{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:40:24Z","timestamp":1774262424764,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":645,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy - Oncolytics"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1038\/mto.2015.1","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T22:38:44Z","timestamp":1424212724000},"page":"15001","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Retargeted oncolytic adenovirus displaying a single variable domain of camelid heavy-chain-only antibody in a fiber protein"],"prefix":"10.1016","volume":"2","author":[{"given":"Elisabeth A","family":"van Erp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyudmila N","family":"Kaliberova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey A","family":"Kaliberov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T","family":"Curiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/mto.2015.1_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/mp100219n","article-title":"Oncolytic adenoviruses for the treatment of human cancer: focus on translational and clinical data","volume":"8","author":"Pesonen","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1038\/mto.2015.1_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jnci\/djj111","article-title":"China approves world's first oncolytic virus therapy for cancer treatment","volume":"98","author":"Garber","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/mto.2015.1_bib3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mt.2009.266","article-title":"Current issues and future directions of oncolytic adenoviruses","volume":"18","author":"Yamamoto","year":"2010","journal-title":"Mol Ther"},{"key":"10.1038\/mto.2015.1_bib4","first-page":"37","article-title":"Conditionally replicating adenoviruses as anticancer agents and ways to improve their efficacy","volume":"4","author":"Oosterhoff","year":"2004","journal-title":"J Exp Ther Oncol"},{"key":"10.1038\/mto.2015.1_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-398342-8.00002-1","article-title":"Chapter two\u2013Adenovirus strategies for tissue-specific targeting","volume":"115","author":"Beatty","year":"2012","journal-title":"Adv Cancer Res"},{"key":"10.1038\/mto.2015.1_bib6","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"Bergelson","year":"1997","journal-title":"Science"},{"key":"10.1038\/mto.2015.1_bib7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1021\/mp050045c","article-title":"Genetic targeting strategies for adenovirus","volume":"2","author":"Noureddini","year":"2005","journal-title":"Mol Pharm"},{"key":"10.1038\/mto.2015.1_bib8","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/sj.cgt.7700928","article-title":"Transductional targeting of adenovirus vectors for gene therapy","volume":"13","author":"Glasgow","year":"2006","journal-title":"Cancer Gene Ther"},{"key":"10.1038\/mto.2015.1_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1517\/14712598.5.1.111","article-title":"Nanobodies as novel agents for cancer therapy","volume":"5","author":"Revets","year":"2005","journal-title":"Expert Opin Biol Ther"},{"key":"10.1038\/mto.2015.1_bib10","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1158\/0008-5472.CAN-03-3935","article-title":"Efficient cancer therapy with a nanobody-based conjugate","volume":"64","author":"Cortez-Retamozo","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/mto.2015.1_bib11","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/labinvest.2014.82","article-title":"Adenoviral targeting using genetically incorporated camelid single variable domains","volume":"94","author":"Kaliberov","year":"2014","journal-title":"Lab Invest"},{"key":"10.1038\/mto.2015.1_bib12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/cgt.2014.26","article-title":"Experimental virotherapy of chemoresistant pancreatic carcinoma using infectivity-enhanced fiber-mosaic oncolytic adenovirus","volume":"21","author":"Kaliberov","year":"2014","journal-title":"Cancer Gene Ther"},{"key":"10.1038\/mto.2015.1_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.274.5286.373","article-title":"An adenovirus mutant that replicates selectively in p53-deficient human tumor cells","volume":"274","author":"Bischoff","year":"1996","journal-title":"Science"},{"key":"10.1038\/mto.2015.1_bib14","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/80474","article-title":"An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy","volume":"6","author":"Heise","year":"2000","journal-title":"Nat Med"},{"key":"10.1038\/mto.2015.1_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.onc.1203251","article-title":"A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo","volume":"19","author":"Fueyo","year":"2000","journal-title":"Oncogene"},{"key":"10.1038\/mto.2015.1_bib16","first-page":"2559","article-title":"Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells","volume":"57","author":"Rodriguez","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/mto.2015.1_bib17","first-page":"6012","article-title":"A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis","volume":"61","author":"Matsubara","year":"2001","journal-title":"Cancer Res"},{"key":"10.1038\/mto.2015.1_bib18","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1038\/sj.onc.1209044","article-title":"Oncolytic adenoviruses - selective retargeting to tumor cells","volume":"24","author":"Mathis","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/mto.2015.1_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10549-007-9587-7","article-title":"Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control","volume":"108","author":"Stoff-Khalili","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1038\/mto.2015.1_bib20","doi-asserted-by":"crossref","first-page":"11009","DOI":"10.1128\/JVI.01608-08","article-title":"Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA","volume":"82","author":"Yl\u00f6sm\u00e4ki","year":"2008","journal-title":"J Virol"},{"key":"10.1038\/mto.2015.1_bib21","doi-asserted-by":"crossref","first-page":"e8916","DOI":"10.1371\/journal.pone.0008916","article-title":"Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability","volume":"5","author":"Leja","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1038\/mto.2015.1_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.virusres.2005.10.002","article-title":"Generation and selection of targeted adenoviruses embodying optimized vector properties","volume":"116","author":"Noureddini","year":"2006","journal-title":"Virus Res"},{"key":"10.1038\/mto.2015.1_bib23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jgm.285","article-title":"Genetic retargeting of adenovirus vectors: functionality of targeting ligands and their influence on virus viability","volume":"4","author":"Magnusson","year":"2002","journal-title":"J Gene Med"},{"key":"10.1038\/mto.2015.1_bib24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1081\/CNV-58878","article-title":"Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer","volume":"23","author":"Goldstein","year":"2005","journal-title":"Cancer Invest"},{"key":"10.1038\/mto.2015.1_bib25","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.surg.2013.03.005","article-title":"Clinical significance of carcinoembryonic antigen in peritoneal lavage from patients with gastric cancer","volume":"154","author":"Kanetaka","year":"2013","journal-title":"Surgery"},{"key":"10.1038\/mto.2015.1_bib26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.lungcan.2011.11.012","article-title":"Carcinoembryonic antigen (CEA) as tumor marker in lung cancer","volume":"76","author":"Grunnet","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1038\/mto.2015.1_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000217926","article-title":"Carcinoembryonic antigen in staging and follow-up of patients with solid tumors","volume":"16","author":"Ballesta","year":"1995","journal-title":"Tumour Biol"},{"key":"10.1038\/mto.2015.1_bib28","first-page":"1347","article-title":"Emerging targets in cancer management: role of the CXCL12\/CXCR4 axis","volume":"6","author":"Cojoc","year":"2013","journal-title":"Onco Targets Ther"},{"key":"10.1038\/mto.2015.1_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.canlet.2013.10.006","article-title":"The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer","volume":"352","author":"Weitzenfeld","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1038\/mto.2015.1_bib30","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1158\/0008-5472.CAN-05-3497","article-title":"Syrian hamster as a permissive immunocompetent animal model for the study of oncolytic adenovirus vectors","volume":"66","author":"Thomas","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/mto.2015.1_bib31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/156652311796150363","article-title":"Advances and future challenges in adenoviral vector pharmacology and targeting","volume":"11","author":"Khare","year":"2011","journal-title":"Curr Gene Ther"},{"key":"10.1038\/mto.2015.1_bib32","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood-2009-03-208835","article-title":"Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer","volume":"114","author":"Alba","year":"2009","journal-title":"Blood"},{"key":"10.1038\/mto.2015.1_bib33","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1158\/1535-7163.MCT-10-0332","article-title":"Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy","volume":"9","author":"Short","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/mto.2015.1_bib34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.virol.2013.09.020","article-title":"Retargeting of gene expression using endothelium specific hexon modified adenoviral vector","volume":"447","author":"Kaliberov","year":"2013","journal-title":"Virology"},{"key":"10.1038\/mto.2015.1_bib35","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.3390\/v2102290","article-title":"Tropism-modification strategies for targeted gene delivery using adenoviral vectors","volume":"2","author":"Coughlan","year":"2010","journal-title":"Viruses"},{"key":"10.1038\/mto.2015.1_bib36","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/mt.2008.307","article-title":"Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver","volume":"17","author":"Di Paolo","year":"2009","journal-title":"Mol Ther"},{"key":"10.1038\/mto.2015.1_bib37","doi-asserted-by":"crossref","first-page":"11367","DOI":"10.1128\/JVI.77.21.11367-11377.2003","article-title":"Genetically targeted adenovirus vector directed to CD40-expressing cells","volume":"77","author":"Belousova","year":"2003","journal-title":"J Virol"},{"key":"10.1038\/mto.2015.1_bib38","first-page":"3657","article-title":"Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line","volume":"51","author":"Robbins","year":"1991","journal-title":"Cancer Res"}],"container-title":["Molecular Therapy - Oncolytics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770516300055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2372770516300055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T05:23:08Z","timestamp":1537852988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2372770516300055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":38,"alternative-id":["S2372770516300055"],"URL":"https:\/\/doi.org\/10.1038\/mto.2015.1","relation":{},"ISSN":["2372-7705"],"issn-type":[{"value":"2372-7705","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]},"article-number":"15001"}}