{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:52:19Z","timestamp":1767963139999,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":1035,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy - Nucleic Acids"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1038\/mtna.2014.59","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T16:18:51Z","timestamp":1415117931000},"page":"e208","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models"],"prefix":"10.1016","volume":"3","author":[{"given":"Yudan","family":"Chi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildegund C J","family":"Ertl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/mtna.2014.59_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1038\/mtna.2014.59_bib2","first-page":"3143","article-title":"The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression","volume":"59","author":"Li","year":"1999","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1158\/1541-7786.MCR-12-0670","article-title":"Nuclear expression of \u03b2-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells","volume":"11","author":"Han","year":"2013","journal-title":"Mol Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib4","first-page":"5071","article-title":"Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer","volume":"58","author":"Kawasaki","year":"1998","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib5","first-page":"5315","article-title":"IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs","volume":"58","author":"Tamm","year":"1998","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib6","first-page":"1808","article-title":"Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas","volume":"58","author":"Lu","year":"1998","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib7","first-page":"137","article-title":"Analysis of Bcl-2, Bax and Survivin genes in uterine cancer","volume":"15","author":"Saitoh","year":"1999","journal-title":"Int J Oncol"},{"key":"10.1038\/mtna.2014.59_bib8","first-page":"127","article-title":"Expression of survivin and its relationship to loss of apoptosis in breast carcinomas","volume":"6","author":"Tanaka","year":"2000","journal-title":"Clin Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2141.2001.02902.x","article-title":"Aberrant expression of caspase cascade regulatory genes in adult T-cell leukaemia: survivin is an important determinant for prognosis","volume":"114","author":"Kamihira","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1038\/mtna.2014.59_bib10","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1021\/bi001603q","article-title":"An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7","volume":"40","author":"Shin","year":"2001","journal-title":"Biochemistry"},{"key":"10.1038\/mtna.2014.59_bib11","first-page":"383","article-title":"Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis","volume":"18","author":"Wang","year":"2007","journal-title":"Oncol Rep"},{"key":"10.1038\/mtna.2014.59_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1476-5586(04)80051-4","article-title":"Upregulation of survivin in G2\/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis","volume":"6","author":"Chandele","year":"2004","journal-title":"Neoplasia"},{"key":"10.1038\/mtna.2014.59_bib13","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1242\/jcs.01242","article-title":"Survivin dynamics increases at centromeres during G2\/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity","volume":"117","author":"Beardmore","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1038\/mtna.2014.59_bib14","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bbrc.2006.09.143","article-title":"Nuclear interaction of Smac\/DIABLO with Survivin at G2\/M arrest prompts docetaxel-induced apoptosis in DU145 prostate cancer cells","volume":"350","author":"Kim","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/mtna.2014.59_bib15","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1038\/mtna.2014.59_bib16","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.4049\/jimmunol.1301728","article-title":"MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation","volume":"191","author":"Aucher","year":"2013","journal-title":"J Immunol"},{"key":"10.1038\/mtna.2014.59_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/cgt.2012.81","article-title":"Targeting microRNAs to modulate TRAIL-induced apoptosis of cancer cells","volume":"20","author":"Lu","year":"2013","journal-title":"Cancer Gene Ther"},{"key":"10.1038\/mtna.2014.59_bib18","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.3390\/ijms10052158","article-title":"Construction of an artificial MicroRNA expression vector for simultaneous inhibition of multiple genes in mammalian cells","volume":"10","author":"Hu","year":"2009","journal-title":"Int J Mol Sci"},{"key":"10.1038\/mtna.2014.59_bib19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neulet.2010.03.051","article-title":"Artificial microRNA-based neurokinin-1 receptor gene silencing reduces alcohol consumption in mice","volume":"475","author":"Baek","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1038\/mtna.2014.59_bib20","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/gt.2011.145","article-title":"Artificial microRNA interference targeting AT(1a) receptors in paraventricular nucleus attenuates hypertension in rats","volume":"19","author":"Fan","year":"2012","journal-title":"Gene Ther"},{"key":"10.1038\/mtna.2014.59_bib21","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.7314\/APJCP.2012.13.6.2813","article-title":"Establishment and characterization of MTDH knockdown by artificial MicroRNA interference - functions as a potential tumor suppressor in breast cancer","volume":"13","author":"Wang","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1038\/mtna.2014.59_bib22","first-page":"3433","article-title":"Inhibition of invasion and metastasis of gastric cancer cells through snail targeting artificial microRNA interference","volume":"12","author":"Guo","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1038\/mtna.2014.59_bib23","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/ijc.23643","article-title":"Expression and prognostic impact of PRL-3 in lymph node metastasis of gastric cancer: its molecular mechanism was investigated using artificial microRNA interference","volume":"123","author":"Wang","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1038\/mtna.2014.59_bib24","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbrc.2007.09.007","article-title":"Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNA","volume":"363","author":"Liang","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/mtna.2014.59_bib25","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.radonc.2012.03.018","article-title":"A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin","volume":"103","author":"Reichert","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1038\/mtna.2014.59_bib26","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1158\/1535-7163.MCT-06-0193","article-title":"Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis","volume":"5","author":"Blum","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/mtna.2014.59_bib27","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0960-9822(03)00205-7","article-title":"S. pombe aurora kinase\/survivin is required for chromosome condensation and the spindle checkpoint attachment response","volume":"13","author":"Petersen","year":"2003","journal-title":"Curr Biol."},{"key":"10.1038\/mtna.2014.59_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1172\/JCI200112983","article-title":"Cancer gene therapy using a survivin mutant adenovirus","volume":"108","author":"Mesri","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1038\/mtna.2014.59_bib29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1517\/14728222.12.4.463","article-title":"Targeting survivin in cancer therapy","volume":"12","author":"Pennati","year":"2008","journal-title":"Expert Opin Ther Targets"},{"key":"10.1038\/mtna.2014.59_bib30","doi-asserted-by":"crossref","first-page":"262967","DOI":"10.1155\/2013\/262967","article-title":"Potential survival benefit of anti-apoptosis protein: survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer\u2013results from phase I clinical trials","volume":"2013","author":"Tanaka","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1038\/mtna.2014.59_bib31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1158\/1535-7163.MCT-10-0756","article-title":"Antisense inhibition of survivin expression as a cancer therapeutic","volume":"10","author":"Carrasco","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/mtna.2014.59_bib32","first-page":"1445","article-title":"SiRNA-mediated survivin inhibition enhances chemo- or radiosensivity of colorectal cancer cells in tumor-bearing nude mice","volume":"57","author":"Chu","year":"2010","journal-title":"Hepatogastroenterology"},{"key":"10.1038\/mtna.2014.59_bib33","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3892\/mmr.2013.1308","article-title":"Recombinant attenuated Salmonella typhimurium carrying a plasmid co-expressing ENDO-VEGI151 and survivin siRNA inhibits the growth of breast cancer in vivo","volume":"7","author":"Li","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1038\/mtna.2014.59_bib34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3727\/096504013X13775486749416","article-title":"Inhibition of lymphatic metastases by a survivin dominant-negative mutant","volume":"20","author":"Xu","year":"2012","journal-title":"Oncol Res."},{"key":"10.1038\/mtna.2014.59_bib35","first-page":"4507","article-title":"The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients","volume":"63","author":"Casati","year":"2003","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib36","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s00262-009-0691-x","article-title":"Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer","volume":"58","author":"Honma","year":"2009","journal-title":"Cancer Immunol Immunother"},{"key":"10.1038\/mtna.2014.59_bib37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02829558","article-title":"Effects of Survivin expression suppressed by short hairpin RNA on MCF-7 cells","volume":"26","author":"Xiong","year":"2006","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.1038\/mtna.2014.59_bib38","first-page":"951","article-title":"[Short hairpin RNA-mediated survivin gene silencing inhibits invasion and metastasis of human colon carcinoma cell line SW480 in vitro]","volume":"27","author":"Wu","year":"2007","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1038\/mtna.2014.59_bib39","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1093\/nar\/gkq354","article-title":"Designing small multiple-target artificial RNAs","volume":"38","author":"De Guire","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1038\/mtna.2014.59_bib40","doi-asserted-by":"crossref","first-page":"e1095","DOI":"10.1038\/cddis.2014.47","article-title":"MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2","volume":"5","author":"Ruan","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1038\/mtna.2014.59_bib41","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.1158\/0008-5472.CAN-10-2010","article-title":"The promise of microRNA replacement therapy","volume":"70","author":"Bader","year":"2010","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib42","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1038\/mtna.2014.59_bib43","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/labinvest.2010.126","article-title":"Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans","volume":"90","author":"Marquez","year":"2010","journal-title":"Lab Invest"},{"key":"10.1038\/mtna.2014.59_bib44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ki.2012.150","article-title":"MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease","volume":"82","author":"Mak","year":"2012","journal-title":"Kidney Int"},{"key":"10.1038\/mtna.2014.59_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/clpt.2012.192","article-title":"Clinical applications for microRNAs in cancer","volume":"93","author":"Nana-Sinkam","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1038\/mtna.2014.59_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ymthe.2005.04.006","article-title":"Gene targeting with viral vectors","volume":"12","author":"Hendrie","year":"2005","journal-title":"Mol Ther"},{"key":"10.1038\/mtna.2014.59_bib47","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3390\/cancers3010603","article-title":"Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer","volume":"3","author":"Norian","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1038\/mtna.2014.59_bib48","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1073\/pnas.91.19.8802","article-title":"An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3","volume":"91","author":"Bett","year":"1994","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1038\/mtna.2014.59_bib49","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1128\/JVI.67.10.5911-5921.1993","article-title":"Packaging capacity and stability of human adenovirus type 5 vectors","volume":"67","author":"Bett","year":"1993","journal-title":"J Virol"},{"key":"10.1038\/mtna.2014.59_bib50","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/nprot.2010.134","article-title":"An efficient method of directly cloning chimpanzee adenovirus as a vaccine vector","volume":"5","author":"Zhou","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1038\/mtna.2014.59_bib51","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.molcel.2012.01.006","article-title":"The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras","volume":"45","author":"Gus-Brautbar","year":"2012","journal-title":"Mol Cell"},{"key":"10.1038\/mtna.2014.59_bib52","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2009.02.051","article-title":"Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells","volume":"282","author":"Yoo","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1038\/mtna.2014.59_bib53","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/jsre.1998.5313","article-title":"Multiply radioiodinated somatostatin analogs induce receptor-specific cytotoxicity","volume":"76","author":"Meyers","year":"1998","journal-title":"J Surg Res."},{"key":"10.1038\/mtna.2014.59_bib54","first-page":"7803","article-title":"Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues","volume":"61","author":"Tu","year":"2001","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib55","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1128\/JVI.77.5.2928-2935.2003","article-title":"Persistent replication of hepatitis C virus replicons expressing the beta-lactamase reporter in subpopulations of highly permissive Huh7 cells","volume":"77","author":"Murray","year":"2003","journal-title":"J Virol"},{"key":"10.1038\/mtna.2014.59_bib56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/376037a0","article-title":"Identification and inhibition of the ICE\/CED-3 protease necessary for mammalian apoptosis","volume":"376","author":"Nicholson","year":"1995","journal-title":"Nature"},{"key":"10.1038\/mtna.2014.59_bib57","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/34214","article-title":"Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis","volume":"391","author":"Sakahira","year":"1998","journal-title":"Nature"},{"key":"10.1038\/mtna.2014.59_bib58","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/jmbi.1994.1129","article-title":"Formation of two-dimensional arrays of annexin V on phosphatidylserine-containing liposomes","volume":"236","author":"Pigault","year":"1994","journal-title":"J Mol Biol."},{"key":"10.1038\/mtna.2014.59_bib59","first-page":"1965","article-title":"bcl-xs gene therapy induces apoptosis of human mammary tumors in nude mice","volume":"56","author":"Ealovega","year":"1996","journal-title":"Cancer Res."},{"key":"10.1038\/mtna.2014.59_bib60","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.febslet.2012.05.054","article-title":"miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma","volume":"586","author":"Zheng","year":"2012","journal-title":"FEBS Lett"}],"container-title":["Molecular Therapy - Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S216225311630347X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S216225311630347X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T12:13:27Z","timestamp":1598444007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S216225311630347X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":60,"alternative-id":["S216225311630347X"],"URL":"https:\/\/doi.org\/10.1038\/mtna.2014.59","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"article-number":"e208"}}