, Matsuo K, Tajima K, Mizutani M, Iwata H, Iwase T et al. Limited association between a catechol-O-methyltransferase (COMT) polymorphism and breast cancer risk in Japan. Int J Clin Oncol 2001; 6: 13\u201318.","journal-title":"Int J Clin Oncol"},{"key":"BFmp200856_CR26","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1002\/1522-2683()22:6<1102::AID-ELPS1102>3.0.CO;2-3","volume":"22","author":"Z Ronai","year":"2001","unstructured":"Ronai Z, Barta C, Guttman A, Lakatos K, Gervai J, Staub M et al. Genotyping the \u2013521C\/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene. Electrophoresis 2001; 22: 1102\u20131105.","journal-title":"Electrophoresis"},{"key":"BFmp200856_CR27","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1017\/S1461145704004663","volume":"7","author":"YY Huang","year":"2004","unstructured":"Huang YY, Battistuzzi C, Oquendo MA, Harkavy-Friedman J, Greenhill L, Zalsman G et al. Human 5-HT1A receptor C(\u20131019)G polymorphism and psychopathology. Int J Neuropsychopharmacol 2004; 7: 441\u2013451.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFmp200856_CR28","first-page":"141","volume":"24","author":"R Joober","year":"1999","unstructured":"Joober R, Benkelfat C, Brisebois K, Toulouse A, Turecki G, Lal S et al. T102C polymorphism in the 5-HT2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci 1999; 24: 141\u2013146.","journal-title":"J Psychiatry Neurosci"},{"key":"BFmp200856_CR29","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1093\/bioinformatics\/bti275","volume":"21","author":"X Di","year":"2005","unstructured":"Di X, Matsuzaki H, Webster TA, Hubbell E, Liu G, Dong S et al. Dynamic model based algorithms for screening and genotyping over 100\u2009K SNPs on oligonucleotide microarrays. Bioinformatics 2005; 21: 1958\u20131963.","journal-title":"Bioinformatics"},{"key":"BFmp200856_CR30","unstructured":"BRLMM: an improved genotype calling method for the GeneChip\u00ae Human Mapping 500\u2009K Array Set. Affymetrix Web site. Available at: http:\/\/www.affymetrix.com\/support\/technical\/whitepapers\/brlmm_whitepaper.pdf (accessed 26 July)."},{"issue":"Suppl 1","key":"BFmp200856_CR31","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1186\/1471-2350-8-S1-S6","volume":"8","author":"JM Murabito","year":"2007","unstructured":"Murabito JM, Rosenberg CL, Finger D, Kreger BE, Levy D, Splansky GL et al. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. BMC Med Genet 2007; 8 (Suppl 1): S6.","journal-title":"BMC Med Genet"},{"issue":"Suppl 1","key":"BFmp200856_CR32","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1186\/1471-2350-8-S1-S7","volume":"8","author":"C Newton-Cheh","year":"2007","unstructured":"Newton-Cheh C, Guo CY, Wang TJ, O\u2019donnell CJ, Levy D, Larson MG . Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med Genet 2007; 8 (Suppl 1): S7.","journal-title":"BMC Med Genet"},{"issue":"Suppl 1","key":"BFmp200856_CR33","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1186\/1471-2350-8-S1-S9","volume":"8","author":"DJ Gottlieb","year":"2007","unstructured":"Gottlieb DJ, O\u2019Connor GT, Wilk JB . Genome-wide association of sleep and circadian phenotypes. BMC Med Genet 2007; 8 (Suppl 1): S9.","journal-title":"BMC Med Genet"},{"key":"BFmp200856_CR34","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/ng1790","volume":"38","author":"DE Arking","year":"2006","unstructured":"Arking DE, Pfeufer A, Post W, Kao WHL, Newton-Cheh C, Ikeda M et al. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 2006; 38: 644\u2013651.","journal-title":"Nat Genet"},{"key":"BFmp200856_CR35","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1136\/jmg.40.5.325","volume":"40","author":"D Kamnasaran","year":"2003","unstructured":"Kamnasaran D, Muir WJ, Ferguson-Smith MA, Cox DW . Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. J Med Genet 2003; 40: 325\u2013332.","journal-title":"J Med Genet"},{"key":"BFmp200856_CR36","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.gene.2005.10.037","volume":"370","author":"G Calenda","year":"2006","unstructured":"Calenda G, Peng J, Redman CM, Sha Q, Wu X, Lee S . Identification of two new members, XPLAC and XTES, of the XK family. Gene 2006; 370: 6\u201316.","journal-title":"Gene"},{"key":"BFmp200856_CR37","doi-asserted-by":"publisher","first-page":"722","DOI":"10.4088\/JCP.v65n0520c","volume":"65","author":"HH Jung","year":"2004","unstructured":"Jung HH, Haker H . Schizophrenia as a manifestation of X-linked McLeod-Neuroacanthocytosis syndrome. J Clin Psychiatry 2004; 65: 722\u2013723.","journal-title":"J Clin Psychiatry"},{"key":"BFmp200856_CR38","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/j.1440-1819.2006.01568.x","volume":"60","author":"C-Y Wu","year":"2006","unstructured":"Wu C-Y, Chiu C-C . Usher syndrome with psychotic symptoms: two cases in the same family. Psychiatry Clin Neurosci 2006; 60: 626\u2013628.","journal-title":"Psychiatry Clin Neurosci"},{"key":"BFmp200856_CR39","doi-asserted-by":"publisher","first-page":"8157","DOI":"10.1074\/jbc.271.14.8157","volume":"271","author":"B Carnemolla","year":"1996","unstructured":"Carnemolla B, Leprini A, Borsi L, Querze G, Urbini S, Zardi L . Human tenascin-R: complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24. J Biol Chem 1996; 271: 8157\u20138160.","journal-title":"J Biol Chem"},{"key":"BFmp200856_CR40","doi-asserted-by":"publisher","first-page":"31251","DOI":"10.1074\/jbc.271.49.31251","volume":"271","author":"A Leprini","year":"1996","unstructured":"Leprini A, Gherzi R, Siri A, Querze G, Viti F, Zardi L . The human tenascin-R gene. J Biol Chem 1996; 271: 31251\u201331254.","journal-title":"J Biol Chem"},{"key":"BFmp200856_CR41","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/ajmg.b.20093","volume":"125B","author":"J Wei","year":"2004","unstructured":"Wei J, Hemmings GP . TNXB locus may be a candidate gene predisposing to schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004; 125B: 43\u201349.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFmp200856_CR42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ajmg.b.10041","volume":"116B","author":"C Makino","year":"2003","unstructured":"Makino C, Fujii Y, Kikuta R, Hirata N, Tani A, Shibata A et al. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. Am J Med Genet B Neuropsychiatr Genet 2003; 116B: 17\u201322.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFmp200856_CR43","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/sj.ejhg.5200646","volume":"9","author":"E Blaveri","year":"2001","unstructured":"Blaveri E, Kalsi G, Lawrence J, Quested D, Moorey H, Lamb G et al. Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1). Eur J Hum Genet 2001; 9: 469\u2013472.","journal-title":"Eur J Hum Genet"},{"key":"BFmp200856_CR44","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/1734","volume":"20","author":"JL Blouin","year":"1998","unstructured":"Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998; 20: 70\u201373.","journal-title":"Nat Genet"},{"key":"BFmp200856_CR45","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1086\/342734","volume":"71","author":"H Stefansson","year":"2002","unstructured":"Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71: 877\u2013892.","journal-title":"Am J Hum Genet"},{"key":"BFmp200856_CR46","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.neulet.2003.12.089","volume":"357","author":"A Michelato","year":"2004","unstructured":"Michelato A, Bonvicini C, Ventriglia M, Scassellati C, Randazzo R, Bignotti S et al. 3\u2032 UTR (AGG)n repeat of glial cell line-derived neurotrophic factor (GDNF) gene polymorphism in schizophrenia. Neurosci Lett 2004; 357: 235\u2013237.","journal-title":"Neurosci Lett"},{"key":"BFmp200856_CR47","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/sj.npp.1300901","volume":"31","author":"M Ikeda","year":"2006","unstructured":"Ikeda M, Iwata N, Kitajima T, Suzuki T, Yamanouchi Y, Kinoshita Y et al. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Neuropsychopharmacology 2006; 31: 866\u2013871.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp200856_CR48","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/ng1195-321","volume":"11","author":"HW Moises","year":"1995","unstructured":"Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F et al. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 1995; 11: 321\u2013324.","journal-title":"Nat Genet"},{"key":"BFmp200856_CR49","doi-asserted-by":"publisher","first-page":"14052","DOI":"10.1073\/pnas.0506713102","volume":"102","author":"AA Pieper","year":"2005","unstructured":"Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC et al. The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice. Proc Natl Acad Sci USA 2005; 102: 14052\u201314057.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp200856_CR50","doi-asserted-by":"publisher","first-page":"13648","DOI":"10.1073\/pnas.0405310101","volume":"101","author":"C Erbel-Sieler","year":"2004","unstructured":"Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T et al. Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci USA 2004; 101: 13648\u201313653.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp200856_CR51","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/ajmg.b.30191","volume":"137B","author":"C Goldberger","year":"2005","unstructured":"Goldberger C, Gourion D, Leroy S, Schurhoff F, Bourdel M-C, Leboyer M et al. Population-based and family-based association study of 5\u2032UTR polymorphism of the reelin gene and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2005; 137B: 51\u201355.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFmp200856_CR52","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.95.26.15718","volume":"95","author":"F Impagnatiello","year":"1998","unstructured":"Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc Natl Acad Sci USA 1998; 95: 15718\u201315723.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp200856_CR53","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.neulet.2004.07.079","volume":"369","author":"S Guo","year":"2004","unstructured":"Guo S, Shi Y, Zhao X, Duan S, Zhou J, Meng J et al. No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population. Neurosci Lett 2004; 369: 168\u2013172.","journal-title":"Neurosci Lett"},{"key":"BFmp200856_CR54","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1177\/0269881106073126","volume":"21","author":"JM Stone","year":"2007","unstructured":"Stone JM, Morrison PD, Pilowsky LS . Glutamate and dopamine dysregulation in schizophrenia\u2014a synthesis and selective review. J Psychopharmacol 2007; 21: 440\u2013452.","journal-title":"J Psychopharmacol"},{"key":"BFmp200856_CR55","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.molbrainres.2004.02.011","volume":"124","author":"J Semba","year":"2004","unstructured":"Semba J, Akanuma N, Wakuta M, Tanaka N, Suhara T . Alterations in the expressions of mRNA for GDNF and its receptors in the ventral midbrain of rats exposed to subchronic phencyclidine. Brain Res Mol Brain Res 2004; 124: 88\u201395.","journal-title":"Brain Res Mol Brain Res"},{"key":"BFmp200856_CR56","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0014-2999(96)00840-0","volume":"317","author":"S Kongsamut","year":"1996","unstructured":"Kongsamut S, Roehr JE, Cai J, Hartman HB, Weissensee P, Kerman LL et al. Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol 1996; 317: 417\u2013423.","journal-title":"Eur J Pharmacol"},{"key":"BFmp200856_CR57","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1101\/gr.5663007","volume":"17","author":"JT Forton","year":"2007","unstructured":"Forton JT, Udalova IA, Campino S, Rockett KA, Hull J, Kwiatkowski DP . Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping. Genome Res 2007; 17: 82\u201387.","journal-title":"Genome Res"},{"key":"BFmp200856_CR58","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1371\/journal.pbio.0030007","volume":"3","author":"A Woolfe","year":"2005","unstructured":"Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, Vavouri T et al. Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol 2005; 3: e7.","journal-title":"PLoS Biol"},{"key":"BFmp200856_CR59","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1038\/nbt1144","volume":"23","author":"S Washietl","year":"2005","unstructured":"Washietl S, Hofacker IL, Lukasser M, Huttenhofer A, Stadler PF . Mapping of conserved RNA secondary structures predicts thousands of functional noncoding RNAs in the human genome. Nat Biotechnol 2005; 23: 1383\u20131390.","journal-title":"Nat Biotechnol"},{"key":"BFmp200856_CR60","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/sj.mp.4002009","volume":"8","author":"MJ Arranz","year":"2007","unstructured":"Arranz MJ, de Leon J . Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research. Mol Psychiatry 2007; 8: 707\u2013747.","journal-title":"Mol Psychiatry"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp200856.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp200856","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp200856.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T14:59:08Z","timestamp":1738249148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp200856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,3]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["BFmp200856"],"URL":"https:\/\/doi.org\/10.1038\/mp.2008.56","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,3]]},"assertion":[{"value":"3 September 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}