{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:31:35Z","timestamp":1792405895317,"version":"4.4.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T00:00:00Z","timestamp":1187049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T00:00:00Z","timestamp":1187049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Syst Biol"],"published-print":{"date-parts":[[2007,8,14]]},"DOI":"10.1038\/msb4100173","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T08:11:07Z","timestamp":1187079067000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":328,"title":["Environmental signal integration by a modular AND gate"],"prefix":"10.1038","volume":"3","author":[{"given":"J Christopher","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P","family":"Arkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,8,14]]},"reference":[{"key":"BFMSB4100173_CR1","doi-asserted-by":"crossref","first-page":"7060","DOI":"10.1073\/pnas.092071899","volume":"99","author":"P Ames","year":"2002","unstructured":"Ames P, Studdert CA, Reiser RH, Parkinson JS (2002) Collaborative signaling by mixed chemoreceptor teams in Escherichia coli. Proc Natl Acad Sci USA 99: 7060\u20137065","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFMSB4100173_CR2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jmb.2005.10.076","volume":"355","author":"JC Anderson","year":"2006","unstructured":"Anderson JC, Clarke EJ, Arkin AP, Voigt CA (2006) Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol 355: 619\u2013627","journal-title":"J Mol Biol"},{"key":"BFMSB4100173_CR3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1074-5521(02)00094-7","volume":"9","author":"JC Anderson","year":"2002","unstructured":"Anderson JC, Magliery TJ, Schultz PG (2002) Exploring the limits of codon and anticodon size. Chem Biol 9: 237\u2013244","journal-title":"Chem Biol"},{"key":"BFMSB4100173_CR4","doi-asserted-by":"publisher","unstructured":"Andrianantoandro E, Basu S, Karig DK, Weiss R (2006) Synthetic biology: new engineering rules for an emerging discipline. Mol Syst Biol 2, 2006.0028 https:\/\/doi.org\/10.1038\/msb4100073","DOI":"10.1038\/msb4100073"},{"key":"BFMSB4100173_CR5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cell.2006.04.001","volume":"125","author":"BL Bassler","year":"2006","unstructured":"Bassler BL, Losick R (2006) Bacterially speaking. Cell 125: 237\u2013246","journal-title":"Cell"},{"key":"BFMSB4100173_CR6","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nature03461","volume":"434","author":"S Basu","year":"2005","unstructured":"Basu S, Gerchman Y, Collins CH, Arnold FH, Weiss R (2005) A synthetic multicellular system for programmed pattern formation. Nature 434: 1130\u20131134","journal-title":"Nature"},{"key":"BFMSB4100173_CR7","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1073\/pnas.0307571101","volume":"101","author":"S Basu","year":"2004","unstructured":"Basu S, Mehreja R, Thiberge S, Chen MT, Weiss R (2004) Spatiotemporal control of gene expression with pulse\u2010generating networks. Proc Natl Acad Sci USA 101: 6355\u20136360","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFMSB4100173_CR8","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1126\/science.277.5331.1453","volume":"277","author":"FR Blattner","year":"1997","unstructured":"Blattner FR, Plunkett Gr, Bloch CA, Perna NT, Burland V, Riley M, Collado\u2010Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y (1997) The complete genome sequence of Escherichia coli K\u201012. Science 277: 1453\u20131474","journal-title":"Science"},{"key":"BFMSB4100173_CR9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.sbi.2006.06.011","volume":"16","author":"JW Chin","year":"2006","unstructured":"Chin JW (2006) Programming and engineering biological networks. Curr Opin Struct Biol 16: 551\u2013556","journal-title":"Curr Opin Struct Biol"},{"key":"BFMSB4100173_CR10","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1126\/science.1085945","volume":"301","author":"JE Dueber","year":"2003","unstructured":"Dueber JE, Yeh BJ, Chak K, Lim WA (2003) Reprogramming control of an allosteric signaling switch through modular recombination. Science 301: 1904\u20131908","journal-title":"Science"},{"key":"BFMSB4100173_CR11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nature04342","volume":"438","author":"D Endy","year":"2005","unstructured":"Endy D (2005) Foundations for engineering biology. Nature 438: 449\u2013453","journal-title":"Nature"},{"key":"BFMSB4100173_CR12","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1529\/biophysj.104.044131","volume":"87","author":"XJ Feng","year":"2004","unstructured":"Feng XJ, Hooshangi S, Chen D, Li GY, Weiss R, Rabitz H (2004) Optimizing genetic circuits by global sensitivity analysis. Biophys J 87: 2195\u20132202","journal-title":"Biophys J"},{"key":"BFMSB4100173_CR13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jtbi.2005.08.007","volume":"239","author":"MA Gilchrist","year":"2006","unstructured":"Gilchrist MA, Wagner A (2006) A model of protein translation including codon bias, nonsense errors, and ribosome recycling. J Theor Biol 239: 417\u2013434","journal-title":"J Theor Biol"},{"key":"BFMSB4100173_CR14","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1067407","volume":"296","author":"CC Guet","year":"2002","unstructured":"Guet CC, Elowitz MB, Hsing W, Leibler S (2002) Combinatorial synthesis of genetic networks. Science 296: 1466\u20131470","journal-title":"Science"},{"key":"BFMSB4100173_CR15","doi-asserted-by":"crossref","DOI":"10.1128\/9781555818319","volume-title":"Two\u2010Component Signal Transduction","author":"JA Hoch","year":"1995","unstructured":"Hoch JA, Silhavy TJ (1995) Two\u2010Component Signal Transduction. ASM Press: Washington DC"},{"key":"BFMSB4100173_CR16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1128\/jb.103.1.32-36.1970","volume":"103","author":"EP Hoffman","year":"1970","unstructured":"Hoffman EP, Wilhelm RC (1970) Genetic mapping and dominance of the amber suppressor, Su1 (supD), in Escherichia coli K\u201012. J Bacteriol 103: 32\u201336","journal-title":"J Bacteriol"},{"key":"BFMSB4100173_CR17","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nbt986","volume":"22","author":"FJ Isaacs","year":"2004","unstructured":"Isaacs FJ, Dwyer DJ, Ding C, Pervouchine DD, Cantor CR, Collins JJ (2004) Engineered riboregulators enable post\u2010transcriptional control of gene expression. Nat Biotechnol 22: 841\u2013847","journal-title":"Nat Biotechnol"},{"key":"BFMSB4100173_CR18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0092-8674(87)90335-7","volume":"50","author":"RR Isberg","year":"1987","unstructured":"Isberg RR, Voorhis DL, Falkow S (1987) Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell 50: 769\u2013778","journal-title":"Cell"},{"key":"BFMSB4100173_CR19","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1128\/JB.181.17.5516-5520.1999","volume":"181","author":"A Kato","year":"1999","unstructured":"Kato A, Tanabe H, Utsumi R (1999) Molecular characterization of the PhoP\u2010PhoQ two\u2010component system in Escherichia coli K\u201012: identification of extracellular Mg2+\u2010responsive promoters. J Bacteriol 181: 5516\u20135520","journal-title":"J Bacteriol"},{"key":"BFMSB4100173_CR20","unstructured":"Knight TK, Sussman GJ (1997) Cellular gate technology. Unconventional Models of Computation 257\u2013272"},{"key":"BFMSB4100173_CR21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/bit.20142","volume":"87","author":"BP Kramer","year":"2004","unstructured":"Kramer BP, Fischer C, Fussenegger M (2004) BioLogic gates enable logical transcription control in mammalian cells. Biotechnol Bioeng 87: 478\u2013484","journal-title":"Biotechnol Bioeng"},{"key":"BFMSB4100173_CR22","doi-asserted-by":"crossref","first-page":"W516","DOI":"10.1093\/nar\/gkl209","volume":"34","author":"JG Mandell","year":"2006","unstructured":"Mandell JG, Barbas CFr (2006) Zinc Finger Tools: custom DNA\u2010binding domains for transcription factors and nucleases. Nucleic Acids Res 34: W516\u2013W523","journal-title":"Nucleic Acids Res"},{"key":"BFMSB4100173_CR23","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1094\/MPMI.2000.13.11.1243","volume":"13","author":"WG Miller","year":"2000","unstructured":"Miller WG, Leveau JH, Lindow SE (2000) Improved gfp and inaZ broad\u2010host\u2010range promoter\u2013probe vectors. Mol Plant Microbe Interact 13: 1243\u20131250","journal-title":"Mol Plant Microbe Interact"},{"key":"BFMSB4100173_CR24","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1128\/JB.185.13.3696-3702.2003","volume":"185","author":"S Minagawa","year":"2003","unstructured":"Minagawa S, Ogasawara H, Kato A, Yamamoto K, Eguchi Y, Oshima T, Mori H, Ishihama A, Utsumi R (2003) Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli. J Bacteriol 185: 3696\u20133702","journal-title":"J Bacteriol"},{"key":"BFMSB4100173_CR25","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/nbt742","volume":"20","author":"SW Santoro","year":"2002","unstructured":"Santoro SW, Wang L, Herberich B, King DS, Schultz PG (2002) An efficient system for the evolution of aminoacyl\u2010tRNA synthetase specificity. Nat Biotechnol 20: 1044\u20131048","journal-title":"Nat Biotechnol"},{"key":"BFMSB4100173_CR26","doi-asserted-by":"crossref","first-page":"7702","DOI":"10.1073\/pnas.1230759100","volume":"100","author":"Y Setty","year":"2003","unstructured":"Setty Y, Mayo AE, Surette MG, Alon U (2003) Detailed map of a cis\u2010regulatory input function. Proc Natl Acad Sci USA 100: 7702\u20137707","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFMSB4100173_CR27","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-2958.1995.mmi_17050801.x","volume":"17","author":"DM Sitnikov","year":"1995","unstructured":"Sitnikov DM, Schineller JB, Baldwin TO (1995) Transcriptional regulation of bioluminesence genes from Vibrio fischeri. Mol Microbiol 17: 801\u2013812","journal-title":"Mol Microbiol"},{"key":"BFMSB4100173_CR28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1039\/B618473C","volume":"3","author":"C Tan","year":"2007","unstructured":"Tan C, Song H, Niemi J, You L (2007) A synthetic biology challenge: making cells compute. Mol Biosyst 3: 343\u2013353","journal-title":"Mol Biosyst"},{"key":"BFMSB4100173_CR29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.copbio.2006.09.001","volume":"17","author":"CA Voigt","year":"2006","unstructured":"Voigt CA (2006) Genetic devices to program bacteria. Curr Opin Biotech 17: 548\u2013557","journal-title":"Curr Opin Biotech"},{"key":"BFMSB4100173_CR30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.biophys.35.101105.121507","volume":"35","author":"L Wang","year":"2006","unstructured":"Wang L, Xie J, Schultz PG (2006) Expanding the genetic code. Annu Rev Biophys Biomol Struct 35: 225\u2013249","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"BFMSB4100173_CR31","unstructured":"Weiss R, Homsy GE, Knight TF (1999) Toward in vivo digital circuits. In: DIMACS Workshop on Evolution as Computation. Princeton University"},{"key":"BFMSB4100173_CR32","doi-asserted-by":"crossref","first-page":"16587","DOI":"10.1073\/pnas.252535999","volume":"99","author":"Y Yokobayashi","year":"2002","unstructured":"Yokobayashi Y, Weiss R, Arnold FH (2002) Directed evolution of a genetic circuit. Proc Natl Acad Sci USA 99: 16587\u201316591","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFMSB4100173_CR33","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature02491","volume":"428","author":"L You","year":"2004","unstructured":"You L, Cox Sr R, Weiss R, Arnold FH (2004) Programmed population control by cell\u2013cell communication and regulated killing. Nature 428: 868\u2013871","journal-title":"Nature"}],"container-title":["Molecular Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fmsb4100173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/msb4100173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1038\/msb4100173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/msb4100173\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.1038\/msb4100173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/msb4100173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T19:28:00Z","timestamp":1779737280000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/msb4100173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,14]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,8,14]]}},"alternative-id":["BFMSB4100173"],"URL":"https:\/\/doi.org\/10.1038\/msb4100173","relation":{},"ISSN":["1744-4292"],"issn-type":[{"value":"1744-4292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,14]]},"assertion":[{"value":"12 March 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"MSB4100173"}}