{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:25:06Z","timestamp":1776882306690,"version":"3.51.2"},"reference-count":46,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":1194,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1038\/mt.2013.93","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T08:18:19Z","timestamp":1369729099000},"page":"1403-1412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enhanced CRAd Activity Using Enhancer Motifs Driven by a Nucleosome Positioning Sequence"],"prefix":"10.1016","volume":"21","author":[{"given":"Soraya","family":"Bravo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cruzat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo G","family":"Cafferata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo V","family":"De Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Montecino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo L","family":"Podhajcer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2013.93_bib1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3748\/wjg.v12.i3.380","article-title":"Gene therapy for gastric cancer: is it promising?","volume":"12","author":"Sutter","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1038\/mt.2013.93_bib2","first-page":"49","article-title":"COX-derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention","volume":"1825","author":"Cathcart","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/mt.2013.93_bib3","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3892\/ol.2012.628","article-title":"The pathobiological features of gastrointestinal cancers (Review)","volume":"3","author":"Yang","year":"2012","journal-title":"Oncol Lett"},{"key":"10.1038\/mt.2013.93_bib4","first-page":"249","article-title":"Epidemiology of gastrointestinal and liver tumors","volume":"14","author":"Hersz\u00e9nyi","year":"2010","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1038\/mt.2013.93_bib5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bpg.2005.10.004","article-title":"Gene therapy developments for pancreatic cancer","volume":"20","author":"Bhattacharyya","year":"2006","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1038\/mt.2013.93_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000334677","article-title":"Recent advances in diagnosis and treatment for malignancies of the gastrointestinal tract","volume":"85","author":"Watanabe","year":"2012","journal-title":"Digestion"},{"key":"10.1038\/mt.2013.93_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7150\/jca.4090","article-title":"HER2 as a Prognostic Marker in Gastric Cancer - A Systematic Analysis of Data from the Literature","volume":"3","author":"J\u00f8rgensen","year":"2012","journal-title":"J Cancer"},{"key":"10.1038\/mt.2013.93_bib8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1517\/14712598.4.8.1241","article-title":"Conditionally replicative adenovirus for gastrointestinal cancers","volume":"4","author":"Yamamoto","year":"2004","journal-title":"Expert Opin Biol Ther"},{"key":"10.1038\/mt.2013.93_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mt.2009.266","article-title":"Current issues and future directions of oncolytic adenoviruses","volume":"18","author":"Yamamoto","year":"2010","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2013.93_bib10","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/sj.cgt.7700541","article-title":"Adenoviral vectors: Systemic delivery and tumor targeting","volume":"9","author":"Green","year":"2002","journal-title":"Cancer Gene Ther"},{"key":"10.1038\/mt.2013.93_bib11","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/sj.gt.3301512","article-title":"Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial","volume":"8","author":"Reid","year":"2001","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2013.93_bib12","first-page":"6070","article-title":"Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints","volume":"62","author":"Reid","year":"2002","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2013.93_bib13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/sj.gt.3301398","article-title":"Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial","volume":"8","author":"Mulvihill","year":"2001","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2013.93_bib14","first-page":"555","article-title":"A phase I\/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma","volume":"9","author":"Hecht","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1038\/mt.2013.93_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1517\/14712598.4.5.683","article-title":"Tissue-specific promoters for cancer gene therapy","volume":"4","author":"Saukkonen","year":"2004","journal-title":"Expert Opin Biol Ther"},{"key":"10.1038\/mt.2013.93_bib16","doi-asserted-by":"crossref","first-page":"6839","DOI":"10.1128\/jvi.70.10.6839-6846.1996","article-title":"Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism","volume":"70","author":"Krasnykh","year":"1996","journal-title":"J Virol"},{"key":"10.1038\/mt.2013.93_bib17","first-page":"113","article-title":"Fiber-modified adenoviruses for targeted gene therapy","volume":"434","author":"Wu","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1038\/mt.2013.93_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.tig.2010.08.003","article-title":"Gene regulation by nucleosome positioning","volume":"26","author":"Bai","year":"2010","journal-title":"Trends Genet"},{"key":"10.1038\/mt.2013.93_bib19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1139\/O07-070","article-title":"Nucleosome organization and targeting of SWI\/SNF chromatin-remodeling complexes: contributions of the DNA sequence","volume":"85","author":"Montecino","year":"2007","journal-title":"Biochem Cell Biol"},{"key":"10.1038\/mt.2013.93_bib20","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1021\/bi0013896","article-title":"Interaction of CBF alpha\/AML\/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site","volume":"39","author":"Guti\u00e9rrez","year":"2000","journal-title":"Biochemistry"},{"key":"10.1038\/mt.2013.93_bib21","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1074\/jbc.M609847200","article-title":"Chromatin remodeling by SWI\/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter","volume":"282","author":"Guti\u00e9rrez","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/mt.2013.93_bib22","doi-asserted-by":"crossref","first-page":"22695","DOI":"10.1074\/jbc.M511640200","article-title":"Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT\/enhancer-binding protein beta-dependent recruitment of SWI\/SNF activity","volume":"281","author":"Villagra","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/mt.2013.93_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrg1427","article-title":"Wnt and \u03b2-catenin signaling: diseases and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nature Rev"},{"key":"10.1038\/mt.2013.93_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000066755","article-title":"Wnt\/beta-catenin\/tcf signaling: a critical pathway in gastrointestinal tumorigenesis","volume":"66","author":"Kolligs","year":"2002","journal-title":"Digestion"},{"key":"10.1038\/mt.2013.93_bib25","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-\/- colon carcinoma","volume":"275","author":"Korinek","year":"1997","journal-title":"Science"},{"key":"10.1038\/mt.2013.93_bib26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1097-2765(01)00213-1","article-title":"PUMA induces the rapid apoptosis of colorectal cancer cells","volume":"7","author":"Yu","year":"2001","journal-title":"Mol Cell"},{"key":"10.1038\/mt.2013.93_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.cgt.7700904","article-title":"Targeting of autonomous parvoviruses to colon cancer by insertion of Tcf sites in the P4 promoter","volume":"13","author":"Malerba","year":"2006","journal-title":"Cancer Gene Ther"},{"key":"10.1038\/mt.2013.93_bib28","doi-asserted-by":"crossref","first-page":"10127","DOI":"10.1158\/0008-5472.CAN-06-2744","article-title":"Effective treatment of tumors with strong beta-catenin\/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector","volume":"66","author":"Kuroda","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/mt.2013.93_bib29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/hum.2010.128","article-title":"A novel conditionally replicating \u201carmed\u201d adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling","volume":"22","author":"Liu","year":"2011","journal-title":"Hum Gene Ther"},{"key":"10.1038\/mt.2013.93_bib30","doi-asserted-by":"crossref","first-page":"e18562","DOI":"10.1371\/journal.pone.0018562","article-title":"Wnt\/\u03b2-catenin signaling enhances cyclooxygenase-2(COX2) transcriptional activity in gastric cancer cells","volume":"6","author":"Nu\u00f1ez","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1038\/mt.2013.93_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000078762","article-title":"Expression of Reg 1\u03b1 protein in human gastric cancers","volume":"69","author":"Fukui","year":"2003","journal-title":"Digestion"},{"key":"10.1038\/mt.2013.93_bib32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000321808","article-title":"Immunohistochemical analysis of REG Ia expression in ulcerative colitis-associated neoplastic lesions","volume":"83","author":"Tanaka","year":"2011","journal-title":"Digestion"},{"key":"10.1038\/mt.2013.93_bib33","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/ijc.25188","article-title":"Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes","volume":"127","author":"Zhou","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1038\/mt.2013.93_bib34","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1158\/1078-0432.CCR-08-1161","article-title":"A novel A33 promoter based conditionally replicative adenovirus suppresses tumor growth and eradicates hepatic metastases in human colon cancer models","volume":"15","author":"Cafferata","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1038\/mt.2013.93_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/jid.2013.191","article-title":"Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to melanoma microenvironment","author":"Viale","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1038\/mt.2013.93_bib36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/dnares\/dsm006","article-title":"Intrinsic promoter activities of primary DNA sequences in the human genome","volume":"14","author":"Sakakibara","year":"2007","journal-title":"DNA Res"},{"key":"10.1038\/mt.2013.93_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.50","article-title":"Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments","volume":"20","author":"Stein","year":"2010","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1038\/mt.2013.93_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pharmtox.38.1.97","article-title":"Cyclooxygenases 1 and 2","volume":"38","author":"Vane","year":"1998","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1038\/mt.2013.93_bib39","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/sj.gt.3301177","article-title":"Increasing endothelial cell specific expression by the use of heterologous hypoxic and cytokine-inducible enhancers","volume":"7","author":"Modlich","year":"2000","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2013.93_bib40","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/mt.2009.103","article-title":"Suppression of cancer growth by nonviral gene therapy based on a novel reactive oxygen species-responsive promoter","volume":"17","author":"Policastro","year":"2009","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2013.93_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1476-4598-5-57","article-title":"MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERalpha) in regulation of the MUC1 gene expression","volume":"5","author":"Zaretsky","year":"2006","journal-title":"Mol Cancer"},{"key":"10.1038\/mt.2013.93_bib42","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/mt.2010.26","article-title":"Transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1 for targeting prostate tumors","volume":"18","author":"Lee","year":"2010","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2013.93_bib43","doi-asserted-by":"crossref","first-page":"e18966","DOI":"10.1371\/journal.pone.0018966","article-title":"Multiple Wnt\/\u00df-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops","volume":"6","author":"Yochum","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1038\/mt.2013.93_bib44","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"key":"10.1038\/mt.2013.93_bib45","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1038\/mt.2012.147","article-title":"A tumor-stroma targeted oncolytic adenovirus replicated in human ovary cancer samples and inhibited growth of disseminated solid tumors in mice","volume":"20","author":"Lopez","year":"2012","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2013.93_bib46","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1128\/MCB.24.20.8847-8861.2004","article-title":"Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells","volume":"24","author":"Paredes","year":"2004","journal-title":"Mol Cell Biol"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616319645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616319645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:51:56Z","timestamp":1761501116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616319645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1525001616319645"],"URL":"https:\/\/doi.org\/10.1038\/mt.2013.93","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced CRAd Activity Using Enhancer Motifs Driven by a Nucleosome Positioning Sequence","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mt.2013.93","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The American Society of Gene & Cell Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}