{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:06:28Z","timestamp":1791515188595,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T00:00:00Z","timestamp":1221523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1038\/mp.2008.97","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T08:10:32Z","timestamp":1221552632000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities"],"prefix":"10.1038","volume":"15","author":[{"given":"K","family":"Katayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V G","family":"Ornthanalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N P","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Aruga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,16]]},"reference":[{"key":"BFmp200897_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S1044-7431(03)00129-5","volume":"24","author":"J Aruga","year":"2003","unstructured":"Aruga J, Mikoshiba K . Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. Mol Cell Neurosci 2003; 24: 117\u2013129.","journal-title":"Mol Cell Neurosci"},{"key":"BFmp200897_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0378-1119(03)00715-7","volume":"315","author":"J Aruga","year":"2003","unstructured":"Aruga J, Yokota N, Mikoshiba K . Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Gene 2003; 315: 87\u201394.","journal-title":"Gene"},{"key":"BFmp200897_CR3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/0959-440X(95)80105-7","volume":"5","author":"B Kobe","year":"1995","unstructured":"Kobe B, Deisenhofer J . Proteins with leucine-rich repeats. Curr Opin Struct Biol 1995; 5: 409\u2013416.","journal-title":"Curr Opin Struct Biol"},{"key":"BFmp200897_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0959-4388(99)00066-5","volume":"10","author":"K Brose","year":"2000","unstructured":"Brose K, Tessier-Lavigne M . Slit proteins: key regulators of axon guidance, axonal branching, and cell migration. Curr Opin Neurobiol 2000; 10: 95\u2013102.","journal-title":"Curr Opin Neurobiol"},{"key":"BFmp200897_CR5","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/S0959-4388(00)00208-7","volume":"11","author":"A Patapoutian","year":"2001","unstructured":"Patapoutian A, Reichardt LF . Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 2001; 11: 272\u2013280.","journal-title":"Curr Opin Neurobiol"},{"key":"BFmp200897_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.brainresrev.2005.11.005","volume":"51","author":"Y Chen","year":"2006","unstructured":"Chen Y, Aulia S, Li L, Tang BL . AMIGO and friends: an emerging family of brain-enriched, neuronal growth modulating, type I transmembrane proteins with leucine-rich repeats (LRR) and cell adhesion molecule motifs. Brain Res Brain Res Rev 2006; 51: 265\u2013274.","journal-title":"Brain Res Brain Res Rev"},{"key":"BFmp200897_CR7","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1126\/science.1116502","volume":"310","author":"JF Abelson","year":"2005","unstructured":"Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM et al. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 2005; 310: 317\u2013320.","journal-title":"Science"},{"key":"BFmp200897_CR8","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/sj.mp.4001898","volume":"11","author":"S Z\u00fcchner","year":"2006","unstructured":"Z\u00fcchner S, Cuccaro ML, Tran-Viet KN, Cope H, Krishnan RR, Pericak-Vance MA et al. SLITRK1 mutations in trichotillomania. Mol Psychiatry 2006; 11: 887\u2013889.","journal-title":"Mol Psychiatry"},{"key":"BFmp200897_CR9","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(02)11526-1","volume":"360","author":"JF Leckman","year":"2002","unstructured":"Leckman JF . Tourette's syndrome. Lancet 2002; 360: 1577\u20131586.","journal-title":"Lancet"},{"key":"BFmp200897_CR10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/YPG.0b013e328015b937","volume":"17","author":"MM Robertson","year":"2007","unstructured":"Robertson MM, Cavanna AE . The Gilles de la Tourette syndrome: a principal component factor analytic study of a large pedigree. Psychiatr Genet 2007; 17: 143\u2013152.","journal-title":"Psychiatr Genet"},{"key":"BFmp200897_CR11","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1067\/mjd.2002.122749","volume":"46","author":"G Hautmann","year":"2002","unstructured":"Hautmann G, Hercogova J, Lotti T . Trichotillomania. J Am Acad Dermatol 2002; 46: 807\u2013821; quiz 822\u2013806.","journal-title":"J Am Acad Dermatol"},{"key":"BFmp200897_CR12","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ydbio.2004.02.017","volume":"270","author":"T Inoue","year":"2004","unstructured":"Inoue T, Hatayama M, Tohmonda T, Itohara S, Aruga J, Mikoshiba K . Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol 2004; 270: 146\u2013162.","journal-title":"Dev Biol"},{"key":"BFmp200897_CR13","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1006\/bbrc.1997.7111","volume":"237","author":"K Sakai","year":"1997","unstructured":"Sakai K, Miyazaki J . A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem Biophys Res Commun 1997; 237: 318\u2013324.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFmp200897_CR14","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1172\/JCI29031","volume":"117","author":"T Sadakata","year":"2007","unstructured":"Sadakata T, Washida M, Iwayama Y, Shoji S, Sato Y, Ohkura T et al. Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest 2007; 117: 931\u2013943.","journal-title":"J Clin Invest"},{"key":"BFmp200897_CR15","doi-asserted-by":"publisher","first-page":"10765","DOI":"10.1523\/JNEUROSCI.0117-07.2007","volume":"27","author":"Y Satoh","year":"2007","unstructured":"Satoh Y, Endo S, Ikeda T, Yamada K, Ito M, Kuroki M et al. Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. J Neurosci 2007; 27: 10765\u201310776.","journal-title":"J Neurosci"},{"key":"BFmp200897_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/43432","volume":"401","author":"YP Tang","year":"1999","unstructured":"Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M et al. Genetic enhancement of learning and memory in mice. Nature 1999; 401: 63\u201369.","journal-title":"Nature"},{"key":"BFmp200897_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0014-2999(79)90366-2","volume":"57","author":"RD Porsolt","year":"1979","unstructured":"Porsolt RD, Bertin A, Blavet N, Deniel M, Jalfre M . Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity. Eur J Pharmacol 1979; 57: 201\u2013210.","journal-title":"Eur J Pharmacol"},{"key":"BFmp200897_CR18","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.neuropharm.2007.01.007","volume":"52","author":"A Wesolowska","year":"2007","unstructured":"Wesolowska A, Nikiforuk A . Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 2007; 52: 1274\u20131283.","journal-title":"Neuropharmacology"},{"key":"BFmp200897_CR19","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00213-004-1873-z","volume":"176","author":"RH Silva","year":"2004","unstructured":"Silva RH, Kameda SR, Carvalho RC, Takatsu-Coleman AL, Niigaki ST, Abilio VC et al. Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice. Psychopharmacology (Berl) 2004; 176: 115\u2013122.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFmp200897_CR20","first-page":"523","volume":"16","author":"T Pringsheim","year":"2003","unstructured":"Pringsheim T, Davenport WJ, Lang A . Tics. Curr Opin Neurol 2003; 16: 523\u2013527.","journal-title":"Curr Opin Neurol"},{"key":"BFmp200897_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00787-006-0505-z","volume":"15","author":"MM Robertson","year":"2006","unstructured":"Robertson MM . Attention deficit hyperactivity disorder, tics and Tourette's syndrome: the relationship and treatment implications. A commentary. Eur Child Adolesc Psychiatry 2006; 15: 1\u201311.","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"BFmp200897_CR22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0361-9230(98)00068-9","volume":"47","author":"E Schlicker","year":"1998","unstructured":"Schlicker E, G\u00f6thert M . Interactions between the presynaptic \u03b12-autoreceptor and presynaptic inhibitory heteroreceptors on noradrenergic neurones. Brain Res Bull 1998; 47: 129\u2013132.","journal-title":"Brain Res Bull"},{"key":"BFmp200897_CR23","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.cell.2007.09.017","volume":"131","author":"H Hu","year":"2007","unstructured":"Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL et al. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell 2007; 131: 160\u2013173.","journal-title":"Cell"},{"key":"BFmp200897_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<28::AID-SYN4>3.0.CO;2-J","volume":"23","author":"JD Bremner","year":"1996","unstructured":"Bremner JD, Krystal JH, Southwick SM, Charney DS . Noradrenergic mechanisms in stress and anxiety. I. Preclinical studies. Synapse 1996; 23: 28\u201338.","journal-title":"Synapse"},{"key":"BFmp200897_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1056\/NEJMra073096","volume":"358","author":"RH Belmaker","year":"2008","unstructured":"Belmaker RH, Agam G . Major depressive disorder. N Engl J Med 2008; 358: 55\u201368.","journal-title":"N Engl J Med"},{"key":"BFmp200897_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<39::AID-SYN5>3.0.CO;2-I","volume":"23","author":"JD Bremner","year":"1996","unstructured":"Bremner JD, Krystal JH, Southwick SM, Charney DS . Noradrenergic mechanisms in stress and anxiety. II. Clinical studies. Synapse 1996; 23: 39\u201351.","journal-title":"Synapse"},{"key":"BFmp200897_CR27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/00008877-199504000-00009","volume":"6","author":"RJ Rodgers","year":"1995","unstructured":"Rodgers RJ, Cole JC . Effects of scopolamine and its quaternary analogue in the murine elevated plus-maze test of anxiety. Behav Pharmacol 1995; 6: 283\u2013289.","journal-title":"Behav Pharmacol"},{"key":"BFmp200897_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-2999(93)90498-7","volume":"238","author":"JD Brioni","year":"1993","unstructured":"Brioni JD, O'Neill AB, Kim DJ, Decker MW . Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test. Eur J Pharmacol 1993; 238: 1\u20138.","journal-title":"Eur J Pharmacol"},{"key":"BFmp200897_CR29","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0091-3057(01)00548-2","volume":"69","author":"J Szyndler","year":"2001","unstructured":"Szyndler J, Sienkiewicz-Jarosz H, Maciejak P, Siemiatkowski M, Rokicki D, Czlonkowska AI et al. The anxiolytic-like effect of nicotine undergoes rapid tolerance in a model of contextual fear conditioning in rats. Pharmacol Biochem Behav 2001; 69: 511\u2013518.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFmp200897_CR30","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/(SICI)1099-1166(199706)12:6<648::AID-GPS575>3.0.CO;2-C","volume":"12","author":"MF Weiner","year":"1997","unstructured":"Weiner MF, Svetlik D, Risser RC . What depressive symptoms are reported in Alzheimer's patients? Int J Geriatr Psychiatry 1997; 12: 648\u2013652.","journal-title":"Int J Geriatr Psychiatry"},{"key":"BFmp200897_CR31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.tig.2006.04.003","volume":"22","author":"MA Grados","year":"2006","unstructured":"Grados MA, Walkup JT . A new gene for Tourette's syndrome: a window into causal mechanisms? Trends Genet 2006; 22: 291\u2013293.","journal-title":"Trends Genet"},{"key":"BFmp200897_CR32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1254\/jjp.90.197","volume":"90","author":"H Takeuchi","year":"2002","unstructured":"Takeuchi H, Yatsugi S, Yamaguchi T . Effect of YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT 2A receptor antagonistic activity, on a marble-burying behavior test as an obsessive-compulsive disorder model. Jpn J Pharmacol 2002; 90: 197\u2013200.","journal-title":"Jpn J Pharmacol"},{"key":"BFmp200897_CR33","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1254\/jphs.FP0050144","volume":"99","author":"M Matsushita","year":"2005","unstructured":"Matsushita M, Egashira N, Harada S, Okuno R, Mishima K, Iwasaki K et al. Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder. J Pharmacol Sci 2005; 99: 154\u2013159.","journal-title":"J Pharmacol Sci"},{"key":"BFmp200897_CR34","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1212\/WNL.59.3.414","volume":"59","author":"R Kurlan","year":"2002","unstructured":"Kurlan R, Como PG, Miller B, Palumbo D, Deeley C, Andresen EM et al. The behavioral spectrum of tic disorders: a community-based study. Neurology 2002; 59: 414\u2013420.","journal-title":"Neurology"},{"key":"BFmp200897_CR35","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jpsychores.2006.07.019","volume":"61","author":"MM Robertson","year":"2006","unstructured":"Robertson MM . Mood disorders and Gilles de la Tourette's syndrome: an update on prevalence, etiology, comorbidity, clinical associations, and implications. J Psychosom Res 2006; 61: 349\u2013358.","journal-title":"J Psychosom Res"},{"key":"BFmp200897_CR36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/(SICI)1096-8628(20000207)96:1<24::AID-AJMG7>3.0.CO;2-E","volume":"96","author":"MM Weissman","year":"2000","unstructured":"Weissman MM, Fyer AJ, Haghighi F, Heiman G, Deng Z, Hen R et al. Potential panic disorder syndrome: clinical and genetic linkage evidence. Am J Med Genet 2000; 96: 24\u201335.","journal-title":"Am J Med Genet"},{"key":"BFmp200897_CR37","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/sj.mp.4001012","volume":"7","author":"JA Badner","year":"2002","unstructured":"Badner JA, Gershon ES . Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7: 405\u2013411.","journal-title":"Mol Psychiatry"},{"key":"BFmp200897_CR38","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1176\/appi.ajp.160.4.680","volume":"160","author":"JB Potash","year":"2003","unstructured":"Potash JB, Zandi PP, Willour VL, Lan TH, Huo Y, Avramopoulos D et al. Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder. Am J Psychiatry 2003; 160: 680\u2013686.","journal-title":"Am J Psychiatry"},{"key":"BFmp200897_CR39","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1093\/hmg\/ddi363","volume":"14","author":"P McGuffin","year":"2005","unstructured":"McGuffin P, Knight J, Breen G, Brewster S, Boyd PR, Craddock N et al. Whole genome linkage scan of recurrent depressive disorder from the depression network study. Hum Mol Genet 2005; 14: 3337\u20133345.","journal-title":"Hum Mol Genet"},{"key":"BFmp200897_CR40","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/S0006-3223(99)00246-2","volume":"46","author":"GM Sullivan","year":"1999","unstructured":"Sullivan GM, Coplan JD, Kent JM, Gorman JM . The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias. Biol Psychiatry 1999; 46: 1205\u20131218.","journal-title":"Biol Psychiatry"},{"key":"BFmp200897_CR41","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/3-540-28082-0_8","volume":"169","author":"A Neumeister","year":"2005","unstructured":"Neumeister A, Daher RJ, Charney DS . Anxiety disorders: noradrenergic neurotransmission. Handb Exp Pharmacol 2005; 169: 205\u2013223.","journal-title":"Handb Exp Pharmacol"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp200897.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp200897","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp200897.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:36:22Z","timestamp":1648780582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp200897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,16]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["BFmp200897"],"URL":"https:\/\/doi.org\/10.1038\/mp.2008.97","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,16]]},"assertion":[{"value":"15 January 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}