{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:10:27Z","timestamp":1792062627025,"version":"4.4.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T00:00:00Z","timestamp":1289865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T00:00:00Z","timestamp":1289865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1038\/mp.2010.115","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T09:10:06Z","timestamp":1289898606000},"page":"62-70","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice"],"prefix":"10.1038","volume":"17","author":[{"given":"D","family":"Ehninger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Dies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D H","family":"Geschwind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-S","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J K","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Whittemore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,16]]},"reference":[{"key":"BFmp2010115_CR1","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cell.2008.10.017","volume":"135","author":"RJ Kelleher III","year":"2008","unstructured":"Kelleher III RJ, Bear MF . The autistic neuron: troubled translation? Cell 2008; 135: 401\u2013406.","journal-title":"Cell"},{"key":"BFmp2010115_CR2","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nm0809-849","volume":"15","author":"D Ehninger","year":"2009","unstructured":"Ehninger D, Silva AJ . Genetics and neuropsychiatric disorders: treatment during adulthood. Nat Med 2009; 15: 849\u2013850.","journal-title":"Nat Med"},{"key":"BFmp2010115_CR3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1023\/A:1025054610557","volume":"33","author":"E Fombonne","year":"2003","unstructured":"Fombonne E . Epidemiological surveys of autism and other pervasive developmental disorders: an update. J Autism Dev Disord 2003; 33: 365\u2013382.","journal-title":"J Autism Dev Disord"},{"key":"BFmp2010115_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1023\/A:1026052421693","volume":"28","author":"SL Smalley","year":"1998","unstructured":"Smalley SL . Autism and tuberous sclerosis. J Autism Dev Disord 1998; 28: 407\u2013414.","journal-title":"J Autism Dev Disord"},{"key":"BFmp2010115_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/BF01048239","volume":"22","author":"SL Smalley","year":"1992","unstructured":"Smalley SL, Tanguay PE, Smith M, Gutierrez G . Autism and tuberous sclerosis. J Autism Dev Disord 1992; 22: 339\u2013355.","journal-title":"J Autism Dev Disord"},{"key":"BFmp2010115_CR6","doi-asserted-by":"publisher","first-page":"16834","DOI":"10.1073\/pnas.0605296103","volume":"103","author":"DB Campbell","year":"2006","unstructured":"Campbell DB, Sutcliffe JS, Ebert PJ, Militerni R, Bravaccio C, Trillo S et al. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci USA 2006; 103: 16834\u201316839.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp2010115_CR7","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/jmg.2004.024646","volume":"42","author":"MG Butler","year":"2005","unstructured":"Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN et al. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet 2005; 42: 318\u2013321.","journal-title":"J Med Genet"},{"key":"BFmp2010115_CR8","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1023\/A:1026012414193","volume":"28","author":"PG Williams","year":"1998","unstructured":"Williams PG, Hersh JH . Brief report: the association of neurofibromatosis type 1 and autism. J Autism Dev Disord 1998; 28: 567\u2013571.","journal-title":"J Autism Dev Disord"},{"key":"BFmp2010115_CR9","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.braindev.2006.09.003","volume":"29","author":"DI Zafeiriou","year":"2007","unstructured":"Zafeiriou DI, Ververi A, Vargiami E . Childhood autism and associated comorbidities. Brain Dev 2007; 29: 257\u2013272.","journal-title":"Brain Dev"},{"key":"BFmp2010115_CR10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1136\/jmg.2009.066852","volume":"46","author":"M Neves-Pereira","year":"2009","unstructured":"Neves-Pereira M, Muller B, Massie D, Williams JH, O'Brien PC, Hughes A et al. Deregulation of EIF4E: a novel mechanism for autism. J Med Genet 2009; 46: 759\u2013765.","journal-title":"J Med Genet"},{"key":"BFmp2010115_CR11","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1601-183X.2005.00134.x","volume":"4","author":"PW Vanderklish","year":"2005","unstructured":"Vanderklish PW, Edelman GM . Differential translation and fragile X syndrome. Genes Brain Behav 2005; 4: 360\u2013384.","journal-title":"Genes Brain Behav"},{"key":"BFmp2010115_CR12","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1523\/JNEUROSCI.3696-09.2010","volume":"30","author":"A Sharma","year":"2010","unstructured":"Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E et al. Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci 2010; 30: 694\u2013702.","journal-title":"J Neurosci"},{"key":"BFmp2010115_CR13","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.bbr.2008.12.016","volume":"204","author":"PH Patterson","year":"2009","unstructured":"Patterson PH . Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res 2009; 204: 313\u2013321.","journal-title":"Behav Brain Res"},{"key":"BFmp2010115_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/BF01537741","volume":"1","author":"S Chess","year":"1971","unstructured":"Chess S . Autism in children with congenital rubella. J Autism Child Schizophr 1971; 1: 33\u201347.","journal-title":"J Autism Child Schizophr"},{"key":"BFmp2010115_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF01531116","volume":"7","author":"S Chess","year":"1977","unstructured":"Chess S . Follow-up report on autism in congenital rubella. J Autism Child Schizophr 1977; 7: 69\u201381.","journal-title":"J Autism Child Schizophr"},{"key":"BFmp2010115_CR16","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0022-3476(78)80921-4","volume":"93","author":"S Chess","year":"1978","unstructured":"Chess S, Fernandez P, Korn S . Behavioral consequences of congenital rubella. J Pediatr 1978; 93: 699\u2013703.","journal-title":"J Pediatr"},{"key":"BFmp2010115_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13550280590900553","volume":"11","author":"JE Libbey","year":"2005","unstructured":"Libbey JE, Sweeten TL, McMahon WM, Fujinami RS . Autistic disorder and viral infections. J Neurovirol 2005; 11: 1\u201310.","journal-title":"J Neurovirol"},{"key":"BFmp2010115_CR18","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/oxfordjournals.aje.a112726","volume":"109","author":"EY Deykin","year":"1979","unstructured":"Deykin EY, MacMahon B . Viral exposure and autism. Am J Epidemiol 1979; 109: 628\u2013638.","journal-title":"Am J Epidemiol"},{"key":"BFmp2010115_CR19","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s10803-004-2552-y","volume":"34","author":"TL Sweeten","year":"2004","unstructured":"Sweeten TL, Posey DJ, McDougle CJ . Brief report: autistic disorder in three children with cytomegalovirus infection. J Autism Dev Disord 2004; 34: 583\u2013586.","journal-title":"J Autism Dev Disord"},{"key":"BFmp2010115_CR20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1023\/A:1025023131029","volume":"33","author":"Y Yamashita","year":"2003","unstructured":"Yamashita Y, Fujimoto C, Nakajima E, Isagai T, Matsuishi T . Possible association between congenital cytomegalovirus infection and autistic disorder. J Autism Dev Disord 2003; 33: 455\u2013459.","journal-title":"J Autism Dev Disord"},{"key":"BFmp2010115_CR21","doi-asserted-by":"crossref","unstructured":"Atladottir HO, Thorsen P, Ostergaard L, Schendel DE, Lemcke S, Abdallah M et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord 2010 [e-pub ahead of print].","DOI":"10.1007\/s10803-010-1006-y"},{"key":"BFmp2010115_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1146\/annurev.ne.18.030195.000533","volume":"18","author":"AL Ciaranello","year":"1995","unstructured":"Ciaranello AL, Ciaranello RD . The neurobiology of infantile autism. Annu Rev Neurosci 1995; 18: 101\u2013128.","journal-title":"Annu Rev Neurosci"},{"key":"BFmp2010115_CR23","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.pediatrneurol.2007.01.012","volume":"36","author":"MG Chez","year":"2007","unstructured":"Chez MG, Dowling T, Patel PB, Khanna P, Kominsky M . Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatr Neurol 2007; 36: 361\u2013365.","journal-title":"Pediatr Neurol"},{"key":"BFmp2010115_CR24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","volume":"57","author":"DL Vargas","year":"2005","unstructured":"Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA . Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2005; 57: 67\u201381.","journal-title":"Ann Neurol"},{"key":"BFmp2010115_CR25","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/sj.mp.4000730","volume":"5","author":"H Nawa","year":"2000","unstructured":"Nawa H, Takahashi M, Patterson PH . Cytokine and growth factor involvement in schizophrenia--support for the developmental model. Mol Psychiatry 2000; 5: 594\u2013603.","journal-title":"Mol Psychiatry"},{"key":"BFmp2010115_CR26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.ijdevneu.2004.05.005","volume":"23","author":"L Shi","year":"2005","unstructured":"Shi L, Tu N, Patterson PH . Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus. Int J Dev Neurosci 2005; 23: 299\u2013305.","journal-title":"Int J Dev Neurosci"},{"key":"BFmp2010115_CR27","doi-asserted-by":"publisher","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","volume":"27","author":"SE Smith","year":"2007","unstructured":"Smith SE, Li J, Garbett K, Mirnics K, Patterson PH . Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 2007; 27: 10695\u201310702.","journal-title":"J Neurosci"},{"key":"BFmp2010115_CR28","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s00213-003-1461-7","volume":"169","author":"L Zuckerman","year":"2003","unstructured":"Zuckerman L, Weiner I . Post-pubertal emergence of disrupted latent inhibition following prenatal immune activation. Psychopharmacology (Berl) 2003; 169: 308\u2013313.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFmp2010115_CR29","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.cell.2007.05.058","volume":"130","author":"DF Lee","year":"2007","unstructured":"Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 2007; 130: 440\u2013455.","journal-title":"Cell"},{"key":"BFmp2010115_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature06730","volume":"452","author":"R Colina","year":"2008","unstructured":"Colina R, Costa-Mattioli M, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ et al. Translational control of the innate immune response through IRF-7. Nature 2008; 452: 323\u2013328.","journal-title":"Nature"},{"key":"BFmp2010115_CR31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1165\/rcmb.2008-0290OC","volume":"41","author":"E Lorne","year":"2009","unstructured":"Lorne E, Zhao X, Zmijewski JW, Liu G, Park YJ, Tsuruta Y et al. Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol 2009; 41: 237\u2013245.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFmp2010115_CR32","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/ni.1645","volume":"9","author":"W Cao","year":"2008","unstructured":"Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N et al. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol 2008; 9: 1157\u20131164.","journal-title":"Nat Immunol"},{"key":"BFmp2010115_CR33","doi-asserted-by":"publisher","first-page":"7018","DOI":"10.4049\/jimmunol.178.11.7018","volume":"178","author":"HR Turnquist","year":"2007","unstructured":"Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW . Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007; 178: 7018\u20137031.","journal-title":"J Immunol"},{"key":"BFmp2010115_CR34","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1172\/JCI7319","volume":"104","author":"H Onda","year":"1999","unstructured":"Onda H, Lueck A, Marks PW, Warren HB, Kwiatkowski DJ . Tsc2(+\/\u2212) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 1999; 104: 687\u2013695.","journal-title":"J Clin Invest"},{"key":"BFmp2010115_CR35","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","volume":"3","author":"SS Moy","year":"2004","unstructured":"Moy SS, Nadler JJ, Perez A, Barbaro RP, Johns JM, Magnuson TR et al. Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav 2004; 3: 287\u2013302.","journal-title":"Genes Brain Behav"},{"key":"BFmp2010115_CR36","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nm1788","volume":"14","author":"D Ehninger","year":"2008","unstructured":"Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ et al. Reversal of learning deficits in a Tsc2+\/\u2212 mouse model of tuberous sclerosis. Nat Med 2008; 14: 843\u2013848.","journal-title":"Nat Med"},{"key":"BFmp2010115_CR37","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1001\/archpsyc.63.9.1026","volume":"63","author":"A Reichenberg","year":"2006","unstructured":"Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S et al. Advancing paternal age and autism. Arch Gen Psychiatry 2006; 63: 1026\u20131032.","journal-title":"Arch Gen Psychiatry"},{"key":"BFmp2010115_CR38","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/ajmg.c.30081","volume":"142","author":"SS Moy","year":"2006","unstructured":"Moy SS, Nadler JJ, Magnuson TR, Crawley JN . Mouse models of autism spectrum disorders: the challenge for behavioral genetics. Am J Med Genet C Semin Med Genet 2006; 142: 40\u201351.","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"BFmp2010115_CR39","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/0960-0760(91)90265-7","volume":"39","author":"CJ Wysocki","year":"1991","unstructured":"Wysocki CJ, Lepri JJ . Consequences of removing the vomeronasal organ. J Steroid Biochem Mol Biol 1991; 39: 661\u2013669.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BFmp2010115_CR40","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1126\/science.285.5436.2122","volume":"285","author":"A Di Cristofano","year":"1999","unstructured":"Di Cristofano A, Kotsi P, Peng YF, Cordon-Cardo C, Elkon KB, Pandolfi PP . Impaired Fas response and autoimmunity in Pten+\/\u2212 mice. Science 1999; 285: 2122\u20132125.","journal-title":"Science"},{"key":"BFmp2010115_CR41","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1096\/fasebj.14.7.895","volume":"14","author":"LR Borlado","year":"2000","unstructured":"Borlado LR, Redondo C, Alvarez B, Jimenez C, Criado LM, Flores J et al. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. FASEB J 2000; 14: 895\u2013903.","journal-title":"FASEB J"},{"key":"BFmp2010115_CR42","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/intimm\/dxm017","volume":"19","author":"C Xie","year":"2007","unstructured":"Xie C, Patel R, Wu T, Zhu J, Henry T, Bhaskarabhatla M et al. PI3K\/AKT\/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr. Int Immunol 2007; 19: 509\u2013522.","journal-title":"Int Immunol"},{"key":"BFmp2010115_CR43","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/j.1478-3231.2005.01043.x","volume":"25","author":"C Okada","year":"2005","unstructured":"Okada C, Akbar SM, Horiike N, Onji M . Early development of primary biliary cirrhosis in female C57BL\/6 mice because of poly I:C administration. Liver Int 2005; 25: 595\u2013603.","journal-title":"Liver Int"},{"key":"BFmp2010115_CR44","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jaut.2004.01.006","volume":"22","author":"J Paronen","year":"2004","unstructured":"Paronen J, Liu E, Moriyama H, Devendra D, Ide A, Taylor R et al. Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetes. J Autoimmun 2004; 22: 307\u2013313.","journal-title":"J Autoimmun"},{"key":"BFmp2010115_CR45","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.4049\/jimmunol.172.5.3173","volume":"172","author":"L Wen","year":"2004","unstructured":"Wen L, Peng J, Li Z, Wong FS . The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol 2004; 172: 3173\u20133180.","journal-title":"J Immunol"},{"key":"BFmp2010115_CR46","doi-asserted-by":"publisher","first-page":"5539","DOI":"10.1073\/pnas.082120099","volume":"99","author":"H Moriyama","year":"2002","unstructured":"Moriyama H, Wen L, Abiru N, Liu E, Yu L, Miao D et al. Induction and acceleration of insulitis\/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci USA 2002; 99: 5539\u20135544.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp2010115_CR47","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/j.1432-2277.2009.01041.x","volume":"23","author":"M Haidinger","year":"2010","unstructured":"Haidinger M, Hecking M, Weichhart T, Poglitsch M, Enkner W, Vonbank K et al. Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity. Transpl Int 2010; 23: 777\u2013785.","journal-title":"Transpl Int"},{"key":"BFmp2010115_CR48","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0969-9961(03)00127-X","volume":"14","author":"M Maldonado","year":"2003","unstructured":"Maldonado M, Baybis M, Newman D, Kolson DL, Chen W, McKhann II G et al. Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiol Dis 2003; 14: 279\u2013290.","journal-title":"Neurobiol Dis"},{"key":"BFmp2010115_CR49","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1365-3016.2007.00919.x","volume":"22","author":"LC Lee","year":"2008","unstructured":"Lee LC, Newschaffer CJ, Lessler JT, Lee BK, Shah R, Zimmerman AW . Variation in season of birth in singleton and multiple births concordant for autism spectrum disorders. Paediatr Perinat Epidemiol 2008; 22: 172\u2013179.","journal-title":"Paediatr Perinat Epidemiol"},{"key":"BFmp2010115_CR50","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1097\/01.ede.0000254064.92806.13","volume":"18","author":"HO Atladottir","year":"2007","unstructured":"Atladottir HO, Parner ET, Schendel D, Dalsgaard S, Thomsen PH, Thorsen P . Variation in incidence of neurodevelopmental disorders with season of birth. Epidemiology 2007; 18: 240\u2013245.","journal-title":"Epidemiology"},{"key":"BFmp2010115_CR51","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1076\/1380-3395(200006)22:3;1-V;FT399","volume":"22","author":"MC Stevens","year":"2000","unstructured":"Stevens MC, Fein DH, Waterhouse LH . Season of birth effects in autism. J Clin Exp Neuropsychol 2000; 22: 399\u2013407.","journal-title":"J Clin Exp Neuropsychol"},{"key":"BFmp2010115_CR52","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1469-7610.1992.tb00888.x","volume":"33","author":"P Bolton","year":"1992","unstructured":"Bolton P, Pickles A, Harrington R, Macdonald H, Rutter M . Season of birth: issues, approaches and findings for autism. J Child Psychol Psychiatry 1992; 33: 509\u2013530.","journal-title":"J Child Psychol Psychiatry"},{"key":"BFmp2010115_CR53","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1176\/ajp.152.5.798","volume":"152","author":"Y Barak","year":"1995","unstructured":"Barak Y, Ring A, Sulkes J, Gabbay U, Elizur A . Season of birth and autistic disorder in Israel. Am J Psychiatry 1995; 152: 798\u2013800.","journal-title":"Am J Psychiatry"},{"key":"BFmp2010115_CR54","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.1600-0447.1990.tb01373.x","volume":"82","author":"C Gillberg","year":"1990","unstructured":"Gillberg C . Do children with autism have March birthdays? Acta Psychiatr Scand 1990; 82: 152\u2013156.","journal-title":"Acta Psychiatr Scand"},{"key":"BFmp2010115_CR55","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1023\/A:1023030911527","volume":"29","author":"EC Landau","year":"1999","unstructured":"Landau EC, Cicchetti DV, Klin A, Volkmar FR . Season of birth in autism: a fiction revisited. J Autism Dev Disord 1999; 29: 385\u2013393.","journal-title":"J Autism Dev Disord"}],"updated-by":[{"DOI":"10.1038\/mp.2011.39","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T00:00:00Z","timestamp":1332720000000}}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp2010115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2010115","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2010115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:39:58Z","timestamp":1648784398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp2010115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,16]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["BFmp2010115"],"URL":"https:\/\/doi.org\/10.1038\/mp.2010.115","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/mp.2011.39","asserted-by":"object"}]},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,16]]},"assertion":[{"value":"16 May 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}