{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:55:46Z","timestamp":1760608546485},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":2716,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1038\/mt.2009.32","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T11:28:14Z","timestamp":1236684494000},"page":"906-913","source":"Crossref","is-referenced-by-count":27,"title":["Adoptive Transfer of Human Papillomavirus E7-specific CTL Enhances Tumor Chemoresponse Through the Perforin\/Granzyme-mediated Pathway"],"prefix":"10.1016","volume":"17","author":[{"given":"Jeong-Im","family":"Sin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hwa","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Sup","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hun Mo","family":"Ryoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2009.32_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0042-6822(91)90816-T","article-title":"Human papillomaviruses in the pathogenesis of anogenital cancer","volume":"184","author":"zur Hausen","year":"1991","journal-title":"Virology"},{"key":"10.1038\/mt.2009.32_bib2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(01)05965-7","article-title":"Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis","volume":"358","author":"Green","year":"2001","journal-title":"Lancet"},{"key":"10.1038\/mt.2009.32_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4143\/crt.2005.37.1.37","article-title":"A preliminary results of a randomized trial comparing monthly 5-flourouracil and cisplatin to weekly cisplatin alone combined with concurrent radiotherapy for locally advanced cervical cancer","volume":"37","author":"Kim","year":"2005","journal-title":"Cancer Res Treat"},{"key":"10.1038\/mt.2009.32_bib4","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1056\/NEJM199904153401502","article-title":"Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer","volume":"340","author":"Rose","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1038\/mt.2009.32_bib5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1086\/513992","article-title":"Cytotoxic T lymphocyte responses to E6 and E7 proteins of human papillomavirus type 16: relationship to cervical intraepithelial neoplasia","volume":"175","author":"Nakagawa","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1038\/mt.2009.32_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1086\/315706","article-title":"Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens","volume":"182","author":"Nakagawa","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1038\/mt.2009.32_bib7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1158\/1078-0432.CCR-06-1838","article-title":"Therapeutic synergy of human papillomavirus E7 subunit vaccines plus cisplatin in an animal tumor model: causal involvement of increased sensitivity of cisplatin-treated tumors to CTL-mediated killing in therapeutic synergy","volume":"13","author":"Bae","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1038\/mt.2009.32_bib8","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/sj.mt.6300149","article-title":"Increased sensitivity of radiated murine cervical cancer tumors to E7 subunit vaccine-driven CTL-mediated killing induces synergistic antitumor activity","volume":"15","author":"Ye","year":"2007","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2009.32_bib9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1615\/CritRevImmunol.v15.i3-4.90","article-title":"Mechanisms of lysis by cytotoxic T cells","volume":"15","author":"Atkinson","year":"1995","journal-title":"Crit Rev Immunol"},{"key":"10.1038\/mt.2009.32_bib10","first-page":"17","article-title":"Killing mechanisms of cytotoxic T lymphocytes","volume":"13","author":"Groscurth","year":"1998","journal-title":"News Physiol Sci"},{"key":"10.1038\/mt.2009.32_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1074-7613(00)00026-1","article-title":"Eradication of established tumors by CD8+ T cell adoptive immunotherapy","volume":"13","author":"Hanson","year":"2000","journal-title":"Immunity"},{"key":"10.1038\/mt.2009.32_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1089\/dna.2006.25.277","article-title":"Antitumor therapeutic effects of E7 subunit and DNA vaccines in an animal cervical cancer model: antitumor efficacy of E7 therapeutic vaccines is dependent on tumor sizes, vaccine doses, and vaccine delivery routes","volume":"25","author":"Sin","year":"2006","journal-title":"DNA Cell Biol"},{"key":"10.1038\/mt.2009.32_bib13","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1158\/1078-0432.CCR-05-2750","article-title":"Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer","volume":"12","author":"Ferris","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1038\/mt.2009.32_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00262-006-0183-1","article-title":"Immune selective pressure and HLA class I antigen defects in malignant lesions","volume":"56","author":"Chang","year":"2007","journal-title":"Cancer Immunol Immunother"},{"key":"10.1038\/mt.2009.32_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nature03954","article-title":"Sporadic immunogenic tumors avoid destruction by inducing T-cell tolerance","volume":"437","author":"Willimsky","year":"2005","journal-title":"Nature"},{"key":"10.1038\/mt.2009.32_bib16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/intimm\/dxg078","article-title":"Successful elimination of large established tumors and avoidance of antigen-loss variants by aggressive adoptive T cell immunotherapy","volume":"15","author":"Matsui","year":"2003","journal-title":"Int Immunol"},{"key":"10.1038\/mt.2009.32_bib17","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1200\/JCO.2008.16.5449","article-title":"Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens","volume":"26","author":"Dudley","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1038\/mt.2009.32_bib18","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1158\/0008-5472.CAN-07-0224","article-title":"Therapeutic vaccination against murine lymphoma by intratumoral injection of recombinant fowlpox virus encoding CD40 ligand","volume":"67","author":"Liu","year":"2007","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.32_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s002620100229","article-title":"Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes","volume":"50","author":"Bergmann-Leitner","year":"2001","journal-title":"Cancer Immunol Immunother"},{"key":"10.1038\/mt.2009.32_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ijc.10969","article-title":"Treatment of colon and breast carcinoma cells with 5-fluorouracil enhances expression of carcinoembryonic antigen and susceptibility to HLA-A(*)02.01 restricted, CEA-peptide-specific cytotoxic T cells in vitro","volume":"104","author":"Correale","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1038\/mt.2009.32_bib21","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.4049\/jimmunol.172.7.4599","article-title":"Treatment of melanoma with 5-fluorouracil or dacarbazine in vitro sensitizes cells to antigen-specific CTL lysis through perforin\/granzyme- and Fas-mediated pathways","volume":"172","author":"Yang","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/mt.2009.32_bib22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1089\/10430340252809847","article-title":"Cancer immunotherapy using Sindbis virus replicon particles encoding a VP22-antigen fusion","volume":"13","author":"Cheng","year":"2002","journal-title":"Hum Gene Ther"},{"key":"10.1038\/mt.2009.32_bib23","first-page":"7234","article-title":"Both E7 and CpG-ODN are required for protective immunity against challenge with human papillomavirus 16 (E6\/E7)-immortalized tumor cells: involvement of CD4+ and CD8+ T cells in protection","volume":"62","author":"Kim","year":"2002","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.32_bib24","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1089\/104303403769211619","article-title":"A therapy modality using recombinant IL-12 adenovirus plus E7 protein in a human papillomavirus 16 E6\/E7-associated cervical cancer animal model","volume":"14","author":"Ahn","year":"2003","journal-title":"Hum. Gene Ther"},{"key":"10.1038\/mt.2009.32_bib25","doi-asserted-by":"crossref","first-page":"15101","DOI":"10.1073\/pnas.2135379100","article-title":"An adenoviral vector cancer vaccine that delivers a tumor-associated antigen\/CD40-ligand fusion protein to dendritic cells","volume":"100","author":"Zhang","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2009.32_bib26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1586\/14760584.5.6.783","article-title":"Human paillomavirus vaccines for the treatment of cervical cancer","volume":"5","author":"Sin","year":"2006","journal-title":"Expert Rev Vaccines"},{"key":"10.1038\/mt.2009.32_bib27","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1158\/1078-0432.CCR-08-0037","article-title":"Pretreatment with cisplatin enhances E7-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination","volume":"14","author":"Tseng","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1038\/mt.2009.32_bib28","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.170.12.6338","article-title":"Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy","volume":"170","author":"Chakraborty","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/mt.2009.32_bib29","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1158\/0008-5472.CAN-04-0073","article-title":"External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing","volume":"64","author":"Chakraborty","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.32_bib30","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1158\/0008-5472.CAN-04-1525","article-title":"Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes","volume":"64","author":"Garnett","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.32_bib31","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1084\/jem.20052494","article-title":"Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy","volume":"203","author":"Reits","year":"2006","journal-title":"J Exp Med"},{"key":"10.1038\/mt.2009.32_bib32","first-page":"3823","article-title":"The CD95 (APO-1\/Fas) system mediates drug-induced apoptosis in neuroblastoma cells","volume":"57","author":"Fulda","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.32_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-2999(98)00335-5","article-title":"Chemotherapy primes malignant glioma cells for CD95 ligand-induced apoptosis up-stream of caspase 3 activation","volume":"352","author":"Hueber","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/mt.2009.32_bib34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1172\/JCI119174","article-title":"Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1\/Fas) receptor\/ligand system and involves activation of wild-type p53","volume":"99","author":"Muller","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1038\/mt.2009.32_bib35","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/(SICI)1097-0215(19990517)81:4<573::AID-IJC12>3.0.CO;2-W","article-title":"Blockade of the Fas-triggered intracellular signaling pathway in human melanomas is circumvented by cytotoxic lymphocytes","volume":"81","author":"Ferrarini","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1038\/mt.2009.32_bib36","first-page":"21","article-title":"Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen","volume":"56","author":"Lin","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.32_bib37","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1002\/eji.1830230929","article-title":"Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells","volume":"23","author":"Feltkamp","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1038\/mt.2009.32_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2567.2004.01851.x","article-title":"CpG-ODN-stimulated dendritic cells act as a potent adjuvant for E7 protein delivery to induce antigen-specific anti-tumor immunity in a HPV 16 (E6\/E7)-associated tumor animal model","volume":"112","author":"Kim","year":"2004","journal-title":"Immunology"},{"key":"10.1038\/mt.2009.32_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2567.2005.02219.x","article-title":"Both antigen optimization and lysosomal targeting are required for enhanced anti-tumour protective immunity in a human papillomavirus E7-expressing animal tumour model","volume":"116","author":"Kim","year":"2005","journal-title":"Immunology"},{"key":"10.1038\/mt.2009.32_bib40","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1084\/jem.179.4.1215","article-title":"In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression","volume":"179","author":"Levitsky","year":"1994","journal-title":"J Exp Med"},{"key":"10.1038\/mt.2009.32_bib41","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1074\/jbc.272.1.353","article-title":"Synthesis and turnover of 2-microglobulin in Ad12-transformed cells defective in assembly and transport of class I major histocompatibility complex molecules","volume":"272","author":"Mey-Tal","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/mt.2009.32_bib42","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1128\/IAI.69.4.2589-2595.2001","article-title":"Immunological studies of chronic ocular toxoplasmosis: up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6","volume":"69","author":"Lyons","year":"2001","journal-title":"Infect Immunity"},{"key":"10.1038\/mt.2009.32_bib43","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.1073\/pnas.96.12.6643","article-title":"Hemoglobin induction in mouse macrophages","volume":"96","author":"Liu","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2009.32_bib44","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1095\/biolreprod61.1.231","article-title":"Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos","volume":"61","author":"Exley","year":"1999","journal-title":"Biol Reprod"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616317919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616317919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:24:52Z","timestamp":1545351892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616317919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S1525001616317919"],"URL":"https:\/\/doi.org\/10.1038\/mt.2009.32","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}