{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:23:24Z","timestamp":1775197404650,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 EY022349"],"award-info":[{"award-number":["R01 EY022349"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 EY021453-04"],"award-info":[{"award-number":["T32 EY021453-04"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 EY008126"],"award-info":[{"award-number":["P30 EY008126"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XW-10-1-0528"],"award-info":[{"award-number":["W81XW-10-1-0528"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001641","name":"Glaucoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001641","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002089","name":"Fight for Sight Summer Research Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1038\/mt.2015.198","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T08:21:04Z","timestamp":1445934064000},"page":"230-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma"],"prefix":"10.1016","volume":"24","author":[{"given":"Wesley S","family":"Bond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Hines-Beard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YPaul L","family":"GoldenMerry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Farooque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M","family":"Sappington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Calkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonia S","family":"Rex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2015.198_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00055735-200404000-00011","article-title":"Current management of glaucoma","volume":"15","author":"Schwartz","year":"2004","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1038\/mt.2015.198_bib2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.ophtha.2004.12.035","article-title":"Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension an evidence-based review","volume":"112","author":"Olthoff","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1038\/mt.2015.198_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1084\/jem.20122760","article-title":"Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration","volume":"210","author":"Broxmeyer","year":"2013","journal-title":"J Exp Med"},{"key":"10.1038\/mt.2015.198_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.critrevonc.2007.03.001","article-title":"Role of erythropoietin in the brain","volume":"64","author":"Noguchi","year":"2007","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1038\/mt.2015.198_bib5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3389\/fimmu.2014.00523","article-title":"Evidence that erythropoietin modulates neuroinflammation through differential action on neurons, astrocytes, and microglia","volume":"5","author":"Bond","year":"2014","journal-title":"Front Immunol"},{"key":"10.1038\/mt.2015.198_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2125.1990.tb03692.x","article-title":"The pharmacokinetics of recombinant human erythropoietin after intravenous and subcutaneous administration to healthy subjects","volume":"29","author":"Salmonson","year":"1990","journal-title":"Br J Clin Pharmacol"},{"key":"10.1038\/mt.2015.198_bib7","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1089\/hum.2011.052","article-title":"Systemic adeno-associated virus-mediated gene therapy preserves retinal ganglion cells and visual function in DBA\/2J glaucomatous mice","volume":"22","author":"Sullivan","year":"2011","journal-title":"Hum Gene Ther"},{"key":"10.1038\/mt.2015.198_bib8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s11064-010-0272-6","article-title":"Systemic gene delivery protects the photoreceptors in the retinal degeneration slow mouse","volume":"36","author":"Sullivan","year":"2011","journal-title":"Neurochem Res"},{"key":"10.1038\/mt.2015.198_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.exer.2012.01.006","article-title":"Dose-dependent treatment of optic nerve crush by exogenous systemic mutant erythropoietin","volume":"96","author":"Sullivan","year":"2012","journal-title":"Exp Eye Res"},{"key":"10.1038\/mt.2015.198_bib10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ymthe.2004.07.027","article-title":"Systemic but not intraocular Epo gene transfer protects the retina from light-and genetic-induced degeneration","volume":"10","author":"Rex","year":"2004","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2015.198_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/gbb.12001","article-title":"A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism","volume":"12","author":"Dhanushkodi","year":"2013","journal-title":"Genes Brain Behav"},{"key":"10.1038\/mt.2015.198_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/15665232113139990024","article-title":"Identification of a therapeutic dose of continuously delivered erythropoietin in the eye using an inducible promoter system","volume":"13","author":"Hines-Beard","year":"2013","journal-title":"Curr Gene Ther"},{"key":"10.1038\/mt.2015.198_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1167\/iovs.09-3947","article-title":"The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice","volume":"51","author":"Sappington","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib14","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1523\/JNEUROSCI.4089-13.2014","article-title":"Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection","volume":"34","author":"Ward","year":"2014","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2015.198_bib15","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1084\/jem.20022041","article-title":"By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA\/2J pigmentary glaucoma","volume":"197","author":"Mo","year":"2003","journal-title":"J Exp Med"},{"key":"10.1038\/mt.2015.198_bib16","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1523\/JNEUROSCI.4443-07.2008","article-title":"Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma","volume":"28","author":"Buckingham","year":"2008","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2015.198_bib17","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1073\/pnas.0913141107","article-title":"Distal axonopathy with structural persistence in glaucomatous neurodegeneration","volume":"107","author":"Crish","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2015.198_bib18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.preteyeres.2012.07.001","article-title":"Critical pathogenic events underlying progression of neurodegeneration in glaucoma","volume":"31","author":"Calkins","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1038\/mt.2015.198_bib19","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib20","series-title":"Principles of Laboratory Animal Science, revised edn","first-page":"pp. 19","article-title":"Biology and husbandry of laboratory animals","author":"Havenaar","year":"2001"},{"key":"10.1038\/mt.2015.198_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroscience.2012.10.069","article-title":"Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target","volume":"229","author":"Crish","year":"2013","journal-title":"Neuroscience"},{"key":"10.1038\/mt.2015.198_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2013.07.001","article-title":"Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy","volume":"59","author":"Dapper","year":"2013","journal-title":"Neurobiol Dis"},{"key":"10.1038\/mt.2015.198_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-1326-6-4","article-title":"Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons","volume":"6","author":"Lambert","year":"2011","journal-title":"Mol Neurodegener"},{"key":"10.1038\/mt.2015.198_bib24","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/mt.2008.76","article-title":"Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection","volume":"16","author":"Zincarelli","year":"2008","journal-title":"Mol Ther"},{"key":"10.1038\/mt.2015.198_bib25","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1167\/iovs.05-0925","article-title":"Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA\/2 mouse model of glaucoma","volume":"47","author":"Inman","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib26","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1167\/iovs.10-6340","article-title":"Postnatal elongation of eye size in DBA\/2J mice compared with C57BL\/6J mice: in vivo analysis with whole-eye OCT","volume":"52","author":"Chou","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib27","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1073\/pnas.0407357102","article-title":"High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma","volume":"102","author":"Anderson","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2015.198_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2202-7-66","article-title":"Progressive ganglion cell loss and optic nerve degeneration in DBA\/2J mice is variable and asymmetric","volume":"7","author":"Schlamp","year":"2006","journal-title":"BMC Neurosci"},{"key":"10.1038\/mt.2015.198_bib29","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1167\/iovs.05-1407","article-title":"Interleukin-6 protects retinal ganglion cells from pressure-induced death","volume":"47","author":"Sappington","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib30","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1172\/JCI61135","article-title":"Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma","volume":"122","author":"Howell","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1038\/mt.2015.198_bib31","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1167\/iovs.14-15094","article-title":"Radiation pretreatment does not protect the rat optic nerve from elevated intraocular pressure-induced injury","volume":"56","author":"Johnson","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.coph.2012.09.008","article-title":"Oxidative stress and mitochondrial dysfunction in glaucoma","volume":"13","author":"Chrysostomou","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1038\/mt.2015.198_bib33","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1167\/iovs.10-5289","article-title":"Oxidative stress and the regulation of complement activation in human glaucoma","volume":"51","author":"Tezel","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/IJG.0b013e31815c3a7f","article-title":"Oxidative stress in primary open-angle glaucoma","volume":"17","author":"Zanon-Moreno","year":"2008","journal-title":"J Glaucoma"},{"key":"10.1038\/mt.2015.198_bib35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/02713680903548970","article-title":"Oxidative stress markers in patients with primary open-angle glaucoma","volume":"35","author":"Ghanem","year":"2010","journal-title":"Curr Eye Res"},{"key":"10.1038\/mt.2015.198_bib36","first-page":"2242","article-title":"Ganglion cell losses underlying visual field defects from experimental glaucoma","volume":"40","author":"Harwerth","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib37","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.survophthal.2008.08.006","article-title":"Risk factors for glaucoma onset and progression","volume":"53","author":"Coleman","year":"2008","journal-title":"Surv Ophthalmol"},{"key":"10.1038\/mt.2015.198_bib38","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.22516","article-title":"Early microglia activation in a mouse model of chronic glaucoma","volume":"519","author":"Bosco","year":"2011","journal-title":"J Comp Neurol"},{"key":"10.1038\/mt.2015.198_bib39","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1167\/iovs.14-14421","article-title":"Loss of outer retinal neurons and circuitry alterations in the DBA\/2J mouse","volume":"55","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2015.198_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/gt.2015.12","article-title":"Safety and angiogenic effects of systemic gene delivery of a modified erythropoietin","volume":"22","author":"de Lucas Cerrillo","year":"2015","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2015.198_bib41","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jgm.686","article-title":"Gene transfer into skeletal muscle using novel AAV serotypes","volume":"7","author":"Louboutin","year":"2005","journal-title":"J Gene Med"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500161630329X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500161630329X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:50:41Z","timestamp":1761501041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152500161630329X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S152500161630329X"],"URL":"https:\/\/doi.org\/10.1038\/mt.2015.198","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mt.2015.198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Gene & Cell Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}