{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:31:29Z","timestamp":1791415889366,"version":"4.3.3"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":645,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1038\/mtm.2015.3","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T16:05:07Z","timestamp":1424880307000},"page":"15003","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss"],"prefix":"10.1016","volume":"2","author":[{"given":"H\u00e9l\u00e8ne","family":"Cwerman-Thibault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Lechauve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ayache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Ellouze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Alain","family":"Sahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Corral-Debrinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mtm.2015.3_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/346066","article-title":"The epidemiology of Leber hereditary optic neuropathy in the North East of England","volume":"72","author":"Man","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1038\/mtm.2015.3_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","article-title":"Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies","volume":"30","author":"Yu-Wai-Man","year":"2011","journal-title":"Prog Retin Eye Res"},{"key":"10.1038\/mtm.2015.3_bib3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bbabio.2009.02.024","article-title":"Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders","volume":"1787","author":"Carelli","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"Pt 9","key":"10.1038\/mtm.2015.3_bib4","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/brain\/awr170","article-title":"A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy","volume":"134","author":"Klopstock","year":"2011","journal-title":"Brain"},{"issue":"Pt 9","key":"10.1038\/mtm.2015.3_bib5","doi-asserted-by":"crossref","first-page":"e188","DOI":"10.1093\/brain\/awr180","article-title":"Idebenone treatment in Leber's hereditary optic neuropathy","volume":"134","author":"Carelli","year":"2011","journal-title":"Brain"},{"key":"10.1038\/mtm.2015.3_bib6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1001\/archneurol.2011.2972","article-title":"Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy","volume":"69","author":"Sadun","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1038\/mtm.2015.3_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrneurol.2012.167","article-title":"Treatment of hereditary optic neuropathies","volume":"8","author":"Newman","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"10.1038\/mtm.2015.3_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.crvi.2013.11.011","article-title":"Gene therapy for mitochondrial diseases: Leber Hereditary Optic Neuropathy as the first candidate for a clinical trial","volume":"337","author":"Cwerman-Thibault","year":"2014","journal-title":"C R Biol"},{"key":"10.1038\/mtm.2015.3_bib9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.mad.2011.05.002","article-title":"Mitochondrial transfection for studying organellar DNA repair, genome maintenance and aging","volume":"132","author":"Mileshina","year":"2011","journal-title":"Mech Ageing Dev"},{"key":"10.1038\/mtm.2015.3_bib10","first-page":"1668","article-title":"Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice","volume":"18","author":"Yu","year":"2012","journal-title":"Mol Vis"},{"key":"10.1038\/mtm.2015.3_bib11","doi-asserted-by":"crossref","first-page":"E1238","DOI":"10.1073\/pnas.1119577109","article-title":"Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model","volume":"109","author":"Yu","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mtm.2015.3_bib12","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1432-1033.1995.0762m.x","article-title":"Limitations to in vivo import of hydrophobic proteins into yeast mitochondria. The case of a cytoplasmically synthesized apocytochrome b","volume":"228","author":"Claros","year":"1995","journal-title":"Eur J Biochem"},{"key":"10.1038\/mtm.2015.3_bib13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/genetics\/165.2.707","article-title":"Limitations of allotopic expression of mitochondrial genes in mammalian cells","volume":"165","author":"Oca-Cossio","year":"2003","journal-title":"Genetics"},{"key":"10.1038\/mtm.2015.3_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/rej.2006.9.455","article-title":"Expression of algal nuclear ATP synthase subunit 6 in human cells results in protein targeting to mitochondria but no assembly into ATP synthase","volume":"9","author":"Bokori-Brown","year":"2006","journal-title":"Rejuvenation Res"},{"key":"10.1038\/mtm.2015.3_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/nar\/gkq769","article-title":"Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?","volume":"39","author":"Perales-Clemente","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/mtm.2015.3_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mito.2010.09.003","article-title":"What limits the allotopic expression of nucleus-encoded mitochondrial genes? The case of the chimeric Cox3 and Atp6 genes","volume":"11","author":"Figueroa-Mart\u00ednez","year":"2011","journal-title":"Mitochondrion"},{"key":"10.1038\/mtm.2015.3_bib17","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/ana.10354","article-title":"Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy","volume":"52","author":"Guy","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1038\/mtm.2015.3_bib18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/ng851","article-title":"Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus","volume":"30","author":"Manfredi","year":"2002","journal-title":"Nat Genet"},{"key":"10.1038\/mtm.2015.3_bib19","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1002\/pmic.200900201","article-title":"Recent advances in yeast organelle and membrane proteomics","volume":"9","author":"Premsler","year":"2009","journal-title":"Proteomics"},{"key":"10.1038\/mtm.2015.3_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.65.1.1","article-title":"Cytoplasmic type 80S ribosomes associated with yeast mitochondria. IV. Attachment of ribosomes to the outer membrane of isolated mitochondria","volume":"65","author":"Kellems","year":"1975","journal-title":"J Cell Biol"},{"key":"10.1038\/mtm.2015.3_bib21","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.1016\/S0021-9258(18)43480-1","article-title":"The products of mitochondria-bound cytoplasmic polysomes in yeast","volume":"255","author":"Ades","year":"1980","journal-title":"J Biol Chem"},{"key":"10.1038\/mtm.2015.3_bib22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1091\/mbc.E06-09-0827","article-title":"Mitochondria-associated yeast mRNAs and the biogenesis of molecular complexes","volume":"18","author":"Garcia","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1038\/mtm.2015.3_bib23","doi-asserted-by":"crossref","first-page":"e2293","DOI":"10.1371\/journal.pone.0002293","article-title":"Yeast mitochondrial biogenesis: a role for the PUF RNA-binding protein Puf3p in mRNA localization","volume":"3","author":"Saint-Georges","year":"2008","journal-title":"PLoS One"},{"key":"10.1038\/mtm.2015.3_bib24","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1091\/mbc.E03-02-0074","article-title":"The role of the 3\u2019 untranslated region in mRNA sorting to the vicinity of mitochondria is conserved from yeast to human cells","volume":"14","author":"Sylvestre","year":"2003","journal-title":"Mol Biol Cell"},{"key":"10.1038\/mtm.2015.3_bib25","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1261\/rna.18206","article-title":"mRNA localization to the mitochondrial surface allows the efficient translocation inside the organelle of a nuclear recoded ATP6 protein","volume":"12","author":"Kaltimbacher","year":"2006","journal-title":"RNA"},{"key":"10.1038\/mtm.2015.3_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1937-6448(08)01802-9","article-title":"Import of nuclear-encoded mitochondrial proteins: a cotranslational perspective","volume":"273","author":"Ahmed","year":"2009","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1038\/mtm.2015.3_bib27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/rej.2006.0526","article-title":"Allotopic mRNA localization to the mitochondrial surface rescues respiratory chain defects in fibroblasts harboring mitochondrial DNA mutations affecting complex I or v subunits","volume":"10","author":"Bonnet","year":"2007","journal-title":"Rejuvenation Res"},{"key":"10.1038\/mtm.2015.3_bib28","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbamcr.2008.04.018","article-title":"The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes","volume":"1783","author":"Bonnet","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/mtm.2015.3_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ajhg.2008.08.013","article-title":"Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction","volume":"83","author":"Ellouze","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1038\/mtm.2015.3_bib30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.visres.2007.07.027","article-title":"Versatility of AAV vectors for retinal gene transfer","volume":"48","author":"Surace","year":"2008","journal-title":"Vision Res"},{"key":"10.1038\/mtm.2015.3_bib31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/gt.2008.178","article-title":"Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection","volume":"16","author":"Hellstr\u00f6m","year":"2009","journal-title":"Gene Ther"},{"key":"10.1038\/mtm.2015.3_bib32","doi-asserted-by":"crossref","first-page":"e110612","DOI":"10.1371\/journal.pone.0110612","article-title":"Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts","volume":"9","author":"Mead","year":"2014","journal-title":"PLoS One"},{"key":"10.1038\/mtm.2015.3_bib33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.visres.2008.09.029","article-title":"A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats","volume":"49","author":"Salinas-Navarro","year":"2009","journal-title":"Vision Res"},{"key":"10.1038\/mtm.2015.3_bib34","first-page":"1540","article-title":"Gamma-synuclein as a marker of retinal ganglion cells","volume":"14","author":"Surgucheva","year":"2008","journal-title":"Mol Vis"},{"key":"10.1038\/mtm.2015.3_bib35","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1167\/iovs.08-3267","article-title":"Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas","volume":"50","author":"Nadal-Nicol\u00e1s","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mtm.2015.3_bib36","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.visres.2005.09.037","article-title":"High resolution fundus imaging by confocal scanning laser ophthalmoscopy in the mouse","volume":"46","author":"Paques","year":"2006","journal-title":"Vision Res"},{"key":"10.1038\/mtm.2015.3_bib37","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1017\/S0952523805225166","article-title":"Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system","volume":"22","author":"Douglas","year":"2005","journal-title":"Vis Neurosci"},{"key":"10.1038\/mtm.2015.3_bib38","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1167\/iovs.09-4021","article-title":"In vivo imaging of retinal ganglion cell axons within the nerve fiber layer","volume":"51","author":"Kanamori","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mtm.2015.3_bib39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ymeth.2008.06.014","article-title":"Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay","volume":"45","author":"S\u00f6derberg","year":"2008","journal-title":"Methods"},{"key":"10.1038\/mtm.2015.3_bib40","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1523\/JNEUROSCI.3701-09.2010","article-title":"Nicotinamide adenine dinucleotide-dependent binding of the neuronal Ca2+ sensor protein GCAP2 to photoreceptor synaptic ribbons","volume":"30","author":"Venkatesan","year":"2010","journal-title":"J Neurosci"},{"key":"10.1038\/mtm.2015.3_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2014.12.009","article-title":"Relationship between rat retinal degeneration and potassium channel KCNQ5 expression","volume":"131","author":"Caminos","year":"2015","journal-title":"Exp Eye Res"},{"key":"10.1038\/mtm.2015.3_bib42","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1074\/jbc.M114.607465","article-title":"Characterization of Cav1.4 Complexes (alpha11.4, beta2, alpha2delta4) in HEK293T cells and in the retina","volume":"290","author":"Lee","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1038\/mtm.2015.3_bib43","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbamcr.2012.08.004","article-title":"The dynamin GTPase OPA1: more than mitochondria?","volume":"1833","author":"Belenguer","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"Pt 2","key":"10.1038\/mtm.2015.3_bib44","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/brain\/awm335","article-title":"OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion","volume":"131","author":"Zanna","year":"2008","journal-title":"Brain"},{"key":"10.1038\/mtm.2015.3_bib45","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.bbabio.2007.07.008","article-title":"Human mitochondrial complex I assembly: a dynamic and versatile process","volume":"1767","author":"Vogel","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/mtm.2015.3_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ymeth.2008.09.023","article-title":"Electrophoresis techniques to investigate defects in oxidative phosphorylation","volume":"46","author":"Calvaruso","year":"2008","journal-title":"Methods"},{"key":"10.1038\/mtm.2015.3_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1634\/stemcells.2004-0163","article-title":"In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells","volume":"23","author":"Schindeh\u00fctte","year":"2005","journal-title":"Stem Cells"},{"key":"10.1038\/mtm.2015.3_bib48","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/mt.2014.44","article-title":"Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice","volume":"22","author":"Lechauve","year":"2014","journal-title":"Mol Ther"},{"key":"10.1038\/mtm.2015.3_bib49","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0140-6736(91)90057-V","article-title":"Assessment of the mitochondrial respiratory chain","volume":"338","author":"Rustin","year":"1991","journal-title":"Lancet"},{"key":"10.1038\/mtm.2015.3_bib50","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI104637","article-title":"A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study","volume":"41","author":"Luft","year":"1962","journal-title":"J Clin Invest"},{"key":"10.1038\/mtm.2015.3_bib51","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/331717a0","article-title":"Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies","volume":"331","author":"Holt","year":"1988","journal-title":"Nature"},{"key":"10.1038\/mtm.2015.3_bib52","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy","volume":"242","author":"Wallace","year":"1988","journal-title":"Science"},{"key":"10.1038\/mtm.2015.3_bib53","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S1474-4422(10)70116-2","article-title":"A neurological perspective on mitochondrial disease","volume":"9","author":"McFarland","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1038\/mtm.2015.3_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.21217","article-title":"Prevalence of mitochondrial DNA disease in adults","volume":"63","author":"Schaefer","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1038\/mtm.2015.3_bib55","first-page":"CD004426","article-title":"Treatment for mitochondrial disorders","volume":"4","author":"Pfeffer","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1038\/mtm.2015.3_bib56","doi-asserted-by":"crossref","first-page":"120ra15","DOI":"10.1126\/scitranslmed.3002865","article-title":"AAV2 gene therapy readministration in three adults with congenital blindness","volume":"4","author":"Bennett","year":"2012","journal-title":"Sci Transl Med"},{"issue":"Pt 7","key":"10.1038\/mtm.2015.3_bib57","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1093\/brain\/awm114","article-title":"Novel mutations of ND genes in complex I deficiency associated with mitochondrial encephalopathy","volume":"130","author":"Malfatti","year":"2007","journal-title":"Brain"},{"key":"10.1038\/mtm.2015.3_bib58","doi-asserted-by":"crossref","first-page":"20065","DOI":"10.1073\/pnas.1217113109","article-title":"Mouse mtDNA mutant model of Leber hereditary optic neuropathy","volume":"109","author":"Lin","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/mtm.2015.3_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.06-0789","article-title":"The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse","volume":"48","author":"Qi","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mtm.2015.3_bib60","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1167\/iovs.08-3214","article-title":"Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system","volume":"50","author":"Guy","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mtm.2015.3_bib61","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ejhg.2012.112","article-title":"Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy","volume":"21","author":"Chadderton","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1038\/mtm.2015.3_bib62","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/jamaophthalmol.2013.7630","article-title":"Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial","volume":"132","author":"Koilkonda","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1038\/mtm.2015.3_bib63","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1167\/iovs.14-15388","article-title":"LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile","volume":"55","author":"Koilkonda","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/mtm.2015.3_bib64","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2049-3002-1-11","article-title":"Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells","volume":"1","author":"Calabrese","year":"2013","journal-title":"Cancer Metab"},{"key":"10.1038\/mtm.2015.3_bib65","doi-asserted-by":"crossref","first-page":"541245","DOI":"10.1155\/2012\/541245","article-title":"Nuclear expression of a mitochondrial DNA gene: mitochondrial targeting of allotopically expressed mutant ATP6 in transgenic mice","volume":"2012","author":"Dunn","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1038\/mtm.2015.3_bib66","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1038\/mtm.2015.3_bib67","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0022-510X(92)90181-J","article-title":"Molecular genetics of Leber's hereditary optic neuropathy: study of a six-generation family from Western Australia","volume":"108","author":"Sudoyo","year":"1992","journal-title":"J Neurol Sci"},{"key":"10.1038\/mtm.2015.3_bib68","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/01.wno.0000176631.87234.49","article-title":"Proportion of 11778 mutant mitochondrial DNA and clinical expression in a thai population with leber hereditary optic neuropathy","volume":"25","author":"Chuenkongkaew","year":"2005","journal-title":"J Neuroophthalmol"},{"key":"10.1038\/mtm.2015.3_bib69","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/WNO.0b013e3182745600","article-title":"Retinal ganglion cell functional plasticity and optic neuropathy: a comprehensive model","volume":"32","author":"Porciatti","year":"2012","journal-title":"J Neuroophthalmol"},{"key":"10.1038\/mtm.2015.3_bib70","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuroimage.2013.05.032","article-title":"Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss","volume":"81","author":"d'Almeida","year":"2013","journal-title":"Neuroimage"}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050116300158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050116300158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T19:02:22Z","timestamp":1651345342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050116300158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":70,"alternative-id":["S2329050116300158"],"URL":"https:\/\/doi.org\/10.1038\/mtm.2015.3","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]},"article-number":"15003"}}