{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:41:06Z","timestamp":1782877266607,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":519,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1038\/mt.2015.64","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T11:26:29Z","timestamp":1429615589000},"page":"1222-1233","source":"Crossref","is-referenced-by-count":34,"title":["Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels"],"prefix":"10.1016","volume":"23","author":[{"given":"William W","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Wan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindi Cindy","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaan","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianru","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Spaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey N","family":"Krylov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton B","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2015.64_bib1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1478-3231.2011.02463.x","article-title":"Animal models in nonalcoholic steatohepatitis research: utility and clinical translation","volume":"31","author":"Anstee","year":"2011","journal-title":"Liver Int"},{"key":"10.1038\/mt.2015.64_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1440-1746.2008.05640.x","article-title":"Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C","volume":"24","author":"Yatsuji","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1038\/mt.2015.64_bib3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/MOG.0b013e328337b0c4","article-title":"Recent advances in nonalcoholic fatty liver disease","volume":"26","author":"Cheung","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1038\/mt.2015.64_bib4","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s11745-001-0850-1","article-title":"Effect of dexamethasone on the fatty acid composition of total liver microsomal lipids and phosphatidylcholine molecular species","volume":"36","author":"Brenner","year":"2001","journal-title":"Lipids"},{"key":"10.1038\/mt.2015.64_bib5","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1021\/bi00072a015","article-title":"cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor","volume":"32","author":"Sher","year":"1993","journal-title":"Biochemistry"},{"key":"10.1038\/mt.2015.64_bib6","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI6223","article-title":"Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting","volume":"103","author":"Kersten","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1038\/mt.2015.64_bib7","doi-asserted-by":"crossref","first-page":"865604","DOI":"10.1155\/2013\/865604","article-title":"Inhibitors of fatty acid synthesis induce PPAR \u03b1 -regulated fatty acid \u03b2 -oxidative genes: synergistic roles of L-FABP and glucose","volume":"2013","author":"Huang","year":"2013","journal-title":"PPAR Res"},{"key":"10.1038\/mt.2015.64_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00041433-200106000-00002","article-title":"Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice","volume":"12","author":"Torra","year":"2001","journal-title":"Curr Opin Lipidol"},{"key":"10.1038\/mt.2015.64_bib9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0022-2275(20)42003-6","article-title":"Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression","volume":"37","author":"Schoonjans","year":"1996","journal-title":"J Lipid Res"},{"issue":"Pt 3","key":"10.1038\/mt.2015.64_bib10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1042\/bj20031565","article-title":"Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level","volume":"378","author":"Lee","year":"2004","journal-title":"Biochem J"},{"key":"10.1038\/mt.2015.64_bib11","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.01118.2002","article-title":"PPAR-alpha effects on the heart and other vascular tissues","volume":"285","author":"Francis","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1038\/mt.2015.64_bib12","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","article-title":"Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation","volume":"315","author":"Mayr","year":"2007","journal-title":"Science"},{"key":"10.1038\/mt.2015.64_bib13","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cell.2005.04.016","article-title":"Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development","volume":"121","author":"Leaman","year":"2005","journal-title":"Cell"},{"key":"10.1038\/mt.2015.64_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1074\/jbc.M112.418830","article-title":"The intermediate filament vimentin mediates microRNA miR-378 function in cellular self-renewal by regulating the expression of the Sox2 transcription factor","volume":"288","author":"Deng","year":"2013","journal-title":"J Biol Chem"},{"issue":"Pt 6","key":"10.1038\/mt.2015.64_bib15","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1242\/jcs.118299","article-title":"MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling","volume":"126","author":"Du","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1038\/mt.2015.64_bib16","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/nature03816","article-title":"Stem cell division is regulated by the microRNA pathway","volume":"435","author":"Hatfield","year":"2005","journal-title":"Nature"},{"key":"10.1038\/mt.2015.64_bib17","doi-asserted-by":"crossref","first-page":"e7535","DOI":"10.1371\/journal.pone.0007535","article-title":"MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7","volume":"4","author":"Kahai","year":"2009","journal-title":"PLoS One"},{"key":"10.1038\/mt.2015.64_bib18","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1016\/j.bbamcr.2013.09.008","article-title":"Specificity of miR-378a-5p targeting rodent fibronectin","volume":"1833","author":"Liu","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/mt.2015.64_bib19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature03076","article-title":"A pancreatic islet-specific microRNA regulates insulin secretion","volume":"432","author":"Poy","year":"2004","journal-title":"Nature"},{"key":"10.1038\/mt.2015.64_bib20","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1126\/science.1136319","article-title":"Suppression of microRNA-silencing pathway by HIV-1 during virus replication","volume":"315","author":"Triboulet","year":"2007","journal-title":"Science"},{"key":"10.1038\/mt.2015.64_bib21","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.3748\/wjg.v17.i20.2536","article-title":"microRNAs: fad or future of liver disease","volume":"17","author":"Lakner","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1038\/mt.2015.64_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting","volume":"3","author":"Esau","year":"2006","journal-title":"Cell Metab"},{"issue":"Pt 6","key":"10.1038\/mt.2015.64_bib23","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1242\/jcs.122895","article-title":"Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways","volume":"126","author":"Shan","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1038\/mt.2015.64_bib24","doi-asserted-by":"crossref","first-page":"e1355","DOI":"10.1038\/cddis.2014.305","article-title":"miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7","volume":"5","author":"Du","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1038\/mt.2015.64_bib25","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/ncb1917","article-title":"MicroRNA MiR-17 retards tissue growth and represses fibronectin expression","volume":"11","author":"Shan","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1038\/mt.2015.64_bib26","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1074\/jbc.273.10.5678","article-title":"Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)","volume":"273","author":"Aoyama","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1038\/mt.2015.64_bib27","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","article-title":"A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders","volume":"96","author":"Leone","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2015.64_bib28","doi-asserted-by":"crossref","first-page":"27307","DOI":"10.1074\/jbc.272.43.27307","article-title":"Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice","volume":"272","author":"Peters","year":"1997","journal-title":"J Biol Chem"},{"issue":"2 Suppl 1","key":"10.1038\/mt.2015.64_bib29","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: from steatosis to cirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/mt.2015.64_bib30","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1038\/mt.2015.64_bib31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1096\/fj.04-2291fje","article-title":"A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats","volume":"19","author":"Carmiel-Haggai","year":"2005","journal-title":"FASEB J"},{"key":"10.1038\/mt.2015.64_bib32","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"key":"10.1038\/mt.2015.64_bib33","doi-asserted-by":"crossref","first-page":"9688","DOI":"10.1093\/nar\/gkt680","article-title":"Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion","volume":"41","author":"Yang","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/mt.2015.64_bib34","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.18632\/oncotarget.1614","article-title":"MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression","volume":"5","author":"Fang","year":"2014","journal-title":"Oncotarget"},{"key":"10.1038\/mt.2015.64_bib35","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1038\/ncomms3914","article-title":"The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs","volume":"5","author":"Rutnam","year":"2014","journal-title":"Nat Commun"},{"key":"10.1038\/mt.2015.64_bib36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1096\/fj.12-220905","article-title":"Versican 3\u2019-untranslated region (3\u2019-UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity","volume":"27","author":"Fang","year":"2013","journal-title":"FASEB J"},{"key":"10.1038\/mt.2015.64_bib37","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/mt.2014.115","article-title":"Anti-microRNA-378a enhances wound healing process by upregulating integrin beta-3 and vimentin","volume":"22","author":"Li","year":"2014","journal-title":"Mol Ther"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616301538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616301538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T16:50:44Z","timestamp":1651769444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616301538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1525001616301538"],"URL":"https:\/\/doi.org\/10.1038\/mt.2015.64","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}