{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:10:36Z","timestamp":1792113036854,"version":"4.4.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1038\/mp.2014.83","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T08:00:11Z","timestamp":1409040011000},"page":"602-608","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time"],"prefix":"10.1038","volume":"20","author":[{"given":"B A A","family":"Bus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Molendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Tendolkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B W J H","family":"Penninx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Prickaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B M","family":"Elzinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R C O","family":"Voshaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,26]]},"reference":[{"key":"BFmp201483_CR1","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","volume":"59","author":"RS Duman","year":"2006","unstructured":"Duman RS, Monteggia LM . A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59: 1116\u20131127.","journal-title":"Biol Psychiatry"},{"key":"BFmp201483_CR2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jad.2011.03.027","volume":"133","author":"BW Penninx","year":"2011","unstructured":"Penninx BW, Nolen WA, Lamers F, Zitman FG, Smit JH, Spinhoven P et al. Two-year course of depressive and anxiety disorders: results from the Netherlands Study of Depression and Anxiety (NESDA). J Affect Disord 2011; 133: 76\u201385.","journal-title":"J Affect Disord"},{"key":"BFmp201483_CR3","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1001\/archpsyc.61.11.1097","volume":"61","author":"T Vos","year":"2004","unstructured":"Vos T, Haby MM, Barendregt JJ, Kruijshaar M, Corry J, Andrews G . The burden of major depression avoidable by longer-term treatment strategies. Arch Gen Psychiatry 2004; 61: 1097\u20131103.","journal-title":"Arch Gen Psychiatry"},{"key":"BFmp201483_CR4","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1176\/appi.ajp.158.4.582","volume":"158","author":"KS Kendler","year":"2001","unstructured":"Kendler KS, Thornton LM, Gardner CO . Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. Am J Psychiatry 2001; 158: 582\u2013586.","journal-title":"Am J Psychiatry"},{"key":"BFmp201483_CR5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1017\/S0033291707001249","volume":"38","author":"OJ Robinson","year":"2008","unstructured":"Robinson OJ, Sahakian BJ . Recurrence in major depressive disorder: a neurocognitive perspective. Psychol Med 2008; 38: 315\u2013318.","journal-title":"Psychol Med"},{"key":"BFmp201483_CR6","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.psyneuen.2012.08.004","volume":"38","author":"SH Booij","year":"2013","unstructured":"Booij SH, Bouma EM, de Jonge P, Ormel J, Oldehinkel AJ . Chronicity of depressive problems and the cortisol response to psychosocial stress in adolescents: the TRAILS study. Psychoneuroendocrinology 2013; 38: 659\u2013666.","journal-title":"Psychoneuroendocrinology"},{"key":"BFmp201483_CR7","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/mp.2013.105","volume":"19","author":"ML Molendijk","year":"2013","unstructured":"Molendijk ML, Spinhoven P, Polak M, Bus BA, Penninx BW, Elzinga BM . Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Mol Psychiatry 2013; 19: 791\u2013800.","journal-title":"Mol Psychiatry"},{"key":"BFmp201483_CR8","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/mp.2010.98","volume":"11","author":"ML Molendijk","year":"2011","unstructured":"Molendijk ML, Bus BA, Spinhoven P, Penninx BW, Kenis G, Prickaerts J et al. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol Psychiatry 2011; 11: 1088\u20131095.","journal-title":"Mol Psychiatry"},{"key":"BFmp201483_CR9","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/01.jcp.0000426188.19174.a2","volume":"33","author":"R Yoshimura","year":"2013","unstructured":"Yoshimura R, Hori H, Sugita-Ikenouchi A, Umene-Nakano W, Katsuki A, Nakamura J . Serum brain-derived neurotrophic factor levels at 6 months after remission are not associated with subsequent depressive episodes. J Clin Psychopharmacol 2013; 33: 142\u2013143.","journal-title":"J Clin Psychopharmacol"},{"key":"BFmp201483_CR10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/mpr.256","volume":"17","author":"BW Penninx","year":"2008","unstructured":"Penninx BW, Beekman AT, Smit JH, Zitman FG, Nolen WA, Spinhoven P et al. The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. Int J Methods Psychiatr Res 2008; 17: 121\u2013140.","journal-title":"Int J Methods Psychiatr Res"},{"key":"BFmp201483_CR11","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1017\/S0033291700035558","volume":"26","author":"AJ Rush","year":"1996","unstructured":"Rush AJ, Gullion CM, Basco MR, Jarrett RB, Trivedi MH . The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychol Med 1996; 26: 477\u2013486.","journal-title":"Psychol Med"},{"key":"BFmp201483_CR12","first-page":"143","volume":"4","author":"CG Lyketsos","year":"1994","unstructured":"Lyketsos CG, Nestadt G, Cwi J, Heithoff K, Eaton WW . The Life Chart Interview - a standardized method to describe the course of psychopathology. Int J Method Psych 1994; 4: 143\u2013155.","journal-title":"Int J Method Psych"},{"key":"BFmp201483_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1037\/1040-3590.15.2.137","volume":"15","author":"DW Levine","year":"2003","unstructured":"Levine DW, Kripke DF, Kaplan RM, Lewis MA, Naughton MJ, Bowen DJ et al. Reliability and validity of the Women's Health Initiative Insomnia Rating Scale. Psychol Assess 2003; 15: 137\u2013148.","journal-title":"Psychol Assess"},{"key":"BFmp201483_CR14","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jad.2004.03.001","volume":"82","author":"R de Graaf","year":"2004","unstructured":"de Graaf R, Bijl RV, Ten Have M, Beekman AT, Vollebergh WA . Pathways to comorbidity: the transition of pure mood, anxiety and substance use disorders into comorbid conditions in a longitudinal population-based study. J Affect Disord 2004; 82: 461\u2013467.","journal-title":"J Affect Disord"},{"key":"BFmp201483_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1017\/S003329170002105X","volume":"15","author":"T Brugha","year":"1985","unstructured":"Brugha T, Bebbington P, Tennant C, Hurry J . The List of Threatening Experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med 1985; 15: 189\u2013194.","journal-title":"Psychol Med"},{"key":"BFmp201483_CR16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1600-0447.1990.tb01360.x","volume":"82","author":"TS Brugha","year":"1990","unstructured":"Brugha TS, Cragg D . The List of Threatening Experiences: the reliability and validity of a brief life events questionnaire. Acta Psychiat Scand 1990; 82: 77\u201381.","journal-title":"Acta Psychiat Scand"},{"key":"BFmp201483_CR17","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.psyneuen.2010.07.013","volume":"36","author":"BA Bus","year":"2011","unstructured":"Bus BA, Molendijk ML, Penninx BJ, Buitelaar JK, Kenis G, Prickaerts J et al. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology 2011; 36: 228\u2013239.","journal-title":"Psychoneuroendocrinology"},{"key":"BFmp201483_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3109\/15622975.2010.545187","volume":"13","author":"BA Bus","year":"2012","unstructured":"Bus BA, Tendolkar I, Franke B, de GJ, Heijer MD, Buitelaar JK et al. Serum brain-derived neurotrophic factor: Determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people. World J Biol Psychiatry 2012; 13: 39\u201347.","journal-title":"World J Biol Psychiatry"},{"key":"BFmp201483_CR19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0306-4603(89)90043-9","volume":"14","author":"TF Babor","year":"1989","unstructured":"Babor TF, Kranzler HR, Lauerman RJ . Early detection of harmful alcohol consumption: comparison of clinical, laboratory, and self-report screening procedures. Addict Behav 1989; 14: 139\u2013157.","journal-title":"Addict Behav"},{"key":"BFmp201483_CR20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","volume":"1","author":"KJ Rothman","year":"1990","unstructured":"Rothman KJ . No adjustments are needed for multiple comparisons. Epidemiology 1990; 1: 43\u201346.","journal-title":"Epidemiology"},{"key":"BFmp201483_CR21","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1136\/bmj.310.6973.170","volume":"310","author":"JM Bland","year":"1995","unstructured":"Bland JM, Altman DG . Multiple significance tests: the Bonferroni method. BMJ 1995; 310: 170.","journal-title":"BMJ"},{"key":"BFmp201483_CR22","first-page":"41","volume":"34","author":"MC McKinnon","year":"2009","unstructured":"McKinnon MC, Yucel K, Nazarov A, MacQueen GM . A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 2009; 34: 41\u201354.","journal-title":"J Psychiatry Neurosci"},{"key":"BFmp201483_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0091-3057(96)00169-4","volume":"56","author":"JA Siuciak","year":"1997","unstructured":"Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM . Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 1997; 56: 131\u2013137.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFmp201483_CR24","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1038\/npp.2010.114","volume":"35","author":"HD Schmidt","year":"2010","unstructured":"Schmidt HD, Duman RS . Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 2010; 35: 2378\u20132391.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp201483_CR25","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.neuropharm.2011.07.017","volume":"62","author":"N Dreimuller","year":"2012","unstructured":"Dreimuller N, Schlicht KF, Wagner S, Peetz D, Borysenko L, Hiemke C et al. Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression. Neuropharmacology 2012; 62: 264\u2013269.","journal-title":"Neuropharmacology"},{"key":"BFmp201483_CR26","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.pnpbp.2010.08.011","volume":"35","author":"A Tadic","year":"2011","unstructured":"Tadic A, Wagner S, Schlicht KF, Peetz D, Borysenko L, Dreimuller N et al. The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 415\u2013420.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFmp201483_CR27","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.biopsych.2008.05.005","volume":"64","author":"S Sen","year":"2008","unstructured":"Sen S, Duman R, Sanacora G . Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008; 64: 527\u2013532.","journal-title":"Biol Psychiatry"},{"key":"BFmp201483_CR28","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3109\/15622975.2011.587892","volume":"13","author":"ML Molendijk","year":"2012","unstructured":"Molendijk ML, Bus BA, Spinhoven P, Penninx BW, Prickaerts J, Oude Voshaar RC et al. Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety. World J Biol Psychiatry 2012; 13: 535\u2013543.","journal-title":"World J Biol Psychiatry"},{"key":"BFmp201483_CR29","first-page":"31","volume":"9","author":"R Pies","year":"2012","unstructured":"Pies R . Are antidepressants effective in the acute and long-term treatment of depression? Sic et Non. Innov Clin Neurosci 2012; 9: 31\u201340.","journal-title":"Innov Clin Neurosci"},{"key":"BFmp201483_CR30","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.neurobiolaging.2006.06.011","volume":"28","author":"AA Ziegenhorn","year":"2007","unstructured":"Ziegenhorn AA, Schulte-Herbruggen O, Danker-Hopfe H, Malbranc M, Hartung HD, Anders D et al. Serum neurotrophins\u2014a study on the time course and influencing factors in a large old age sample. Neurobiol Aging 2007; 28: 1436\u20131445.","journal-title":"Neurobiol Aging"},{"key":"BFmp201483_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2004.03.002","volume":"26","author":"M Lommatzsch","year":"2005","unstructured":"Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 2005; 26: 115\u2013123.","journal-title":"Neurobiol Aging"},{"key":"BFmp201483_CR32","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.biopsych.2005.01.008","volume":"57","author":"F Karege","year":"2005","unstructured":"Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry JM, Bertschy G . Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005; 57: 1068\u20131072.","journal-title":"Biol Psychiatry"},{"key":"BFmp201483_CR33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0924-9338(03)00006-3","volume":"18","author":"F Lederbogen","year":"2003","unstructured":"Lederbogen F, Horer E, Hellweg R, Heuser I, Deuschle M . Platelet counts in depressed patients treated with amitriptyline or paroxetine. Eur Psychiatry 2003; 18: 89\u201391.","journal-title":"Eur Psychiatry"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp201483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp201483","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp201483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:06:01Z","timestamp":1648782361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp201483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,26]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["BFmp201483"],"URL":"https:\/\/doi.org\/10.1038\/mp.2014.83","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,26]]},"assertion":[{"value":"6 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare noconflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}