{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:43:34Z","timestamp":1780397014678,"version":"3.54.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1038\/mt.2016.102","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T20:12:43Z","timestamp":1463861563000},"page":"1712-1725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Boosting Central Nervous System Axon Regeneration by Circumventing Limitations of Natural Cytokine Signaling"],"prefix":"10.1016","volume":"24","author":[{"given":"Marco","family":"Leibinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Andreadaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Gobrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Diekmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mt.2016.102_bib1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1038\/mt.2016.102_bib2","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.preteyeres.2012.06.005","article-title":"Promoting optic nerve regeneration","volume":"31","author":"Fischer","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1038\/mt.2016.102_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.conb.2014.03.007","article-title":"Signaling regulations of neuronal regenerative ability","volume":"27","author":"Lu","year":"2014","journal-title":"Curr Opin Neurobiol"},{"key":"10.1038\/mt.2016.102_bib4","doi-asserted-by":"crossref","first-page":"e805","DOI":"10.1038\/cddis.2013.310","article-title":"Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration","volume":"4","author":"Leibinger","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1038\/mt.2016.102_bib5","doi-asserted-by":"crossref","first-page":"14334","DOI":"10.1523\/JNEUROSCI.2770-09.2009","article-title":"Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor","volume":"29","author":"Leibinger","year":"2009","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2016.102_bib6","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1038\/mt.2016.102_bib7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1167\/iovs.09-4203","article-title":"Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys","volume":"51","author":"Hauk","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2016.102_bib8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.mcn.2007.11.002","article-title":"Crystallins of the beta\/gamma-superfamily mimic the effects of lens injury and promote axon regeneration","volume":"37","author":"Fischer","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"10.1038\/mt.2016.102_bib9","first-page":"3943","article-title":"Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture","volume":"41","author":"Fischer","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2016.102_bib10","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","article-title":"Lens injury stimulates axon regeneration in the mature rat optic nerve","volume":"20","author":"Leon","year":"2000","journal-title":"J Neurosci"},{"issue":"Pt 4","key":"10.1038\/mt.2016.102_bib11","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/brain\/awl015","article-title":"Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo","volume":"129","author":"Pernet","year":"2006","journal-title":"Brain"},{"key":"10.1038\/mt.2016.102_bib12","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/j.1460-9568.2005.04034.x","article-title":"Lens injury stimulates adult mouse retinal ganglion cell axon regeneration via both macrophage- and lens-derived factors","volume":"21","author":"Lorber","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1038\/mt.2016.102_bib13","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1073\/pnas.1423221112","article-title":"Neuroinflammation triggered by \u03b2-glucan\/dectin-1 signaling enables CNS axon regeneration","volume":"112","author":"Baldwin","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1038\/mt.2016.102_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.nbd.2011.08.008","article-title":"Activated retinal glia mediated axon regeneration in experimental glaucoma","volume":"45","author":"Lorber","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1038\/mt.2016.102_bib15","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/jnr.22095","article-title":"Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E","volume":"87","author":"Lorber","year":"2009","journal-title":"J Neurosci Res"},{"issue":"Pt 12","key":"10.1038\/mt.2016.102_bib16","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1093\/brain\/awm257","article-title":"Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation","volume":"130","author":"M\u00fcller","year":"2007","journal-title":"Brain"},{"key":"10.1038\/mt.2016.102_bib17","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/sj.gt.3302791","article-title":"AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells","volume":"13","author":"Leaver","year":"2006","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2016.102_bib18","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1111\/j.1460-9568.2006.05230.x","article-title":"Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice","volume":"24","author":"Leaver","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1038\/mt.2016.102_bib19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.nbd.2012.11.011","article-title":"Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve","volume":"51","author":"Pernet","year":"2013","journal-title":"Neurobiol Dis"},{"issue":"Pt 1","key":"10.1038\/mt.2016.102_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/brain\/awm284","article-title":"ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells","volume":"131","author":"Lingor","year":"2008","journal-title":"Brain"},{"key":"10.1038\/mt.2016.102_bib21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 deletion promotes optic nerve regeneration in vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"key":"10.1038\/mt.2016.102_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mcn.2009.04.002","article-title":"Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration in injured retina","volume":"41","author":"Park","year":"2009","journal-title":"Mol Cell Neurosci"},{"key":"10.1038\/mt.2016.102_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature10594","article-title":"Sustained axon regeneration induced by co-deletion of PTEN and SOCS3","volume":"480","author":"Sun","year":"2011","journal-title":"Nature"},{"key":"10.1038\/mt.2016.102_bib24","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.expneurol.2013.03.001","article-title":"Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury","volume":"247","author":"Luo","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1038\/mt.2016.102_bib25","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1523\/JNEUROSCI.4340-10.2010","article-title":"Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion","volume":"30","author":"Kurimoto","year":"2010","journal-title":"J Neurosci"},{"issue":"Pt 1","key":"10.1038\/mt.2016.102_bib26","first-page":"1","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem J"},{"key":"10.1038\/mt.2016.102_bib27","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/cne.21174","article-title":"Immunohistochemical localization of CNTFRalpha in adult mouse retina and optic nerve following intraorbital nerve crush: evidence for the axonal loss of a trophic factor receptor after injury","volume":"500","author":"Miotke","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1038\/mt.2016.102_bib28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","article-title":"Plasticity and cross-talk of interleukin 6-type cytokines","volume":"23","author":"Garbers","year":"2012","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1038\/mt.2016.102_bib29","article-title":"Stressor-dependent alterations in glycoprotein 130: implications for glial cell reactivity, cytokine signaling and ganglion cell health in glaucoma","volume":"4","author":"Echevarria","year":"2013","journal-title":"J Clin Exp Ophthalmol"},{"key":"10.1038\/mt.2016.102_bib30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/nbt0297-142","article-title":"A bioreactive designer cytokine for human hematopoietic progenitor cell expansion","volume":"1","author":"Fischer","year":"1997","journal-title":"Nat Biotechnol"},{"key":"10.1038\/mt.2016.102_bib31","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.4049\/jimmunol.161.7.3575","article-title":"In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6","volume":"161","author":"Peters","year":"1998","journal-title":"J Immunol"},{"key":"10.1038\/mt.2016.102_bib32","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1189\/jlb.0410217","article-title":"gp130 at the nexus of inflammation, autoimmunity, and cancer","volume":"88","author":"Silver","year":"2010","journal-title":"J Leukoc Biol"},{"key":"10.1038\/mt.2016.102_bib33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.nbd.2012.01.004","article-title":"Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation","volume":"46","author":"Leibinger","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1038\/mt.2016.102_bib34","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1523\/JNEUROSCI.0815-06.2006","article-title":"The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth","volume":"26","author":"Cao","year":"2006","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2016.102_bib35","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","article-title":"Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation","volume":"24","author":"Fischer","year":"2004","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2016.102_bib36","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1038\/cddis.2013.126","article-title":"Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation","volume":"4","author":"Leibinger","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1038\/mt.2016.102_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0912942107","article-title":"What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?","volume":"107","author":"Fischer","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mt.2016.102_bib38","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jhep.2010.08.017","article-title":"Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K\/AKT activation","volume":"54","author":"Nechemia-Arbely","year":"2011","journal-title":"J Hepatol"},{"key":"10.1038\/mt.2016.102_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2009.03.002","article-title":"Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF","author":"M\u00fcller","year":"2009","journal-title":"Mol Cell Neurosci"},{"key":"10.1038\/mt.2016.102_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/07853899708998744","article-title":"The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines","volume":"29","author":"Taga","year":"1997","journal-title":"Ann Med"},{"key":"10.1038\/mt.2016.102_bib41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1084\/jem.20131780","article-title":"B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS","volume":"211","author":"O'Donovan","year":"2014","journal-title":"J Exp Med"},{"key":"10.1038\/mt.2016.102_bib42","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/107999099313974","article-title":"The IL-6\/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons","volume":"19","author":"Sch\u00e4fer","year":"1999","journal-title":"J Interferon Cytokine Res"},{"key":"10.1038\/mt.2016.102_bib43","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1074\/jbc.274.3.1257","article-title":"The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro","volume":"274","author":"Rakemann","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1038\/mt.2016.102_bib44","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nn.2603","article-title":"PTEN deletion enhances the regenerative ability of adult corticospinal neurons","volume":"13","author":"Liu","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1038\/mt.2016.102_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.expneurol.2009.12.032","article-title":"PTEN\/mTOR and axon regeneration","volume":"223","author":"Park","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1038\/mt.2016.102_bib46","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1523\/JNEUROSCI.4885-10.2011","article-title":"Taxol facilitates axon regeneration in the mature CNS","volume":"31","author":"Sengottuvel","year":"2011","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2016.102_bib47","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1523\/JNEUROSCI.5119-03.2004","article-title":"Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state","volume":"24","author":"Fischer","year":"2004","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2016.102_bib48","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuron.2015.03.060","article-title":"Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics","volume":"86","author":"Belin","year":"2015","journal-title":"Neuron"},{"key":"10.1038\/mt.2016.102_bib49","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/gt.2015.51","article-title":"Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target","volume":"22","author":"Yungher","year":"2015","journal-title":"Gene Ther"},{"key":"10.1038\/mt.2016.102_bib50","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4161\/cib.15552","article-title":"Facilitating axon regeneration in the injured CNS by microtubules stabilization","volume":"4","author":"Sengottuvel","year":"2011","journal-title":"Commun Integr Biol"},{"key":"10.1038\/mt.2016.102_bib51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1152\/physiolgenomics.00067.2002","article-title":"Of mice and models: improved animal models for biomedical research","volume":"11","author":"Bockamp","year":"2002","journal-title":"Physiol Genomics"},{"key":"10.1038\/mt.2016.102_bib52","first-page":"3292","article-title":"Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa","volume":"43","author":"Tao","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mt.2016.102_bib53","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1523\/JNEUROSCI.23-06-02284.2003","article-title":"Macrophage-derived factors stimulate optic nerve regeneration","volume":"23","author":"Yin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2016.102_bib54","first-page":"Unit3.22","article-title":"A method for preparing primary retinal cell cultures for evaluating the neuroprotective and neuritogenic effect of factors on axotomized mature CNS neurons","volume":"Chapter 3","author":"Grozdanov","year":"2010","journal-title":"Curr Protoc Neurosci"},{"key":"10.1038\/mt.2016.102_bib55","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1096\/fj.05-5339fje","article-title":"TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin","volume":"20","author":"Ahmed","year":"2006","journal-title":"FASEB J"},{"key":"10.1038\/mt.2016.102_bib56","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1523\/JNEUROSCI.17-12-04623.1997","article-title":"Expression of specific tubulin isotypes increases during regeneration of injured CNS neurons, but not after the application of brain-derived neurotrophic factor (BDNF)","volume":"17","author":"Fournier","year":"1997","journal-title":"J Neurosci"},{"key":"10.1038\/mt.2016.102_bib57","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1038\/ncomms5561","article-title":"Sustained GSK3 activity markedly facilitates nerve regeneration","volume":"5","author":"Gobrecht","year":"2014","journal-title":"Nat Commun"},{"key":"10.1038\/mt.2016.102_bib58","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2013.04.001","article-title":"CXCL12\/SDF-1 facilitates optic nerve regeneration","volume":"55","author":"Heskamp","year":"2013","journal-title":"Neurobiol Dis"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616454018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616454018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:52:00Z","timestamp":1761501120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616454018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1525001616454018"],"URL":"https:\/\/doi.org\/10.1038\/mt.2016.102","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Boosting Central Nervous System Axon Regeneration by Circumventing Limitations of Natural Cytokine Signaling","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/mt.2016.102","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Gene & Cell Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}