{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:34:34Z","timestamp":1771493674681,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":2624,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1038\/mt.2009.114","type":"journal-article","created":{"date-parts":[[2009,5,26]],"date-time":"2009-05-26T14:03:40Z","timestamp":1243346620000},"page":"1373-1380","source":"Crossref","is-referenced-by-count":5,"title":["Abrogation of Microsatellite-instable Tumors Using a Highly Selective Suicide Gene\/Prodrug Combination"],"prefix":"10.1016","volume":"17","author":[{"given":"Cristina","family":"Ferr\u00e1s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim AF","family":"Oude Vrielink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan WA","family":"Verspuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein","family":"te Riele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Tsaalbi-Shtylik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"de Wind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2009.114_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/cr.2007.115","article-title":"Mechanisms and functions of DNA mismatch repair","volume":"18","author":"Li","year":"2008","journal-title":"Cell Res"},{"key":"10.1038\/mt.2009.114_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.mad.2008.02.012","article-title":"DNA mismatch repair: molecular mechanism, cancer, and ageing","volume":"129","author":"Hsieh","year":"2008","journal-title":"Mech Ageing Dev"},{"key":"10.1038\/mt.2009.114_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/carcin\/bgm228","article-title":"Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics","volume":"29","author":"Imai","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1038\/mt.2009.114_bib4","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1038\/sj.onc.1206941","article-title":"A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage","volume":"22","author":"Meyers","year":"2003","journal-title":"Oncogene"},{"key":"10.1038\/mt.2009.114_bib5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejca.2008.07.016","article-title":"The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status","volume":"45","author":"Jover","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1038\/mt.2009.114_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcb.21824","article-title":"The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine","volume":"105","author":"Liu","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1038\/mt.2009.114_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO;2-H","article-title":"Gene directed enzyme\/prodrug therapy of cancer: historical appraisal and future prospectives","volume":"187","author":"Greco","year":"2001","journal-title":"J Cell Physiol"},{"key":"10.1038\/mt.2009.114_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/path.1896","article-title":"Viral gene therapy strategies: from basic science to clinical application","volume":"208","author":"Young","year":"2006","journal-title":"J Pathol"},{"key":"10.1038\/mt.2009.114_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mam.2006.12.001","article-title":"Suicide genes for cancer therapy","volume":"28","author":"Portsmouth","year":"2007","journal-title":"Mol Aspects Med"},{"key":"10.1038\/mt.2009.114_bib10","first-page":"3813","article-title":"In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase\/uracil phosphoribosyltransferase fusion gene","volume":"60","author":"Erbs","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.114_bib11","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/sj.gt.3301557","article-title":"In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase","volume":"8","author":"Chung-Faye","year":"2001","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2009.114_bib12","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.3748\/wjg.v11.i44.6910","article-title":"Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model","volume":"11","author":"Graepler","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1038\/mt.2009.114_bib13","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/jgm.944","article-title":"Combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice","volume":"8","author":"Khatri","year":"2006","journal-title":"J Gene Med"},{"key":"10.1038\/mt.2009.114_bib14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1099\/0022-1317-73-3-723","article-title":"The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49","volume":"73","author":"Elliott","year":"1992","journal-title":"J Gen Virol"},{"key":"10.1038\/mt.2009.114_bib15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/sj.mt.6300013","article-title":"Evidence for intercellular trafficking of VP22 in living cells","volume":"15","author":"Lemken","year":"2007","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2009.114_bib16","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00705-008-0094-x","article-title":"Efficient secretion of the herpes simplex virus tegument protein VP22 from living mammalian cells","volume":"153","author":"Mori","year":"2008","journal-title":"Arch Virol"},{"key":"10.1038\/mt.2009.114_bib17","first-page":"1153","article-title":"Fusion of HSV-1 VP22 to a bifunctional chimeric SuperCD suicide gene compensates for low suicide gene transduction efficiencies","volume":"30","author":"Lemken","year":"2007","journal-title":"Int J Oncol"},{"key":"10.1038\/mt.2009.114_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrg2141","article-title":"Engineering targeted viral vectors for gene therapy","volume":"8","author":"Waehler","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1038\/mt.2009.114_bib19","first-page":"5193","article-title":"Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses","volume":"61","author":"Meyers","year":"2001","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.114_bib20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/ng1045","article-title":"Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling","volume":"32","author":"Kielman","year":"2002","journal-title":"Nat Genet"},{"key":"10.1038\/mt.2009.114_bib21","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1074\/jbc.M412105200","article-title":"DNA mismatch repair-dependent response to fluoropyrimidine-generated damage","volume":"280","author":"Meyers","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1038\/mt.2009.114_bib22","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1053\/j.gastro.2007.09.003","article-title":"5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems","volume":"133","author":"Fischer","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1038\/mt.2009.114_bib23","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1073\/pnas.1030231100","article-title":"Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers","volume":"100","author":"Goodfellow","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2009.114_bib24","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1128\/MCB.17.5.2851","article-title":"Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes","volume":"17","author":"Sia","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1038\/mt.2009.114_bib25","first-page":"8113","article-title":"Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability","volume":"63","author":"Cejka","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.114_bib26","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/gt.2008.40","article-title":"Taming the Trojan horse: optimizing dynamic carrier cell\/oncolytic virus systems for cancer biotherapy","volume":"15","author":"Power","year":"2008","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2009.114_bib27","first-page":"d1516","article-title":"Cancer gene therapy: \u201cdelivery, delivery, delivery\u201d","volume":"7","author":"Greco","year":"2002","journal-title":"Front Biosci"},{"key":"10.1038\/mt.2009.114_bib28","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1038\/mt.2009.114_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0092-8674(95)90319-4","article-title":"Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer","volume":"82","author":"de Wind","year":"1995","journal-title":"Cell"},{"key":"10.1038\/mt.2009.114_bib30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/15544","article-title":"HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions","volume":"23","author":"de Wind","year":"1999","journal-title":"Nat Genet"},{"key":"10.1038\/mt.2009.114_bib31","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1073\/pnas.89.11.5128","article-title":"Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs","volume":"89","author":"te Riele","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2009.114_bib32","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/oxfordjournals.jbchem.a021860","article-title":"Efficiency of recombination by Cre transient expression in embryonic stem cells: comparison of various promoters","volume":"122","author":"Araki","year":"1997","journal-title":"J Biochem"},{"key":"10.1038\/mt.2009.114_bib33","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.dnarep.2008.04.015","article-title":"Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells","volume":"7","author":"Hendriks","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"10.1038\/mt.2009.114_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mrfmmm.2005.01.021","article-title":"Spontaneous and mutagen-induced loss of DNA mismatch repair in Msh2-heterozygous mammalian cells","volume":"574","author":"Borgdorff","year":"2005","journal-title":"Mutat Res"},{"key":"10.1038\/mt.2009.114_bib35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0076-6879(05)09012-9","article-title":"Methods for determining spontaneous mutation rates","volume":"409","author":"Foster","year":"2006","journal-title":"Meth Enzymol"},{"key":"10.1038\/mt.2009.114_bib36","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1053\/j.gastro.2008.01.015","article-title":"Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers","volume":"134","author":"Schwitalle","year":"2008","journal-title":"Gastroenterology"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616318585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616318585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T09:52:06Z","timestamp":1545213126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616318585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S1525001616318585"],"URL":"https:\/\/doi.org\/10.1038\/mt.2009.114","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}