{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:09:03Z","timestamp":1784758143363,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":1035,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy - Nucleic Acids"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1038\/mtna.2014.4","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T12:21:38Z","timestamp":1395145298000},"page":"e154","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes"],"prefix":"10.1016","volume":"3","author":[{"given":"Yasuhiro","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erina","family":"Suemitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Kajimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsana","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritada","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyoshi","family":"Harashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/mtna.2014.4_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/er.2009-0017","article-title":"Pathomechanisms of type 2 diabetes genes","volume":"30","author":"Staiger","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1038\/mtna.2014.4_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nrendo.2011.183","article-title":"The worldwide epidemiology of type 2 diabetes mellitus\u2013present and future perspectives","volume":"8","author":"Chen","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1038\/mtna.2014.4_bib3","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2174\/187153007782794353","article-title":"Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets?","volume":"7","author":"Buechler","year":"2007","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1038\/mtna.2014.4_bib4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1248\/bpb.33.1033","article-title":"DNA microarray analysis of whole blood cells and insulin-sensitive tissues reveals the usefulness of blood RNA profiling as a source of markers for predicting type 2 diabetes","volume":"33","author":"Hayashi","year":"2010","journal-title":"Biol Pharm Bull"},{"key":"10.1038\/mtna.2014.4_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.nutr.012809.104747","article-title":"Physiological insights gained from gene expression analysis in obesity and diabetes","volume":"30","author":"Keller","year":"2010","journal-title":"Annu Rev Nutr"},{"key":"10.1038\/mtna.2014.4_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrd3480","article-title":"How were new medicines discovered?","volume":"10","author":"Swinney","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/mtna.2014.4_bib7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd3478","article-title":"Trends in the exploitation of novel drug targets","volume":"10","author":"Rask-Andersen","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/mtna.2014.4_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrd2372","article-title":"Strategies for the discovery and development of therapies for metastatic breast cancer","volume":"11","author":"Eckhardt","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/mtna.2014.4_bib9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature03711","article-title":"Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes","volume":"436","author":"Yang","year":"2005","journal-title":"Nature"},{"key":"10.1038\/mtna.2014.4_bib10","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.1016\/j.jprot.2012.06.013","article-title":"Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer","volume":"75","author":"Sugihara","year":"2012","journal-title":"J Proteomics"},{"key":"10.1038\/mtna.2014.4_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature10423","article-title":"Deep sequencing reveals 50 novel genes for recessive cognitive disorders","volume":"478","author":"Najmabadi","year":"2011","journal-title":"Nature"},{"key":"10.1038\/mtna.2014.4_bib12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/msb.2009.10","article-title":"A systems approach to prion disease","volume":"5","author":"Hwang","year":"2009","journal-title":"Mol Syst Biol."},{"key":"10.1038\/mtna.2014.4_bib13","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.2337\/db10-0367","article-title":"A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease","volume":"59","author":"Mori","year":"2010","journal-title":"Diabetes"},{"key":"10.1038\/mtna.2014.4_bib14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1038\/mtna.2014.4_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature04688","article-title":"RNAi-mediated gene silencing in non-human primates","volume":"441","author":"Zimmermann","year":"2006","journal-title":"Nature"},{"key":"10.1038\/mtna.2014.4_bib16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1172\/JCI37515","article-title":"Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice","volume":"119","author":"Judge","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1038\/mtna.2014.4_bib17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1126\/science.1149859","article-title":"Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target","volume":"319","author":"Peer","year":"2008","journal-title":"Science"},{"key":"10.1038\/mtna.2014.4_bib18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ijpharm.2011.07.038","article-title":"Cell penetrating peptide-mediated systemic siRNA delivery to the liver","volume":"419","author":"Hayashi","year":"2011","journal-title":"Int J Pharm"},{"key":"10.1038\/mtna.2014.4_bib19","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1016\/j.biomaterials.2011.02.045","article-title":"Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid","volume":"32","author":"Hatakeyama","year":"2011","journal-title":"Biomaterials"},{"key":"10.1038\/mtna.2014.4_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jconrel.2012.09.009","article-title":"A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo","volume":"163","author":"Sato","year":"2012","journal-title":"J Control Release"},{"key":"10.1038\/mtna.2014.4_bib21","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1073\/pnas.132274899","article-title":"Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase","volume":"99","author":"Yen","year":"2002","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1038\/mtna.2014.4_bib22","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1194\/jlr.P025536","article-title":"Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver","volume":"53","author":"Hall","year":"2012","journal-title":"J Lipid Res."},{"key":"10.1038\/mtna.2014.4_bib23","doi-asserted-by":"crossref","first-page":"13656","DOI":"10.1073\/pnas.1203218109","article-title":"Nuclear receptor PPAR?-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis","volume":"109","author":"Lee","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1038\/mtna.2014.4_bib24","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrd1469","article-title":"Lipid metabolic enzymes: emerging drug targets for the treatment of obesity","volume":"3","author":"Shi","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/mtna.2014.4_bib25","doi-asserted-by":"crossref","first-page":"13860","DOI":"10.1074\/jbc.M300139200","article-title":"Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2","volume":"278","author":"Cao","year":"2003","journal-title":"J Biol Chem."},{"key":"10.1038\/mtna.2014.4_bib26","doi-asserted-by":"crossref","first-page":"18532","DOI":"10.1074\/jbc.M301633200","article-title":"MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine","volume":"278","author":"Yen","year":"2003","journal-title":"J Biol Chem."},{"key":"10.1038\/mtna.2014.4_bib27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nm.1937","article-title":"Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding","volume":"15","author":"Yen","year":"2009","journal-title":"Nat Med"},{"key":"10.1038\/mtna.2014.4_bib28","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat Med"},{"key":"10.1038\/mtna.2014.4_bib29","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature03001","article-title":"Finishing the euchromatic sequence of the human genome","volume":"431","author":"International Human Genome Sequencing Consortium","year":"2004","journal-title":"Nature"},{"key":"10.1038\/mtna.2014.4_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2337\/db09-1894","article-title":"P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance","volume":"60","author":"Sato","year":"2011","journal-title":"Diabetes"},{"key":"10.1038\/mtna.2014.4_bib31","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1073\/pnas.1114513109","article-title":"Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes","volume":"109","author":"Kodama","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1038\/mtna.2014.4_bib32","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1016\/j.ejca.2006.07.008","article-title":"Gene expression profile analysis of an isogenic tumour metastasis model reveals a functional role for oncogene AF1Q in breast cancer metastasis","volume":"42","author":"Li","year":"2006","journal-title":"Eur J Cancer"},{"key":"10.1038\/mtna.2014.4_bib33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1186\/1471-2164-11-675","article-title":"Age and sex dependent changes in liver gene expression during the life cycle of the rat","volume":"11","author":"Kwekel","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1038\/mtna.2014.4_bib34","first-page":"R1025","article-title":"Dietary obesity in nine inbred mouse strains","volume":"262","author":"West","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1038\/mtna.2014.4_bib35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cmet.2009.01.002","article-title":"Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy","volume":"9","author":"Cort\u00e9s","year":"2009","journal-title":"Cell Metab"},{"key":"10.1038\/mtna.2014.4_bib36","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1016\/j.biomaterials.2010.04.031","article-title":"2-Methacryloyloxyethyl phosphorylcholine polymer (MPC)-coating improves the transfection activity of GALA-modified lipid nanoparticles by assisting the cellular uptake and intracellular dissociation of plasmid DNA in primary hepatocytes","volume":"31","author":"Ukawa","year":"2010","journal-title":"Biomaterials"},{"key":"10.1038\/mtna.2014.4_bib37","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1210\/en.2009-1349","article-title":"Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover","volume":"151","author":"Watanabe","year":"2010","journal-title":"Endocrinology"}],"container-title":["Molecular Therapy - Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S216225311630292X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S216225311630292X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:00:26Z","timestamp":1538773226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S216225311630292X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":37,"alternative-id":["S216225311630292X"],"URL":"https:\/\/doi.org\/10.1038\/mtna.2014.4","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"article-number":"e154"}}