{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:45:06Z","timestamp":1783532706307,"version":"3.55.0"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/mp.2016.251","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T09:02:53Z","timestamp":1484643773000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer\u2019s disease"],"prefix":"10.1038","volume":"22","author":[{"given":"T M","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-1958","authenticated-orcid":false,"given":"P","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"BFmp2016251_CR1","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM . Clinical diagnosis of Alzheimer's disease Report of the NINCDS\u2010ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939\u2013944.","journal-title":"Neurology"},{"key":"BFmp2016251_CR2","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","volume":"45","author":"JL Price","year":"1999","unstructured":"Price JL, Morris JC . Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer's disease. Ann Neurol 1999; 45: 358\u2013368.","journal-title":"Ann Neurol"},{"key":"BFmp2016251_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1001\/jamaneurol.2015.3098","volume":"73","author":"RC Petersen","year":"2016","unstructured":"Petersen RC, Wiste HJ, Weigand SD, Rocca WA, Roberts RO, Mielke MM et al. Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community. JAMA Neurol 2016; 73: 85\u201392.","journal-title":"JAMA Neurol"},{"key":"BFmp2016251_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","volume":"12","author":"VL Villemagne","year":"2013","unstructured":"Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O et al. Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. Lancet Neurol 2013; 12: 357\u2013367.","journal-title":"Lancet Neurol"},{"key":"BFmp2016251_CR5","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/ana.24040","volume":"74","author":"CC Rowe","year":"2013","unstructured":"Rowe CC, Bourgeat P, Ellis KA, Brown B, Lim YY, Mulligan R et al. Predicting Alzheimer disease with \u03b2\u2010amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing. Ann Neurol 2013; 74: 905\u2013913.","journal-title":"Ann Neurol"},{"key":"BFmp2016251_CR6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S1350-9462(00)00024-0","volume":"20","author":"E Sernagor","year":"2001","unstructured":"Sernagor E, Eglen SJ, Wong RO . Development of retinal ganglion cell structure and function. Prog Retin Eye Res 2001; 20: 139\u2013174.","journal-title":"Prog Retin Eye Res"},{"key":"BFmp2016251_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1161\/01.STR.0000195134.04355.e5","volume":"37","author":"LS Cooper","year":"2006","unstructured":"Cooper LS, Wong TY, Klein R, Sharrett AR, Bryan RN, Hubbard LD et al. Retinal microvascular abnormalities and MRI-defined subclinical cerebral infarction the atherosclerosis risk in communities study. Stroke 2006; 37: 82\u201386.","journal-title":"Stroke"},{"key":"BFmp2016251_CR8","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","volume":"9","author":"A London","year":"2012","unstructured":"London A, Benhar I, Schwartz M . The retina as a window to the brain\u2014from eye research to CNS disorders. Nat Rev Neurol 2012; 9: 44\u201353.","journal-title":"Nat Rev Neurol"},{"key":"BFmp2016251_CR9","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.preteyeres.2008.09.003","volume":"27","author":"C Kaur","year":"2008","unstructured":"Kaur C, Foulds W, Ling E . Blood\u2013retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog Retin Eye Res 2008; 27: 622\u2013647.","journal-title":"Prog Retin Eye Res"},{"key":"BFmp2016251_CR10","doi-asserted-by":"publisher","first-page":"S204","DOI":"10.1016\/j.neuroimage.2010.06.020","volume":"54","author":"M Koronyo-Hamaoui","year":"2011","unstructured":"Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL et al. Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage 2011; 54: S204\u2013S217.","journal-title":"Neuroimage"},{"key":"BFmp2016251_CR11","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/S0140-6736(03)12981-9","volume":"361","author":"LE Goldstein","year":"2003","unstructured":"Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X et al. Cytosolic \u03b2-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet 2003; 361: 1258\u20131265.","journal-title":"Lancet"},{"key":"BFmp2016251_CR12","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1177\/1533317513520214","volume":"30","author":"C Kerbage","year":"2015","unstructured":"Kerbage C, Sadowsky CH, Tariot PN, Agronin M, Alva G, Turner FD et al. Detection of amyloid beta signature in the lens and its correlation in the brain to aid in the diagnosis of Alzheimer's disease. Am J Alzheimers Dis Other Demen 2015; 30: 738\u2013745.","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"BFmp2016251_CR13","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/ana.24548","volume":"79","author":"C La Morgia","year":"2016","unstructured":"La Morgia C, Ross-Cisneros FN, Koronyo Y, Hannibal J, Gallassi R, Cantalupo G et al. Melanopsin retinal ganglion cell loss in Alzheimer disease. Ann Neurol 2016; 79: 90\u2013109.","journal-title":"Ann Neurol"},{"key":"BFmp2016251_CR14","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1076\/0271-3683(200006)2061-YFT462","volume":"20","author":"PH Frederikse","year":"2000","unstructured":"Frederikse PH . Amyloid-like protein structure in mammalian ocular lenses. Curr Eye Res 2000; 20: 462\u2013468.","journal-title":"Curr Eye Res"},{"key":"BFmp2016251_CR15","doi-asserted-by":"publisher","first-page":"10169","DOI":"10.1074\/jbc.271.17.10169","volume":"271","author":"PH Frederikse","year":"1996","unstructured":"Frederikse PH, Garland D, Zigler JS Jr., Piatigorsky J . Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells. J Biol Chem 1996; 271: 10169\u201310174.","journal-title":"J Biol Chem"},{"key":"BFmp2016251_CR16","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1076\/ceyr.17.9.947.5135","volume":"17","author":"PH Frederikse","year":"1998","unstructured":"Frederikse PH, Zigler JS Jr . Presenilin expression in the ocular lens. Curr Eye Res 1998; 17: 947\u2013952.","journal-title":"Curr Eye Res"},{"key":"BFmp2016251_CR17","first-page":"179","volume":"9","author":"G Li","year":"2003","unstructured":"Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH . Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens. Mol Vis 2003; 9: 179\u2013183.","journal-title":"Mol Vis"},{"key":"BFmp2016251_CR18","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/j.1471-4159.1993.tb02147.x","volume":"61","author":"PJ Morin","year":"1993","unstructured":"Morin PJ, Abraham CR, Amaratunga A, Johnson RJ, Huber G, Sandell JH et al. Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized. J Neurochem 1993; 61: 464\u2013473.","journal-title":"J Neurochem"},{"key":"BFmp2016251_CR19","doi-asserted-by":"publisher","first-page":"e29892","DOI":"10.1371\/journal.pone.0029892","volume":"7","author":"T Ho","year":"2012","unstructured":"Ho T, Vessey KA, Cappai R, Dinet V, Mascarelli F, Ciccotosto GD et al. Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina. PLoS One 2012; 7: e29892.","journal-title":"PLoS One"},{"key":"BFmp2016251_CR20","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.3233\/JAD-2010-100210","volume":"20","author":"A Prakasam","year":"2010","unstructured":"Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao KJ et al. Differential accumulation of secreted A\u03b2PP metabolites in ocular fluids. J Alzheimers Dis 2010; 20: 1243\u20131253.","journal-title":"J Alzheimers Dis"},{"key":"BFmp2016251_CR21","doi-asserted-by":"publisher","first-page":"e13127","DOI":"10.1371\/journal.pone.0013127","volume":"5","author":"JH Kam","year":"2010","unstructured":"Kam JH, Lenassi E, Jeffery G . Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages. PLoS One 2010; 5: e13127.","journal-title":"PLoS One"},{"key":"BFmp2016251_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.exer.2015.03.023","volume":"135","author":"JH Kam","year":"2015","unstructured":"Kam JH, Lynch A, Begum R, Cunea A, Jeffery G . Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice. Exp Eye Res 2015; 135: 59\u201366.","journal-title":"Exp Eye Res"},{"key":"BFmp2016251_CR23","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1016\/j.neurobiolaging.2011.12.002","volume":"33","author":"V Lee","year":"2012","unstructured":"Lee V, Rekhi E, Hoh Kam J, Jeffery G . Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function. Neurobiol Aging 2012; 33: 2382\u20132389.","journal-title":"Neurobiol Aging"},{"key":"BFmp2016251_CR24","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/nature04533","volume":"440","author":"S Lesn\u00e9","year":"2006","unstructured":"Lesn\u00e9 S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A et al. A specific amyloid-\u03b2 protein assembly in the brain impairs memory. Nature 2006; 440: 352\u2013357.","journal-title":"Nature"},{"key":"BFmp2016251_CR25","doi-asserted-by":"publisher","first-page":"5085","DOI":"10.1167\/iovs.06-1249","volume":"48","author":"D Goldblum","year":"2007","unstructured":"Goldblum D, Kipfer-Kauer A, Sarra G-M, Wolf S, Frueh BE . Distribution of amyloid precursor protein and amyloid-\u03b2 immunoreactivity in DBA\/2J glaucomatous mouse retinas. Invest Ophthalmol Vis Sci 2007; 48: 5085\u20135090.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.bbrc.2012.05.085","volume":"423","author":"J Wang","year":"2012","unstructured":"Wang J, Ohno-Matsui K, Morita I . Elevated amyloid beta production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid beta in age-related macular degeneration. Biochem Biophys Res Commun 2012; 423: 73\u201378.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFmp2016251_CR27","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1002\/ar.21438","volume":"294","author":"J Wang","year":"2011","unstructured":"Wang J, Zhu C, Xu Y, Liu B, Wang M, Wu K . Development and expression of amyloid\u2010\u03b2 peptide 42 in retinal ganglion cells in rats. Anat Rec 2011; 294: 1401\u20131405.","journal-title":"Anat Rec"},{"key":"BFmp2016251_CR28","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.bbrc.2012.07.014","volume":"424","author":"J Wang","year":"2012","unstructured":"Wang J, Ohno-Matsui K, Morita I . Cholesterol enhances amyloid beta deposition in mouse retina by modulating the activities of Abeta-regulating enzymes in retinal pigment epithelial cells. Biochem Biophys Res Commun 2012; 424: 704\u2013709.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFmp2016251_CR29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.exer.2014.10.012","volume":"129","author":"LY Guo","year":"2014","unstructured":"Guo LY, Alekseev O, Li Y, Song Y, Dunaief JL . Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res 2014; 129: 31\u201337.","journal-title":"Exp Eye Res"},{"key":"BFmp2016251_CR30","doi-asserted-by":"publisher","first-page":"6760","DOI":"10.1038\/ncomms7760","volume":"6","author":"S Ayton","year":"2015","unstructured":"Ayton S, Faux NG, Bush AI, ADNI. Ferritin levels in the cerebrospinal fluid predict Alzheimer\u2019s disease outcomes and are regulated by APOE. Nat Commun 2015; 6: 6760.","journal-title":"Nat Commun"},{"key":"BFmp2016251_CR31","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/sj.mp.4001854","volume":"11","author":"IJ Martins","year":"2006","unstructured":"Martins IJ, Hone E, Foster JK, Sunram-Lea SI, Gnjec A, Fuller SJ et al. Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Mol Psychiatry 2006; 11: 721\u2013736.","journal-title":"Mol Psychiatry"},{"key":"BFmp2016251_CR32","first-page":"24","volume":"36","author":"K L\u00f6ffler","year":"1995","unstructured":"L\u00f6ffler K, Edward DP, Tso M . Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest Ophthalmol Vis Sci 1995; 36: 24\u201331.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR33","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1167\/iovs.07-1072","volume":"49","author":"A Seth","year":"2008","unstructured":"Seth A, Cui J, To E, Kwee M, Matsubara J . Complement-associated deposits in the human retina. Invest Ophthalmol Vis Sci 2008; 49: 743\u2013750.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/NEN.0b013e31820376cc","volume":"70","author":"F Leger","year":"2011","unstructured":"Leger F, Fernagut P-O, Canron M-H, L\u00e9oni S, Vital C, Tison F et al. Protein aggregation in the aging retina. J Neuropathol Exp Neurol 2011; 70: 63\u201368.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFmp2016251_CR35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.exer.2015.06.027","volume":"138","author":"R Parthasarathy","year":"2015","unstructured":"Parthasarathy R, Chow KM, Derafshi Z, Fautsch MP, Hetling JR, Rodgers DW et al. Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin. Exp Eye Res 2015; 138: 134\u2013144.","journal-title":"Exp Eye Res"},{"key":"BFmp2016251_CR36","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/00001756-199702100-00027","volume":"8","author":"ST Chen","year":"1997","unstructured":"Chen ST, Patel AJ, Garey LJ, Jen LS . Expression of beta-amyloid precursor protein immunoreactivity in the retina of the rat during normal development and after neonatal optic tract lesion. Neuroreport 1997; 8: 713\u2013717.","journal-title":"Neuroreport"},{"key":"BFmp2016251_CR37","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00401-010-0762-2","volume":"121","author":"V Dinet","year":"2011","unstructured":"Dinet V, An N, Ciccotosto GD, Bruban J, Maoui A, Bellingham SA et al. APP involvement in retinogenesis of mice. Acta Neuropathol 2011; 121: 351\u2013363.","journal-title":"Acta Neuropathol"},{"key":"BFmp2016251_CR38","doi-asserted-by":"publisher","first-page":"163","DOI":"10.14336\/AD.2015.0907","volume":"7","author":"S Plummer","year":"2016","unstructured":"Plummer S, Van den Heuvel C, Thornton E, Corrigan F, Cappai R . The neuroprotective properties of the amyloid precursor protein following traumatic brain injury. Aging Dis 2016; 7: 163\u2013179.","journal-title":"Aging Dis"},{"key":"BFmp2016251_CR39","doi-asserted-by":"crossref","unstructured":"C\u00e1rdenas-Aguayo MdC, Silva-Lucero MdC, Cortes-Ortiz M, Jim\u00e9nez-Ramos B, G\u00f3mez-Virgilio L, Ram\u00edrez-Rodr\u00edguez G et al. Physiological role of amyloid beta in neural cells: the cellular trophic activity. InTech: Rijeka, Croatia, 2014.","DOI":"10.5772\/57398"},{"key":"BFmp2016251_CR40","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1167\/iovs.12-10821","volume":"54","author":"K Cunvong","year":"2013","unstructured":"Cunvong K, Huffmire D, Ethell DW, Cameron DJ . Amyloid-beta increases capillary bed density in the adult zebrafish retina. Invest Ophthalmol Vis Sci 2013; 54: 1516\u20131521.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR41","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/j.1474-9726.2009.00456.x","volume":"8","author":"J Bruban","year":"2009","unstructured":"Bruban J, Glotin A-L, Dinet V, Chalour N, Sennlaub F, Jonet L et al. Amyloid-\u03b2(1-42) alters structure and function of retinal pigmented epithelial cells. Aging Cell 2009; 8: 162\u2013177.","journal-title":"Aging Cell"},{"key":"BFmp2016251_CR42","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1167\/iovs.08-1849","volume":"49","author":"A Ning","year":"2008","unstructured":"Ning A, Cui J, To E, Ashe KH, Matsubara J . Amyloid-\u03b2 deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Invest Ophthalmol Vis Sci 2008; 49: 5136\u20135143.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR43","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1167\/iovs.08-2384","volume":"50","author":"SE Perez","year":"2009","unstructured":"Perez SE, Lumayag S, Kovacs B, Mufson EJ, Xu S . \u03b2-amyloid deposition and functional impairment in the retina of the APPswe\/PS1\u0394E9 transgenic mouse model of Alzheimer\u2019s disease. Invest Ophthalmol Vis Sci 2009; 50: 793\u2013800.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR44","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.nbd.2003.08.009","volume":"14","author":"J Wang","year":"2003","unstructured":"Wang J, Tanila H, Puolivali J, Kadish I, van Groen T . Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice. Neurobiol Dis 2003; 14: 318\u2013327.","journal-title":"Neurobiol Dis"},{"key":"BFmp2016251_CR45","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s00417-009-1060-3","volume":"247","author":"RM Dutescu","year":"2009","unstructured":"Dutescu RM, Li Q-X, Crowston J, Masters CL, Baird PN, Culvenor JG . Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer\u2019s disease. Graefes Arch Clin Exp Ophthalmol 2009; 247: 1213\u20131221.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFmp2016251_CR46","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol 2015; 14: 388\u2013405.","journal-title":"Lancet Neurol"},{"key":"BFmp2016251_CR47","first-page":"112","volume":"8","author":"I Morales","year":"2014","unstructured":"Morales I, Guzman-Martinez L, Cerda-Troncoso C, Farias GA, Maccioni RB . Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci 2014; 8: 112.","journal-title":"Front Cell Neurosci"},{"key":"BFmp2016251_CR48","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/WNR.0b013e3283497334","volume":"22","author":"PN Alexandrov","year":"2011","unstructured":"Alexandrov PN, Pogue A, Bhattacharjee S, Lukiw WJ . Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease. Neuroreport 2011; 22: 623\u2013627.","journal-title":"Neuroreport"},{"key":"BFmp2016251_CR49","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.exer.2014.08.006","volume":"127","author":"MM Edwards","year":"2014","unstructured":"Edwards MM, Rodr\u00edguez JJ, Gutierrez-Lanza R, Yates J, Verkhratsky A, Lutty GA . Retinal macroglia changes in a triple transgenic mouse model of Alzheimer's disease. Exp Eye Res 2014; 127: 252\u2013260.","journal-title":"Exp Eye Res"},{"key":"BFmp2016251_CR50","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1167\/iovs.13-12888","volume":"55","author":"Y Tsai","year":"2014","unstructured":"Tsai Y, Lu B, Ljubimov AV, Girman S, Ross-Cisneros FN, Sadun AA et al. Ocular changes in TgF344-AD rat model of Alzheimer's disease. Invest Ophthalmol Vis Sci 2014; 55: 523\u2013534.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR51","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/glia.20967","volume":"58","author":"M Olabarria","year":"2010","unstructured":"Olabarria M, Noristani HN, Verkhratsky A, Rodriguez JJ . Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 2010; 58: 831\u2013838.","journal-title":"Glia"},{"key":"BFmp2016251_CR52","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/00005072-200606000-00010","volume":"65","author":"AC McKee","year":"2006","unstructured":"McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA et al. Visual association pathology in preclinical Alzheimer disease. J Neuropathol Exp Neurol 2006; 65: 621\u2013630.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFmp2016251_CR53","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1471-4159.2008.05606.x","volume":"107","author":"M Shimazawa","year":"2008","unstructured":"Shimazawa M, Inokuchi Y, Okuno T, Nakajima Y, Sakaguchi G, Kato A et al. Reduced retinal function in amyloid precursor protein\u2010over\u2010expressing transgenic mice via attenuating glutamate\u2010N\u2010methyl\u2010d\u2010aspartate receptor signaling. J Neurochem 2008; 107: 279\u2013290.","journal-title":"J Neurochem"},{"key":"BFmp2016251_CR54","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1016\/j.neurobiolaging.2014.03.008","volume":"35","author":"SW Park","year":"2014","unstructured":"Park SW, Kim JH, Mook-Jung I, Kim K-W, Park WJ, Park KH et al. Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice. Neurobiol Aging 2014; 35: 2013\u20132020.","journal-title":"Neurobiol Aging"},{"key":"BFmp2016251_CR55","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.2353\/ajpath.2009.090159","volume":"175","author":"B Liu","year":"2009","unstructured":"Liu B, Rasool S, Yang Z, Glabe CG, Schreiber SS, Ge J et al. Amyloid-peptide vaccinations reduce \u03b2-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer\u2019s transgenic mice. Am J Pathol 2009; 175: 2099\u20132110.","journal-title":"Am J Pathol"},{"key":"BFmp2016251_CR56","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1021\/cn500242z","volume":"6","author":"SS More","year":"2015","unstructured":"More SS, Vince R . Hyperspectral imaging signatures detect amyloidopathy in Alzheimer\u2019s mouse retina well before onset of cognitive decline. ACS Chem Neurosci 2015; 6: 306\u2013315.","journal-title":"ACS Chem Neurosci"},{"key":"BFmp2016251_CR57","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1167\/iovs.12-9662","volume":"53","author":"MJ Mattapallil","year":"2012","unstructured":"Mattapallil MJ, Wawrousek EF, Chan C-C, Zhao H, Roychoudhury J, Ferguson TA et al. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL\/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes rd8 mutation in vendor B6 Mice and ES cells. Invest Ophthalmol Vis Sci 2012; 53: 2921\u20132927.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR58","doi-asserted-by":"publisher","first-page":"e10659","DOI":"10.1371\/journal.pone.0010659","volume":"5","author":"JA Moncaster","year":"2010","unstructured":"Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG et al. Alzheimer's disease amyloid-\u03b2 links lens and brain pathology in down syndrome. PLoS One 2010; 5: e10659.","journal-title":"PLoS One"},{"key":"BFmp2016251_CR59","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fneur.2013.00062","volume":"4","author":"C Kerbage","year":"2013","unstructured":"Kerbage C, Sadowsky CH, Jennings D, Cagle GD, Hartung PD . Alzheimer's disease diagnosis by detecting exogenous fluorescent signal of ligand bound to Beta amyloid in the lens of human eye: an exploratory study. Front Neurol 2013; 4: 62.","journal-title":"Front Neurol"},{"key":"BFmp2016251_CR60","doi-asserted-by":"publisher","first-page":"P234","DOI":"10.1016\/j.jalz.2014.04.341","volume":"10","author":"S Frost","year":"2014","unstructured":"Frost S, Kanagasingam Y, Macaulay L, Koronyo-Hamaoui M, Koronyo Y, Biggs D et al. Retinal amyloid fluorescence imaging predicts cerebral amyloid burden and Alzheimer's disease. Alzheimers Demen 2014; 10: P234\u2013P235.","journal-title":"Alzheimers Demen"},{"key":"BFmp2016251_CR61","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fnbeh.2015.00239","volume":"9","author":"MS Rafii","year":"2015","unstructured":"Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC et al. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci 2015; 9: 239.","journal-title":"Front Behav Neurosci"},{"key":"BFmp2016251_CR62","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4172\/2324-8599.1000145","volume":"3","author":"U Kayabasi","year":"2014","unstructured":"Kayabasi U, Sergott R, Rispoli M . Retinal examination for the diagnosis of Alzheimer\u2019s disease. Int J Ophthalmic Pathol 2014; 3: 4.","journal-title":"Int J Ophthalmic Pathol"},{"key":"BFmp2016251_CR63","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.exer.2012.10.012","volume":"106","author":"R Michael","year":"2013","unstructured":"Michael R, Rosandi\u0107 J, Montenegro GA, Lobato E, Tresserra F, Barraquer RI et al. Absence of beta-amyloid in cortical cataracts of donors with and without Alzheimer's disease. Exp Eye Res 2013; 106: 5\u201313.","journal-title":"Exp Eye Res"},{"key":"BFmp2016251_CR64","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.exer.2013.11.016","volume":"119","author":"R Michael","year":"2014","unstructured":"Michael R, Otto C, Lenferink A, Gelpi E, Montenegro GA, Rosandi\u0107 J et al. Absence of amyloid-beta in lenses of Alzheimer patients: a confocal Raman microspectroscopic study. Exp Eye Res 2014; 119: 44\u201353.","journal-title":"Exp Eye Res"},{"key":"BFmp2016251_CR65","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/0006-8993(89)90653-7","volume":"501","author":"JC Blanks","year":"1989","unstructured":"Blanks JC, Hinton DR, Sadun AA, Miller CA . Retinal ganglion cell degeneration in Alzheimer's disease. Brain Res 1989; 501: 364\u2013372.","journal-title":"Brain Res"},{"key":"BFmp2016251_CR66","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1056\/NEJM198608213150804","volume":"315","author":"DR Hinton","year":"1986","unstructured":"Hinton DR, Sadun AA, Blanks JC, Miller CA . Optic-nerve degeneration in Alzheimer's disease. N Engl J Med 1986; 315: 485\u2013487.","journal-title":"N Engl J Med"},{"key":"BFmp2016251_CR67","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/bpa.12070","volume":"24","author":"CY Ho","year":"2014","unstructured":"Ho CY, Troncoso JC, Knox D, Stark W, Eberhart CG . Beta\u2010amyloid, phospho\u2010tau and alpha\u2010synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients. Brain Pathol 2014; 24: 25\u201332.","journal-title":"Brain Pathol"},{"key":"BFmp2016251_CR68","doi-asserted-by":"publisher","first-page":"e53547","DOI":"10.1371\/journal.pone.0053547","volume":"7","author":"C Sch\u00f6n","year":"2012","unstructured":"Sch\u00f6n C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S et al. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS One 2012; 7: e53547.","journal-title":"PLoS One"},{"key":"BFmp2016251_CR69","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2174\/156720510790274491","volume":"7","author":"L Guo","year":"2010","unstructured":"Guo L, Duggan J, Cordeiro M . Alzheimer's disease and retinal neurodegeneration. Curr Alzheimer Resarch 2010; 7: 3\u201314.","journal-title":"Curr Alzheimer Resarch"},{"key":"BFmp2016251_CR70","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2217\/nmt.14.19","volume":"4","author":"MH Dehabadi","year":"2014","unstructured":"Dehabadi MH, Davis BM, Wong TK, Cordeiro MF . Retinal manifestations of Alzheimer's disease. Neurodegener Dis Manag 2014; 4: 241\u2013252.","journal-title":"Neurodegener Dis Manag"},{"key":"BFmp2016251_CR71","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1471-2415-13-28","volume":"13","author":"A Laude","year":"2013","unstructured":"Laude A, Lascaratos G, Henderson RD, Starr JM, Deary IJ, Dhillon B . Retinal nerve fiber layer thickness and cognitive ability in older people: the Lothian Birth Cohort 1936 study. BMC Ophthalmology 2013; 13: 28\u201328.","journal-title":"BMC Ophthalmology"},{"key":"BFmp2016251_CR72","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fncel.2013.00142","volume":"7","author":"Y Shen","year":"2013","unstructured":"Shen Y, Shi Z, Jia R, Zhu Y, Cheng Y, Feng W et al. The attenuation of retinal nerve fiber layer thickness and cognitive deterioration. Front Cell Neurosci 2013; 7: 142.","journal-title":"Front Cell Neurosci"},{"key":"BFmp2016251_CR73","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0733-8619(02)00107-X","volume":"21","author":"GR Jackson","year":"2003","unstructured":"Jackson GR, Owsley C . Visual dysfunction, neurodegenerative diseases, and aging. Neurol Clin 2003; 21: 709\u2013728.","journal-title":"Neurol Clin"},{"key":"BFmp2016251_CR74","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fneur.2016.00055","volume":"7","author":"FZ Javaid","year":"2016","unstructured":"Javaid FZ, Brenton J, Guo L, Cordeiro MF . Visual and ocular manifestations of Alzheimer\u2019s disease and their use as biomarkers for diagnosis and progression. Front Neurol 2016; 7: 55.","journal-title":"Front Neurol"},{"key":"BFmp2016251_CR75","doi-asserted-by":"publisher","first-page":"447","DOI":"10.4103\/1673-5374.179057","volume":"11","author":"L Li","year":"2016","unstructured":"Li L, Luo J, Chen D, Tong JB, Zeng LP, Cao YQ et al. BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease. Neural Regen Res 2016; 11: 447\u2013453.","journal-title":"Neural Regen Res"},{"key":"BFmp2016251_CR76","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s10384-004-0156-x","volume":"49","author":"S Yoneda","year":"2005","unstructured":"Yoneda S, Hara H, Hirata A, Fukushima M, Inomata Y, Tanihara H . Vitreous fluid levels of beta-amyloid(1-42) and tau in patients with retinal diseases. Jpn J Ophthalmol 2005; 49: 106\u2013108.","journal-title":"Jpn J Ophthalmol"},{"key":"BFmp2016251_CR77","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3233\/JAD-2012-120571","volume":"32","author":"CL Bitel","year":"2012","unstructured":"Bitel CL, Kasinathan C, Kaswala RH, Klein WL, Frederikse PH . Amyloid-beta and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model. J Alzheimers Dis 2012; 32: 291\u2013305.","journal-title":"J Alzheimers Dis"},{"key":"BFmp2016251_CR78","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1248\/bpb.b14-00819","volume":"38","author":"N Nagai","year":"2015","unstructured":"Nagai N, Ito Y, Tanino T . Effect of high glucose levels on amyloid beta production in retinas of spontaneous diabetes mellitus Otsuka Long-Evans Tokushima fatty rats. Biol Pharm Bull 2015; 38: 601\u2013610.","journal-title":"Biol Pharm Bull"},{"key":"BFmp2016251_CR79","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.exer.2003.10.011","volume":"78","author":"DH Anderson","year":"2004","unstructured":"Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, Johnson LV . Characterization of \u03b2 amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res 2004; 78: 243\u2013256.","journal-title":"Exp Eye Res"},{"key":"BFmp2016251_CR80","doi-asserted-by":"publisher","first-page":"11830","DOI":"10.1073\/pnas.192203399","volume":"99","author":"LV Johnson","year":"2002","unstructured":"Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH . The Alzheimer's A\u03b2-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci USA 2002; 99: 11830\u201311835.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp2016251_CR81","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.1093\/emboj\/cdf609","volume":"21","author":"A Sandilands","year":"2002","unstructured":"Sandilands A, Hutcheson AM, Long HA, Prescott AR, Vrensen G, L\u00f6ster J et al. Altered aggregation properties of mutant \u03b3\u2010crystallins cause inherited cataract. EMBO J 2002; 21: 6005\u20136014.","journal-title":"EMBO J"},{"key":"BFmp2016251_CR82","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/BF01273271","volume":"42","author":"J Ogata","year":"1978","unstructured":"Ogata J, Okayama M, Goto I, Inomata H, Yoshida I, Omae T . Primary familial amyloidosis with vitreous opacities. Acta Neuropathol 1978; 42: 67\u201370.","journal-title":"Acta Neuropathol"},{"key":"BFmp2016251_CR83","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/0301-4738.151481","volume":"63","author":"R Alberto","year":"2015","unstructured":"Alberto R, Luigi S, Ambrogio F, Daniele D . Bilateral optic neuropathy and intraretinal deposits after pars plana vitrectomy in amyloidosis. Indian J Ophthalmol 2015; 63: 72\u201374.","journal-title":"Indian J Ophthalmol"},{"key":"BFmp2016251_CR84","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s004170100357","volume":"239","author":"J Berlau","year":"2001","unstructured":"Berlau J, Lorenz P, Beck R, Makovitzky J, Schl\u00f6tzer-Schrehardt U, Thiesen H-J et al. Analysis of aqueous humour proteins of eyes with and without pseudoexfoliation syndrome. Graefes Arch Clin Exp Ophthalmol 2001; 239: 743\u2013746.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BFmp2016251_CR85","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1096\/fasebj.14.7.835","volume":"14","author":"RF Mullins","year":"2000","unstructured":"Mullins RF, Russell SR, Anderson DH, Hageman GS . Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 2000; 14: 835\u2013846.","journal-title":"FASEB J"},{"key":"BFmp2016251_CR86","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/0-387-25919-8_12","volume-title":"Protein Misfolding, Aggregation, and Conformational Diseases","author":"R Linke","year":"2006","unstructured":"Linke R . Congo red staining of amyloid: improvements and practical guide for a more precise diagnosis of amyloid and the different amyloidoses. In: Uversky V, Fink A (ed). Protein Misfolding, Aggregation, and Conformational Diseases. Springer: USA, 2006, p 239\u2013276."},{"key":"BFmp2016251_CR87","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/eye.1995.192","volume":"9","author":"CJ Kennedy","year":"1995","unstructured":"Kennedy CJ, Rakoczy PE, Constable IJ . Lipofuscin of the retinal pigment epithelium: a review. Eye 1995; 9: 763\u2013771.","journal-title":"Eye"},{"key":"BFmp2016251_CR88","first-page":"1855","volume":"42","author":"FC Delori","year":"2001","unstructured":"Delori FC, Goger DG, Dorey CK . Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci 2001; 42: 1855\u20131866.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR89","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84882-710-3","volume-title":"Medical Imaging in Clinical Trials","author":"C Miller","year":"2014","unstructured":"Miller C, Krasnow J, Schwartz LH . Medical Imaging in Clinical Trials. Springer: London, UK, 2014."},{"key":"BFmp2016251_CR90","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0039-6257(87)90115-9","volume":"31","author":"RW Young","year":"1987","unstructured":"Young RW . Pathophysiology of age-related macular degeneration. Surv Ophthalmol 1987; 31: 291\u2013306.","journal-title":"Surv Ophthalmol"},{"key":"BFmp2016251_CR91","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1350-9462(01)00010-6","volume":"20","author":"GS Hageman","year":"2001","unstructured":"Hageman GS, Luthert PJ, Chong NV, Johnson LV, Anderson DH, Mullins RF . An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res 2001; 20: 705\u2013732.","journal-title":"Prog Retin Eye Res"},{"key":"BFmp2016251_CR92","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1172\/JCI25843","volume":"116","author":"V Luibl","year":"2006","unstructured":"Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J . Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest 2006; 116: 378\u2013385.","journal-title":"J Clin Invest"},{"key":"BFmp2016251_CR93","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0002-9394(14)75576-X","volume":"109","author":"D Pauleikhoff","year":"1990","unstructured":"Pauleikhoff D, Barondes M, Minassian D, Chisholm I, Bird A . Drusen as risk factors in age-related macular disease. Am J Ophthalmol 1990; 109: 38\u201343.","journal-title":"Am J Ophthalmol"},{"key":"BFmp2016251_CR94","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1167\/iovs.09-4207","volume":"51","author":"JM Isas","year":"2010","unstructured":"Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG et al. Soluble and mature amyloid fibrils in drusen deposits. Invest Ophthalmol Vis Sci 2010; 51: 1304\u20131310.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFmp2016251_CR95","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.preteyeres.2011.02.004","volume":"30","author":"K Ohno-Matsui","year":"2011","unstructured":"Ohno-Matsui K . Parallel findings in age-related macular degeneration and Alzheimer's disease. Prog Retin Eye Res 2011; 30: 217\u2013238.","journal-title":"Prog Retin Eye Res"},{"key":"BFmp2016251_CR96","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-319-17121-0_1","volume":"854","author":"KA Toops","year":"2016","unstructured":"Toops KA, Tan LX, Lakkaraju A . Apolipoprotein E isoforms and AMD. Adv Exp Med Biol 2016; 854: 3\u20139.","journal-title":"Adv Exp Med Biol"},{"key":"BFmp2016251_CR97","doi-asserted-by":"publisher","first-page":"209","DOI":"10.5414\/NPP29209","volume":"29","author":"E Uro-Coste","year":"2009","unstructured":"Uro-Coste E, Russano dPG, Guilbeau-Frugier C, Sastre N, Ousset P, da Silva N et al. Cerebral amyloid angiopathy and microhemorrhages after amyloid beta vaccination: case report and brief review. Clin Neuropathol 2009; 29: 209\u2013216.","journal-title":"Clin Neuropathol"},{"key":"BFmp2016251_CR98","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.visres.2007.07.025","volume":"48","author":"JD Ding","year":"2008","unstructured":"Ding JD, Lin J, Mace BE, Herrmann R, Sullivan P, Bowes Rickman C . Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. Vision Res 2008; 48: 339\u2013345.","journal-title":"Vision Res"},{"key":"BFmp2016251_CR99","doi-asserted-by":"publisher","first-page":"E279","DOI":"10.1073\/pnas.1100901108","volume":"108","author":"JD Ding","year":"2011","unstructured":"Ding JD, Johnson LV, Herrmann R, Farsiu S, Smith SG, Groelle M et al. Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. Proc Natl Acad Sci USA 2011; 108: E279\u2013E287.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp2016251_CR100","doi-asserted-by":"publisher","first-page":"13444","DOI":"10.1073\/pnas.0703707104","volume":"104","author":"L Guo","year":"2007","unstructured":"Guo L, Salt TE, Luong V, Wood N, Cheung W, Maass A et al. Targeting amyloid-beta in glaucoma treatment. Proc Natl Acad Sci USA 2007; 104: 13444\u201313449.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp2016251_CR101","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1001\/archopht.124.2.217","volume":"124","author":"YH Yucel","year":"2006","unstructured":"Yucel YH, Gupta N, Zhang Q, Mizisin AP, Kalichman MW, Weinreb RN . Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma. Arch Ophthalmol 2006; 124: 217\u2013225.","journal-title":"Arch Ophthalmol"},{"key":"BFmp2016251_CR102","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1038\/cddis.2009.23","volume":"1","author":"M Almasieh","year":"2010","unstructured":"Almasieh M, Zhou Y, Kelly ME, Casanova C, Di Polo A . Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors. Cell Death Dis 2010; 1: e27.","journal-title":"Cell Death Dis"},{"key":"BFmp2016251_CR103","first-page":"884","volume":"8","author":"YM Yi","year":"2015","unstructured":"Yi YM, Cai L, Shao Y, Xu M, Yi JL . The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Int J Ophthalmol 2015; 8: 884\u2013890.","journal-title":"Int J Ophthalmol"},{"key":"BFmp2016251_CR104","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.freeradbiomed.2004.10.023","volume":"38","author":"S Melov","year":"2005","unstructured":"Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI . Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic Biol Med 2005; 38: 258\u2013261.","journal-title":"Free Radic Biol Med"},{"key":"BFmp2016251_CR105","doi-asserted-by":"publisher","first-page":"7091","DOI":"10.1523\/JNEUROSCI.2711-13.2014","volume":"34","author":"MR Durk","year":"2014","unstructured":"Durk MR, Han K, Chow EC, Ahrens R, Henderson JT, Fraser PE et al. 1alpha,25-Dihydroxyvitamin D3 reduces cerebral amyloid-beta accumulation and improves cognition in mouse models of Alzheimer's disease. J Neurosci 2014; 34: 7091\u20137101.","journal-title":"J Neurosci"},{"key":"BFmp2016251_CR106","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1084\/jem.20121239","volume":"209","author":"J Yao","year":"2012","unstructured":"Yao J, Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF . Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease. J Exp Med 2012; 209: 2501\u20132513.","journal-title":"J Exp Med"},{"key":"BFmp2016251_CR107","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1110\/ps.0225503","volume":"12","author":"MS Kosinski\u2010Collins","year":"2003","unstructured":"Kosinski\u2010Collins MS, King J . In vitro unfolding, refolding, and polymerization of human \u03b3D crystallin, a protein involved in cataract formation. Protein Sci 2003; 12: 480\u2013490.","journal-title":"Protein Sci"},{"key":"BFmp2016251_CR108","doi-asserted-by":"publisher","first-page":"063704","DOI":"10.1063\/1.4865197","volume":"104","author":"M Amaro","year":"2014","unstructured":"Amaro M, Wellbrock T, Birch DJ, Rolinski OJ . Inhibition of beta-amyloid aggregation by fluorescent dye labels. Appl Phys Lett 2014; 104: 063704.","journal-title":"Appl Phys Lett"},{"key":"BFmp2016251_CR109","first-page":"901","volume":"18","author":"JM Woo","year":"2012","unstructured":"Woo JM, Shin DY, Lee SJ, Joe Y, Zheng M, Yim JH et al. Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen. Mol Vis 2012; 18: 901\u2013908.","journal-title":"Mol Vis"},{"key":"BFmp2016251_CR110","doi-asserted-by":"crossref","unstructured":"Campbell MC . High Resolution Imaging of the Eye-Implications for Diagnosis and Therapy. In: Bio-Optics Design and Application, Optical Society of America, 2013 (abstract BTh2A-1).","DOI":"10.1364\/BODA.2013.BTh2A.1"},{"key":"BFmp2016251_CR111","doi-asserted-by":"crossref","unstructured":"Campbell MC, Avila F, Emptage L, Kisilak M, Bueno JM . Polarimetry in ex vivo retina from donors with Alzheimer's disease. In: Frontiers in Optics, Optical Society of America, 2013 (abstract FW5F-4).","DOI":"10.1364\/FIO.2013.FW5F.4"},{"key":"BFmp2016251_CR112","doi-asserted-by":"crossref","unstructured":"Campbell MC, Chow WC, Emptage L, Cookson C, Milgram B, Dobson H . Polarization properties of amyloid beta in an animal model of Alzheimer's disease. In: Frontiers in Optics, Optical Society of America, 2014 (abstract FW5F-4).","DOI":"10.1364\/FIO.2014.FW5F.4"},{"key":"BFmp2016251_CR113","doi-asserted-by":"publisher","first-page":"e241","DOI":"10.1111\/aos.12609","volume":"93","author":"S Jentsch","year":"2015","unstructured":"Jentsch S, Schweitzer D, Schmidtke KU, Peters S, Dawczynski J, Bar KJ et al. Retinal fluorescence lifetime imaging ophthalmoscopy measures depend on the severity of Alzheimer's disease. Acta Ophthalmol 2015; 93: e241\u2013e247.","journal-title":"Acta Ophthalmol"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/mp2016251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2016251","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/mp2016251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T21:17:12Z","timestamp":1719004632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp2016251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":113,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["BFmp2016251"],"URL":"https:\/\/doi.org\/10.1038\/mp.2016.251","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]},"assertion":[{"value":"29 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}