{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:46:34Z","timestamp":1789559194694,"version":"build-2803163510"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1038\/mp.2016.4","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T04:39:32Z","timestamp":1456202372000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Progression from selective to general involvement of hippocampal subfields in schizophrenia"],"prefix":"10.1038","volume":"22","author":[{"given":"N F","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Y","family":"Sum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C N","family":"Kuswanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Y","family":"Sitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"De Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Fischl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Roffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"BFmp20164_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00213-003-1761-y","volume":"174","author":"PJ Harrison","year":"2004","unstructured":"Harrison PJ . The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berl) 2004; 174: 151\u2013162.","journal-title":"Psychopharmacology (Berl)"},{"key":"BFmp20164_CR2","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1176\/appi.ajp.2010.09081187","volume":"167","author":"CA Tamminga","year":"2010","unstructured":"Tamminga CA, Stan AD, Wagner AD . The hippocampal formation in schizophrenia. Am J Psychiatry 2010; 167: 1178\u20131193.","journal-title":"Am J Psychiatry"},{"key":"BFmp20164_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nrn3085","volume":"12","author":"SA Small","year":"2011","unstructured":"Small SA, Schobel SA, Buxton RB, Witter MP, Barnes CA . A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nat Rev Neurosci 2011; 12: 585\u2013601.","journal-title":"Nat Rev Neurosci"},{"key":"BFmp20164_CR4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1177\/1073858410395147","volume":"18","author":"F Adriano","year":"2012","unstructured":"Adriano F, Caltagirone C, Spalletta G . Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. Neuroscientist 2012; 18: 180\u2013200.","journal-title":"Neuroscientist"},{"key":"BFmp20164_CR5","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1192\/bjp.188.6.510","volume":"188","author":"RG Steen","year":"2006","unstructured":"Steen RG, Mull C, McClure R, Hamer RM, Lieberman JA . Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 2006; 188: 510\u2013518.","journal-title":"Br J Psychiatry"},{"key":"BFmp20164_CR6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.schres.2005.11.004","volume":"82","author":"A Vita","year":"2006","unstructured":"Vita A, De Peri L, Silenzi C, Dieci M . Brain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studies. Schizophr Res 2006; 82: 75\u201388.","journal-title":"Schizophr Res"},{"issue":"4","key":"BFmp20164_CR7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/mp.2015.63","volume":"21","author":"T G M van Erp","year":"2015","unstructured":"van Erp TG, Hibar DP, Rasmussen JM, Glahn DC, Pearlson GD, Andreassen OA et al. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry 2015; e-pub ahead of print 2 June 2015; doi:10.1038\/mp.2015.63.","journal-title":"Molecular Psychiatry"},{"key":"BFmp20164_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0920-9964(01)00175-X","volume":"52","author":"SJ Wood","year":"2001","unstructured":"Wood SJ, Velakoulis D, Smith DJ, Bond D, Stuart GW, McGorry PD et al. A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia. Schizophr Res 2001; 52: 37\u201346.","journal-title":"Schizophr Res"},{"key":"BFmp20164_CR9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.pscychresns.2005.07.006","volume":"140","author":"AB Whitworth","year":"2005","unstructured":"Whitworth AB, Kemmler G, Honeder M, Kremser C, Felber S, Hausmann A et al. Longitudinal volumetric MRI study in first- and multiple-episode male schizophrenia patients. Psychiatry Res 2005; 140: 225\u2013237.","journal-title":"Psychiatry Res"},{"key":"BFmp20164_CR10","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0006-3223(01)01067-8","volume":"49","author":"J Lieberman","year":"2001","unstructured":"Lieberman J, Chakos M, Wu H, Alvir J, Hoffman E, Robinson D et al. Longitudinal study of brain morphology in first episode schizophrenia. Biol Psychiatry 2001; 49: 487\u2013499.","journal-title":"Biol Psychiatry"},{"key":"BFmp20164_CR11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fpsyt.2012.00096","volume":"3","author":"D Mamah","year":"2012","unstructured":"Mamah D, Harms MP, Barch D, Styner M, Lieberman JA, Wang L . Hippocampal shape and volume changes with antipsychotics in early stage psychotic illness. Front Psychiatry 2012; 3: 96.","journal-title":"Front Psychiatry"},{"key":"BFmp20164_CR12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1001\/archpsyc.63.2.139","volume":"63","author":"D Velakoulis","year":"2006","unstructured":"Velakoulis D, Wood SJ, Wong MT, McGorry PD, Yung A, Phillips L et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 2006; 63: 139\u2013149.","journal-title":"Arch Gen Psychiatry"},{"key":"BFmp20164_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/S1461145710000817","volume":"14","author":"BH Ebdrup","year":"2011","unstructured":"Ebdrup BH, Skimminge A, Rasmussen H, Aggernaes B, Oranje B, Lublin H et al. Progressive striatal and hippocampal volume loss in initially antipsychotic-naive, first-episode schizophrenia patients treated with quetiapine: relationship to dose and symptoms. Int J Neuropsychopharmacol 2011; 14: 69\u201382.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFmp20164_CR14","doi-asserted-by":"publisher","first-page":"e87997","DOI":"10.1371\/journal.pone.0087997","volume":"9","author":"E Rizos","year":"2014","unstructured":"Rizos E, Papathanasiou MA, Michalopoulou PG, Laskos E, Mazioti A, Kastania A et al. A longitudinal study of alterations of hippocampal volumes and serum BDNF levels in association to atypical antipsychotics in a sample of first-episode patients with schizophrenia. PLoS One 2014; 9: e87997.","journal-title":"PLoS One"},{"key":"BFmp20164_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.schres.2004.05.018","volume":"73","author":"AP Weiss","year":"2005","unstructured":"Weiss AP, Dewitt I, Goff D, Ditman T, Heckers S . Anterior and posterior hippocampal volumes in schizophrenia. Schizophr Res 2005; 73: 103\u2013112.","journal-title":"Schizophr Res"},{"key":"BFmp20164_CR16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/B978-012370509-9.00117-0","volume-title":"Learning and Memory: A Comprehensive Reference","author":"RD Burwell","year":"2008","unstructured":"Burwell RD, Agster KL . Anatomy of the Hippocampus and the Declarative Memory System. In: Eichenbaum HE (ed). Learning and Memory: A Comprehensive Reference, vol. 3. Elsevier: Oxford, 2008, pp 47\u201366."},{"key":"BFmp20164_CR17","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrn1178","volume":"4","author":"JS Simons","year":"2003","unstructured":"Simons JS, Spiers HJ . Prefrontal and medial temporal lobe interactions in long-term memory. Nat Rev Neurosci 2003; 4: 637\u2013648.","journal-title":"Nat Rev Neurosci"},{"key":"BFmp20164_CR18","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1126\/science.1152882","volume":"319","author":"A Bakker","year":"2008","unstructured":"Bakker A, Kirwan CB, Miller M, Stark CE . Pattern separation in the human hippocampal CA3 and dentate gyrus. Science 2008; 319: 1640\u20131642.","journal-title":"Science"},{"key":"BFmp20164_CR19","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1126\/science.1135801","volume":"315","author":"JK Leutgeb","year":"2007","unstructured":"Leutgeb JK, Leutgeb S, Moser MB, Moser EI . Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 2007; 315: 961\u2013966.","journal-title":"Science"},{"key":"BFmp20164_CR20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1126\/science.1140263","volume":"317","author":"TJ McHugh","year":"2007","unstructured":"McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK et al. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 2007; 317: 94\u201399.","journal-title":"Science"},{"key":"BFmp20164_CR21","first-page":"98","volume":"7","author":"ET Rolls","year":"2013","unstructured":"Rolls ET . A quantitative theory of the functions of the hippocampal CA3 network in memory. Front Cell Neurosci 2013; 7: 98.","journal-title":"Front Cell Neurosci"},{"key":"BFmp20164_CR22","doi-asserted-by":"publisher","first-page":"19462","DOI":"10.1073\/pnas.1214107109","volume":"109","author":"EA Mankin","year":"2012","unstructured":"Mankin EA, Sparks FT, Slayyeh B, Sutherland RJ, Leutgeb S, Leutgeb JK . Neuronal code for extended time in the hippocampus. Proc Natl Acad Sci USA 2012; 109: 19462\u201319467.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFmp20164_CR23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3389\/fnhum.2012.00290","volume":"6","author":"HM Bonnici","year":"2012","unstructured":"Bonnici HM, Chadwick MJ, Kumaran D, Hassabis D, Weiskopf N, Maguire EA . Multi-voxel pattern analysis in human hippocampal subfields. Front Hum Neurosci 2012; 6: 290.","journal-title":"Front Hum Neurosci"},{"key":"BFmp20164_CR24","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.neuroimage.2010.06.040","volume":"53","author":"PA Yushkevich","year":"2010","unstructured":"Yushkevich PA, Wang H, Pluta J, Das SR, Craige C, Avants BB et al. Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI. Neuroimage 2010; 53: 1208\u20131224.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR25","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.neuroimage.2008.09.016","volume":"44","author":"MA Yassa","year":"2009","unstructured":"Yassa MA, Stark CE . A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe. Neuroimage 2009; 44: 319\u2013327.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1101\/lm.1971111","volume":"18","author":"JW Lacy","year":"2011","unstructured":"Lacy JW, Yassa MA, Stark SM, Muftuler LT, Stark CE . Distinct pattern separation related transfer functions in human CA3\/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn Mem 2011; 18: 15\u201318.","journal-title":"Learn Mem"},{"key":"BFmp20164_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuroimage.2009.03.017","volume":"47","author":"AD Ekstrom","year":"2009","unstructured":"Ekstrom AD, Bazih AJ, Suthana NA, Al-Hakim R, Ogura K, Zeineh M et al. Advances in high-resolution imaging and computational unfolding of the human hippocampus. Neuroimage 2009; 47: 42\u201349.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.neuroimage.2013.02.003","volume":"74","author":"JL Winterburn","year":"2013","unstructured":"Winterburn JL, Pruessner JC, Chavez S, Schira MM, Lobaugh NJ, Voineskos AN et al. A novel in vivo atlas of human hippocampal subfields using high-resolution 3 T magnetic resonance imaging. Neuroimage 2013; 74: 254\u2013265.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR29","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/j.neuroimage.2003.11.011","volume":"21","author":"KL Narr","year":"2004","unstructured":"Narr KL, Thompson PM, Szeszko P, Robinson D, Jang S, Woods RP et al. Regional specificity of hippocampal volume reductions in first-episode schizophrenia. Neuroimage 2004; 21: 1563\u20131575.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR30","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1093\/brain\/aws335","volume":"136","author":"KC Zierhut","year":"2013","unstructured":"Zierhut KC, Grassmann R, Kaufmann J, Steiner J, Bogerts B, Schiltz K . Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophrenia. Brain 2013; 136: 804\u2013814.","journal-title":"Brain"},{"key":"BFmp20164_CR31","doi-asserted-by":"publisher","first-page":"e127","DOI":"10.1038\/tp.2012.51","volume":"2","author":"S Kuhn","year":"2012","unstructured":"Kuhn S, Musso F, Mobascher A, Warbrick T, Winterer G, Gallinat J . Hippocampal subfields predict positive symptoms in schizophrenia: first evidence from brain morphometry. Transl Psychiatry 2012; 2: e127.","journal-title":"Transl Psychiatry"},{"key":"BFmp20164_CR32","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1001\/jamapsychiatry.2014.453","volume":"71","author":"I Mathew","year":"2014","unstructured":"Mathew I, Gardin TM, Tandon N, Eack S, Francis AN, Seidman LJ et al. Medial temporal lobe structures and hippocampal subfields in psychotic disorders: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Study. JAMA Psychiatry 2014; 71: 769\u2013777.","journal-title":"JAMA Psychiatry"},{"key":"BFmp20164_CR33","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.biopsych.2014.06.020","volume":"77","author":"UK Haukvik","year":"2014","unstructured":"Haukvik UK, Westlye LT, Morch-Johnsen L, Jorgensen KN, Lange EH, Dale AM et al. In vivo hippocampal subfield volumes in schizophrenia and bipolar disorder. Biol Psychiatry 2014; 77: 581\u2013588.","journal-title":"Biol Psychiatry"},{"key":"BFmp20164_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3233\/JAD-2012-111931","volume":"31","author":"J Pluta","year":"2012","unstructured":"Pluta J, Yushkevich P, Das S, Wolk D . In vivo analysis of hippocampal subfield atrophy in mild cognitive impairment via semi-automatic segmentation of T2-weighted MRI. J Alzheimer' Dis 2012; 31: 85\u201399.","journal-title":"J Alzheimer' Dis"},{"key":"BFmp20164_CR35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","volume":"115","author":"JEAJ Iglesias","year":"2015","unstructured":"Iglesias JE AJ, Nguyen K, Player CM, Player A, Wright M, Roy N et al. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI. Neuroimage 2015; 115: 117\u2013137.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR36","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fnagi.2014.00261","volume":"6","author":"LE Wisse","year":"2014","unstructured":"Wisse LE, Biessels GJ, Geerlings MI . A critical appraisal of the hippocampal subfield segmentation package in FreeSurfer. Front Aging Neurosci 2014; 6: 261.","journal-title":"Front Aging Neurosci"},{"key":"BFmp20164_CR37","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","volume":"115","author":"JE Iglesias","year":"2015","unstructured":"Iglesias JE, Augustinack JC, Nguyen K, Player CM, Player A, Wright M et al. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI. Neuroimage 2015; 115: 117\u2013137.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR38","unstructured":"First MBSR, Gibbon M, Williams JBW . Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition With Psychotic Screen Biometrics Research, New York State Psychiatric Institute: New York, 2002."},{"key":"BFmp20164_CR39","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","volume":"13","author":"SR Kay","year":"1987","unstructured":"Kay SR, Fiszbein A, Opler LA . The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261\u2013276.","journal-title":"Schizophr Bull"},{"key":"BFmp20164_CR40","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.neuroimage.2004.07.016","volume":"23","author":"B Fischl","year":"2004","unstructured":"Fischl B, Salat DH, van der Kouwe AJ, Makris N, Segonne F, Quinn BT et al. Sequence-independent segmentation of magnetic resonance images. Neuroimage 2004; 23: S69\u2013S84.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/nimg.1998.0395","volume":"9","author":"AM Dale","year":"1999","unstructured":"Dale AM, Fischl B, Sereno MI . Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999; 9: 179\u2013194.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR42","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002; 33: 341\u2013355.","journal-title":"Neuron"},{"key":"BFmp20164_CR43","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1006\/nimg.1998.0396","volume":"9","author":"B Fischl","year":"1999","unstructured":"Fischl B, Sereno MI, Dale AM . Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system. Neuroimage 1999; 9: 195\u2013207.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR44","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","volume":"61","author":"M Reuter","year":"2012","unstructured":"Reuter M, Schmansky NJ, Rosas HD, Fischl B . Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage 2012; 61: 1402\u20131418.","journal-title":"Neuroimage"},{"key":"BFmp20164_CR45","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1002\/hipo.20615","volume":"19","author":"K Van Leemput","year":"2009","unstructured":"Van Leemput K, Bakkour A, Benner T, Wiggins G, Wald LL, Augustinack J et al. Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI. Hippocampus 2009; 19: 549\u2013557.","journal-title":"Hippocampus"},{"key":"BFmp20164_CR46","unstructured":"The R Core Team. R: A language and environment for statistical computing. R foundation for statistical computing. Vienna, Austria, 2014."},{"key":"BFmp20164_CR47","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.biopsych.2007.01.004","volume":"63","author":"NE van Haren","year":"2008","unstructured":"van Haren NE, Hulshoff Pol HE, Schnack HG, Cahn W, Brans R, Carati I et al. Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood. Biol Psychiatry 2008; 63: 106\u2013113.","journal-title":"Biol Psychiatry"},{"key":"BFmp20164_CR48","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1176\/appi.ajp.2010.10050681","volume":"168","author":"A Mattai","year":"2011","unstructured":"Mattai A, Hosanagar A, Weisinger B, Greenstein D, Stidd R, Clasen L et al. Hippocampal volume development in healthy siblings of childhood-onset schizophrenia patients. Am J Psychiatry 2011; 168: 427\u2013435.","journal-title":"Am J Psychiatry"},{"key":"BFmp20164_CR49","first-page":"423","volume":"33","author":"T Frodl","year":"2008","unstructured":"Frodl T, Jager M, Smajstrlova I, Born C, Bottlender R, Palladino T et al. Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study. J Psychiatry Neurosci 2008; 33: 423\u2013430.","journal-title":"J Psychiatry Neurosci"},{"key":"BFmp20164_CR50","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/sj.npp.1301405","volume":"33","author":"K Yucel","year":"2008","unstructured":"Yucel K, Taylor VH, McKinnon MC, Macdonald K, Alda M, Young LT et al. Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment. Neuropsychopharmacology 2008; 33: 361\u2013367.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp20164_CR51","first-page":"65","volume":"6","author":"S Holm","year":"1979","unstructured":"Holm S . A simple sequentially rejective multiple test procedure. Scand J Stat 1979; 6: 65\u201370.","journal-title":"Scand J Stat"},{"key":"BFmp20164_CR52","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1001\/archpsyc.56.2.133","volume":"56","author":"D Velakoulis","year":"1999","unstructured":"Velakoulis D, Pantelis C, McGorry PD, Dudgeon P, Brewer W, Cook M et al. Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Arch Gen Psychiatry 1999; 56: 133\u2013141.","journal-title":"Arch Gen Psychiatry"},{"key":"BFmp20164_CR53","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1192\/bjp.186.1.26","volume":"186","author":"MH Chakos","year":"2005","unstructured":"Chakos MH, Schobel SA, Gu H, Gerig G, Bradford D, Charles C et al. Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Br J Psychiatry 2005; 186: 26\u201331.","journal-title":"Br J Psychiatry"},{"key":"BFmp20164_CR54","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S0006-3223(99)00136-5","volume":"46","author":"FM Benes","year":"1999","unstructured":"Benes FM . Evidence for altered trisynaptic circuitry in schizophrenic hippocampus. Biol Psychiatry 1999; 46: 589\u2013599.","journal-title":"Biol Psychiatry"},{"key":"BFmp20164_CR55","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.neuron.2013.02.011","volume":"78","author":"SA Schobel","year":"2013","unstructured":"Schobel SA, Chaudhury NH, Khan UA, Paniagua B, Styner MA, Asllani I et al. Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver. Neuron 2013; 78: 81\u201393.","journal-title":"Neuron"},{"key":"BFmp20164_CR56","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1001\/archgenpsychiatry.2009.115","volume":"66","author":"SA Schobel","year":"2009","unstructured":"Schobel SA, Lewandowski NM, Corcoran CM, Moore H, Brown T, Malaspina D et al. Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders. Arch Gen Psychiatry 2009; 66: 938\u2013946.","journal-title":"Arch Gen Psychiatry"},{"key":"BFmp20164_CR57","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.nicl.2014.07.004","volume":"5","author":"P Talati","year":"2014","unstructured":"Talati P, Rane S, Kose S, Blackford JU, Gore J, Donahue MJ et al. Increased hippocampal CA1 cerebral blood volume in schizophrenia. Neuroimage Clin 2014; 5: 359\u2013364.","journal-title":"Neuroimage Clin"},{"key":"BFmp20164_CR58","doi-asserted-by":"publisher","first-page":"4718","DOI":"10.1002\/hbm.22506","volume":"35","author":"JC Schoene-Bake","year":"2014","unstructured":"Schoene-Bake JC, Keller SS, Niehusmann P, Volmering E, Elger C, Deppe M et al. In vivo mapping of hippocampal subfields in mesial temporal lobe epilepsy: relation to histopathology. Hum Brain Map 2014; 35: 4718\u20134728.","journal-title":"Hum Brain Map"},{"key":"BFmp20164_CR59","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.molbrainres.2004.12.005","volume":"135","author":"SJ Coultrap","year":"2005","unstructured":"Coultrap SJ, Nixon KM, Alvestad RM, Valenzuela CF, Browning MD . Differential expression of NMDA receptor subunits and splice variants among the CA1, CA3 and dentate gyrus of the adult rat. Brain Res Mol Brain Res 2005; 135: 104\u2013111.","journal-title":"Brain Res Mol Brain Res"},{"key":"BFmp20164_CR60","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.schres.2011.06.007","volume":"131","author":"C Konradi","year":"2011","unstructured":"Konradi C, Yang CK, Zimmerman EI, Lohmann KM, Gresch P, Pantazopoulos H et al. Hippocampal interneurons are abnormal in schizophrenia. Schizophr Res 2011; 131: 165\u2013173.","journal-title":"Schizophr Res"},{"key":"BFmp20164_CR61","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.schres.2014.09.041","volume":"167","author":"S Heckers","year":"2015","unstructured":"Heckers S, Konradi C . GABAergic mechanisms of hippocampal hyperactivity in schizophrenia. Schizophr Res 2015; 167: 4\u201311.","journal-title":"Schizophr Res"},{"key":"BFmp20164_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0893-133X(01)00225-1","volume":"25","author":"FM Benes","year":"2001","unstructured":"Benes FM, Berretta S . GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 2001; 25: 1\u201327.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp20164_CR63","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/7854_2010_43","volume":"4","author":"S Heckers","year":"2010","unstructured":"Heckers S, Konradi C . Hippocampal pathology in schizophrenia. Curr Topics Behav Neurosci 2010; 4: 529\u2013553.","journal-title":"Curr Topics Behav Neurosci"},{"key":"BFmp20164_CR64","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.tins.2008.02.005","volume":"31","author":"JE Lisman","year":"2008","unstructured":"Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci 2008; 31: 234\u2013242.","journal-title":"Trends Neurosci"},{"key":"BFmp20164_CR65","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/npp.2011.181","volume":"37","author":"B Moghaddam","year":"2012","unstructured":"Moghaddam B, Javitt D . From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology 2012; 37: 4\u201315.","journal-title":"Neuropsychopharmacology"},{"key":"BFmp20164_CR66","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.tips.2011.05.001","volume":"32","author":"DJ Lodge","year":"2011","unstructured":"Lodge DJ, Grace AA . Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia. Trends Pharmacol Sci 2011; 32: 507\u2013513.","journal-title":"Trends Pharmacol Sci"},{"key":"BFmp20164_CR67","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1016\/j.neubiorev.2013.06.001","volume":"37","author":"P Fusar-Poli","year":"2013","unstructured":"Fusar-Poli P, Smieskova R, Kempton MJ, Ho BC, Andreasen NC, Borgwardt S . Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neurosci Biobehav Rev 2013; 37: 1680\u20131691.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFmp20164_CR68","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.4088\/JCP.10m06745","volume":"72","author":"V Mondelli","year":"2011","unstructured":"Mondelli V, Cattaneo A, Belvederi Murri M, Di Forti M, Handley R, Hepgul N et al. Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. J Clin Psychiatry 2011; 72: 1677\u20131684.","journal-title":"J Clin Psychiatry"},{"key":"BFmp20164_CR69","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jpsychires.2013.12.004","volume":"50","author":"CE Schneider","year":"2014","unstructured":"Schneider CE, White T, Hass J, Geisler D, Wallace SR, Roessner V et al. Smoking status as a potential confounder in the study of brain structure in schizophrenia. J Psychiatr Res 2014; 50: 84\u201391.","journal-title":"J Psychiatr Res"},{"key":"BFmp20164_CR70","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1002\/hipo.22427","volume":"25","author":"MJ Smith","year":"2015","unstructured":"Smith MJ, Cobia DJ, Reilly JL, Gilman JM, Roberts AG, Alpert KI et al. Cannabis-related episodic memory deficits and hippocampal morphological differences in healthy individuals and schizophrenia subjects. Hippocampus 2015; 25: 1042\u20131051.","journal-title":"Hippocampus"},{"key":"BFmp20164_CR71","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.schres.2012.10.040","volume":"143","author":"N Solowij","year":"2013","unstructured":"Solowij N, Walterfang M, Lubman DI, Whittle S, Lorenzetti V, Styner M et al. Alteration to hippocampal shape in cannabis users with and without schizophrenia. Schizophr Res 2013; 143: 179\u2013184.","journal-title":"Schizophr Res"},{"key":"BFmp20164_CR72","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1192\/bjp.bp.114.151407","volume":"206","author":"V Lorenzetti","year":"2015","unstructured":"Lorenzetti V, Solowij N, Whittle S, Fornito A, Lubman DI, Pantelis C et al. Gross morphological brain changes with chronic, heavy cannabis use. Br J Psychiatry 2015; 206: 77\u201378.","journal-title":"Br J Psychiatry"},{"key":"BFmp20164_CR73","doi-asserted-by":"publisher","first-page":"183","DOI":"10.4088\/JCP.v66n0205","volume":"66","author":"DC Goff","year":"2005","unstructured":"Goff DC, Cather C, Evins AE, Henderson DC, Freudenreich O, Copeland PM et al. Medical morbidity and mortality in schizophrenia: guidelines for psychiatrists. J Clin Psychiatry 2005; 66: 183\u2013194, quiz 147, 273-184.","journal-title":"J Clin Psychiatry"},{"key":"BFmp20164_CR74","doi-asserted-by":"publisher","first-page":"e71343","DOI":"10.1371\/journal.pone.0071343","volume":"8","author":"J Jiang","year":"2013","unstructured":"Jiang J, See YM, Subramaniam M, Lee J . Investigation of cigarette smoking among male schizophrenia patients. PLoS One 2013; 8: e71343.","journal-title":"PLoS One"},{"key":"BFmp20164_CR75","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1192\/bjp.bp.111.105700","volume":"202","author":"P Brambilla","year":"2013","unstructured":"Brambilla P, Perlini C, Rajagopalan P, Saharan P, Rambaldelli G, Bellani M et al. Schizophrenia severity, social functioning and hippocampal neuroanatomy: three-dimensional mapping study. Br J Psychiatry 2013; 202: 50\u201355.","journal-title":"Br J Psychiatry"},{"key":"BFmp20164_CR76","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/schbul\/sbs135","volume":"39","author":"RB Zipursky","year":"2013","unstructured":"Zipursky RB, Reilly TJ, Murray RM . The myth of schizophrenia as a progressive brain disease. Schizophr Bull 2013; 39: 1363\u20131372.","journal-title":"Schizophr Bull"},{"issue":"6","key":"BFmp20164_CR77","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/mp.2015.69","volume":"21","author":"L Schmaal","year":"2015","unstructured":"Schmaal L, Veltman DJ, van Erp TG, Samann PG, Frodl T, Jahanshad N et al. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. Mol Psychiatry 2015; e-pub ahead of print 30 June 2015; doi:10.1038\/mp.2015.69.","journal-title":"Molecular Psychiatry"},{"key":"BFmp20164_CR78","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1148\/radiol.2512081548","volume":"251","author":"S Lui","year":"2009","unstructured":"Lui S, Parkes LM, Huang X, Zou K, Chan RC, Yang H et al. Depressive disorders: focally altered cerebral perfusion measured with arterial spin-labeling MR imaging. Radiology 2009; 251: 476\u2013484.","journal-title":"Radiology"},{"key":"BFmp20164_CR79","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1034\/j.1600-0447.2002.02245.x","volume":"106","author":"P Videbech","year":"2002","unstructured":"Videbech P, Ravnkilde B, Pedersen TH, Hartvig H, Egander A, Clemmensen K et al. The Danish PET\/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis. Acta Psychiatr Scand 2002; 106: 35\u201344.","journal-title":"Acta Psychiatr Scand"},{"key":"BFmp20164_CR80","first-page":"1053","volume":"65","author":"AM Brickman","year":"2008","unstructured":"Brickman AM, Schupf N, Manly JJ, Luchsinger JA, Andrews H, Tang MX et al. Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan. Arch Neurol 2008; 65: 1053\u20131061.","journal-title":"Arch Neurol"},{"key":"BFmp20164_CR81","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1162\/jocn.2010.21513","volume":"23","author":"MW Chee","year":"2011","unstructured":"Chee MW, Zheng H, Goh JO, Park D, Sutton BP . Brain structure in young and old East Asians and Westerners: comparisons of structural volume and cortical thickness. J Cogn Neurosci 2011; 23: 1065\u20131079.","journal-title":"J Cogn Neurosci"},{"key":"BFmp20164_CR82","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pscychresns.2009.10.013","volume":"182","author":"Y Yang","year":"2010","unstructured":"Yang Y, Raine A, Han CB, Schug RA, Toga AW, Narr KL . Reduced hippocampal and parahippocampal volumes in murderers with schizophrenia. Psychiatry Res 2010; 182: 9\u201313.","journal-title":"Psychiatry Res"},{"key":"BFmp20164_CR83","doi-asserted-by":"publisher","first-page":"e96021","DOI":"10.1371\/journal.pone.0096021","volume":"9","author":"SV Kalmady","year":"2014","unstructured":"Kalmady SV, Venkatasubramanian G, Shivakumar V, Gautham S, Subramaniam A, Jose DA et al. Relationship between Interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naive schizophrenia: evidence for differential susceptibility? PLoS One 2014; 9: e96021.","journal-title":"PLoS One"},{"key":"BFmp20164_CR84","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/hbm.20106","volume":"25","author":"SH Kim","year":"2005","unstructured":"Kim SH, Lee JM, Kim HP, Jang DP, Shin YW, Ha TH et al. Asymmetry analysis of deformable hippocampal model using the principal component in schizophrenia. Hum Brain Map 2005; 25: 361\u2013369.","journal-title":"Hum Brain Map"},{"key":"BFmp20164_CR85","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pscychresns.2004.05.004","volume":"131","author":"H Yamasue","year":"2004","unstructured":"Yamasue H, Iwanami A, Hirayasu Y, Yamada H, Abe O, Kuroki N et al. Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation study. Psychiatry Res 2004; 131: 195\u2013207.","journal-title":"Psychiatry Res"},{"key":"BFmp20164_CR86","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1176\/jnp.2009.21.1.24","volume":"21","author":"S Verma","year":"2009","unstructured":"Verma S, Sitoh YY, Ho YC, Poon LY, Subramaniam M, Chan YH et al. Hippocampal volumes in first-episode psychosis. J Neuropsychiatry Clin Neurosci 2009; 21: 24\u201329.","journal-title":"J Neuropsychiatry Clin Neurosci"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/mp20164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mp20164","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/mp20164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:16:36Z","timestamp":1684419396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/mp20164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["BFmp20164"],"URL":"https:\/\/doi.org\/10.1038\/mp.2016.4","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]},"assertion":[{"value":"13 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}