{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:10:13Z","timestamp":1791205813985,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6896","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2002,7]]},"DOI":"10.1038\/nature00878","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T17:36:01Z","timestamp":1027877761000},"page":"426-430","source":"Crossref","is-referenced-by-count":831,"title":["Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness"],"prefix":"10.1038","volume":"418","author":[{"given":"Paul","family":"Van Eerdewegh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall D.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9e","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Del Mastro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Falls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Torrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Pandit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"McKenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Braunschweiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Folz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Bawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Saracino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Thackston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Benchekroun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neva","family":"Capparell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Adair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"FitzGerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Pedan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvyn R.","family":"Danzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby P.","family":"Umland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis M.","family":"Cuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steuart","family":"Rorke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne B.","family":"Clough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Holgate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim P.","family":"Keith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,7,10]]},"reference":[{"key":"BFnature00878_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1375\/1369052012191","volume":"4","author":"H Los","year":"2001","unstructured":"Los, H., Postmus, P. E. & Boomsma, D. I. Asthma genetics and intermediate phenotypes: a review from twin studies. Twin Res. 4, 81\u201393 (2001)","journal-title":"Twin Res."},{"key":"BFnature00878_CR2","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1164\/ajrccm.156.6.9611068","volume":"156","author":"The European Community Respiratory Health Survey","year":"1997","unstructured":"The European Community Respiratory Health Survey. Group genes for asthma? An analysis of the European Community Respiratory Health Survey. Am. J. Respir. Crit. Care Med. 156, 1773\u20131780 (1997)","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"BFnature00878_CR3","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/bioinformatics\/14.9.827","volume":"14","author":"M Wjst","year":"1998","unstructured":"Wjst, M. & Immervoll, T. An internet linkage and mutation database for the complex phenotype asthma. Bioinformatics 14, 827\u2013828 (1998)","journal-title":"Bioinformatics"},{"key":"BFnature00878_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0378-1119(01)00818-6","volume":"282","author":"T Yoshinaka","year":"2002","unstructured":"Yoshinaka, T. et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene 282, 227\u2013236 (2002)","journal-title":"Gene"},{"key":"BFnature00878_CR5","first-page":"27","volume":"11","author":"J Mullberg","year":"2000","unstructured":"Mullberg, J., Althoff, K., Jostock, T. & Rose-John, S. The importance of shedding of membrane proteins for cytokine biology. Eur. Cytokine Netw. 11, 27\u201338 (2000)","journal-title":"Eur. Cytokine Netw."},{"key":"BFnature00878_CR6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/genetics\/151.1.373","volume":"151","author":"J Dupuis","year":"1999","unstructured":"Dupuis, J. & Siegmund, D. Statistical methods for mapping quantitative trait loci from a dense set of markers. Genetics 151, 373\u2013386 (1999)","journal-title":"Genetics"},{"key":"BFnature00878_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/ng1095-150","volume":"11","author":"GT De Sanctis","year":"1995","unstructured":"De Sanctis, G. T. et al. Quantitative locus analysis of airway hyperresponsiveness in A\/J and C57BL\/6J mice. Nature Genet. 11, 150\u2013154 (1995)","journal-title":"Nature Genet."},{"key":"BFnature00878_CR8","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1023\/A:1020692710029","volume":"18","author":"AL Stone","year":"1999","unstructured":"Stone, A. L., Kroeger, M. & Sang, Q. X. A. Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins. J. Prot. Chem. 18, 447\u2013465 (1999)","journal-title":"J. Prot. Chem."},{"key":"BFnature00878_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0168-9525(99)01926-5","volume":"16","author":"P Primakoff","year":"2000","unstructured":"Primakoff, P. & Myles, D. G. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Genet. 16, 83\u201387 (2000)","journal-title":"Trends Genet."},{"key":"BFnature00878_CR10","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/S0955-0674(98)80042-2","volume":"10","author":"RA Black","year":"1998","unstructured":"Black, R. A. & White, J. M. ADAMs: focus on the protease domain. Curr. Opin. Cell Biol. 10, 654\u2013659 (1998)","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnature00878_CR11","doi-asserted-by":"publisher","first-page":"13427","DOI":"10.1074\/jbc.274.19.13427","volume":"274","author":"F Loechel","year":"1999","unstructured":"Loechel, F., Overgaard, M. T., Oxvig, C., Albrechtsen, R. & Wewer, U. M. Regulation of human ADAM 12 protease by the prodomain. J. Biol. Chem. 274, 13427\u201313433 (1999)","journal-title":"J. Biol. Chem."},{"key":"BFnature00878_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/bj3480021","volume":"348","author":"L Howard","year":"2000","unstructured":"Howard, L., Maciewicz, R. A. & Blobel, C. Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28. Biochem. J. 348, 21\u201327 (2000)","journal-title":"Biochem. J."},{"key":"BFnature00878_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1152\/physiolgenomics.2001.6.2.57","volume":"6","author":"M Das","year":"2001","unstructured":"Das, M., Harvey, I., Chu, L. L., Sinha, M. & Pelletier, J. Full length cDNAs: more than just reaching ends. Physiol. Genom. 6, 57\u201380 (2001)","journal-title":"Physiol. Genom."},{"key":"BFnature00878_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/83759","volume":"27","author":"LE Maquat","year":"2001","unstructured":"Maquat, L. E. The power of point mutations. Nature Genet. 27, 5\u20136 (2001)","journal-title":"Nature Genet."},{"key":"BFnature00878_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0091-6749(00)90066-6","volume":"105","author":"ST Holgate","year":"2000","unstructured":"Holgate, S. T. et al. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J. Allergy Clin. Immunol. 105, 193\u2013204 (2000)","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFnature00878_CR16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1165\/ajrcmb.25.3.4437","volume":"25","author":"A Richter","year":"2001","unstructured":"Richter, A. et al. The contribution of interleukin (il)-4 and il-13 to the epithelial-mesenchymal trophic unit in asthma. Am. J. Respir. Cell. Mol. Biol. 25, 385\u2013391 (2001)","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"BFnature00878_CR17","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/377652a0","volume":"377","author":"T Yagami-Hiromasa","year":"1995","unstructured":"Yagami-Hiromasa, T. et al. A metalloprotease-disintegrin participating in myoblast fusion. Nature 377, 652\u2013656 (1995)","journal-title":"Nature"},{"key":"BFnature00878_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1006\/geno.1998.5485","volume":"53","author":"P Wilkinson","year":"1998","unstructured":"Wilkinson, P. et al. Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores. Genomics 53, 251\u2013259 (1998)","journal-title":"Genomics"},{"key":"BFnature00878_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1101\/gr.7.2.165","volume":"7","author":"S Ghosh","year":"1997","unstructured":"Ghosh, S. et al. Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labelled dinucleotide markers. Genome Res. 7, 165\u2013178 (1997)","journal-title":"Genome Res."},{"key":"BFnature00878_CR20","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/gepi.1370050611","volume":"5","author":"K Lange","year":"1988","unstructured":"Lange, K., Weeks, D. & Boehnke, M. Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genet. Epidemiol. 5, 471\u2013472 (1988)","journal-title":"Genet. Epidemiol."},{"key":"BFnature00878_CR21","first-page":"22","volume":"48","author":"M Boehnke","year":"1991","unstructured":"Boehnke, M. Allele frequency estimation from data on relatives. Am. J. Hum. Genet. 48, 22\u201325 (1991)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature00878_CR22","first-page":"439","volume":"57","author":"L Kruglyak","year":"1995","unstructured":"Kruglyak, L. & Lander, E. S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet. 57, 439\u2013454 (1995)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature00878_CR23","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/ng0494-384","volume":"6","author":"TC Matise","year":"1994","unstructured":"Matise, T. C., Perlin, M. & Chakravarti, A. Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Nature Genet. 6, 384\u2013390 (1994)","journal-title":"Nature Genet."},{"key":"BFnature00878_CR24","first-page":"183","volume":"68","author":"RG Del Mastro","year":"1997","unstructured":"Del Mastro, R. G. & Lovett, M. Isolation of coding sequences from genomic regions using direct selection. Methods Mol. Biol. 68, 183\u2013199 (1997)","journal-title":"Methods Mol. Biol."},{"key":"BFnature00878_CR25","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/B978-0-08-092639-1.50020-4","volume-title":"Automated DNA Sequencing and Analysis","author":"MB Soares","year":"1994","unstructured":"Soares, M. B. in Automated DNA Sequencing and Analysis (eds Adams, M. D., Fields, C. & Venter, J. C.) 110\u2013114 (Academic, New York, 1994)"},{"key":"BFnature00878_CR26","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/352337a0","volume":"352","author":"HC Dietz","year":"1991","unstructured":"Dietz, H. C. et al. Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature 352, 337\u2013339 (1991)","journal-title":"Nature"},{"key":"BFnature00878_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/bioinformatics\/16.2.182","volume":"16","author":"GR Abecasis","year":"2000","unstructured":"Abecasis, G. R. & Cookson, W. O. C. GOLD-graphical overview of linkage disequilibrium. Bioinformatics 16, 182\u2013183 (2000)","journal-title":"Bioinformatics"},{"key":"BFnature00878_CR28","first-page":"921","volume":"12","author":"L Excoffier","year":"1995","unstructured":"Excoffier, L. & Slatkin, M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol. 12, 921\u2013927 (1995)","journal-title":"Mol. Biol. Evol."},{"key":"BFnature00878_CR29","first-page":"506","volume":"52","author":"RS Spielman","year":"1993","unstructured":"Spielman, R. S., McGinnis, R. E. & Ewens, W. J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506\u2013516 (1993)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature00878_CR30","first-page":"1347","volume":"58","author":"L Kruglyak","year":"1996","unstructured":"Kruglyak, L., Daly, M. J., Reeve-Daly, M. P. & Lander, E. S. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am. J. Hum. Genet. 58, 1347\u20131363 (1996)","journal-title":"Am. J. Hum. Genet."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature00878.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature00878","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature00878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nature00878.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:08:25Z","timestamp":1684418905000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature00878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":30,"journal-issue":{"issue":"6896","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["BFnature00878"],"URL":"https:\/\/doi.org\/10.1038\/nature00878","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1008849.113660","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1008849.113463","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}