{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:14:26Z","timestamp":1791648866321,"version":"4.3.4"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1038\/mp.2011.29","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T08:02:20Z","timestamp":1303200140000},"page":"826-835","source":"Crossref","is-referenced-by-count":94,"title":["Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans"],"prefix":"10.1038","volume":"16","author":[{"given":"E A","family":"Rabiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Beaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Makwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Searle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R D","family":"Newbould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Reiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Passchier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P M","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E T","family":"Bullmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"BFmp201129_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/267495a0","volume":"267","author":"JAH Lord","year":"1977","unstructured":"Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW . Endogenous opioid peptides: multiple agonists and receptors. Nature 1977; 267: 495\u2013499.","journal-title":"Nature"},{"key":"BFmp201129_CR2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0006-8993(95)00928-J","volume":"700","author":"A Mansour","year":"1995","unstructured":"Mansour A, Hoversten MT, Taylor LP, Watson SJ, Akil H . The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. Brain Res 1995; 700: 89\u201398.","journal-title":"Brain Res"},{"key":"BFmp201129_CR3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0165-6147(03)00066-X","volume":"24","author":"SH Snyder","year":"2003","unstructured":"Snyder SH, Pasternak GW . Historical review: opioid receptors. Trends Pharmacol Sci 2003; 24: 198\u2013205.","journal-title":"Trends Pharmacol Sci"},{"key":"BFmp201129_CR4","first-page":"412","volume":"21","author":"SF Leibowitz","year":"1985","unstructured":"Leibowitz SF . Brain neurotransmitters and appetite regulation. Psychopharmacol Bull 1985; 21: 412\u2013418.","journal-title":"Psychopharmacol Bull"},{"key":"BFmp201129_CR5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1210\/edrv-8-3-256","volume":"8","author":"JE Morley","year":"1987","unstructured":"Morley JE . Neuropeptide regulation of appetite and weight. Endocr Rev 1987; 8: 256\u2013287.","journal-title":"Endocr Rev"},{"key":"BFmp201129_CR6","first-page":"239","volume-title":"Handbook of Experimental Pharmacology","author":"S Cooper","year":"1993","unstructured":"Cooper S, Kirkham T . Opioid mechanisms in the control of food consumption and taste preferences. Opioids II. In: Herz A (ed). Handbook of Experimental Pharmacology 1993, Springer-Verlag: Berlin, pp 239\u2013262."},{"key":"BFmp201129_CR7","unstructured":"Gosnell B, Levine A . Stimulation of ingestive behavior by preferential and selective opioid agonists. Cooper SJ, Clifton PG (eds). In: Drug receptor subtypes and ingestive behavior. 1996, Academic Press: London, UK, pp 147\u2013166."},{"key":"BFmp201129_CR8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1054\/npep.1999.0050","volume":"33","author":"MJ Glass","year":"1999","unstructured":"Glass MJ, Billington CJ, Levine AS . Opioids and food intake: distributed functional neural pathways? Neuropeptides 1999; 33: 360\u2013368.","journal-title":"Neuropeptides"},{"key":"BFmp201129_CR9","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1017\/S146114570900039X","volume":"12","author":"PJ Nathan","year":"2009","unstructured":"Nathan PJ, Bullmore ET . From taste hedonics to motivational drive: central opioid receptors and binge-eating behaviour. Int J Neuropsychopharmacol 2009; 12: 995\u20131008.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFmp201129_CR10","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/0024-3205(86)90243-2","volume":"38","author":"BA Gosnell","year":"1986","unstructured":"Gosnell BA, Levine AS, Morley JE . The stimulation of food intake by selective agonists of mu, kappa and delta opioid receptors. Life Sci 1986; 38: 1081\u20131088.","journal-title":"Life Sci"},{"key":"BFmp201129_CR11","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0022-3565(25)38247-9","volume":"265","author":"VP Bakshi","year":"1993","unstructured":"Bakshi VP, Kelley AE . Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes. J Pharmacol Exp Ther 1993; 265: 1253\u20131260.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFmp201129_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1615\/CritRevNeurobiol.v12.i4.10","volume":"12","author":"TS Shippenberg","year":"1998","unstructured":"Shippenberg TS, Elmer GI . The neurobiology of opiate reinforcement. Crit Rev Neurobiol 1998; 12: 267\u2013303.","journal-title":"Crit Rev Neurobiol"},{"key":"BFmp201129_CR13","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0031-9384(02)00751-5","volume":"76","author":"AE Kelley","year":"2002","unstructured":"Kelley AE, Bakshi VP, Haber SN, Steininger TL, Will MJ, Zhang M . Opioid modulation of taste hedonics within the ventral striatum. Physiol Behav 2002; 76: 365\u2013377.","journal-title":"Physiol Behav"},{"key":"BFmp201129_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pbb.2010.03.002","volume":"97","author":"DP Figlewicz","year":"2010","unstructured":"Figlewicz DP, Sipols AJ . Energy regulatory signals and food reward. Pharmacol Biochem Behav 2010; 97: 15\u201324.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFmp201129_CR15","doi-asserted-by":"publisher","first-page":"11777","DOI":"10.1523\/JNEUROSCI.2329-05.2005","volume":"25","author":"S Peci\u00f1a","year":"2005","unstructured":"Peci\u00f1a S, Berridge KC . Hedonic hot spot in nucleus accumbens shell: where do \u03bc-opioids cause increased hedonic impact of sweetness? J Neurosci 2005; 25: 11777\u201311786.","journal-title":"J Neurosci"},{"key":"BFmp201129_CR16","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s002130050355","volume":"132","author":"M Zhang","year":"1997","unstructured":"Zhang M, Kelley AE . Opiate agonists microinjected into the nucleus accumbens enhance sucrose drinking in rats. Psychopharmacology 1997; 132: 350\u2013360.","journal-title":"Psychopharmacology"},{"key":"BFmp201129_CR17","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1523\/JNEUROSCI.16-05-01877.1996","volume":"16","author":"CI Wright","year":"1996","unstructured":"Wright CI, Beijer AVJ, Groenewegen HJ . Basal amygdaloid complex afferents to the rat nucleus accumbens are compartmentally organized. J Neurosci 1996; 16: 1877\u20131893.","journal-title":"J Neurosci"},{"key":"BFmp201129_CR18","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/BF00237437","volume":"56","author":"S Azuma","year":"1984","unstructured":"Azuma S, Yamamoto T, Kawamura Y . Studies on gustatory responses of amygdaloid neurons in rats. Exp Brain Res 1984; 56: 12\u201322.","journal-title":"Exp Brain Res"},{"key":"BFmp201129_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0166-4328(94)90097-3","volume":"65","author":"T Yamamoto","year":"1994","unstructured":"Yamamoto T, Shimura T, Sako N, Yasoshima Y, Sakai N . Neural substrates for conditioned taste aversion in the rat. Behav Brain Res 1994; 65: 123\u2013137.","journal-title":"Behav Brain Res"},{"key":"BFmp201129_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0149-7634(02)00007-6","volume":"26","author":"RN Cardinal","year":"2002","unstructured":"Cardinal RN, Parkinson JA, Hall J, Everitt BJ . Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 2002; 26: 321\u2013352.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFmp201129_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.physbeh.2005.06.018","volume":"86","author":"AE Kelley","year":"2005","unstructured":"Kelley AE, Schiltz CA, Landry CF . Neural systems recruited by drug- and food-related cues: studies of gene activation in corticolimbic regions. Physiol Behav 2005; 86: 11\u201314.","journal-title":"Physiol Behav"},{"key":"BFmp201129_CR22","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1097\/00001756-200408260-00004","volume":"15","author":"MJ Will","year":"2004","unstructured":"Will MJ, Franzblau EB, Kelley AE . The amygdala is critical for opioid-mediated binge eating of fat. NeuroReport 2004; 15: 1857\u20131860.","journal-title":"NeuroReport"},{"key":"BFmp201129_CR23","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0149-7634(02)00041-6","volume":"26","author":"MR Yeomans","year":"2002","unstructured":"Yeomans MR, Gray RW . Opioid peptides and the control of human ingestive behaviour. Neurosci Biobehav Rev 2002; 26: 713\u2013728.","journal-title":"Neurosci Biobehav Rev"},{"issue":"1 Pt 2","key":"BFmp201129_CR24","doi-asserted-by":"publisher","first-page":"R91","DOI":"10.1152\/ajpregu.1986.251.1.R91","volume":"251","author":"M Fantino","year":"1986","unstructured":"Fantino M, Hosotte J, Apfelbaum M . An opioid antagonist, naltrexone, reduces preference for sucrose in humans. Am J Physiol Regul Integr Comp Physiol 1986; 251 (1 Pt 2): R91\u2013R96.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFmp201129_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0195-6663(91)90062-W","volume":"16","author":"MR Yeomans","year":"1991","unstructured":"Yeomans MR, Wright P . Lower pleasantness of palatable foods in nalmefene-treated human volunteers. Appetite 1991; 16: 249\u2013259.","journal-title":"Appetite"},{"key":"BFmp201129_CR26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1006\/appe.1996.0040","volume":"27","author":"MR Yeomans","year":"1996","unstructured":"Yeomans MR . Palatability and the micro-structure of feeding in humans: the appetizer effect. Appetite 1996; 27: 119\u2013133.","journal-title":"Appetite"},{"key":"BFmp201129_CR27","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1093\/ajcn\/61.6.1206","volume":"61","author":"A Drewnowski","year":"1995","unstructured":"Drewnowski A, Krahn DD, Demitrack MA, Nairn K, Gosnell BA . Naloxone, an opiate blocker, reduces the consumption of sweet high-fat foods in obese and lean female binge eaters. Am J Clin Nutr 1995; 61: 1206\u20131212.","journal-title":"Am J Clin Nutr"},{"key":"BFmp201129_CR28","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0031-9384(92)90155-U","volume":"51","author":"A Drewnowski","year":"1992","unstructured":"Drewnowski A, Krahn DD, Demitrack MA, Nairn K, Gosnell BA . Taste responses and preferences for sweet high-fat foods: evidence for opioid involvement. Physiol Behav 1992; 51: 371\u2013379.","journal-title":"Physiol Behav"},{"key":"BFmp201129_CR29","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1124\/jpet.106.118810","volume":"321","author":"D Wang","year":"2007","unstructured":"Wang D, Sun X, Sadee W . Different effects of opioid antagonists on \u03bc-, \u03b4-, and \u03ba-opioid receptors with and without agonist pretreatment. J Pharmacol Exp Ther 2007; 321: 544\u2013552.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFmp201129_CR30","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1016\/j.bmcl.2009.03.095","volume":"19","author":"AL Pelotte","year":"2009","unstructured":"Pelotte AL, Smith RM, Ayestas M, Dersch CM, Bilsky EJ, Rothman RB et al. Design, synthesis, and characterization of 6\u03b2-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes. Bioorg Med Chem Lett 2009; 19: 2811\u20132814.","journal-title":"Bioorg Med Chem Lett"},{"key":"BFmp201129_CR31","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1124\/jpet.105.094409","volume":"316","author":"MCH Ko","year":"2006","unstructured":"Ko MCH, Divin MF, Lee H, Woods JH, Traynor JR . Differential in vivo potencies of naltrexone and 6\u03b2-naltrexol in the monkey. J Pharmacol Exp Ther 2006; 316: 772\u2013779.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFmp201129_CR32","first-page":"15","volume":"45","author":"MC Meyer","year":"1984","unstructured":"Meyer MC, Straughn AB, Lo MW . Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration. J Clin Psychiatry 1984; 45: 15\u201319.","journal-title":"J Clin Psychiatry"},{"key":"BFmp201129_CR33","doi-asserted-by":"crossref","unstructured":"Nathan PJ, O\u2019Neill BV, Bush MA, Koch A, Tao WX, Maltby K et al. Opioid receptor modulation of hedonic taste preference and food intake: a single dose safety, pharmacokinetic and pharmacodynamic investigation with GSK1521498, a novel mu opioid receptor inverse agonist. J Clin Pharmacol 2011 (in press).","DOI":"10.1177\/0091270011399577"},{"key":"BFmp201129_CR34","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0896-6273(02)00603-7","volume":"33","author":"JP O\u2019Doherty","year":"2002","unstructured":"O\u2019Doherty JP, Deichmann R, Critchley HD, Dolan RJ . Neural responses during anticipation of a primary taste reward. Neuron 2002; 33: 815\u2013826.","journal-title":"Neuron"},{"key":"BFmp201129_CR35","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/sj.npp.1301513","volume":"33","author":"FM Filbey","year":"2008","unstructured":"Filbey FM, Claus E, Audette AR, Niculescu M, Banich MT, Tanabe J et al. Exposure to the taste of alcohol elicits activation of the mesocorticolimbic neurocircuitry. Neuropsychopharmacology 2008; 33: 1391\u20131401.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp201129_CR36","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1037\/a0013600","volume":"117","author":"E Stice","year":"2008","unstructured":"Stice E, Spoor S, Bohon C, Veldhuizen MG, Small DM . Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study. J Abnorm Psychol 2008; 117: 924\u2013935.","journal-title":"J Abnorm Psychol"},{"key":"BFmp201129_CR37","doi-asserted-by":"publisher","first-page":"10509","DOI":"10.1523\/JNEUROSCI.2807-08.2008","volume":"28","author":"P Petrovic","year":"2008","unstructured":"Petrovic P, Pleger B, Seymour B, Kl\u00f6ppel S, De Martino B, Critchley H et al. Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses. J Neurosci 2008; 28: 10509\u201310516.","journal-title":"J Neurosci"},{"key":"BFmp201129_CR38","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1001\/archpsyc.65.4.466","volume":"65","author":"H Myrick","year":"2008","unstructured":"Myrick H, Anton RF, Li X, Henderson S, Randall PK, Voronin K . Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people. Arch Gen Psychiatry 2008; 65: 466\u2013475.","journal-title":"Arch Gen Psychiatry"},{"key":"BFmp201129_CR39","doi-asserted-by":"publisher","first-page":"14346","DOI":"10.1523\/JNEUROSCI.3323-10.2010","volume":"30","author":"PC Fletcher","year":"2010","unstructured":"Fletcher PC, Napolitano A, Skeggs A, Miller SR, Delafont B, Cambridge VC et al. Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum. J Neurosci 2010; 30: 14346\u201314355.","journal-title":"J Neurosci"},{"key":"BFmp201129_CR40","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/jcbfm.2010.175","volume":"31","author":"S Abanades","year":"2011","unstructured":"Abanades S, van der Aart J, Barletta JA, Marzano C, Searle GE, Salinas CA et al. Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy. J Cereb Blood Flow Metab 2011; 31: 944\u2013952.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFmp201129_CR41","unstructured":"In British National Formulary, 59, Royal Pharmaceutical Society: London, UK, 2010."},{"key":"BFmp201129_CR42","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0969-8051(01)00226-8","volume":"28","author":"DM Jewett","year":"2001","unstructured":"Jewett DM . A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC. Nucl Med Biol 2001; 28: 733\u2013734.","journal-title":"Nucl Med Biol"},{"key":"BFmp201129_CR43","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.neuroimage.2010.06.044","volume":"54","author":"AC Tziortzi","year":"2010","unstructured":"Tziortzi AC, Searle GE, Tzimopoulou S, Salinas C, Beaver JD, Jenkinson M et al. Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy. NeuroImage 2010; 54: 264\u2013277.","journal-title":"NeuroImage"},{"key":"BFmp201129_CR44","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","volume":"27","author":"RB Innis","year":"2007","unstructured":"Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 2007; 27: 1533\u20131539.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFmp201129_CR45","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1006\/nimg.1997.0303","volume":"6","author":"RN Gunn","year":"1997","unstructured":"Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ . Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 1997; 6: 279\u2013287.","journal-title":"Neuroimage"},{"key":"BFmp201129_CR46","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1002\/jmri.21049","volume":"27","author":"CR Jack Jr","year":"2008","unstructured":"Jack Jr CR, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D et al. The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods. J Magn Reson Imaging 2008; 27: 685\u2013691.","journal-title":"J Magn Reson Imaging"},{"key":"BFmp201129_CR47","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1038\/sj.ijo.0801442","volume":"24","author":"J Karlsson","year":"2000","unstructured":"Karlsson J, Persson LO, Sj\u00f6str\u00f6m L, Sullivan M . Psychometric properties and factor structure of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women. Results from the Swedish Obese Subjects (SOS) study. Int J Obes 2000; 24: 1715\u20131725.","journal-title":"Int J Obes"},{"key":"BFmp201129_CR48","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1","volume":"51","author":"JH Patton","year":"1995","unstructured":"Patton JH, Stanford MS, Barratt ES . Factor structure of the Barratt Impulsiveness Scale. J Clin Psychol 1995; 51: 768\u2013774.","journal-title":"J Clin Psychol"},{"key":"BFmp201129_CR49","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1023\/A:1011907920641","volume":"16","author":"H Derendorf","year":"1999","unstructured":"Derendorf H, Meibohm B . Modeling of pharmacokinetic\/pharmacodynamic (PK\/PD) relationships: concepts and perspectives. Pharm Res 1999; 16: 176\u2013185.","journal-title":"Pharm Res"},{"key":"BFmp201129_CR50","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00429-010-0266-9","volume":"214","author":"DM Small","year":"2010","unstructured":"Small DM . Taste representation in the human insula. Brain Structure Func 2010; 214: 551\u2013561.","journal-title":"Brain Structure Func"},{"key":"BFmp201129_CR51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00221-005-2376-9","volume":"166","author":"DM Small","year":"2005","unstructured":"Small DM, Prescott J . Odor\/taste integration and the perception of flavor. Exp Brain Res 2005; 166: 345\u2013357.","journal-title":"Exp Brain Res"},{"key":"BFmp201129_CR52","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/0006-8993(94)91470-2","volume":"656","author":"TD Wolinsky","year":"1994","unstructured":"Wolinsky TD, Carr KD, Hiller JM, Simon EJ . Effects of chronic food restriction on mu and kappa opioid binding in rat forebrain: a quantitative autoradiographic study. Brain Res 1994; 656: 274\u2013280.","journal-title":"Brain Res"},{"key":"BFmp201129_CR53","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0006-8993(95)01337-7","volume":"706","author":"TD Wolinsky","year":"1996","unstructured":"Wolinsky TD, Carr KD, Hiller JM, Simon EJ . Chronic food restriction alters \u03bc and \u03ba opioid receptor binding in the parabrachial nucleus of the rat: a quantitative autoradiographic study. Brain Res 1996; 706: 333\u2013336.","journal-title":"Brain Res"},{"key":"BFmp201129_CR54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.brainresrev.2009.09.008","volume":"62","author":"AW Bruijnzeel","year":"2009","unstructured":"Bruijnzeel AW . kappa-opioid receptor signaling and brain reward function. Brain Res Rev 2009; 62: 127\u2013146.","journal-title":"Brain Res Rev"},{"key":"BFmp201129_CR55","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.pharmthera.2007.06.011","volume":"116","author":"TS Shippenberg","year":"2007","unstructured":"Shippenberg TS, Zapata A, Chefer VI . Dynorphin and the pathophysiology of drug addiction. Pharmacol Ther 2007; 116: 306\u2013321.","journal-title":"Pharmacol Ther"},{"key":"BFmp201129_CR56","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1124\/jpet.104.082966","volume":"313","author":"KM Raehal","year":"2005","unstructured":"Raehal KM, Lowery JJ, Bhamidipati CM, Paolino RM, Blair JR, Wang D et al. In vivo characterization of 6\u03b2-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J Pharmacol Exp Ther 2005; 313: 1150\u20131162.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFmp201129_CR57","first-page":"1349","volume":"46","author":"B Bencherif","year":"2005","unstructured":"Bencherif B, Guarda AS, Colantuoni C, Ravert HT, Dannals RF, Frost JJ . Regional \u03bc-opioid receptor binding in insular cortex is decreased in bulimia nervosa and correlates inversely with fasting behavior. J Nucl Med 2005; 46: 1349\u20131351.","journal-title":"J Nucl Med"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mp201129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mp201129","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mp201129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T04:20:53Z","timestamp":1741148453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp201129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,19]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["BFmp201129"],"URL":"https:\/\/doi.org\/10.1038\/mp.2011.29","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,19]]}}}