{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:23:56Z","timestamp":1790817836596,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":2655,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1038\/mt.2009.78","type":"journal-article","created":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T14:01:14Z","timestamp":1239717674000},"page":"1164-1172","source":"Crossref","is-referenced-by-count":40,"title":["Oncolytic Rat Parvovirus H-1PV, a Candidate for the Treatment of Human Lymphoma: In Vitro and In Vivo Studies"],"prefix":"10.1016","volume":"17","author":[{"given":"Assia L","family":"Angelova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Aprahamian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginette","family":"Balboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri-Jacques","family":"Delecluse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Feederle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kiprianova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svitlana P","family":"Grekova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel S","family":"Galabov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Witzens-Harig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rommelaere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahari","family":"Raykov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2009.78_bib1","series-title":"Fields Virology","first-page":"2397","article-title":"Epstein-Barr virus","author":"Rickinson","year":"1996"},{"key":"10.1038\/mt.2009.78_bib2","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1136\/jcp.2006.044586","article-title":"Epstein-Barr virus-associated tumours: an update for the attention of the working pathologist","volume":"60","author":"Delecluse","year":"2007","journal-title":"J Clin Pathol"},{"key":"10.1038\/mt.2009.78_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/07357900701788098","article-title":"Comparison of ICE (ifosfamide-carboplatin-etoposide) versus DHAP (cytosine arabinoside-cisplatin-dexamethasone) as salvage chemotherapy in patients with relapsed or refractory lymphoma","volume":"26","author":"Abali","year":"2008","journal-title":"Cancer Invest"},{"issue":"Suppl. 1","key":"10.1038\/mt.2009.78_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/annonc\/11.suppl_1.S113","article-title":"Humanized anti-CD20 monoclonal antibody (Rituximab) in post transplant B-lymphoproliferative disorder: a retrospective analysis on 32 patients","volume":"11","author":"Milpied","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1038\/mt.2009.78_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1439-0450.2005.00877.x","article-title":"Oncolytic potential of rodent parvoviruses for cancer therapy in humans: a brief review","volume":"52","author":"Geletneky","year":"2005","journal-title":"J Vet Med B Infect Dis Vet Public Health"},{"key":"10.1038\/mt.2009.78_bib6","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.090485297","article-title":"Cyclin A activates the DNA polymerase delta-dependent elongation machinery in vitro: A parvovirus DNA replication model","volume":"97","author":"Bashir","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2009.78_bib7","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1128\/JVI.69.9.5506-5515.1995","article-title":"Upstream CREs participate in the basal activity of minute virus of mice promoter P4 and in its stimulation in ras-transformed cells","volume":"69","author":"Perros","year":"1995","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib8","doi-asserted-by":"crossref","first-page":"6446","DOI":"10.1128\/JVI.68.10.6446-6453.1994","article-title":"The cytotoxicity of the autonomous parvovirus minute virus of mice nonstructural proteins in FR3T3 rat cells depends on oncogene expression","volume":"68","author":"Mousset","year":"1994","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib9","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1002\/j.1460-2075.1990.tb07491.x","article-title":"Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non-structural proteins","volume":"9","author":"Caillet-Fauquet","year":"1990","journal-title":"EMBO J"},{"key":"10.1038\/mt.2009.78_bib10","doi-asserted-by":"crossref","first-page":"8893","DOI":"10.1128\/JVI.72.11.8893-8903.1998","article-title":"Induction of programmed cell death by parvovirus H-1 in U937 cells: connection with the tumor necrosis factor alpha signalling pathway","volume":"72","author":"Rayet","year":"1998","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0168-1702(99)00115-X","article-title":"Parvovirus H-1-induced cell death: influence of intracellular NAD consumption on the regulation of necrosis and apoptosis","volume":"65","author":"Ran","year":"1999","journal-title":"Virus Res"},{"key":"10.1038\/mt.2009.78_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/sj.cgt.7700288","article-title":"Effective infection, apoptotic cell killing and gene transfer of human hepatoma cells but not primary hepatocytes by parvovirus H1 and derived vectors","volume":"8","author":"Moehler","year":"2001","journal-title":"Cancer Gene Ther"},{"key":"10.1038\/mt.2009.78_bib13","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1128\/JVI.02601-06","article-title":"Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells","volume":"81","author":"Di Piazza","year":"2007","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib14","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/(SICI)1097-0215(19980209)75:4<584::AID-IJC15>3.0.CO;2-9","article-title":"Dose-dependent regression of HeLa cell-derived tumours in SCID mice after parvovirus H-1 infection","volume":"75","author":"Faisst","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1038\/mt.2009.78_bib15","first-page":"3203","article-title":"Inhibition by parvovirus H-1 of the formation of tumors in nude mice and colonies in vitro by transformed human mammary epithelial cells","volume":"49","author":"Dupressoir","year":"1989","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2009.78_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1158\/1078-0432.CCR-08-1088","article-title":"Improvement of gemcitabine-based therapy of pancreatic carcinoma by means of oncolytic parvovirus H-1PV","volume":"15","author":"Angelova","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1038\/mt.2009.78_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0166-0934(91)90024-T","article-title":"Antineoplastic activity of parvoviruses","volume":"33","author":"Rommelaere","year":"1991","journal-title":"J Virol Methods"},{"key":"10.1038\/mt.2009.78_bib18","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1128\/JVI.63.5.2152-2158.1989","article-title":"Transformation of human cells by oncogenic viruses supports permissiveness for parvovirus H-1 propagation","volume":"63","author":"Faisst","year":"1989","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0168-1702(90)90024-6","article-title":"Persistence of parvovirus H-1 DNA in human B- and T-lymphoma cells","volume":"16","author":"Faisst","year":"1990","journal-title":"Virus Res"},{"key":"10.1038\/mt.2009.78_bib20","series-title":"Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age","article-title":"Lymphoma and reticuloendothelial neoplasms","author":"O'Leary","year":"2006"},{"key":"10.1038\/mt.2009.78_bib21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1182\/asheducation-2005.1.260","article-title":"Biology and treatment of Epstein-Barr virus-associated non-Hodgkin lymphomas","author":"Heslop","year":"2005","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1038\/mt.2009.78_bib22","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/ijc.22421","article-title":"MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells","volume":"120","author":"Wetzel","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1038\/mt.2009.78_bib23","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1128\/JVI.79.10.6005-6022.2005","article-title":"Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential","volume":"79","author":"Wollmann","year":"2005","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib24","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1182\/blood.V97.5.1392","article-title":"Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin","volume":"97","author":"Ghetie","year":"2001","journal-title":"Blood"},{"key":"10.1038\/mt.2009.78_bib25","doi-asserted-by":"crossref","first-page":"8702","DOI":"10.1073\/pnas.90.18.8702","article-title":"A model for tumor suppression using H-1 parvovirus","volume":"90","author":"Telerman","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2009.78_bib26","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/j.1460-2075.1991.tb07837.x","article-title":"p53 is frequently mutated in Burkitt's lymphoma cell lines","volume":"10","author":"Farrell","year":"1991","journal-title":"EMBO J"},{"key":"10.1038\/mt.2009.78_bib27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJM199708213370804","article-title":"Mutations of the p53 gene as a prognostic factor in aggressive B-cell lymphoma","volume":"337","author":"Ichikawa","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1038\/mt.2009.78_bib28","first-page":"781","article-title":"The non-structural proteins of the autonomous parvovirus minute virus of mice interfere with the cell cycle, inducing accumulation in G2","volume":"6","author":"Op De Beeck","year":"1995","journal-title":"Cell Growth Differ"},{"key":"10.1038\/mt.2009.78_bib29","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1128\/JVI.67.11.6768-6777.1993","article-title":"Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6","volume":"67","author":"Flamand","year":"1993","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2180-2-20","article-title":"Epstein-Barr virus reactivation after superinfection of the BJAB-B1 and P3HR-1 cell lines with cytomegalovirus","volume":"2","author":"Arcenas","year":"2002","journal-title":"BMC Microbiol"},{"key":"10.1038\/mt.2009.78_bib31","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1073\/pnas.80.7.1987","article-title":"Chromosome site for Epstein-Barr virus DNA in a Burkitt tumor cell line and in lymphocytes growth-transformed in vitro","volume":"80","author":"Henderson","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2009.78_bib32","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/sj.leu.2401236","article-title":"Xenotransplantation of human lymphoid malignancies is optimized in mice with multiple immunologic defects","volume":"12","author":"Hudson","year":"1998","journal-title":"Leukemia"},{"key":"10.1038\/mt.2009.78_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/sj.leu.2405034","article-title":"Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7\/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis","volume":"22","author":"Qian","year":"2008","journal-title":"Leukemia"},{"issue":"Suppl. 1","key":"10.1038\/mt.2009.78_bib34","first-page":"S26","article-title":"Ras signalling as a marker for application of oncolytic herpes mutant against lymphoma","volume":"9","author":"Farassati","year":"2004","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2009.78_bib35","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1182\/blood-2002-02-0503","article-title":"Reovirus therapy of lymphoid malignancies","volume":"100","author":"Alain","year":"2002","journal-title":"Blood"},{"key":"10.1038\/mt.2009.78_bib36","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1182\/blood.V97.12.3746","article-title":"Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice","volume":"97","author":"Grote","year":"2001","journal-title":"Blood"},{"key":"10.1038\/mt.2009.78_bib37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1128\/AAC.15.3.420","article-title":"Large-scale production and concentration of human lymphoid interferon","volume":"15","author":"Klein","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1038\/mt.2009.78_bib38","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0140-6736(64)92345-1","article-title":"Cytology of Burkitt's tumour (African lymphoma)","volume":"1","author":"Pulvertaft","year":"1964","journal-title":"Lancet"},{"key":"10.1038\/mt.2009.78_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ijc.2910350404","article-title":"Distinctions between endemic and sporadic forms of Epstein-Barr virus-positive Burkitt's lymphoma","volume":"35","author":"Rowe","year":"1985","journal-title":"Int J Cancer"},{"key":"10.1038\/mt.2009.78_bib40","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000149930","article-title":"An EBV-genome-negative cell line established from an American Burkitt lymphoma; receptor characteristics. EBV infectibility and permanent conversion into EBV-positive sublines by in vitro infection","volume":"5","author":"Klein","year":"1975","journal-title":"Intervirology"},{"key":"10.1038\/mt.2009.78_bib41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00571929","article-title":"An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA","volume":"5","author":"Takada","year":"1991","journal-title":"Virus Genes"},{"key":"10.1038\/mt.2009.78_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0165-4608(86)90106-8","article-title":"Cytogenetic investigations in Hodgkin's disease: I. Involvement of specific chromosomes in marker formation","volume":"20","author":"Fonatsch","year":"1986","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/mt.2009.78_bib43","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF02981944","article-title":"A Hodgkin's disease cell line, KM-H2, shows biphenotypic features of dendritic cells and B cells","volume":"73","author":"Uehira","year":"2001","journal-title":"Int J Hematol"},{"key":"10.1038\/mt.2009.78_bib44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0145-2126(86)90084-6","article-title":"Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles","volume":"10","author":"Drexler","year":"1986","journal-title":"Leuk Res"},{"key":"10.1038\/mt.2009.78_bib45","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1128\/JVI.77.6.3851-3858.2003","article-title":"Chimeric and pseudotyped parvoviruses minimize the contamination of recombinant stocks with replication-competent viruses and identify a DNA sequence that restricts parvovirus H-1 in mouse cells","volume":"77","author":"Wrzesinski","year":"2003","journal-title":"J Virol"},{"key":"10.1038\/mt.2009.78_bib46","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/sj.cgt.7700457","article-title":"Suppression of metastatic hemangiosarcoma by a parvovirus MVMp vector transducing the IP-10 chemokine into immunocompetent mice","volume":"9","author":"Giese","year":"2002","journal-title":"Cancer Gene Ther"},{"key":"10.1038\/mt.2009.78_bib47","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1128\/JVI.68.3.1397-1406.1994","article-title":"Use of an autonomous parvovirus vector for selective transfer of a foreign gene into transformed human cells of different tissue origins and its expression therein","volume":"68","author":"Dupont","year":"1994","journal-title":"J Virol"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616318263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616318263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T13:03:26Z","timestamp":1589720606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616318263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S1525001616318263"],"URL":"https:\/\/doi.org\/10.1038\/mt.2009.78","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}