{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:19:18Z","timestamp":1793643558452,"version":"4.5.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":586,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1038\/mt.2014.243","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T09:24:37Z","timestamp":1419240277000},"page":"602-608","source":"Crossref","is-referenced-by-count":154,"title":["Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients"],"prefix":"10.1016","volume":"23","author":[{"given":"Timothy P","family":"Cripe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhtran C","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James I","family":"Geller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystal U","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Currier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Racadio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J","family":"Towbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cliona M","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Pelusio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Ho","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Kirn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J","family":"Breitbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2014.243_bib1","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1200\/JCO.2009.27.0421","article-title":"Outcomes for children and adolescents with cancer: challenges for the twenty-first century","volume":"28","author":"Smith","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1038\/mt.2014.243_bib2","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.2174\/138920112800958814","article-title":"Oncolytic HSV-1 virotherapy: clinical experience and opportunities for progress","volume":"13","author":"Kaur","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1038\/mt.2014.243_bib3","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nrc1750","article-title":"Recent progress in the battle between oncolytic viruses and tumours","volume":"5","author":"Parato","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/mt.2014.243_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1535-6108(03)00241-1","article-title":"VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents","volume":"4","author":"Stojdl","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1038\/mt.2014.243_bib5","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1073\/pnas.101136398","article-title":"Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing","volume":"98","author":"Todo","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2014.243_bib6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1586\/14737175.2014.917964","article-title":"Therapeutic cell carriers: a potential road to cure glioma","volume":"14","author":"Young","year":"2014","journal-title":"Expert Rev Neurother"},{"key":"10.1038\/mt.2014.243_bib7","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1128\/JVI.03406-13","article-title":"Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-\u03baB-dependent autophagy","volume":"88","author":"Shulak","year":"2014","journal-title":"J Virol"},{"key":"10.1038\/mt.2014.243_bib8","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/sj.mt.6300215","article-title":"Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow","volume":"15","author":"Breitbach","year":"2007","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2014.243_bib9","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1128\/JVI.02829-13","article-title":"STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus","volume":"88","author":"Spurrell","year":"2014","journal-title":"J Virol"},{"key":"10.1038\/mt.2014.243_bib10","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/ijc.28631","article-title":"Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer","volume":"134","author":"Goshima","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1038\/mt.2014.243_bib11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jss.2013.10.032","article-title":"Molecular determinants of susceptibility to oncolytic vesicular stomatitis virus in pancreatic adenocarcinoma","volume":"187","author":"Blackham","year":"2014","journal-title":"J Surg Res"},{"key":"10.1038\/mt.2014.243_bib12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/mt.2011.276","article-title":"The oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers","volume":"20","author":"Parato","year":"2012","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2014.243_bib13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbrc.2014.05.102","article-title":"Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs","volume":"450","author":"Kurayoshi","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/mt.2014.243_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1470-2045(08)70107-4","article-title":"Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial","volume":"9","author":"Park","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1038\/mt.2014.243_bib15","doi-asserted-by":"crossref","first-page":"185ra63","DOI":"10.1126\/scitranslmed.3005361","article-title":"Oncolytic and immunotherapeutic vaccinia induces antibody-mediated complement-dependent cancer cell lysis in humans","volume":"5","author":"Kim","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1038\/mt.2014.243_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nm.3089","article-title":"Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer","volume":"19","author":"Heo","year":"2013","journal-title":"Nat Med"},{"key":"10.1038\/mt.2014.243_bib17","doi-asserted-by":"crossref","first-page":"e27138","DOI":"10.4161\/onci.27138","article-title":"Rewiring cancer cell death to enhance oncolytic viro-immunotherapy","volume":"2","author":"Workenhe","year":"2013","journal-title":"Oncoimmunology"},{"key":"10.1038\/mt.2014.243_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature10358","article-title":"Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans","volume":"477","author":"Breitbach","year":"2011","journal-title":"Nature"},{"key":"10.1038\/mt.2014.243_bib19","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/mt.2012.130","article-title":"Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections","volume":"20","author":"Gerdemann","year":"2012","journal-title":"Mol Ther"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616300727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616300727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T16:23:11Z","timestamp":1537978991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616300727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1525001616300727"],"URL":"https:\/\/doi.org\/10.1038\/mt.2014.243","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}