{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:20:35Z","timestamp":1790709635538,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":1375,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS056206"],"award-info":[{"award-number":["NS056206"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1038\/mt.2012.203","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T08:43:31Z","timestamp":1348562611000},"page":"42-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia"],"prefix":"10.1016","volume":"21","author":[{"given":"Anthony D","family":"D'Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A","family":"Parish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane S","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Kaech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald S","family":"Shadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2012.203_bib1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"10.1038\/mt.2012.203_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"Atm-deficient mice: a paradigm of ataxia telangiectasia","volume":"86","author":"Barlow","year":"1996","journal-title":"Cell"},{"key":"10.1038\/mt.2012.203_bib3","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1016\/j.ajpath.2011.02.022","article-title":"Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling","volume":"178","author":"D'Souza","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1038\/mt.2012.203_bib4","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature02989","article-title":"Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells","volume":"431","author":"Ito","year":"2004","journal-title":"Nature"},{"key":"10.1038\/mt.2012.203_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4049\/jimmunol.178.1.103","article-title":"Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes","volume":"178","author":"Ito","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/mt.2012.203_bib6","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1073\/pnas.0913860107","article-title":"ATM signals to TSC2 in the cytoplasm to regulate TORC1 in response to ROS","volume":"107","author":"Alexander","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2012.203_bib7","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice","volume":"61","author":"Kamsler","year":"2001","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2012.203_bib8","doi-asserted-by":"crossref","first-page":"9915","DOI":"10.1073\/pnas.96.17.9915","article-title":"Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs","volume":"96","author":"Barlow","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2012.203_bib9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/15230860260196254","article-title":"Elevated oxidative stress in patients with ataxia telangiectasia","volume":"4","author":"Reichenbach","year":"2002","journal-title":"Antioxid Redox Signal"},{"key":"10.1038\/mt.2012.203_bib10","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.dnarep.2006.05.003","article-title":"Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice","volume":"5","author":"Reliene","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"10.1038\/mt.2012.203_bib11","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/hmg\/ddh189","article-title":"Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice","volume":"13","author":"Schubert","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1038\/mt.2012.203_bib12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bbrc.2009.04.019","article-title":"Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm-\/- mice","volume":"383","author":"Kuang","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/mt.2012.203_bib13","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1172\/JCI31604","article-title":"Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis","volume":"117","author":"Eaton","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1038\/mt.2012.203_bib14","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1093\/hmg\/ddm166","article-title":"Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells","volume":"16","author":"Ambrose","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1038\/mt.2012.203_bib15","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2011-08-373639","article-title":"Mitochondrial dysfunction in ataxia-telangiectasia","volume":"119","author":"Valentin-Vega","year":"2012","journal-title":"Blood"},{"key":"10.1038\/mt.2012.203_bib16","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.2353\/ajpath.2008.071163","article-title":"Expression and maintenance of mitochondrial DNA: new insights into human disease pathology","volume":"172","author":"Shadel","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1038\/mt.2012.203_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"10.1038\/mt.2012.203_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tibs.2011.10.002","article-title":"The ATM protein kinase and cellular redox signaling: beyond the DNA damage response","volume":"37","author":"Ditch","year":"2012","journal-title":"Trends Biochem Sci"},{"key":"10.1038\/mt.2012.203_bib19","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1126\/science.1106653","article-title":"Extension of murine life span by overexpression of catalase targeted to mitochondria","volume":"308","author":"Schriner","year":"2005","journal-title":"Science"},{"key":"10.1038\/mt.2012.203_bib20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ajpath.2011.10.003","article-title":"Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min\/+) mice","volume":"180","author":"Woo","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1038\/mt.2012.203_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1471-2407-11-191","article-title":"Mitochondrial targeted catalase suppresses invasive breast cancer in mice","volume":"11","author":"Goh","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1038\/mt.2012.203_bib22","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/gerona\/63.8.813","article-title":"Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria","volume":"63","author":"Treuting","year":"2008","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1038\/mt.2012.203_bib23","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1073\/pnas.0908786106","article-title":"Age-related hearing loss in C57BL\/6J mice is mediated by Bak-dependent mitochondrial apoptosis","volume":"106","author":"Someya","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2012.203_bib24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cmet.2010.11.004","article-title":"Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance","volume":"12","author":"Lee","year":"2010","journal-title":"Cell Metab"},{"key":"10.1038\/mt.2012.203_bib25","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ Res"},{"key":"10.1038\/mt.2012.203_bib26","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1101\/gad.10.19.2411","article-title":"Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma","volume":"10","author":"Xu","year":"1996","journal-title":"Genes Dev"},{"key":"10.1038\/mt.2012.203_bib27","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1182\/blood.V96.5.1940","article-title":"Abnormal rearrangement within the alpha\/delta T-cell receptor locus in lymphomas from Atm-deficient mice","volume":"96","author":"Liyanage","year":"2000","journal-title":"Blood"},{"key":"10.1038\/mt.2012.203_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00280-004-0870-6","article-title":"Control of Atm-\/- thymic lymphoma cell proliferation in vitro and in vivo by dexamethasone","volume":"55","author":"Kuang","year":"2005","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1038\/mt.2012.203_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2011.09.030","article-title":"Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations","volume":"52","author":"Kalyanaraman","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/mt.2012.203_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bone.2005.05.012","article-title":"Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation","volume":"37","author":"Hishiya","year":"2005","journal-title":"Bone"},{"key":"10.1038\/mt.2012.203_bib31","doi-asserted-by":"crossref","first-page":"25692","DOI":"10.1074\/jbc.M800517200","article-title":"Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells","volume":"283","author":"Yalcin","year":"2008","journal-title":"J Biol Chem"},{"issue":"suppl. 1","key":"10.1038\/mt.2012.203_bib32","doi-asserted-by":"crossref","first-page":"229S","DOI":"10.1093\/jn\/137.1.229S","article-title":"Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice","volume":"137","author":"Reliene","year":"2007","journal-title":"J Nutr"},{"key":"10.1038\/mt.2012.203_bib33","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.freeradbiomed.2004.01.003","article-title":"Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice","volume":"36","author":"Browne","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/mt.2012.203_bib34","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1084\/jem.20081297","article-title":"TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species","volume":"205","author":"Chen","year":"2008","journal-title":"J Exp Med"},{"key":"10.1038\/mt.2012.203_bib35","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1128\/MCB.00347-10","article-title":"Requirement of the ATM\/p53 tumor suppressor pathway for glucose homeostasis","volume":"30","author":"Armata","year":"2010","journal-title":"Mol Cell Biol"},{"key":"10.1038\/mt.2012.203_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11010-007-9575-6","article-title":"AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner","volume":"306","author":"Sun","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/mt.2012.203_bib37","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1096\/fj.00-0601com","article-title":"The ataxia-telangiectasia gene product may modulate DNA turnover and control cell fate by regulating cellular redox in lymphocytes","volume":"15","author":"Yan","year":"2001","journal-title":"FASEB J"},{"key":"10.1038\/mt.2012.203_bib38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbrc.2012.01.008","article-title":"Activation of AMP-activated protein kinase in cerebella of Atm-\/- mice is attributable to accumulation of reactive oxygen species","volume":"418","author":"Kuang","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/mt.2012.203_bib39","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/emboj\/20.7.1538","article-title":"Elevated Cu\/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice","volume":"20","author":"Peter","year":"2001","journal-title":"EMBO J"},{"key":"10.1038\/mt.2012.203_bib40","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.freeradbiomed.2006.04.032","article-title":"Effect of the reduction of superoxide dismutase 1 and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice","volume":"41","author":"Erker","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/mt.2012.203_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"key":"10.1038\/mt.2012.203_bib42","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1009","article-title":"Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells","volume":"4","author":"Kaech","year":"2003","journal-title":"Nat Immunol"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616305597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616305597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T12:44:20Z","timestamp":1739191460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616305597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1525001616305597"],"URL":"https:\/\/doi.org\/10.1038\/mt.2012.203","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mt.2012.203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The American Society of Gene & Cell Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}