{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:59:00Z","timestamp":1773295140107,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:00:00Z","timestamp":1288051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:00:00Z","timestamp":1288051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/mp.2010.108","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T08:08:16Z","timestamp":1288080496000},"page":"325-336","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Functional MRI of sustained attention in bipolar mania"],"prefix":"10.1038","volume":"17","author":[{"given":"D E","family":"Fleck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Eliassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Durling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Adler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"DelBello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P K","family":"Shear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Cerullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Strakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"key":"BFmp2010108_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0920-9964(96)00105-3","volume":"23","author":"J Addington","year":"1997","unstructured":"Addington J, Addington D . Attentional vulnerability indicators in schizophrenia and bipolar disorder. Schizophr Res 1997; 23: 197\u2013204.","journal-title":"Schizophr Res"},{"key":"BFmp2010108_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0920-9964(01)00170-0","volume":"52","author":"DE Fleck","year":"2001","unstructured":"Fleck DE, Sax KW, Strakowski SM . Reaction time measures of sustained attention differentiate bipolar disorder from schizophrenia. Schizophr Res 2001; 52: 251\u2013259.","journal-title":"Schizophr Res"},{"key":"BFmp2010108_CR3","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1176\/appi.ajp.159.6.975","volume":"159","author":"SK Liu","year":"2002","unstructured":"Liu SK, Chiu CH, Chang CJ, Hwang TJ, Hwu HG, Chen WJ . Deficits in sustained attention in schizophrenia and affective disorders: stable versus state-dependent markers. Am J Psychiatry 2002; 159: 975\u2013982.","journal-title":"Am J Psychiatry"},{"key":"BFmp2010108_CR4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0920-9964(91)90069-4","volume":"5","author":"KH Nuechterlein","year":"1991","unstructured":"Nuechterlein KH, Dawson ME, Ventura J, Miklowitz D, Konishi G . Information processing anomalies in the early course of schizophrenia and bipolar disorder. Schizophr Res 1991; 5: 195\u2013196.","journal-title":"Schizophr Res"},{"key":"BFmp2010108_CR5","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/0006-3223(95)00310-D","volume":"37","author":"KW Sax","year":"1995","unstructured":"Sax KW, Strakowski SM, McElroy SL, Keck Jr PE, West SA . Attention and formal thought disorder in mixed and pure mania. Biol Psychiatry 1995; 37: 420\u2013423.","journal-title":"Biol Psychiatry"},{"key":"BFmp2010108_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1017\/S1355617705050071","volume":"11","author":"DE Fleck","year":"2005","unstructured":"Fleck DE, Shear PK, Strakowski SM . Processing efficiency and sustained attention in bipolar disorder. J Int Neuropsychol Soc 2005; 11: 49\u201357.","journal-title":"J Int Neuropsychol Soc"},{"key":"BFmp2010108_CR7","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1034\/j.1399-5618.2001.030202.x","volume":"3","author":"KE Wilder-Willis","year":"2001","unstructured":"Wilder-Willis KE, Sax KW, Rosenberg HL, Fleck DE, Shear PK, Strakowski SM . Persistent attentional dysfunction in remitted bipolar disorder. Bipolar Disord 2001; 3: 58\u201362.","journal-title":"Bipolar Disord"},{"key":"BFmp2010108_CR8","volume-title":"Manic-Depressive Illness","author":"FK Goodwin","year":"1990","unstructured":"Goodwin FK, Jamison KR . Manic-Depressive Illness. Oxford University Press: New York, 1990."},{"key":"BFmp2010108_CR9","first-page":"79","volume-title":"Brain Imaging in Affective Disorders","author":"TA Ketter","year":"2002","unstructured":"Ketter TA, Wang PW, Dieckman NF, Lembke A, Becker OV, Camilleri C et al. Brain anatomic circuits and the pathophysiology of affective disorders. In: JC Soars (ed.). Brain Imaging in Affective Disorders. Marcel Dekker: New York, 2002, pp 79\u2013118."},{"key":"BFmp2010108_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/sj.mp.4001585","volume":"10","author":"SM Strakowski","year":"2005","unstructured":"Strakowski SM, DelBello MP, Adler CM . The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry 2005; 10: 105\u2013116.","journal-title":"Mol Psychiatry"},{"key":"BFmp2010108_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0022-3956(71)90017-3","volume":"8","author":"WJH Nauta","year":"1971","unstructured":"Nauta WJH . The problem of the frontal lobe: a reinterpretation. J Psychiatr Res 1971; 8: 167\u2013187.","journal-title":"J Psychiatr Res"},{"key":"BFmp2010108_CR12","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/cercor\/10.3.206","volume":"10","author":"D Ongur","year":"2000","unstructured":"Ongur D, Price JL . The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys, and humans. Cereb Cortex 2000; 10: 206\u2013219.","journal-title":"Cereb Cortex"},{"key":"BFmp2010108_CR13","first-page":"1","volume-title":"Frontal-Subcortical Circuits in Psychiatric and Neurological Disorders","author":"DG Lichter","year":"2001","unstructured":"Lichter DG, Cummings JL . Introduction and overview. In DG Lichter, JL Cummings (eds). Frontal-Subcortical Circuits in Psychiatric and Neurological Disorders. The Guilford Press: New York, 2001, pp 1\u201343."},{"key":"BFmp2010108_CR14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1212\/WNL.35.12.1731","volume":"35","author":"PJ Eslinger","year":"1985","unstructured":"Eslinger PJ, Damasio AR . Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient E.V.R. Neurology 1985; 35: 228\u2013230.","journal-title":"Neurology"},{"key":"BFmp2010108_CR15","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/hbm.20297","volume":"28","author":"JM Jansma","year":"2007","unstructured":"Jansma JM, Ramsey NF, deZwart JA, van Gelderen P, Duyn JH . fMRI study of effort and information processing in a working memory task. Hum Brain Map 2007; 28: 431\u2013440.","journal-title":"Hum Brain Map"},{"key":"BFmp2010108_CR16","doi-asserted-by":"publisher","first-page":"11447","DOI":"10.1073\/pnas.182176499","volume":"99","author":"H Yamasaki","year":"2002","unstructured":"Yamasaki H, LaBar KS, McCarthy G . Dissociable prefrontal brain systems for attention and emotion. Proc Natl Acad Sci USA 2002; 99: 11447\u201311451.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp2010108_CR17","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1093\/acprof:oso\/9780195134971.003.0027","volume-title":"Principles of Frontal Lobe Function","author":"TS Braver","year":"2002","unstructured":"Braver TS, Cohen JD, Barch DM . The role of prefrontal cortex in normal and disordered cognitive control: a cognitive neuroscience perspective. In DT Stuss, RT Knight (eds). Principles of Frontal Lobe Function. Oxford University Press: Oxford, 2002, pp 428\u2013447."},{"key":"BFmp2010108_CR18","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1001\/archpsyc.60.6.601","volume":"60","author":"HP Blumberg","year":"2003","unstructured":"Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC et al. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-relate dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry 2003; 60: 601\u2013609.","journal-title":"Arch Gen Psychiatry"},{"key":"BFmp2010108_CR19","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1176\/appi.ajp.160.7.1345","volume":"160","author":"HP Blumberg","year":"2003","unstructured":"Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C et al. Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry 2003; 160: 1345\u20131347.","journal-title":"Am J Psychiatry"},{"key":"BFmp2010108_CR20","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S0006-3223(00)00962-8","volume":"48","author":"HP Blumberg","year":"2000","unstructured":"Blumberg HP, Stern E, Martinez D, Ricketts S, de Asis J, White T et al. Increased anterior cingulate and caudate activity in bipolar mania. Biol Psychiatry 2000; 48: 1045\u20131052.","journal-title":"Biol Psychiatry"},{"key":"BFmp2010108_CR21","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1038\/sj.npp.1300492","volume":"29","author":"SM Strakowski","year":"2004","unstructured":"Strakowski SM, Adler CM, Holland SK, Mills N, DelBello MP . A preliminary fMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology 2004; 29: 1734\u20131740.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp2010108_CR22","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1176\/appi.ajp.162.6.1211","volume":"162","author":"L Altshuler","year":"2005","unstructured":"Altshuler L, Bookheimer S, Proenza MA, Townsend J, Sabb F, Firestine A et al. Increased amygdala activation during mania: a functional magnetic resonance imaging study. Am J Psychiatry 2005; 162: 1211\u20131213.","journal-title":"Am J Psychiatry"},{"key":"BFmp2010108_CR23","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.biopsych.2005.09.012","volume":"58","author":"LL Altshuler","year":"2005","unstructured":"Altshuler LL, Bookheimer SY, Townsend J, Proenza MA, Eisenberger N, Sabb F et al. Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biol Psychiatry 2005; 58: 763\u2013769.","journal-title":"Biol Psychiatry"},{"key":"BFmp2010108_CR24","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.biopsych.2009.11.025","volume":"67","author":"A Versace","year":"2010","unstructured":"Versace A, Thompson WK, Zhou D, Almeida JR, Hassel S, Klein CR et al. Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry 2010; 67: 422\u2013431.","journal-title":"Biol Psychiatry"},{"key":"BFmp2010108_CR25","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.biopsych.2009.03.023","volume":"66","author":"F Wang","year":"2009","unstructured":"Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston EE et al. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry 2009; 66: 516\u2013521.","journal-title":"Biol Psychiatry"},{"key":"BFmp2010108_CR26","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1126\/science.1736359","volume":"255","author":"A Baddeley","year":"1992","unstructured":"Baddeley A . Working memory. Science 1992; 255: 556\u2013559.","journal-title":"Science"},{"key":"BFmp2010108_CR27","first-page":"1","volume-title":"Consciousness and Self-Regulation, volume 4","author":"DA Norman","year":"1986","unstructured":"Norman DA, Shallice T . Attention to action: willed and automatic control of behavior. In RJ Davidson, GE Schwartz, D Shapiro (eds). Consciousness and Self-Regulation, volume 4. Plenum Press: New York, 1986, pp 1\u201318."},{"key":"BFmp2010108_CR28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0165-1781(88)90076-5","volume":"26","author":"BA Cornblatt","year":"1988","unstructured":"Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L . The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res 1988; 26: 223\u2013238.","journal-title":"Psychiatry Res"},{"key":"BFmp2010108_CR29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1192\/bjp.133.5.429","volume":"133","author":"RC Young","year":"1978","unstructured":"Young RC, Biggs JT, Ziegler VE, Meyer DA . A rating scale for mania: reliability, validity, and sensitivity. Br J Psychiatry 1978; 133: 429\u2013435.","journal-title":"Br J Psychiatry"},{"key":"BFmp2010108_CR30","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders\u2014Patient Editions (SCID-I\/P)","author":"MB First","year":"1995","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JBW . Structured Clinical Interview for DSM-IV Axis I Disorders\u2014Patient Editions (SCID-I\/P). Biometrics Research Department, New York State Psychiatric Institute: New York, 1995."},{"key":"BFmp2010108_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0022-3956(00)00015-7","volume":"34","author":"SM Strakowski","year":"2000","unstructured":"Strakowski SM, Williams JR, Fleck DE, DelBello MP . Eight-month functional outcome for mania following a first psychiatric hospitalization. J Psychiatr Res 2000; 34: 193\u2013200.","journal-title":"J Psychiatr Res"},{"key":"BFmp2010108_CR32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0740-5472(92)90062-S","volume":"9","author":"AT McClellan","year":"1992","unstructured":"McClellan AT, Kushner H, Metzger D, Peters R, Smith I, Grissom G et al. The fifth edition of the Addiction Severity Index. J Sub Abuse Treatment 1992; 9: 199\u2013213.","journal-title":"J Sub Abuse Treatment"},{"key":"BFmp2010108_CR33","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1192\/bjp.134.4.382","volume":"134","author":"SA Montgomery","year":"1979","unstructured":"Montgomery SA, \u00c5sberg M . A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382\u2013389.","journal-title":"Br J Psychiatry"},{"key":"BFmp2010108_CR34","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO;2-F","volume":"42","author":"RW Cox","year":"1999","unstructured":"Cox RW, Jesmanowicz A . Real-time 3D image registration for functional MRI. Magn Reson Med 1999; 42: 1014\u20131018.","journal-title":"Magn Reson Med"},{"key":"BFmp2010108_CR35","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","volume":"29","author":"RW Cox","year":"1996","unstructured":"Cox RW . AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 1996; 29: 162\u2013173.","journal-title":"Comput Biomed Res"},{"key":"BFmp2010108_CR36","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","volume":"15","author":"N Tzourio-Mazoyer","year":"2002","unstructured":"Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002; 15: 273\u2013289.","journal-title":"Neuroimage"},{"key":"BFmp2010108_CR37","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1109\/42.712135","volume":"17","author":"DL Collins","year":"1998","unstructured":"Collins DL, Zijdenbos AP, Kollokian V, Sled JG, Kabani NJ, Holmes CJ et al. Design and construction of a realistic digital brain phantom. IEEE Trans Med Imaging 1998; 17: 463\u2013468.","journal-title":"IEEE Trans Med Imaging"},{"key":"BFmp2010108_CR38","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1162\/089892900564091","volume":"12","author":"AP Jha","year":"2000","unstructured":"Jha AP, McCarthy G . The influence of memory load upon delay-interval activity in a working-memory task: an event-related functional MRI study. J Cogn Neurosci 2000; 12: 90\u2013105.","journal-title":"J Cogn Neurosci"},{"key":"BFmp2010108_CR39","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1037\/h0031246","volume":"75","author":"JB Grier","year":"1971","unstructured":"Grier JB . Nonparametric indexes for sensitivity and bias. Psychol Bull 1971; 75: 424\u2013429.","journal-title":"Psychol Bull"},{"key":"BFmp2010108_CR40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1080\/17470214808416738","volume":"1","author":"NH Mackworth","year":"1948","unstructured":"Mackworth NH . The breakdown of vigilance during prolonged visual search. Q J Exp Psychol A 1948; 1: 6\u201321.","journal-title":"Q J Exp Psychol A"},{"key":"BFmp2010108_CR41","first-page":"243","volume-title":"Varieties of Attention","author":"R Parasuraman","year":"1984","unstructured":"Parasuraman R . Sustained attention in detection and discrimination. In: R Parasuraman, DR Davies (eds). Varieties of Attention. Academic Press: Orlando, FL, 1984, pp 243\u2013271."},{"key":"BFmp2010108_CR42","volume-title":"The National Adult Reading Test (NART): Test Manual","author":"HE Nelson","year":"1982","unstructured":"Nelson HE . The National Adult Reading Test (NART): Test Manual. Windsor: Berks, UK, 1982."},{"key":"BFmp2010108_CR43","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/13854049108401842","volume":"5","author":"WT Seidel","year":"1991","unstructured":"Seidel WT, Joschko M . Assessment of attention in children. Clin Neuropsychol 1991; 5: 53\u201366.","journal-title":"Clin Neuropsychol"},{"key":"BFmp2010108_CR44","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1530-0277.1994.tb00899.x","volume":"18","author":"PK Shear","year":"1994","unstructured":"Shear PK, Jernigan TL, Butters N . Volumetric magnetic resonance imaging quantification of longitudinal brain changes in abstinent alcoholics. Alcohol Clin Exp Res 1994; 18: 172\u2013176.","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp2010108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2010108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2010108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:38:56Z","timestamp":1648784336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp2010108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,26]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["BFmp2010108"],"URL":"https:\/\/doi.org\/10.1038\/mp.2010.108","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,26]]},"assertion":[{"value":"29 May 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"During calendar year 2009 through 9\/1\/2010, Dr Strakowski served as a consultant to Pfizer and Consensus Medical Communications, and spoke for Adamed and CME Outfitters. Dr Adler served as a speaker for Johnson & Johnson and Schering Plough\/Merck. Dr DelBello served as a speaker or consultant for Eli Lilly, Schering Plough\/Merck, and Bristol-Myers Squibb. No other investigators have any financial relationships to report. The investigators have also received research grants from AstraZeneca, Eli Lilly, Johnson & Johnson, Shire, Janssen, Pfizer, Bristol-Myers Squibb, Repligen, Martek, Somerset, NARSAD, and GlaxoSmithKline for other projects. Although given the nature of this report, we do not believe any of these relationships represent conflicts with the data and results reported, we provide them in the spirit of full disclosure.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}