{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:35:07Z","timestamp":1787002507126,"version":"build-2736575974"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/mp.2016.27","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T05:03:09Z","timestamp":1458622989000},"page":"384-395","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["System-based proteomic and metabonomic analysis of the Df(16)A+\/\u2212 mouse identifies potential miR-185 targets and molecular pathway alterations"],"prefix":"10.1038","volume":"22","author":[{"given":"H","family":"Wesseling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E J","family":"Want","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Guest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Karayiorgou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Gogos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,22]]},"reference":[{"key":"BFmp201627_CR1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrn2841","volume":"11","author":"M Karayiorgou","year":"2010","unstructured":"Karayiorgou M, Simon TJ, Gogos JA . 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat Rev Neurosci 2010; 11: 402\u2013416.","journal-title":"Nat Rev Neurosci"},{"key":"BFmp201627_CR2","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/(SICI)1096-8628(19980710)81:4<328::AID-AJMG10>3.0.CO;2-N","volume":"81","author":"AS Bassett","year":"1998","unstructured":"Bassett AS, Hodgkinson K, Chow EW, Correia S, Scutt LE, Weksberg R . 22q11 deletion syndrome in adults with schizophrenia. Am J Med Genet 1998; 81: 328\u2013337.","journal-title":"Am J Med Genet"},{"key":"BFmp201627_CR3","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1136\/jmg.30.10.822","volume":"30","author":"J Burn","year":"1993","unstructured":"Burn J, Takao A, Wilson D, Cross I, Momma K, Wadey R et al. Conotruncal anomaly face syndrome is associated with a deletion within chromosome 22q11. J Med Genet 1993; 30: 822\u2013824.","journal-title":"J Med Genet"},{"key":"BFmp201627_CR4","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1093\/hmg\/9.16.2421","volume":"9","author":"PJ Scambler","year":"2000","unstructured":"Scambler PJ . The 22q11 deletion syndromes. Hum Mol Genet 2000; 9: 2421\u20132426.","journal-title":"Hum Mol Genet"},{"key":"BFmp201627_CR5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/ng.138","volume":"40","author":"KL Stark","year":"2008","unstructured":"Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R et al. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 2008; 40: 751\u2013760.","journal-title":"Nat Genet"},{"key":"BFmp201627_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ijdevneu.2010.09.007","volume":"29","author":"LJ Drew","year":"2010","unstructured":"Drew LJ, Crabtree GW, Markx S, Stark KL, Chaverneff F, Xu B et al. The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders. Int J Dev Neurosci 2010; 29: 259\u2013281.","journal-title":"Int J Dev Neurosci"},{"key":"BFmp201627_CR7","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/nn.2204","volume":"11","author":"J Mukai","year":"2008","unstructured":"Mukai J, Dhilla A, Drew LJ, Stark KL, Cao L, MacDermott AB et al. Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nat Neurosci 2008; 11: 1302\u20131310.","journal-title":"Nat Neurosci"},{"key":"BFmp201627_CR8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.brainres.2010.03.109","volume":"1338","author":"B Xu","year":"2010","unstructured":"Xu B, Karayiorgou M, Gogos JA . MicroRNAs in psychiatric and neurodevelopmental disorders. Brain Res 2010; 1338: 78\u201388.","journal-title":"Brain Res"},{"key":"BFmp201627_CR9","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cell.2012.11.052","volume":"152","author":"B Xu","year":"2013","unstructured":"Xu B, Hsu PK, Stark KL, Karayiorgou M, Gogos JA . Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Cell 2013; 152: 262\u2013275.","journal-title":"Cell"},{"key":"BFmp201627_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nn1374","volume":"8","author":"SB Rosso","year":"2005","unstructured":"Rosso SB, Sussman D, Wynshaw-Boris A, Salinas PC . Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci 2005; 8: 34\u201342.","journal-title":"Nat Neurosci"},{"key":"BFmp201627_CR11","doi-asserted-by":"publisher","first-page":"14825","DOI":"10.1523\/JNEUROSCI.1611-13.2013","volume":"33","author":"K Fenelon","year":"2013","unstructured":"Fenelon K, Xu B, Lai CS, Mukai J, Markx S, Stark KL et al. The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion. J Neurosci 2013; 33: 14825\u201314839.","journal-title":"J Neurosci"},{"key":"BFmp201627_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1021\/pr5009493","volume":"14","author":"H Wesseling","year":"2015","unstructured":"Wesseling H, Rahmoune H, Tricklebank M, Guest PC, Bahn S . A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases\/phosphatases in rat brain. J Proteome Res 2015; 14: 411\u2013421.","journal-title":"J Proteome Res"},{"key":"BFmp201627_CR13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/2040-2392-5-38","volume":"5","author":"H Wesseling","year":"2014","unstructured":"Wesseling H, Guest PC, Lee CM, Wong EHF, Rahmoune H, Bahn S . Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders. Mol Autism 2014; 5: 38.","journal-title":"Mol Autism"},{"key":"BFmp201627_CR14","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.1073\/pnas.091062498","volume":"98","author":"VG Tusher","year":"2001","unstructured":"Tusher VG, Tibshirani R, Chu G . Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116\u20135121.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp201627_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","volume":"8","author":"EJ Want","year":"2013","unstructured":"Want EJ, Masson P, Michopoulos F, Wilson ID, Theodoridis G, Plumb RS et al. Global metabolic profiling of animal and human tissues via UPLC-MS. Nat Protoc 2013; 8: 17\u201332.","journal-title":"Nat Protoc"},{"key":"BFmp201627_CR16","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1021\/ac051437y","volume":"78","author":"CA Smith","year":"2006","unstructured":"Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G . XCMS: Processing mass spectrometry data for metabolite profiling using Nonlinear peak alignment, matching, and identification. Anal Chem 2006; 78: 779\u2013787.","journal-title":"Anal Chem"},{"key":"BFmp201627_CR17","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1186\/1471-2105-9-504","volume":"9","author":"R Tautenhahn","year":"2008","unstructured":"Tautenhahn R, Bottcher C, Neumann S . Highly sensitive feature detection for high resolution LC\/MS. BMC Bioinformatics 2008; 9: 504.","journal-title":"BMC Bioinformatics"},{"key":"BFmp201627_CR18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y . Controlling the false discovery rate - a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol 1995; 57: 289\u2013300.","journal-title":"J R Stat Soc Ser B Methodol"},{"key":"BFmp201627_CR19","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1093\/bfgp\/elm009","volume":"6","author":"D Martins-de-Souza","year":"2007","unstructured":"Martins-de-Souza D, Menezes de Oliveira B, dos Santos Farias A, Horiuchi RS, Crepaldi Domingues C, de Paula E et al. The use of ASB-14 in combination with CHAPS is the best for solubilization of human brain proteins for two-dimensional gel electrophoresis. Brief Funct Genomic Proteomic 2007; 6: 70\u201375.","journal-title":"Brief Funct Genomic Proteomic"},{"key":"BFmp201627_CR20","doi-asserted-by":"crossref","unstructured":"Wesseling H, Gottschalk MG, Bahn S . Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders. Int J Neuropsychopharmacol 2014; 18.","DOI":"10.1093\/ijnp\/pyu015"},{"key":"BFmp201627_CR21","doi-asserted-by":"publisher","first-page":"3704","DOI":"10.1021\/pr300197d","volume":"11","author":"A Ernst","year":"2012","unstructured":"Ernst A, Ma D, Garcia-Perez I, Tsang TM, Kluge W, Schwarz E et al. Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission. J Proteome Res 2012; 11: 3704\u20133714.","journal-title":"J Proteome Res"},{"key":"BFmp201627_CR22","doi-asserted-by":"crossref","unstructured":"Clough T, Thaminy S, Ragg S, Aebersold R, Vitek O . Statistical protein quantification and significance analysis in label-free LC-MS experiments with complex designs. BMC Bioinformatics 2012; 13 (Suppl 16): S6.","DOI":"10.1186\/1471-2105-13-S16-S6"},{"key":"BFmp201627_CR23","doi-asserted-by":"crossref","unstructured":"Chang CY, Picotti P, Huttenhain R, Heinzelmann-Schwarz V, Jovanovic M, Aebersold R et al. Protein significance analysis in selected reaction monitoring (SRM) measurements. Mol Cell Proteomics 2012; 11.","DOI":"10.1074\/mcp.M111.014662"},{"key":"BFmp201627_CR24","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1021\/pr5009493","volume":"14","author":"H Wesseling","year":"2015","unstructured":"Wesseling H, Rahmoune H, Tricklebank M, Guest PC, Bahn S . A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases\/phosphatases in rat brain. J Proteome Res 2015; 14: 411\u2013421.","journal-title":"J Proteome Res"},{"key":"BFmp201627_CR25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nmeth.1408","volume":"7","author":"P Picotti","year":"2010","unstructured":"Picotti P, Rinner O, Stallmach R, Dautel F, Farrah T, Domon B et al. High-throughput generation of selected reaction-monitoring assays for proteins and proteomes. Nat Methods 2010; 7: 43\u2013U45.","journal-title":"Nat Methods"},{"key":"BFmp201627_CR26","doi-asserted-by":"crossref","unstructured":"Farrah T, Deutsch EW, Omenn GS, Campbell DS, Sun Z, Bletz JA et al. A high-confidence human plasma proteome reference set with estimated concentrations in peptideatlas. Mol Cell Proteomics 2011; 10.","DOI":"10.1074\/mcp.M110.006353"},{"key":"BFmp201627_CR27","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","volume":"26","author":"B MacLean","year":"2010","unstructured":"MacLean B, Tomazela DM, Shulman N, Chambers M, Finney GL, Frewen B et al. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics 2010; 26: 966\u2013968.","journal-title":"Bioinformatics"},{"key":"BFmp201627_CR28","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1021\/pr8010099","volume":"8","author":"AL Oberg","year":"2009","unstructured":"Oberg AL, Vitek O . Statistical design of quantitative mass spectrometry-based proteomic experiments. J Proteome Res 2009; 8: 2144\u20132156.","journal-title":"J Proteome Res"},{"key":"BFmp201627_CR29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.2174\/1570159X1203140511160832","volume":"12","author":"A Ribeiro-Santos","year":"2014","unstructured":"Ribeiro-Santos A, Lucio Teixeira A, Salgado JV . Evidence for an immune role on cognition in schizophrenia: a systematic review. Curr Neuropharmacol 2014; 12: 273\u2013280.","journal-title":"Curr Neuropharmacol"},{"key":"BFmp201627_CR30","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1002\/dneu.22044","volume":"72","author":"M Michel","year":"2012","unstructured":"Michel M, Schmidt MJ, Mirnics K . Immune system gene dysregulation in autism and schizophrenia. Dev Neurobiol 2012; 72: 1277\u20131287.","journal-title":"Dev Neurobiol"},{"key":"BFmp201627_CR31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000356540","volume":"21","author":"N Muller","year":"2014","unstructured":"Muller N . Immunology of major depression. Neuroimmunomodulation 2014; 21: 123\u2013130.","journal-title":"Neuroimmunomodulation"},{"key":"BFmp201627_CR32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.bbi.2012.12.021","volume":"31","author":"HE Ross","year":"2013","unstructured":"Ross HE, Guo Y, Coleman K, Ousley O, Miller AH . Association of IL-12p70 and IL-6:IL-10 ratio with autism-related behaviors in 22q11.2 deletion syndrome: a preliminary report. Brain Behav Immun 2013; 31: 76\u201381.","journal-title":"Brain Behav Immun"},{"key":"BFmp201627_CR33","doi-asserted-by":"publisher","first-page":"14433","DOI":"10.1073\/pnas.2235651100","volume":"100","author":"TM Maynard","year":"2003","unstructured":"Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS . A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proc Natl Acad Sci USA 2003; 100: 14433\u201314438.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp201627_CR34","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1089\/ars.2011.4322","volume":"18","author":"S Lee","year":"2013","unstructured":"Lee S, Kim SM, Lee RT . Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance. Antioxid Redox Signal 2013; 18: 1165\u20131207.","journal-title":"Antioxid Redox Signal"},{"key":"BFmp201627_CR35","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","volume":"45","author":"JD Hayes","year":"2005","unstructured":"Hayes JD, Flanagan JU, Jowsey IR . Glutathione transferases. Annu Rev Pharmacol Toxicol 2005; 45: 51\u201388.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"Pt 1","key":"BFmp201627_CR36","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1042\/bj20020533","volume":"366","author":"H Raza","year":"2002","unstructured":"Raza H, Robin MA, Fang JK, Avadhani NG . Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Biochem J 2002; 366 (Pt 1): 45\u201355.","journal-title":"Biochem J"},{"key":"BFmp201627_CR37","doi-asserted-by":"publisher","first-page":"27302","DOI":"10.1074\/jbc.M402496200","volume":"279","author":"A Patenaude","year":"2004","unstructured":"Patenaude A, Ven Murthy MR, Mirault ME . Mitochondrial thioredoxin system: effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis. J Biol Chem 2004; 279: 27302\u201327314.","journal-title":"J Biol Chem"},{"key":"BFmp201627_CR38","doi-asserted-by":"publisher","first-page":"14132","DOI":"10.1523\/JNEUROSCI.1312-12.2012","volume":"32","author":"LR Earls","year":"2012","unstructured":"Earls LR, Fricke RG, Yu J, Berry RB, Baldwin LT, Zakharenko SS . Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia. J Neurosci 2012; 32: 14132\u201314144.","journal-title":"J Neurosci"},{"key":"BFmp201627_CR39","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.expneurol.2015.08.009","volume":"274","author":"M Ogawa","year":"2015","unstructured":"Ogawa M, Sawaguchi S, Kamemura K, Okajima T . Intracellular and extracellular O-linked N-acetylglucosamine in the nervous system. Exp Neurol 2015; 274: 166\u2013174.","journal-title":"Exp Neurol"},{"key":"BFmp201627_CR40","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.neuron.2012.10.012","volume":"76","author":"K Nakajima","year":"2012","unstructured":"Nakajima K, Yin X, Takei Y, Seog DH, Homma N, Hirokawa N . Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy. Neuron 2012; 76: 945\u2013961.","journal-title":"Neuron"},{"key":"BFmp201627_CR41","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1074\/mcp.R115.053330","volume":"15","author":"G Moya-Alvarado","year":"2015","unstructured":"Moya-Alvarado G, Gershoni-Emek N, Perlson E, Bronfman FC . Neurodegeneration and Alzheimer's disease. What can proteomics tell us about the Alzheimer's brain? Mol Cell Proteomics 2015; 15: 409\u2013425.","journal-title":"Mol Cell Proteomics"},{"key":"BFmp201627_CR42","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1074\/mcp.R115.051482","volume":"15","author":"DC Dieterich","year":"2015","unstructured":"Dieterich DC, Kreutz MR . Proteomics of the synapse - a quantitative approach to neuronal plasticity. Mol Cell Proteomics 2015; 15: 368\u2013381.","journal-title":"Mol Cell Proteomics"},{"key":"BFmp201627_CR43","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1017\/S146114571400008X","volume":"17","author":"H Wesseling","year":"2014","unstructured":"Wesseling H, Guest PC, Lago SG, Bahn S . Technological advances for deciphering the complexity of psychiatric disorders: merging proteomics with cell biology. Int J Neuropsychopharmacol 2014; 17: 1327\u20131341.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFmp201627_CR44","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1152\/physiol.00029.2013","volume":"28","author":"A Yabluchanskiy","year":"2013","unstructured":"Yabluchanskiy A, Ma YG, Iyer RP, Hall ME, Lindsey ML . Matrix metalloproteinase-9: many shades of function in cardiovascular disease. Physiology 2013; 28: 391\u2013403.","journal-title":"Physiology"},{"key":"BFmp201627_CR45","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s00702-014-1205-3","volume":"121","author":"M Lukaszewicz-Zajac","year":"2014","unstructured":"Lukaszewicz-Zajac M, Mroczko B, Slowik A . Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in amyotrophic lateral sclerosis (ALS). J Neural Transm (Vienna) 2014; 121: 1387\u20131397.","journal-title":"J Neural Transm (Vienna)"},{"key":"BFmp201627_CR46","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3109\/00207454.2013.872102","volume":"124","author":"J Kurzepa","year":"2014","unstructured":"Kurzepa J, Kurzepa J, Golab P, Czerska S, Bielewicz J . The significance of matrix metalloproteinase (MMP)-2 and MMP-9 in the ischemic stroke. Int J Neurosci 2014; 124: 707\u2013716.","journal-title":"Int J Neurosci"},{"key":"BFmp201627_CR47","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s12035-013-8538-z","volume":"49","author":"M Chaturvedi","year":"2014","unstructured":"Chaturvedi M, Kaczmarek L . MMP-9 inhibition: a therapeutic strategy in ischemic stroke. Mol Neurobiol 2014; 49: 563\u2013573.","journal-title":"Mol Neurobiol"},{"key":"BFmp201627_CR48","doi-asserted-by":"publisher","first-page":"6643","DOI":"10.1093\/emboj\/cdf676","volume":"21","author":"L Kaczmarek","year":"2002","unstructured":"Kaczmarek L, Lapinska-Dzwonek J, Szymczak S . Matrix metalloproteinases in the adult brain physiology: a link between c-Fos, AP-1 and remodeling of neuronal connections? EMBO J 2002; 21: 6643\u20136648.","journal-title":"EMBO J"},{"key":"BFmp201627_CR49","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.biopsych.2006.09.012","volume":"62","author":"P Okulski","year":"2007","unstructured":"Okulski P, Jay TM, Jaworski J, Duniec K, Dzwonek J, Konopacki FA et al. TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex. Biol Psychiatry 2007; 62: 359\u2013362.","journal-title":"Biol Psychiatry"},{"key":"BFmp201627_CR50","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.schres.2009.02.005","volume":"109","author":"JK Rybakowski","year":"2009","unstructured":"Rybakowski JK, Skibinska M, Kapelski P, Kaczmarek L, Hauser J . Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia. Schizophr Res 2009; 109: 90\u201393.","journal-title":"Schizophr Res"},{"key":"BFmp201627_CR51","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s12017-009-8072-3","volume":"11","author":"JK Rybakowski","year":"2009","unstructured":"Rybakowski JK, Skibinska M, Leszczynska-Rodziewicz A, Kaczmarek L, Hauser J . Matrix metalloproteinase-9 gene and bipolar mood disorder. Neuromolecular Med 2009; 11: 128\u2013132.","journal-title":"Neuromolecular Med"},{"key":"BFmp201627_CR52","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1038\/nn.3261","volume":"15","author":"SR Gilman","year":"2012","unstructured":"Gilman SR, Chang J, Xu B, Bawa TS, Gogos JA, Karayiorgou M et al. Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. Nat Neurosci 2012; 15: 1723\u20131728.","journal-title":"Nat Neurosci"},{"key":"BFmp201627_CR53","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/ng.2446","volume":"44","author":"B Xu","year":"2012","unstructured":"Xu B, Ionita-Laza I, Roos JL, Boone B, Woodrick S, Sun Y et al. De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia. Nat Genet 2012; 44: 1365\u20131369.","journal-title":"Nat Genet"},{"key":"BFmp201627_CR54","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrn3229","volume":"13","author":"H Manji","year":"2012","unstructured":"Manji H, Kato T, Di Prospero NA, Ness S, Beal MF, Krams M et al. Impaired mitochondrial function in psychiatric disorders. Nat Rev Neurosci 2012; 13: 293\u2013307.","journal-title":"Nat Rev Neurosci"},{"key":"BFmp201627_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gm300","volume":"4","author":"M Oresic","year":"2012","unstructured":"Oresic M, Seppanen-Laakso T, Sun D, Tang J, Therman S, Viehman R et al. Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia. Genome Med 2012; 4: 1.","journal-title":"Genome Med"},{"key":"BFmp201627_CR56","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/978-3-7091-1511-4_22","volume":"216","author":"C Muhle","year":"2013","unstructured":"Muhle C, Reichel M, Gulbins E, Kornhuber J . Sphingolipids in psychiatric disorders and pain syndromes. Handb Exp Pharmacol 2013; 216: 431\u2013456.","journal-title":"Handb Exp Pharmacol"},{"key":"BFmp201627_CR57","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3109\/10409238.2014.884535","volume":"49","author":"K Vaidyanathan","year":"2014","unstructured":"Vaidyanathan K, Durning S, Wells L . Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology. Crit Rev Biochem Mol Biol 2014; 49: 140\u2013163.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"BFmp201627_CR58","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bbagen.2009.07.018","volume":"1800","author":"C Butkinaree","year":"2009","unstructured":"Butkinaree C, Park K, Hart GW . O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta 2009; 1800: 96\u2013106.","journal-title":"Biochim Biophys Acta"},{"key":"BFmp201627_CR59","doi-asserted-by":"publisher","first-page":"23549","DOI":"10.1074\/jbc.M111.330910","volume":"287","author":"SM Ranuncolo","year":"2012","unstructured":"Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA . Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem 2012; 287: 23549\u201323561.","journal-title":"J Biol Chem"},{"key":"BFmp201627_CR60","doi-asserted-by":"publisher","first-page":"5169","DOI":"10.1073\/pnas.1300065110","volume":"110","author":"CL Howerton","year":"2013","unstructured":"Howerton CL, Morgan CP, Fischer DB, Bale TL . O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development. Proc Natl Acad Sci USA 2013; 110: 5169\u20135174.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp201627_CR61","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1016\/j.biocel.2009.03.008","volume":"41","author":"BD Lazarus","year":"2009","unstructured":"Lazarus BD, Love DC, Hanover JA . O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol 2009; 41: 2134\u20132146.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFmp201627_CR62","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0304-4165(99)00176-2","volume":"1473","author":"FI Comer","year":"1999","unstructured":"Comer FI, Hart GW . O-GlcNAc and the control of gene expression. Biochim Biophys Acta 1999; 1473: 161\u2013171.","journal-title":"Biochim Biophys Acta"},{"key":"BFmp201627_CR63","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1096\/fj.01-0094rev","volume":"15","author":"JA Hanover","year":"2001","unstructured":"Hanover JA . Glycan-dependent signaling: O-linked N-acetylglucosamine. FASEB J 2001; 15: 1865\u20131876.","journal-title":"FASEB J"},{"key":"BFmp201627_CR64","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1006\/prep.1995.1072","volume":"6","author":"SM Bailer","year":"1995","unstructured":"Bailer SM, Berlin WK, Starr CM, Hanover JA . Characterization of nuclear pore protein p62 produced using baculovirus. Protein Expr Purif 1995; 6: 546\u2013554.","journal-title":"Protein Expr Purif"},{"key":"BFmp201627_CR65","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1096\/fasebj.6.6.1312045","volume":"6","author":"JA Hanover","year":"1992","unstructured":"Hanover JA . The nuclear pore: at the crossroads. FASEB J 1992; 6: 2288\u20132295.","journal-title":"FASEB J"},{"key":"BFmp201627_CR66","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0092-8674(02)00810-3","volume":"110","author":"X Yang","year":"2002","unstructured":"Yang X, Zhang F, Kudlow JE . Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. Cell 2002; 110: 69\u201380.","journal-title":"Cell"},{"key":"BFmp201627_CR67","doi-asserted-by":"publisher","first-page":"10570","DOI":"10.1074\/jbc.M010411200","volume":"276","author":"X Cheng","year":"2001","unstructured":"Cheng X, Hart GW . Alternative O-glycosylation\/O-phosphorylation of serine-16 in murine estrogen receptor beta: post-translational regulation of turnover and transactivation activity. J Biol Chem 2001; 276: 10570\u201310575.","journal-title":"J Biol Chem"},{"key":"BFmp201627_CR68","doi-asserted-by":"publisher","first-page":"18961","DOI":"10.1074\/jbc.270.32.18961","volume":"270","author":"TY Chou","year":"1995","unstructured":"Chou TY, Hart GW, Dang CV . c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas. J Biol Chem 1995; 270: 18961\u201318965.","journal-title":"J Biol Chem"},{"key":"BFmp201627_CR69","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1046\/j.1471-4159.2001.00655.x","volume":"79","author":"RN Cole","year":"2001","unstructured":"Cole RN, Hart GW . Cytosolic O-glycosylation is abundant in nerve terminals. J Neurochem 2001; 79: 1080\u20131089.","journal-title":"J Neurochem"},{"key":"BFmp201627_CR70","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1046\/j.1471-4159.1999.0730418.x","volume":"73","author":"RN Cole","year":"1999","unstructured":"Cole RN, Hart GW . Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating synapsin I interactions. J Neurochem 1999; 73: 418\u2013428.","journal-title":"J Neurochem"},{"key":"BFmp201627_CR71","doi-asserted-by":"publisher","first-page":"12555","DOI":"10.1074\/jbc.271.21.12555","volume":"271","author":"M Ding","year":"1996","unstructured":"Ding M, Vandre DD . High molecular weight microtubule-associated proteins contain O-linked-N-acetylglucosamine. J Biol Chem 1996; 271: 12555\u201312561.","journal-title":"J Biol Chem"},{"key":"BFmp201627_CR72","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1006\/bbrc.1995.2149","volume":"213","author":"LS Griffith","year":"1995","unstructured":"Griffith LS, Schmitz B . O-linked N-acetylglucosamine is upregulated in Alzheimer brains. Biochem Biophys Res Commun 1995; 213: 424\u2013431.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFmp201627_CR73","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.1093\/nar\/gku236","volume":"42","author":"Q Xu","year":"2014","unstructured":"Xu Q, Yang C, Du Y, Chen Y, Liu H, Deng M et al. AMPK regulates histone H2B O-GlcNAcylation. Nucleic Acids Res 2014; 42: 5594\u20135604.","journal-title":"Nucleic Acids Res"},{"key":"BFmp201627_CR74","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/pmic.201300144","volume":"14","author":"RP Deng","year":"2014","unstructured":"Deng RP, He X, Guo SJ, Liu WF, Tao Y, Tao SC . Global identification of O-GlcNAc transferase (OGT) interactors by a human proteome microarray and the construction of an OGT interactome. Proteomics 2014; 14: 1020\u20131030.","journal-title":"Proteomics"},{"key":"BFmp201627_CR75","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s11064-010-0135-1","volume":"35","author":"T Kanno","year":"2010","unstructured":"Kanno T, Yaguchi T, Nagata T, Mukasa T, Nishizaki T . Regulation of AMPA receptor trafficking by O-glycosylation. Neurochem Res 2010; 35: 782\u2013788.","journal-title":"Neurochem Res"},{"key":"BFmp201627_CR76","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1523\/JNEUROSCI.4761-12.2014","volume":"34","author":"EW Taylor","year":"2014","unstructured":"Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM et al. O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. J Neurosci 2014; 34: 10\u201321.","journal-title":"J Neurosci"},{"key":"BFmp201627_CR77","doi-asserted-by":"publisher","first-page":"14719","DOI":"10.1074\/jbc.M113.525790","volume":"289","author":"EP Tan","year":"2014","unstructured":"Tan EP, Villar MT, E L, Lu J, Selfridge JE, Artigues A et al. Altering O-linked beta-N-Acetylglucosamine cycling disrupts mitochondrial function. J Biol Chem 2014; 289: 14719\u201314730.","journal-title":"J Biol Chem"},{"key":"BFmp201627_CR78","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1586\/14789450.2013.820536","volume":"10","author":"J Ma","year":"2013","unstructured":"Ma J, Hart GW . Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics 2013; 10: 365\u2013380.","journal-title":"Expert Rev Proteomics"},{"key":"BFmp201627_CR79","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.bbadis.2014.05.014","volume":"1842","author":"S Forster","year":"2014","unstructured":"Forster S, Welleford AS, Triplett JC, Sultana R, Schmitz B, Butterfield DA . Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain. Biochim Biophys Acta 2014; 1842: 1333\u20131339.","journal-title":"Biochim Biophys Acta"},{"key":"BFmp201627_CR80","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.molcel.2014.04.026","volume":"54","author":"CM Ferrer","year":"2014","unstructured":"Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL et al. O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway. Mol Cell 2014; 54: 820\u2013831.","journal-title":"Mol Cell"},{"key":"BFmp201627_CR81","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/nature06668","volume":"451","author":"X Yang","year":"2008","unstructured":"Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV et al. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 2008; 451: 964\u2013969.","journal-title":"Nature"},{"key":"BFmp201627_CR82","doi-asserted-by":"publisher","first-page":"10695","DOI":"10.1073\/pnas.152346899","volume":"99","author":"DA McClain","year":"2002","unstructured":"McClain DA, Lubas WA, Cooksey RC, Hazel M, Parker GJ, Love DC et al. Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci USA 2002; 99: 10695\u201310699.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp201627_CR83","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/j.1464-5491.2007.02092.x","volume":"24","author":"LM Spelman","year":"2007","unstructured":"Spelman LM, Walsh PI, Sharifi N, Collins P, Thakore JH . Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia. Diabet Med 2007; 24: 481\u2013485.","journal-title":"Diabet Med"},{"issue":"7 Suppl","key":"BFmp201627_CR84","first-page":"S170","volume":"13","author":"JW Newcomer","year":"2007","unstructured":"Newcomer JW . Metabolic syndrome and mental illness. Am J Manag Care 2007; 13 (7 Suppl): S170\u2013S177.","journal-title":"Am J Manag Care"},{"key":"BFmp201627_CR85","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/mp.2009.81","volume":"15","author":"PC Guest","year":"2010","unstructured":"Guest PC, Wang L, Harris LW, Burling K, Levin Y, Ernst A et al. Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naive schizophrenia patients. Mol Psychiatry 2010; 15: 118\u2013119.","journal-title":"Mol Psychiatry"},{"key":"BFmp201627_CR86","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.psyneuen.2012.09.009","volume":"38","author":"LW Harris","year":"2012","unstructured":"Harris LW, Guest PC, Wayland MT, Umrania Y, Krishnamurthy D, Rahmoune H et al. Schizophrenia: metabolic aspects of aetiology, diagnosis and future treatment strategies. Psychoneuroendocrinology 2012; 38: 752\u2013766.","journal-title":"Psychoneuroendocrinology"},{"key":"BFmp201627_CR87","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/mp.2010.71","volume":"16","author":"M Herberth","year":"2010","unstructured":"Herberth M, Koethe D, Cheng TM, Krzyszton ND, Schoeffmann S, Guest PC et al. Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients. Mol Psychiatry 2010; 16: 848\u2013859.","journal-title":"Mol Psychiatry"},{"key":"BFmp201627_CR88","doi-asserted-by":"publisher","first-page":"8993","DOI":"10.1073\/pnas.1432927100","volume":"100","author":"DJ Gerber","year":"2003","unstructured":"Gerber DJ, Hall D, Miyakawa T, Demars S, Gogos JA, Karayiorgou M et al. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc Natl Acad Sci USA 2003; 100: 8993\u20138998.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp201627_CR89","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-2350-14-33","volume":"14","author":"E Sacchetti","year":"2013","unstructured":"Sacchetti E, Scassellati C, Minelli A, Valsecchi P, Bonvicini C, Pasqualetti P et al. Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1 genes. BMC Med Genet 2013; 14: 33.","journal-title":"BMC Med Genet"},{"key":"BFmp201627_CR90","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1038\/tp.2013.111","volume":"4","author":"LF Wockner","year":"2014","unstructured":"Wockner LF, Noble EP, Lawford BR, Young RM, Morris CP, Whitehall VL et al. Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients. Transl Psychiatry 2014; 4: e339.","journal-title":"Transl Psychiatry"},{"key":"BFmp201627_CR91","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.biopsych.2004.12.029","volume":"57","author":"SL Eastwood","year":"2005","unstructured":"Eastwood SL, Burnet PW, Harrison PJ . Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. Biol Psychiatry 2005; 57: 702\u2013710.","journal-title":"Biol Psychiatry"},{"key":"BFmp201627_CR92","first-page":"ra2","volume":"3","author":"Z Wang","year":"2010","unstructured":"Wang Z, Udeshi ND, Slawson C, Compton PD, Sakabe K, Cheung WD et al. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal 2010; 3: ra2.","journal-title":"Sci Signal"},{"key":"BFmp201627_CR93","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1111\/j.1399-5618.2009.00752.x","volume":"11","author":"A Uezato","year":"2009","unstructured":"Uezato A, Meador-Woodruff JH, McCullumsmith RE . Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia. Bipolar Disord 2009; 11: 711\u2013725.","journal-title":"Bipolar Disord"},{"key":"BFmp201627_CR94","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.schres.2004.05.010","volume":"73","author":"SL Eastwood","year":"2005","unstructured":"Eastwood SL, Harrison PJ . Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. Schizophr Res 2005; 73: 159\u2013172.","journal-title":"Schizophr Res"},{"key":"BFmp201627_CR95","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.neuron.2014.09.034","volume":"84","author":"JO Lipton","year":"2014","unstructured":"Lipton JO, Sahin M . The neurology of mTOR. Neuron 2014; 84: 275\u2013291.","journal-title":"Neuron"},{"key":"BFmp201627_CR96","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1038\/nn.3546","volume":"16","author":"M Costa-Mattioli","year":"2013","unstructured":"Costa-Mattioli M, Monteggia LM . mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nat Neurosci 2013; 16: 1537\u20131543.","journal-title":"Nat Neurosci"},{"key":"BFmp201627_CR97","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature11628","volume":"493","author":"CG Gkogkas","year":"2013","unstructured":"Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB et al. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 2013; 493: 371\u2013377.","journal-title":"Nature"},{"key":"BFmp201627_CR98","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1152\/physrev.00038.2014","volume":"95","author":"J Bockaert","year":"2015","unstructured":"Bockaert J, Marin P . mTOR in brain physiology and pathologies. Physiol Rev 2015; 95: 1157\u20131187.","journal-title":"Physiol Rev"},{"key":"BFmp201627_CR99","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.pneurobio.2012.01.005","volume":"96","author":"JA Troca-Marin","year":"2012","unstructured":"Troca-Marin JA, Alves-Sampaio A, Montesinos ML . Deregulated mTOR-mediated translation in intellectual disability. Prog Neurobiol 2012; 96: 268\u2013282.","journal-title":"Prog Neurobiol"},{"key":"BFmp201627_CR100","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.pnpbp.2015.02.009","volume":"60","author":"JA Burket","year":"2015","unstructured":"Burket JA, Benson AD, Tang AH, Deutsch SI . NMDA receptor activation regulates sociability by its effect on mTOR signaling activity. Prog Neuropsychopharmacol Biol Psychiatry 2015; 60: 60\u201365.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFmp201627_CR101","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nature10658","volume":"480","author":"BD Auerbach","year":"2011","unstructured":"Auerbach BD, Osterweil EK, Bear MF . Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature 2011; 480: 63\u201368.","journal-title":"Nature"},{"key":"BFmp201627_CR102","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1523\/JNEUROSCI.5196-05.2006","volume":"26","author":"JL Banko","year":"2006","unstructured":"Banko JL, Hou L, Poulin F, Sonenberg N, Klann E . Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. J Neurosci 2006; 26: 2167\u20132173.","journal-title":"J Neurosci"},{"key":"BFmp201627_CR103","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1073\/pnas.0408305102","volume":"102","author":"E Valjent","year":"2005","unstructured":"Valjent E, Pascoli V, Svenningsson P, Paul S, Enslen H, Corvol JC et al. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci USA 2005; 102: 491\u2013496.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp201627_CR104","doi-asserted-by":"publisher","first-page":"6590","DOI":"10.1523\/JNEUROSCI.5747-03.2004","volume":"24","author":"Y Hao","year":"2004","unstructured":"Hao Y, Creson T, Zhang L, Li P, Du F, Yuan P et al. Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J Neurosci 2004; 24: 6590\u20136599.","journal-title":"J Neurosci"},{"key":"BFmp201627_CR105","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/sj.mp.4001556","volume":"10","author":"S Miyamoto","year":"2005","unstructured":"Miyamoto S, Duncan GE, Marx CE, Lieberman JA . Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 2005; 10: 79\u2013104.","journal-title":"Mol Psychiatry"},{"key":"BFmp201627_CR106","doi-asserted-by":"publisher","first-page":"11953","DOI":"10.1523\/JNEUROSCI.2349-11.2011","volume":"31","author":"Y Satoh","year":"2011","unstructured":"Satoh Y, Endo S, Nakata T, Kobayashi Y, Yamada K, Ikeda T et al. ERK2 contributes to the control of social behaviors in mice. J Neurosci 2011; 31: 11953\u201311967.","journal-title":"J Neurosci"},{"key":"BFmp201627_CR107","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/2040-2392-4-45","volume":"4","author":"TA Lanz","year":"2013","unstructured":"Lanz TA, Guilmette E, Gosink MM, Fischer JE, Fitzgerald LW, Stephenson DT et al. Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action. Mol Autism 2013; 4: 45.","journal-title":"Mol Autism"},{"key":"BFmp201627_CR108","first-page":"315","volume":"84","author":"E Davis","year":"1992","unstructured":"Davis E, Fennoy I, Laraque D, Kanem N, Brown G, Mitchell J . Autism and developmental abnormalities in children with perinatal cocaine exposure. J Natl Med Assoc 1992; 84: 315\u2013319.","journal-title":"J Natl Med Assoc"},{"key":"BFmp201627_CR109","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1111\/j.1601-183X.2011.00723.x","volume":"10","author":"K Yang","year":"2011","unstructured":"Yang K, Sheikh AM, Malik M, Wen G, Zou H, Brown WT et al. Upregulation of Ras\/Raf\/ERK1\/2 signaling and ERK5 in the brain of autistic subjects. Genes Brain Behav 2011; 10: 834\u2013843.","journal-title":"Genes Brain Behav"},{"key":"BFmp201627_CR110","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0006-3223(01)01246-X","volume":"51","author":"EW Chow","year":"2002","unstructured":"Chow EW, Zipursky RB, Mikulis DJ, Bassett AS . Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome. Biol Psychiatry 2002; 51: 208\u2013215.","journal-title":"Biol Psychiatry"},{"key":"BFmp201627_CR111","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1016\/j.neuropsychologia.2006.05.006","volume":"44","author":"M Debbane","year":"2006","unstructured":"Debbane M, Schaer M, Farhoumand R, Glaser B, Eliez S . Hippocampal volume reduction in 22q11.2 deletion syndrome. Neuropsychologia 2006; 44: 2360\u20132365.","journal-title":"Neuropsychologia"},{"key":"BFmp201627_CR112","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1744-9081-3-54","volume":"3","author":"T Deboer","year":"2007","unstructured":"Deboer T, Wu Z, Lee A, Simon TJ . Hippocampal volume reduction in children with chromosome 22q11.2 deletion syndrome is associated with cognitive impairment. Behav Brain Funct 2007; 3: 54.","journal-title":"Behav Brain Funct"},{"key":"BFmp201627_CR113","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1523\/JNEUROSCI.4761-12.2014","volume":"34","author":"EW Taylor","year":"2014","unstructured":"Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM et al. O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. J Neurosci 2014; 34: 10\u201321.","journal-title":"J Neurosci"},{"key":"BFmp201627_CR114","doi-asserted-by":"publisher","first-page":"M111 014662","DOI":"10.1074\/mcp.M111.014662","volume":"11","author":"CY Chang","year":"2011","unstructured":"Chang CY, Picotti P, Huttenhain R, Heinzelmann-Schwarz V, Jovanovic M, Aebersold R et al. Protein significance analysis in selected reaction monitoring (SRM) measurements. Mol Cell Proteomics 2011; 11: M111 014662.","journal-title":"Mol Cell Proteomics"},{"key":"BFmp201627_CR115","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.canlet.2010.11.009","volume":"301","author":"M Liu","year":"2011","unstructured":"Liu M, Lang N, Chen X, Tang Q, Liu S, Huang J et al. miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells. Cancer Lett 2011; 301: 151\u2013160.","journal-title":"Cancer Lett"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mp201627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mp201627","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mp201627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:03:53Z","timestamp":1718417033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp201627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,22]]},"references-count":115,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["BFmp201627"],"URL":"https:\/\/doi.org\/10.1038\/mp.2016.27","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,22]]},"assertion":[{"value":"7 May 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"SB is a director of Psynova Neurotech. The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}