{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:23:56Z","timestamp":1792679036877,"version":"4.5.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1038\/mp.2015.140","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T05:35:25Z","timestamp":1442295325000},"page":"491-499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior"],"prefix":"10.1038","volume":"21","author":[{"given":"A","family":"Belin-Rauscent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-L","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Puaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Jupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sawiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Howett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Caprioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Besson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T W","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"Everitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Dalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-372X","authenticated-orcid":false,"given":"D","family":"Belin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"issue":"Pt 12","key":"BFmp2015140_CR1","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1093\/brain\/awm205","volume":"130","author":"L Menzies","year":"2007","unstructured":"Menzies L, Achard S, Chamberlain S, Fineberg N, Chen C, del Campo N et al. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 2007; 130 (Pt 12): 3223\u20133236.","journal-title":"Brain"},{"key":"BFmp2015140_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tics.2011.11.009","volume":"16","author":"TW Robbins","year":"2012","unstructured":"Robbins TW, Gillan CM, Smith DG, de Wit S, Ersche KD . Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci 2012; 16: 81\u201391.","journal-title":"Trends Cogn Sci"},{"key":"BFmp2015140_CR3","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/j.1530-0277.2010.01217.x","volume":"34","author":"CW Lejuez","year":"2010","unstructured":"Lejuez CW, Magidson JF, Mitchell SH, Sinha R, Stevens MC, de Wit H . Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. Alcohol Clin Exp Res 2010; 34: 1334\u20131345.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFmp2015140_CR4","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","volume":"69","author":"J Dalley","year":"2011","unstructured":"Dalley J, Everitt B, Robbins T . Impulsivity, compulsivity, and top-down cognitive control. Neuron 2011; 69: 680\u2013694.","journal-title":"Neuron"},{"key":"BFmp2015140_CR5","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1176\/appi.ajp.2012.11091421","volume":"169","author":"K Ersche","year":"2012","unstructured":"Ersche K, Turton A, Chamberlain S, Muller U, Bullmore E, Robbins T . Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence. Am J Psychiatry 2012; 169: 926\u2013936.","journal-title":"Am J Psychiatry"},{"key":"BFmp2015140_CR6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00213-011-2485-z","volume":"219","author":"M Fernandez-Serrano","year":"2012","unstructured":"Fernandez-Serrano M, Perales J, Moreno-Lopez L, Perez-Garcia M, Verdejo-Garcia A . Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals. Psychopharmacology (Berl) 2012; 219: 673\u2013683.","journal-title":"Psychopharmacology (Berl)"},{"issue":"Suppl 11","key":"BFmp2015140_CR7","first-page":"4","volume":"68","author":"T Wilens","year":"2007","unstructured":"Wilens T . The nature of the relationship between attention-deficit\/hyperactivity disorder and substance use. J Clin Psychiatry 2007; 68 (Suppl 11): 4\u20138.","journal-title":"J Clin Psychiatry"},{"key":"BFmp2015140_CR8","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1001\/archpediatrics.2010.180","volume":"164","author":"D Brook","year":"2010","unstructured":"Brook D, Brook J, Zhang C, Koppel J . Association between attention-deficit\/hyperactivity disorder in adolescence and substance use disorders in adulthood. Arch Pediatr Adolesc Med 2010; 164: 930\u2013934.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"BFmp2015140_CR9","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/0278-5846(90)90041-E","volume":"14","author":"JJ Lopez-Ibor","year":"1990","unstructured":"Lopez-Ibor JJ . Impulse control in obsessive-compulsive disorder: a biopsychopathological approach. Prog Neuropsychopharmacol Biol Psychiatry 1990; 14: 709\u2013718.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFmp2015140_CR10","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s00213-002-1154-7","volume":"163","author":"TW Robbins","year":"2002","unstructured":"Robbins TW . The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology 2002; 163: 362\u2013380.","journal-title":"Psychopharmacology"},{"key":"BFmp2015140_CR11","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.biopsych.2013.09.031","volume":"75","author":"S Ansquer","year":"2014","unstructured":"Ansquer S, Belin-Rauscent A, Dugast E, Duran T, Benatru I, Mar AC et al. Atomoxetine decreases vulnerability to develop compulsivity in high impulsive rats. Biol Psychiatry 2014; 75: 825\u2013832.","journal-title":"Biol Psychiatry"},{"key":"BFmp2015140_CR12","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1126\/science.1158136","volume":"320","author":"D Belin","year":"2008","unstructured":"Belin D, Mar AC, Dalley JW, Robbins TW, Everitt BJ . High impulsivity predicts the switch to compulsive cocaine-taking. Science 2008; 320: 1352\u20131355.","journal-title":"Science"},{"key":"BFmp2015140_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1901\/jeab.1966.9-19","volume":"9","author":"JL Falk","year":"1966","unstructured":"Falk JL . The motivational properties of schedule-induced polydipsia. J Exp Anal Behav 1966; 9: 19\u201325.","journal-title":"J Exp Anal Behav"},{"key":"BFmp2015140_CR14","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s00213-011-2570-3","volume":"219","author":"M Moreno","year":"2012","unstructured":"Moreno M, Flores P . Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases. Psychopharmacology (Berl) 2012; 219: 647\u2013659.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFmp2015140_CR15","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. The Diagnostic and Statistical Manual of Mental Disorders: DSM 5. Book point US: Washington, DC, 2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"BFmp2015140_CR16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0031-9384(88)90187-4","volume":"43","author":"R Dantzer","year":"1988","unstructured":"Dantzer R, Terlouw C, Mormede P, Le Moal M . Schedule-induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels. Physiol Behav 1988; 43: 275\u2013279.","journal-title":"Physiol Behav"},{"key":"BFmp2015140_CR17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nn1176","volume":"7","author":"HD Critchley","year":"2004","unstructured":"Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ . Neural systems supporting interoceptive awareness. Nat Neurosci 2004; 7: 189\u2013195.","journal-title":"Nat Neurosci"},{"key":"BFmp2015140_CR18","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1017\/S0033291799002652","volume":"30","author":"ML Phillips","year":"2000","unstructured":"Phillips ML, Marks IM, Senior C, Lythgoe D, O'Dwyer AM, Meehan O et al. A differential neural response in obsessive-compulsive disorder patients with washing compared with checking symptoms to disgust. Psychol Med 2000; 30: 1037\u20131050.","journal-title":"Psychol Med"},{"key":"BFmp2015140_CR19","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/npp.2009.185","volume":"35","author":"N Fineberg","year":"2009","unstructured":"Fineberg N, Potenza M, Chamberlain S, Berlin H, Menzies L, Bechara A et al. Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review. Neuropsychopharmacology 2009; 35: 591\u2013604.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp2015140_CR20","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/scan\/nsu077","volume":"10","author":"F Dambacher","year":"2014","unstructured":"Dambacher F, Sack AT, Lobbestael J, Arntz A, Brugman S, Schuhmann T . Out of control evidence for anterior insula involvement in motor impulsivity and reactive aggression. Soc Cogn Affect Neurosci 2014; 10: 508\u2013516.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"BFmp2015140_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/eat.22045","volume":"46","author":"IA Strigo","year":"2013","unstructured":"Strigo IA, Matthews SC, Simmons AN, Oberndorfer T, Klabunde M, Reinhardt LE et al. Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: evidence of interoceptive dysregulation. Int J Eat Disord 2013; 46: 23\u201333.","journal-title":"Int J Eat Disord"},{"key":"BFmp2015140_CR22","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1176\/appi.ajp.2014.13111553","volume":"171","author":"MJ Hoptman","year":"2014","unstructured":"Hoptman MJ, Antonius D, Mauro CJ, Parker EM, Javitt DC . Cortical thinning, functional connectivity, and mood-related impulsivity in schizophrenia: relationship to aggressive attitudes and behavior. Am J Psychiatry 2014; 171: 939\u2013948.","journal-title":"Am J Psychiatry"},{"key":"BFmp2015140_CR23","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1111\/acer.12461","volume":"38","author":"T Chung","year":"2014","unstructured":"Chung T, Clark DB . Insula white matter volume linked to binge drinking frequency through enhancement motives in treated adolescents. Alcohol Clin Exp Res 2014; 38: 1932\u20131940.","journal-title":"Alcohol Clin Exp Res"},{"issue":"Suppl 1","key":"BFmp2015140_CR24","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuropharm.2008.07.035","volume":"56","author":"A Verdejo-Garcia","year":"2009","unstructured":"Verdejo-Garcia A, Bechara A . A somatic marker theory of addiction. Neuropharmacology 2009; 56 (Suppl 1): 48\u201362.","journal-title":"Neuropharmacology"},{"key":"BFmp2015140_CR25","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.biopsych.2006.03.042","volume":"60","author":"MP Paulus","year":"2006","unstructured":"Paulus MP, Stein MB . An insular view of anxiety. Biol Psychiatry 2006; 60: 383\u2013387.","journal-title":"Biol Psychiatry"},{"key":"BFmp2015140_CR26","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1126\/science.1214463","volume":"335","author":"K Ersche","year":"2012","unstructured":"Ersche K, Jones P, Williams G, Turton A, Robbins T, Bullmore E . Abnormal brain structure implicated in stimulant drug addiction. Science 2012; 335: 601\u2013604.","journal-title":"Science"},{"key":"BFmp2015140_CR27","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/brain\/awn267","volume":"132","author":"OA van den Heuvel","year":"2009","unstructured":"van den Heuvel OA, Remijnse PL, Mataix-Cols D, Vrenken H, Groenewegen HJ, Uylings HBM et al. The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. Brain 2009; 132: 853\u2013868.","journal-title":"Brain"},{"key":"BFmp2015140_CR28","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.drugalcdep.2012.02.012","volume":"125","author":"L Moreno-Lopez","year":"2012","unstructured":"Moreno-Lopez L, Catena A, Fernandez-Serrano M, Delgado-Rico E, Stamatakis E, Perez-Garcia M et al. Trait impulsivity and prefrontal gray matter reductions in cocaine dependent individuals. Drug Alcohol Depend 2012; 125: 208\u2013214.","journal-title":"Drug Alcohol Depend"},{"key":"BFmp2015140_CR29","doi-asserted-by":"publisher","first-page":"e22361","DOI":"10.1371\/journal.pone.0022361","volume":"6","author":"A Song","year":"2011","unstructured":"Song A, Jung WH, Jang JH, Kim E, Shim G, Park HY et al. Disproportionate alterations in the anterior and posterior insular cortices in obsessive-compulsive disorder. PLoS One 2011; 6: e22361.","journal-title":"PLoS One"},{"key":"BFmp2015140_CR30","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.neuroimage.2009.08.015","volume":"49","author":"S Velikova","year":"2010","unstructured":"Velikova S, Locatelli M, Insacco C, Smeraldi E, Comi G, Leocani L . Dysfunctional brain circuitry in obsessive-compulsive disorder: source and coherence analysis of EEG rhythms. Neuroimage 2010; 49: 977\u2013983.","journal-title":"Neuroimage"},{"key":"BFmp2015140_CR31","doi-asserted-by":"publisher","first-page":"e59600","DOI":"10.1371\/journal.pone.0059600","volume":"8","author":"P Remijnse","year":"2013","unstructured":"Remijnse P, van den Heuvel O, Nielen M, Vriend C, Hendriks G, Hoogendijk W et al. Cognitive inflexibility in obsessive-compulsive disorder and major depression is associated with distinct neural correlates. PLoS One 2013; 8: e59600.","journal-title":"PLoS One"},{"key":"BFmp2015140_CR32","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.dcn.2013.07.001","volume":"6","author":"JC Churchwell","year":"2013","unstructured":"Churchwell JC, Yurgelun-Todd DA . Age-related changes in insula cortical thickness and impulsivity: significance for emotional development and decision-making. Dev Cogn Neurosci 2013; 6: 80\u201386.","journal-title":"Dev Cogn Neurosci"},{"issue":"Pt 7","key":"BFmp2015140_CR33","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1093\/brain\/awr138","volume":"134","author":"K Ersche","year":"2011","unstructured":"Ersche K, Barnes A, Simon Jones P, Morein-Zamir S, Robbins T, Bullmore E . Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence. Brain 2011; 134 (Pt 7): 2013\u20132024.","journal-title":"Brain"},{"key":"BFmp2015140_CR34","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1177\/0269881113492028","volume":"27","author":"C Li","year":"2013","unstructured":"Li C, Zhu N, Meng X, Li Y, Sui N . Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats. J Psychopharmacol 2013; 27: 837\u2013844.","journal-title":"J Psychopharmacol"},{"key":"BFmp2015140_CR35","doi-asserted-by":"publisher","first-page":"4109","DOI":"10.1007\/s00213-014-3550-1","volume":"231","author":"W Wu","year":"2014","unstructured":"Wu W, Li H, Liu Y, Huang X, Chen L, Zhai H . Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats. Psychopharmacology (Berl) 2014; 231: 4109\u20134118.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFmp2015140_CR36","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bbr.2014.05.010","volume":"270","author":"T Pattij","year":"2014","unstructured":"Pattij T, Schetters D, Schoffelmeer A . Dopaminergic modulation of impulsive decision making in the rat insular cortex. Behav Brain Res 2014; 270: 118\u2013124.","journal-title":"Behav Brain Res"},{"key":"BFmp2015140_CR37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.tins.2008.09.009","volume":"32","author":"N Naqvi","year":"2009","unstructured":"Naqvi N, Bechara A . The hidden island of addiction: the insula. Trends Neurosci 2009; 32: 56\u201367.","journal-title":"Trends Neurosci"},{"key":"BFmp2015140_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.biopsych.2013.09.011","volume":"76","author":"JE Murray","year":"2014","unstructured":"Murray JE, Dilleen R, Pelloux Y, Economidou D, Dalley JW, Belin D et al. Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking. Biol Psychiatry 2014; 76: 15\u201322.","journal-title":"Biol Psychiatry"},{"key":"BFmp2015140_CR39","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1038\/npp.2013.95","volume":"38","author":"M Besson","year":"2013","unstructured":"Besson M, Pelloux Y, Dilleen R, Theobald DE, Lyon A, Belin-Rauscent A et al. Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats. Neuropsychopharmacology 2013; 38: 1963\u20131973.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp2015140_CR40","first-page":"Unit 9.27","volume":"Chapter 9","author":"B Platt","year":"2008","unstructured":"Platt B, Beyer C, Schechter L, Rosenzweig-Lipson S . Schedule-induced polydipsia: a rat model of obsessive-compulsive disorder. Curr Protoc Neurosci 2008; Chapter 9: Unit 9.27.","journal-title":"Curr Protoc Neurosci"},{"key":"BFmp2015140_CR41","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00213-011-2626-4","volume":"222","author":"R Dilleen","year":"2012","unstructured":"Dilleen R, Pelloux Y, Mar A, Molander A, Robbins T, Everitt B et al. High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats. Psychopharmacology (Berl) 2012; 222: 89\u201389.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFmp2015140_CR42","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/npp.2014.204","volume":"40","author":"N Vanhille","year":"2015","unstructured":"Vanhille N, Belin-Rauscent A, Mar AC, Ducret E, Belin D . High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction. Neuropsychopharmacology 2015; 40: 577\u2013589.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp2015140_CR43","doi-asserted-by":"publisher","first-page":"e53361","DOI":"10.1371\/journal.pone.0053361","volume":"7","author":"SJ Sawiak","year":"2012","unstructured":"Sawiak SJ, Wood NI, Carpenter TA, Morton AJ . Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy. PLoS One 2012; 7: e53361.","journal-title":"PLoS One"},{"key":"BFmp2015140_CR44","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.mri.2013.06.001","volume":"31","author":"SJ Sawiak","year":"2013","unstructured":"Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA . Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease. Magnetic Resonance Imaging 2013; 31: 1522\u20131531.","journal-title":"Magnetic Resonance Imaging"},{"key":"BFmp2015140_CR45","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"2005","unstructured":"Paxinos G, Watson C . The Rat Brain in Stereotaxic Coordinates5 edn.Elsevier Academic Press: Amsterdam, 2005."},{"key":"BFmp2015140_CR46","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00213-007-0790-3","volume":"193","author":"D Belin","year":"2007","unstructured":"Belin D, Deroche-Gamonet V, Jaber M . Cocaine-induced sensitization is associated with altered dynamics of transcriptional responses of the dopamine transporter, tyrosine hydroxylase, and dopamine D2 receptors in C57Bl\/6J mice. Psychopharmacology (Berl) 2007; 193: 567\u2013578.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFmp2015140_CR47","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1126\/science.1137073","volume":"315","author":"JW Dalley","year":"2007","unstructured":"Dalley JW, Fryer T, Brichard L, Robinson E, Theobald D, Laane K et al. Nucleus accumbens D2\/3 receptors predict trait impulsivity and cocaine reinforcement. Science 2007; 315: 1267\u20131270.","journal-title":"Science"},{"key":"BFmp2015140_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.903110102","volume":"311","author":"GV Allen","year":"1991","unstructured":"Allen GV, Saper CB, Hurley KM, Cechetto DF . Organization of visceral and limbic connections in the insular cortex of the rat. J Comp Neurol 1991; 311: 1\u201316.","journal-title":"J Comp Neurol"},{"key":"BFmp2015140_CR49","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.neuroimage.2012.05.012","volume":"62","author":"J Zaki","year":"2012","unstructured":"Zaki J, Davis J, Ochsner K . Overlapping activity in anterior insula during interoception and emotional experience. Neuroimage 2012; 62: 493\u2013499.","journal-title":"Neuroimage"},{"key":"BFmp2015140_CR50","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1126\/science.1060818","volume":"292","author":"R Cardinal","year":"2001","unstructured":"Cardinal R, Pennicott DR, Lakmali C, Robbins TW . Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 2001; 292: 2499\u20132501.","journal-title":"Science"},{"key":"BFmp2015140_CR51","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/npp.2009.162","volume":"35","author":"M Besson","year":"2009","unstructured":"Besson M, Belin D, McNamara R, Theobald DE, Castel A, Beckett V et al. Dissociable control of impulsivity in rats by dopamine D2\/3 receptors in the core and shell subregions of the nucleus accumbens. Neuropsychopharmacology 2009; 35: 560\u2013569.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp2015140_CR52","doi-asserted-by":"publisher","first-page":"11757","DOI":"10.1523\/JNEUROSCI.3432-05.2005","volume":"25","author":"SM Reynolds","year":"2005","unstructured":"Reynolds SM, Zahm DS . Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala. J Neurosci 2005; 25: 11757\u201311767.","journal-title":"J Neurosci"},{"key":"BFmp2015140_CR53","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0166-4328(95)00202-2","volume":"75","author":"R Weissenborn","year":"1996","unstructured":"Weissenborn R, Blaha CD, Winn P, Phillips AG . Schedule-induced polydipsia and the nucleus accumbens: electrochemical measurements of dopamine efflux and effects of excitotoxic lesions in the core. Behav Brain Res 1996; 75: 147\u2013158.","journal-title":"Behav Brain Res"},{"key":"BFmp2015140_CR54","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/285409a0","volume":"285","author":"TW Robbins","year":"1980","unstructured":"Robbins TW, Koob GF . Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system. Nature 1980; 285: 409\u2013412.","journal-title":"Nature"},{"key":"BFmp2015140_CR55","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1046\/j.1460-9568.2003.02617.x","volume":"17","author":"K Thomas","year":"2003","unstructured":"Thomas K, Arroyo M, Everitt B . Induction of the learning and plasticity-associated gene Zif268 following exposure to a discrete cocaine-associated stimulus. Eur J Neurosci 2003; 17: 1964\u20131972.","journal-title":"Eur J Neurosci"},{"key":"BFmp2015140_CR56","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1523\/JNEUROSCI.4601-05.2006","volume":"26","author":"E Valjent","year":"2006","unstructured":"Valjent E, Aubier B, Corbille AG, Brami-Cherrier K, Caboche J, Topilko P et al. Plasticity-associated gene Krox24\/Zif268 is required for long-lasting behavioral effects of cocaine. J Neurosci 2006; 26: 4956\u20134960.","journal-title":"J Neurosci"},{"key":"BFmp2015140_CR57","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/(SICI)1096-9861(19981005)399:4<440::AID-CNE2>3.0.CO;2-1","volume":"399","author":"CJ Shi","year":"1998","unstructured":"Shi CJ, Cassell MD . Cortical, thalamic, and amygdaloid connections of the anterior and posterior insular cortices. J Comp Neurol 1998; 399: 440\u2013468.","journal-title":"J Comp Neurol"},{"key":"BFmp2015140_CR58","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbr.2003.09.020","volume":"146","author":"Y Chudasama","year":"2003","unstructured":"Chudasama Y, Passetti F, Rhodes SE, Lopian D, Desai A, Robbins TW . Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav Brain Res 2003; 146: 105\u2013119.","journal-title":"Behav Brain Res"},{"key":"BFmp2015140_CR59","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1111\/j.1476-5381.2011.01422.x","volume":"164","author":"N Fineberg","year":"2011","unstructured":"Fineberg N, Chamberlain S, Hollander E, Boulougouris V, Robbins T . Translational approaches to obsessive-compulsive disorder: from animal models to clinical treatment. Br J Pharmacol 2011; 164: 1044\u20131061.","journal-title":"Br J Pharmacol"},{"key":"BFmp2015140_CR60","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0031-9384(81)90003-2","volume":"26","author":"LP Brett","year":"1981","unstructured":"Brett LP, Levine S . The pituitary-adrenal response to \"minimized\" schedule-induced drinking. Physiol Behav 1981; 26: 153\u2013158.","journal-title":"Physiol Behav"},{"key":"BFmp2015140_CR61","doi-asserted-by":"publisher","first-page":"14652","DOI":"10.1523\/JNEUROSCI.3048-14.2014","volume":"34","author":"W Cai","year":"2014","unstructured":"Cai W, Ryali S, Chen T, Li CS, Menon V . Dissociable roles of right inferior frontal cortex and anterior insula in inhibitory control: evidence from intrinsic and task-related functional parcellation, connectivity, and response profile analyses across multiple datasets. J Neurosci 2014; 34: 14652\u201314667.","journal-title":"J Neurosci"},{"key":"BFmp2015140_CR62","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0165-0173(96)00011-2","volume":"22","author":"JR Augustine","year":"1996","unstructured":"Augustine JR . Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Brain Res Rev 1996; 22: 229\u2013244.","journal-title":"Brain Res Brain Res Rev"},{"key":"BFmp2015140_CR63","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neulet.2007.12.024","volume":"432","author":"EA Schilman","year":"2008","unstructured":"Schilman EA, Uylings HB, Galis-de Graaf Y, Joel D, Groenewegen HJ . The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex. Neurosci Lett 2008; 432: 40\u201345.","journal-title":"Neurosci Lett"},{"key":"BFmp2015140_CR64","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.neuroimage.2012.10.013","volume":"66","author":"YT Cho","year":"2013","unstructured":"Cho YT, Fromm S, Guyer AE, Detloff A, Pine DS, Fudge JL et al. Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents. Neuroimage 2013; 66: 508\u2013521.","journal-title":"Neuroimage"},{"key":"BFmp2015140_CR65","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0301-0082(80)90018-0","volume":"14","author":"GJ Mogenson","year":"1980","unstructured":"Mogenson GJ, Jones DL, Yim CY . From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 1980; 14: 69\u201397.","journal-title":"Prog Neurobiol"},{"key":"BFmp2015140_CR66","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1080\/17470910902934400","volume":"4","author":"J Weller","year":"2009","unstructured":"Weller J, Levin I, Shiv B, Bechara A . The effects of insula damage on decision-making for risky gains and losses. Soc Neurosci 2009; 4: 347\u2013358.","journal-title":"Soc Neurosci"},{"key":"BFmp2015140_CR67","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1475-2891-13-92","volume":"13","author":"Q He","year":"2014","unstructured":"He Q, Xiao L, Xue G, Wong S, Ames S, Schembre S et al. Poor ability to resist tempting calorie rich food is linked to altered balance between neural systems involved in urge and self-control. Nutr J 2014; 13: 92.","journal-title":"Nutr J"},{"key":"BFmp2015140_CR68","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1126\/science.1060818","volume":"292","author":"RN Cardinal","year":"2001","unstructured":"Cardinal RN, Pennicott DR, Sugathapala CL, Robbins TW, Everitt BJ . Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 2001; 292: 2499\u20132501.","journal-title":"Science"},{"key":"BFmp2015140_CR69","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1098\/rstb.2009.0008","volume":"364","author":"A Craig","year":"2009","unstructured":"Craig A . Emotional moments across time: a possible neural basis for time perception in the anterior insula. Philos Trans R Soc Lond B Biol Sci 2009; 364: 1933\u20131942.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"BFmp2015140_CR70","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.bbr.2010.09.004","volume":"216","author":"C Xie","year":"2011","unstructured":"Xie C, Li S, Shao Y, Fu L, Goveas J, Ye E et al. Identification of hyperactive intrinsic amygdala network connectivity associated with impulsivity in abstinent heroin addicts. Behav Brain Res 2011; 216: 639\u2013646.","journal-title":"Behav Brain Res"},{"key":"BFmp2015140_CR71","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.geb.2004.06.010","volume":"52","author":"A Bechara","year":"2005","unstructured":"Bechara A, Damasio AR . The somatic marker hypothesis: a neural theory of economic decision. Game Econ Behav 2005; 52: 336\u2013372.","journal-title":"Game Econ Behav"},{"key":"BFmp2015140_CR72","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/01.wco.0000194141.56429.3c","volume":"18","author":"A Bechara","year":"2005","unstructured":"Bechara A, Van der Linden M . Decision-making and impulse control after frontal lobe injuries. Curr Opin Neurol 2005; 18: 734\u2013739.","journal-title":"Curr Opin Neurol"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp2015140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2015140","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2015140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:10:34Z","timestamp":1718064634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp2015140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,15]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["BFmp2015140"],"URL":"https:\/\/doi.org\/10.1038\/mp.2015.140","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,15]]},"assertion":[{"value":"6 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}